DE69206820T2 - 1,3-Dihydro-2H-Imidano 4,5-b-quinolin-2-ein Derivate als Phosphodiestenase Hemmer - Google Patents

1,3-Dihydro-2H-Imidano 4,5-b-quinolin-2-ein Derivate als Phosphodiestenase Hemmer

Info

Publication number
DE69206820T2
DE69206820T2 DE69206820T DE69206820T DE69206820T2 DE 69206820 T2 DE69206820 T2 DE 69206820T2 DE 69206820 T DE69206820 T DE 69206820T DE 69206820 T DE69206820 T DE 69206820T DE 69206820 T2 DE69206820 T2 DE 69206820T2
Authority
DE
Germany
Prior art keywords
alkyl
compounds
dihydro
halo
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69206820T
Other languages
English (en)
Other versions
DE69206820D1 (de
Inventor
Eddy Freyne
Alfons Raeymaekers
Chaffoy De Courcelles Didie De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE69206820D1 publication Critical patent/DE69206820D1/de
Application granted granted Critical
Publication of DE69206820T2 publication Critical patent/DE69206820T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69206820T 1991-10-30 1992-10-27 1,3-Dihydro-2H-Imidano 4,5-b-quinolin-2-ein Derivate als Phosphodiestenase Hemmer Expired - Lifetime DE69206820T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78495591A 1991-10-30 1991-10-30
PCT/EP1992/002496 WO1993009118A1 (en) 1991-10-30 1992-10-27 1,3-dihydro-2h-imidazo(4,5-b)quinolin-2-one derivatives as phosphodiesterase inhibitors

Publications (2)

Publication Number Publication Date
DE69206820D1 DE69206820D1 (de) 1996-01-25
DE69206820T2 true DE69206820T2 (de) 1996-05-15

Family

ID=25134048

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69206820T Expired - Lifetime DE69206820T2 (de) 1991-10-30 1992-10-27 1,3-Dihydro-2H-Imidano 4,5-b-quinolin-2-ein Derivate als Phosphodiestenase Hemmer

Country Status (24)

Country Link
US (3) US5521187A (de)
EP (2) EP0610372B1 (de)
JP (1) JP3488922B2 (de)
KR (1) KR100251895B1 (de)
CN (1) CN1041726C (de)
AT (1) ATE131479T1 (de)
AU (1) AU660337B2 (de)
CA (1) CA2121230C (de)
DE (1) DE69206820T2 (de)
DK (1) DK0610372T3 (de)
ES (1) ES2083773T3 (de)
FI (1) FI105548B (de)
GR (1) GR3018909T3 (de)
HU (1) HU220608B1 (de)
IL (1) IL103570A (de)
MX (1) MX9206258A (de)
NO (1) NO300976B1 (de)
NZ (1) NZ244779A (de)
PH (1) PH31245A (de)
PL (1) PL170749B1 (de)
RU (1) RU2127273C1 (de)
TW (1) TW249234B (de)
WO (1) WO1993009118A1 (de)
ZA (1) ZA928373B (de)

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US6007992A (en) * 1997-11-10 1999-12-28 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
KR100818965B1 (ko) * 2000-10-02 2008-04-04 얀센 파마슈티카 엔.브이. 대사자극성 글루타메이트 수용체 길항제
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US8598192B2 (en) 2003-11-14 2013-12-03 3M Innovative Properties Company Hydroxylamine substituted imidazoquinolines
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US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
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WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
SE0401762D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
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US9248127B2 (en) 2005-02-04 2016-02-02 3M Innovative Properties Company Aqueous gel formulations containing immune response modifiers
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JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
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Also Published As

Publication number Publication date
DE69206820D1 (de) 1996-01-25
MX9206258A (es) 1993-04-01
ATE131479T1 (de) 1995-12-15
EP0541153A1 (de) 1993-05-12
PL170749B1 (pl) 1997-01-31
CN1072681A (zh) 1993-06-02
NO941497D0 (de) 1994-04-25
KR100251895B1 (ko) 2000-09-01
NZ244779A (en) 1994-10-26
FI942010A0 (fi) 1994-04-29
IL103570A (en) 1996-03-31
JPH07500599A (ja) 1995-01-19
AU660337B2 (en) 1995-06-22
CA2121230A1 (en) 1993-05-13
WO1993009118A1 (en) 1993-05-13
AU2908392A (en) 1993-06-07
JP3488922B2 (ja) 2004-01-19
RU2127273C1 (ru) 1999-03-10
NO941497L (no) 1994-04-25
FI105548B (fi) 2000-09-15
TW249234B (de) 1995-06-11
CN1041726C (zh) 1999-01-20
EP0610372A1 (de) 1994-08-17
IL103570A0 (en) 1993-03-15
ES2083773T3 (es) 1996-04-16
ZA928373B (en) 1994-04-29
US5521187A (en) 1996-05-28
GR3018909T3 (en) 1996-05-31
FI942010A (fi) 1994-04-29
NO300976B1 (no) 1997-08-25
PH31245A (en) 1998-06-18
EP0610372B1 (de) 1995-12-13
US5541325A (en) 1996-07-30
HUT66453A (en) 1994-11-28
CA2121230C (en) 2003-03-11
US5516908A (en) 1996-05-14
HU9401245D0 (en) 1994-08-29
DK0610372T3 (da) 1996-01-29
HU220608B1 (hu) 2002-03-28

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