DE69103865D1 - Verwendung von tetrahydro-isoquinoline-derivate zur herstellung eines arzneimittels mit antitumoraler wirkung. - Google Patents

Verwendung von tetrahydro-isoquinoline-derivate zur herstellung eines arzneimittels mit antitumoraler wirkung.

Info

Publication number
DE69103865D1
DE69103865D1 DE69103865T DE69103865T DE69103865D1 DE 69103865 D1 DE69103865 D1 DE 69103865D1 DE 69103865 T DE69103865 T DE 69103865T DE 69103865 T DE69103865 T DE 69103865T DE 69103865 D1 DE69103865 D1 DE 69103865D1
Authority
DE
Germany
Prior art keywords
tetrahydro
producing
medicinal product
isoquinoline derivatives
antitumoral effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69103865T
Other languages
English (en)
Inventor
Daniel Frechet
Christian Marchandeau
Joerg Czech
Hans Sedlacek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE69103865D1 publication Critical patent/DE69103865D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69103865T 1990-06-08 1991-06-06 Verwendung von tetrahydro-isoquinoline-derivate zur herstellung eines arzneimittels mit antitumoraler wirkung. Expired - Lifetime DE69103865D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR909007137A FR2662940B1 (fr) 1990-06-08 1990-06-08 Utilisation de derives de la tetrahydro isoquinoleine pour la preparation de medicaments anti-tumoraux, application a titre de medicaments de derives de la tetrahydro isoquinoleine et produits derives de cette structure.
PCT/FR1991/000448 WO1991018604A1 (fr) 1990-06-08 1991-06-06 Utilisation de derives de la tetrahydro isoquinoleine pour la preparation de medicaments anti-tumoraux

Publications (1)

Publication Number Publication Date
DE69103865D1 true DE69103865D1 (de) 1994-10-13

Family

ID=9397406

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69103865T Expired - Lifetime DE69103865D1 (de) 1990-06-08 1991-06-06 Verwendung von tetrahydro-isoquinoline-derivate zur herstellung eines arzneimittels mit antitumoraler wirkung.

Country Status (5)

Country Link
EP (1) EP0485583B1 (de)
JP (1) JPH05500972A (de)
DE (1) DE69103865D1 (de)
FR (1) FR2662940B1 (de)
WO (1) WO1991018604A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE386525T1 (de) * 2001-08-27 2008-03-15 Arpida Ag 3-substituierte 6,7- dihydroxytetrahydroisochinolin-derivate zur verwendung als antibkaterielle mittel
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
CN1980672B (zh) 2004-03-15 2011-05-04 Ptc医疗公司 用于抑制血管生成的咔啉衍生物
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
WO2010138652A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating kaposi sarcoma
US8703726B2 (en) 2009-05-27 2014-04-22 Ptc Therapeutics, Inc. Methods for treating prostate conditions
ES2826950T3 (es) 2009-05-27 2021-05-19 Ptc Therapeutics Inc Métodos para tratar cáncer y afecciones no neoplásicas
CN102459263A (zh) 2009-05-27 2012-05-16 Ptc医疗公司 取代的四氢β-咔啉的制备工艺
WO2019028171A1 (en) 2017-08-01 2019-02-07 Ptc Therapeutics, Inc. DHODH INHIBITOR FOR USE IN THE TREATMENT OF HEMATOLOGICAL CANCERS

Also Published As

Publication number Publication date
EP0485583A1 (de) 1992-05-20
FR2662940B1 (fr) 1994-10-14
WO1991018604A1 (fr) 1991-12-12
JPH05500972A (ja) 1993-02-25
EP0485583B1 (de) 1994-09-07
FR2662940A1 (fr) 1991-12-13

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Legal Events

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