DE69025834D1 - Antivirale Verbindungen - Google Patents
Antivirale VerbindungenInfo
- Publication number
- DE69025834D1 DE69025834D1 DE69025834T DE69025834T DE69025834D1 DE 69025834 D1 DE69025834 D1 DE 69025834D1 DE 69025834 T DE69025834 T DE 69025834T DE 69025834 T DE69025834 T DE 69025834T DE 69025834 D1 DE69025834 D1 DE 69025834D1
- Authority
- DE
- Germany
- Prior art keywords
- antiviral compounds
- preparation
- treatment
- methods
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Local Oxidation Of Silicon (AREA)
- Element Separation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898920534A GB8920534D0 (en) | 1989-09-11 | 1989-09-11 | Antiviral compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69025834D1 true DE69025834D1 (de) | 1996-04-18 |
Family
ID=10662891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69025834T Expired - Lifetime DE69025834D1 (de) | 1989-09-11 | 1990-09-07 | Antivirale Verbindungen |
Country Status (19)
Country | Link |
---|---|
EP (2) | EP0417999B1 (de) |
JP (1) | JPH03145497A (de) |
KR (1) | KR910006293A (de) |
AT (1) | ATE135365T1 (de) |
AU (1) | AU644095B2 (de) |
CA (1) | CA2025009A1 (de) |
DD (1) | DD297650A5 (de) |
DE (1) | DE69025834D1 (de) |
FI (1) | FI904445A0 (de) |
GB (1) | GB8920534D0 (de) |
HU (1) | HUT54704A (de) |
IE (1) | IE903269A1 (de) |
MY (1) | MY130035A (de) |
NZ (1) | NZ235244A (de) |
PL (1) | PL164967B1 (de) |
PT (1) | PT95261A (de) |
RU (2) | RU2043361C1 (de) |
TW (2) | TW246641B (de) |
ZA (1) | ZA907187B (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI95384C (fi) * | 1989-04-06 | 1996-01-25 | Squibb Bristol Myers Co | Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita |
US5670633A (en) * | 1990-01-11 | 1997-09-23 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
US6005087A (en) * | 1995-06-06 | 1999-12-21 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
US5872232A (en) * | 1990-01-11 | 1999-02-16 | Isis Pharmaceuticals Inc. | 2'-O-modified oligonucleotides |
US5914396A (en) * | 1990-01-11 | 1999-06-22 | Isis Pharmaceuticals, Inc. | 2'-O-modified nucleosides and phosphoramidites |
US5859221A (en) * | 1990-01-11 | 1999-01-12 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
US6399754B1 (en) | 1991-12-24 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides |
WO1991015498A2 (en) * | 1990-04-04 | 1991-10-17 | Nycomed Imaging As | Nucleoside derivatives |
US5792844A (en) * | 1990-07-27 | 1998-08-11 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent nitrogen atoms |
US5623070A (en) | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5610289A (en) * | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
US5677437A (en) * | 1990-07-27 | 1997-10-14 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5618704A (en) * | 1990-07-27 | 1997-04-08 | Isis Pharmacueticals, Inc. | Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling |
US5378825A (en) * | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
WO1992011276A1 (en) * | 1990-12-18 | 1992-07-09 | Sloan-Kettering Institute For Cancer Research | Novel synthesis of 2'-'up' fluorinated 2''-deoxy-arabinofuranosylpurines |
US5672697A (en) * | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
US5965722A (en) | 1991-05-21 | 1999-10-12 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ras gene with chimeric and alternating oligonucleotides |
US6307040B1 (en) | 1992-03-05 | 2001-10-23 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
US7119184B2 (en) | 1991-08-12 | 2006-10-10 | Isis Pharmaceuticals, Inc. | Oligonucleotides having A-DNA form and B-DNA form conformational geometry |
US5393841A (en) * | 1993-11-09 | 1995-02-28 | Shell Oil Company | Dissimilar arm asymmetric radial or star block copolymers for adhesives and sealants |
US6413410B1 (en) | 1996-06-19 | 2002-07-02 | Lifescan, Inc. | Electrochemical cell |
US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
US9096636B2 (en) | 1996-06-06 | 2015-08-04 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
US7812149B2 (en) | 1996-06-06 | 2010-10-12 | Isis Pharmaceuticals, Inc. | 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations |
EP0917879B1 (de) * | 1997-11-22 | 2002-07-17 | Boehringer Mannheim Gmbh | Verbessertes Verfahren zur Stabilisierung von Proteinen |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
