DE69132519D1 - Quinolin-Derivate - Google Patents
Quinolin-DerivateInfo
- Publication number
- DE69132519D1 DE69132519D1 DE69132519T DE69132519T DE69132519D1 DE 69132519 D1 DE69132519 D1 DE 69132519D1 DE 69132519 T DE69132519 T DE 69132519T DE 69132519 T DE69132519 T DE 69132519T DE 69132519 D1 DE69132519 D1 DE 69132519D1
- Authority
- DE
- Germany
- Prior art keywords
- quinoline derivatives
- quinoline
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP28109490 | 1990-10-19 | ||
JP28109390 | 1990-10-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69132519D1 true DE69132519D1 (de) | 2001-03-01 |
DE69132519T2 DE69132519T2 (de) | 2001-06-13 |
Family
ID=26554052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69132519T Expired - Fee Related DE69132519T2 (de) | 1990-10-19 | 1991-10-15 | Chinolinderivate |
Country Status (8)
Country | Link |
---|---|
US (2) | US5190951A (de) |
EP (2) | EP0481429B1 (de) |
KR (1) | KR100206200B1 (de) |
CA (1) | CA2053640C (de) |
DE (1) | DE69132519T2 (de) |
ES (1) | ES2156853T3 (de) |
HK (1) | HK1011351A1 (de) |
SG (1) | SG44523A1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5190951A (en) * | 1990-10-19 | 1993-03-02 | Ss Pharmaceutical Co., Ltd. | Quinoline derivatives |
ES2167569T3 (es) * | 1995-06-15 | 2002-05-16 | Upjohn Co | Uso de imidazo(1,5-a)quinolonas como agentes neuroprotectores. |
JP2004508272A (ja) * | 1998-06-10 | 2004-03-18 | アリーナ・フアーマシユーチカルズ・インコーポレーテツド | アセチルコリンエンハンサー |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
CN1163224C (zh) | 1998-09-30 | 2004-08-25 | 武田药品工业株式会社 | 改善膀胱***能力的药物 |
US20030220646A1 (en) * | 2002-05-23 | 2003-11-27 | Thelen Sarah L. | Method and apparatus for reducing femoral fractures |
UA72611C2 (uk) * | 2000-05-17 | 2005-03-15 | Орто-Макнейл Фармацевтикал, Інк. | Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази |
JP4916662B2 (ja) | 2002-06-19 | 2012-04-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ホスホジエステラーゼ阻害剤として有用な置換2,4−ジヒドロ−ピロロ(3,4−b)−キノリン−9−オン誘導体 |
GB0522715D0 (en) | 2005-11-08 | 2005-12-14 | Helperby Therapeutics Ltd | New use |
US7465795B2 (en) * | 2005-12-20 | 2008-12-16 | Astrazeneca Ab | Compounds and uses thereof |
US7425556B2 (en) * | 2005-12-20 | 2008-09-16 | Astrazeneca Ab | Compounds and uses thereof |
AR067027A1 (es) * | 2007-06-19 | 2009-09-30 | Astrazeneca Ab | Derivados de 2, 3-dihidro-1h-pirrol[3, 4b]quinolin-1-ona, una composicion farmaceutica que los comprende y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la modulacion de la actividad del receptor gaba a. |
AR067028A1 (es) * | 2007-06-19 | 2009-09-30 | Astrazeneca Ab | Compuestos y usos de los mismos 849 |
CN109662964A (zh) | 2010-02-09 | 2019-04-23 | 约翰斯.霍普金斯大学 | 用于改善认知功能的方法和组合物 |
EP3034079B1 (de) | 2010-11-15 | 2018-01-10 | Agenebio, Inc. | Pyridazinderivate, zusammensetzungen und verfahren zur behandlung von kognitiven störungen |
WO2012154879A2 (en) * | 2011-05-09 | 2012-11-15 | Van Andel Research Institute | Autophagy inhibitors |
CN102875602B (zh) * | 2012-10-25 | 2015-05-20 | 江苏神龙药业有限公司 | 一种米诺膦酸水合物的制备方法 |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神***病を処置するための方法および組成物 |
WO2014144801A1 (en) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Methods and compositions for improving cognitive function |
EP3827820A1 (de) | 2013-03-15 | 2021-06-02 | The Johns Hopkins University | Brivaracetam zur verbesserung der kognitiven funktion |
AU2014368961B2 (en) | 2013-12-20 | 2019-10-17 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
BR112017025031B1 (pt) | 2015-05-22 | 2023-03-21 | Agenebio, Inc | Composições farmacêuticas de liberação prolongada de levetiracetam |
IL256354B (en) | 2015-06-19 | 2022-09-01 | Agenebio Inc | History of benzodiazepines, preparations and their use for the treatment of cognitive impairment |
US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
BR112019012821A2 (pt) | 2016-12-19 | 2019-11-26 | Agenebio Inc | derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo |
WO2019246300A1 (en) | 2018-06-19 | 2019-12-26 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
CN112608326B (zh) * | 2021-01-22 | 2021-10-01 | 河南大学 | 呋喃并[2,3-b]喹啉-3,4(2H,9H)-二酮衍生物、其制备方法及应用 |
CN114989180B (zh) * | 2022-05-26 | 2024-06-04 | 广东海洋大学 | 杨叶肖槿内生真菌来源的化合物及其制备方法与应用 |
US20240132513A1 (en) | 2022-08-19 | 2024-04-25 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ216720A (en) * | 1985-07-08 | 1990-09-26 | Bristol Myers Co | Diazinylpiperidine derivatives and pharmaceutical compositions |
DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
JP2507076B2 (ja) * | 1989-08-11 | 1996-06-12 | 株式会社クボタ | カ―ド式自動販売機 |
US5190951A (en) * | 1990-10-19 | 1993-03-02 | Ss Pharmaceutical Co., Ltd. | Quinoline derivatives |
US5240934A (en) * | 1990-10-19 | 1993-08-31 | Ss Pharmaceutical Co., Ltd. | Quinoline derivatives |
-
1991
- 1991-10-09 US US07/773,432 patent/US5190951A/en not_active Expired - Lifetime
- 1991-10-15 ES ES91117581T patent/ES2156853T3/es not_active Expired - Lifetime
- 1991-10-15 DE DE69132519T patent/DE69132519T2/de not_active Expired - Fee Related
- 1991-10-15 SG SG1996001518A patent/SG44523A1/en unknown
- 1991-10-15 EP EP91117581A patent/EP0481429B1/de not_active Expired - Lifetime
- 1991-10-15 EP EP99124146A patent/EP0987262A1/de not_active Withdrawn
- 1991-10-16 KR KR1019910018237A patent/KR100206200B1/ko not_active IP Right Cessation
- 1991-10-17 CA CA002053640A patent/CA2053640C/en not_active Expired - Fee Related
-
1993
- 1993-04-28 US US08/053,202 patent/US5300517A/en not_active Expired - Fee Related
-
1998
- 1998-11-16 HK HK98112039A patent/HK1011351A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2156853T3 (es) | 2001-08-01 |
EP0481429A2 (de) | 1992-04-22 |
EP0481429A3 (en) | 1992-08-19 |
DE69132519T2 (de) | 2001-06-13 |
KR100206200B1 (ko) | 1999-07-01 |
US5300517A (en) | 1994-04-05 |
SG44523A1 (en) | 1997-12-19 |
KR920008024A (ko) | 1992-05-27 |
HK1011351A1 (en) | 1999-07-09 |
EP0987262A1 (de) | 2000-03-22 |
EP0481429B1 (de) | 2001-01-24 |
CA2053640C (en) | 2001-12-25 |
US5190951A (en) | 1993-03-02 |
CA2053640A1 (en) | 1992-04-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: BIOMEDIX CO., LTD, TOKIO/TOKYO, JP |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: HISAMITSU MEDICAL CO., LTD., TOKIO/TOKYO, JP |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: HISAMITSU PHARMACEUTICAL CO., INC., TOSU, SAGA, JP |
|
8339 | Ceased/non-payment of the annual fee |