DK1058686T3 (da) * | 1998-02-25 | 2007-03-05 | Univ Emory | 2'-fluornukleosider |
PT1411954E (pt) | 2000-10-18 | 2011-03-16 | Pharmasset Inc | Nucleosídeos modificados para o tratamento de infecções virais e proliferação celular anormal |
US7132453B2 (en) | 2002-03-15 | 2006-11-07 | Vanderbilt University | Method of using prostacyclin to treat respiratory syncytial virus infections |
EP1578765A4 (de) | 2002-11-05 | 2008-04-23 | Isis Pharmaceuticals Inc | Oligomere verbindungen,die zuckerersatzstoffe enthalten, und zusammensetzung zur verwendung in dergenmodulation |
US8569474B2 (en) | 2004-03-09 | 2013-10-29 | Isis Pharmaceuticals, Inc. | Double stranded constructs comprising one or more short strands hybridized to a longer strand |
US8394947B2 (en) | 2004-06-03 | 2013-03-12 | Isis Pharmaceuticals, Inc. | Positionally modified siRNA constructs |
US7884086B2 (en) | 2004-09-08 | 2011-02-08 | Isis Pharmaceuticals, Inc. | Conjugates for use in hepatocyte free uptake assays |
WO2008109080A2 (en) * | 2007-03-01 | 2008-09-12 | Siemens Medical Solutions Usa, Inc. | Nucleoside based proliferation imaging markers |
EP2403863B1 (de) | 2009-03-02 | 2013-08-28 | Alnylam Pharmaceuticals Inc. | Chemische modifikationen von nukleinsäure |
US9102938B2 (en) | 2010-04-01 | 2015-08-11 | Alnylam Pharmaceuticals, Inc. | 2′ and 5′ modified monomers and oligonucleotides |
EP2937420A1 (de) * | 2014-04-23 | 2015-10-28 | Synbias Pharma AG | Verfahren zur Synthese von Clofarabin |
WO2018110643A1 (ja) * | 2016-12-14 | 2018-06-21 | ヤマサ醤油株式会社 | 抗ウイルス活性を示すヌクレオシド誘導体 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4751221A (en) * | 1985-10-18 | 1988-06-14 | Sloan-Kettering Institute For Cancer Research | 2-fluoro-arabinofuranosyl purine nucleosides |
CA1340645C (en) * | 1987-04-17 | 1999-07-13 | Victor E. Marquez | Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus |
-
1989
- 1989-09-11 GB GB898920534A patent/GB8920534D0/en active Pending
-
1990
- 1990-09-07 AT AT90309838T patent/ATE135365T1/de not_active IP Right Cessation
- 1990-09-07 EP EP90309838A patent/EP0417999B1/de not_active Expired - Lifetime
- 1990-09-07 EP EP95107762A patent/EP0671410A1/de not_active Withdrawn
- 1990-09-07 DE DE69025834T patent/DE69025834D1/de not_active Expired - Lifetime
- 1990-09-07 DD DD90343871A patent/DD297650A5/de not_active IP Right Cessation
- 1990-09-10 TW TW082105888A patent/TW246641B/zh active
- 1990-09-10 TW TW079107576A patent/TW226333B/zh active
- 1990-09-10 MY MYPI90001550A patent/MY130035A/en unknown
- 1990-09-10 NZ NZ235244A patent/NZ235244A/xx unknown
- 1990-09-10 KR KR1019900014464A patent/KR910006293A/ko not_active Application Discontinuation
- 1990-09-10 IE IE326990A patent/IE903269A1/en unknown
- 1990-09-10 PL PL90286820A patent/PL164967B1/pl unknown
- 1990-09-10 AU AU62350/90A patent/AU644095B2/en not_active Ceased
- 1990-09-10 CA CA002025009A patent/CA2025009A1/en not_active Abandoned
- 1990-09-10 FI FI904445A patent/FI904445A0/fi not_active Application Discontinuation
- 1990-09-10 PT PT95261A patent/PT95261A/pt not_active Application Discontinuation
- 1990-09-10 HU HU905841A patent/HUT54704A/hu unknown
- 1990-09-10 ZA ZA907187A patent/ZA907187B/xx unknown
- 1990-09-10 RU SU904831211A patent/RU2043361C1/ru active
- 1990-09-11 JP JP2241057A patent/JPH03145497A/ja active Pending
-
1994
- 1994-01-14 RU RU94002475/14A patent/RU94002475A/ru unknown
Also Published As
Publication number | Publication date |
---|---|
AU644095B2 (en) | 1993-12-02 |
NZ235244A (en) | 1992-11-25 |
PT95261A (pt) | 1991-05-22 |
EP0417999A1 (de) | 1991-03-20 |
KR910006293A (ko) | 1991-04-29 |
TW246641B (de) | 1995-05-01 |
CA2025009A1 (en) | 1991-03-12 |
MY130035A (en) | 2007-05-31 |
DD297650A5 (de) | 1992-01-16 |
TW226333B (de) | 1994-07-11 |
RU94002475A (ru) | 1996-11-10 |
ZA907187B (en) | 1992-05-27 |
JPH03145497A (ja) | 1991-06-20 |
EP0417999B1 (de) | 1996-03-13 |
PL286820A1 (en) | 1991-04-22 |
RU2043361C1 (ru) | 1995-09-10 |
AU6235090A (en) | 1991-03-14 |
IE903269A1 (en) | 1991-03-27 |
ATE135365T1 (de) | 1996-03-15 |
PL164967B1 (pl) | 1994-10-31 |
FI904445A0 (fi) | 1990-09-10 |
EP0671410A1 (de) | 1995-09-13 |
GB8920534D0 (en) | 1989-10-25 |
HUT54704A (en) | 1991-03-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |