DE69024965D1 - Dehydrodidemnin b - Google Patents

Dehydrodidemnin b

Info

Publication number: DE69024965D1
Authority: DE; Germany
Prior art keywords: dehydrodidemnin; synthesized; isolated; formula; biological activity
Prior art date: 1989-09-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69024965T

Other languages

English (en)

Other versions

DE69024965T2 (de

Inventor

Kenneth Rinehart

A Lithgow-Bertelloni

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmamar SA

Original Assignee

Pharmamar SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-29

Filing date

1990-10-01

Publication date

1996-02-29

1990-10-01 Application filed by Pharmamar SA filed Critical Pharmamar SA

1996-02-29 Application granted granted Critical

1996-02-29 Publication of DE69024965D1 publication Critical patent/DE69024965D1/de

1996-08-22 Publication of DE69024965T2 publication Critical patent/DE69024965T2/de

2010-10-02 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

UUSZLLQJYRSZIS-LXNNNBEUSA-N plitidepsin Chemical compound CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)=O UUSZLLQJYRSZIS-LXNNNBEUSA-N 0.000 title abstract 2
229950008499 plitidepsin Drugs 0.000 title abstract 2
108010049948 plitidepsin Proteins 0.000 title abstract 2
230000004071 biological effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
- Y10S530/857—Fish; fish eggs; shell fish; crustacea
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Oncology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Virology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE69024965T 1989-09-29 1990-10-01 Dehydrodidemnin b Expired - Lifetime DE69024965T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898922026A GB8922026D0 (en)	1989-09-29	1989-09-29	Novel anti-viral and cytotoxic agent
PCT/GB1990/001495 WO1991004985A1 (en)	1989-09-29	1990-10-01	Dehydrodidemnin b

Publications (2)

Publication Number	Publication Date
DE69024965D1 true DE69024965D1 (de)	1996-02-29
DE69024965T2 DE69024965T2 (de)	1996-08-22

Family

ID=10663828

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69024965T Expired - Lifetime DE69024965T2 (de)	1989-09-29	1990-10-01	Dehydrodidemnin b

Country Status (10)

Country	Link
US (4)	US5834586A (de)
EP (1)	EP0493480B1 (de)
JP (1)	JP2919965B2 (de)
AT (1)	ATE133181T1 (de)
AU (1)	AU642169B2 (de)
DE (1)	DE69024965T2 (de)
DK (1)	DK0493480T3 (de)
ES (1)	ES2082003T3 (de)
GB (1)	GB8922026D0 (de)
WO (1)	WO1991004985A1 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030148933A1 (en) *	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
GB8922026D0 (en)	1989-09-29	1989-11-15	Pharma Mar Sa	Novel anti-viral and cytotoxic agent
US5859031A (en)	1995-06-07	1999-01-12	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
ES2102322B1 (es) *	1995-07-13	1998-03-01	Pharma Mar Sa	Procedimiento de preparacion de didemnina a.
US5801197A (en) *	1995-10-31	1998-09-01	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US5786378A (en) *	1996-09-25	1998-07-28	Gpi Nil Holdings, Inc.	Heterocyclic thioesters
US5801187A (en)	1996-09-25	1998-09-01	Gpi-Nil Holdings, Inc.	Heterocyclic esters and amides
US6218424B1 (en)	1996-09-25	2001-04-17	Gpi Nil Holdings, Inc.	Heterocyclic ketone and thioester compounds and uses
US6034058A (en) *	1997-04-15	2000-03-07	Rinehart; Kenneth L.	Semi-synthetic alanyl dilemnin analogs
EP0981352B8 (de) *	1997-05-07	2009-06-17	Pharma Mar, S.A.	Verwendung von Aplidine zur Behandlung von kardiovaskulären Erkrankungen
US6271244B1 (en)	1998-06-03	2001-08-07	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6274602B1 (en)	1998-06-03	2001-08-14	Gpi Nil Holdings, Inc.	Heterocyclic thioester and ketone hair growth compositions and uses
US6187784B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Pipecolic acid derivative hair growth compositions and uses
US5945441A (en)	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
US6187796B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Sulfone hair growth compositions and uses
AT405400B (de) *	1997-11-12	1999-07-26	Chemie Linz Gmbh	Verfahren zur herstellung von 1-pyruvyl-l-prolin
AT405399B (de) *	1997-08-06	1999-07-26	Chemie Linz Gmbh	Verfahren zur herstellung von 1-pyruvoyl-l-prolin
CZ291417B6 (cs) *	1997-08-06	2003-03-12	Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg	Způsob výroby 1-pyruvyl-L-prolinu
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
US6429215B1 (en)	1998-06-03	2002-08-06	Gpi Nil Holdings, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
WO1999062487A1 (en)	1998-06-03	1999-12-09	Gpi Nil Holdings, Inc.	Heterocyclic ester and amide hair growth compositions and uses
US6331537B1 (en)	1998-06-03	2001-12-18	Gpi Nil Holdings, Inc.	Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6172087B1 (en)	1998-06-03	2001-01-09	Gpi Nil Holding, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US7338976B1 (en)	1998-08-14	2008-03-04	Gpi Nil Holdings, Inc.	Heterocyclic esters or amides for vision and memory disorders
US6333340B1 (en)	1998-08-14	2001-12-25	Gpi Nil Holdings, Inc.	Small molecule sulfonamides for vision and memory disorders
US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6506788B1 (en)	1998-08-14	2003-01-14	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6376517B1 (en)	1998-08-14	2002-04-23	Gpi Nil Holdings, Inc.	Pipecolic acid derivatives for vision and memory disorders
US6384056B1 (en)	1998-08-14	2002-05-07	Gpi Nil Holdings, Inc.	Heterocyclic thioesters or ketones for vision and memory disorders
US6335348B1 (en)	1998-08-14	2002-01-01	Gpi Nil Holdings, Inc.	Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6337340B1 (en)	1998-08-14	2002-01-08	Gpi Nil Holdings, Inc.	Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6395758B1 (en)	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
US6339101B1 (en)	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6218423B1 (en)	1998-08-14	2001-04-17	Gpi Nil Holdings, Inc.	Pyrrolidine derivatives for vision and memory disorders
US6462072B1 (en)	1998-09-21	2002-10-08	Gpi Nil Holdings, Inc.	Cyclic ester or amide derivatives
BR0015811A (pt) *	1999-11-15	2002-08-06	Pharma Mar Sa	Tratamento de c nceres com aplidina
UA76718C2 (uk)	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
ES2243555T3 (es)	2000-10-12	2005-12-01	Pharma Mar, S.A.	Tratamiento de canceres mediante aplidina en conjuncion con carnitina o acetilcarnitina.
CA2424823A1 (en) *	2000-10-12	2002-04-18	Pharma Mar, S.A.	Treatment of cancers by aplidine in conjunction with a myoprotector
ES2315404T3 (es) *	2001-10-19	2009-04-01	Pharma Mar, S.A.	Uso de aplidina para el tratamiento de cancer de pancreas.
ES2312979T3 (es)	2003-03-12	2009-03-01	Dana-Farber Cancer Institute, Inc.	Aplidina para el tratamiento de mieloma multiple.
CA2516572A1 (en) *	2003-03-12	2004-09-23	Pharma Mar, S.A.	Improved antitumoral treatments
EP1942944A2 (de) *	2005-10-31	2008-07-16	Genentech, Inc.	Makrozyklische depsipeptid-antikörper-wirkstoff-konjugate und entsprechende verfahren
AU2007220050B2 (en)	2006-02-28	2013-08-29	Pharma Mar, S.A.	Improved antitumoral treatments
WO2008080956A1 (en) *	2006-12-29	2008-07-10	Pharma Mar, S.A.	Prognostic molecular markers for the cancer therapy with aplidine
WO2009050296A1 (en) *	2007-10-19	2009-04-23	Pharma Mar, S.A.	Improved antitumoral treatments
CN101965191A (zh) *	2008-03-07	2011-02-02	法马马有限公司	改善的抗癌治疗
US9644005B2 (en)	2011-09-21	2017-05-09	King Abdullah University Of Science And Technology	Didemnin biosynthetic gene cluster in Tistrella mobilis
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
KR20220150348A (ko) *	2020-03-02	2022-11-10	파르마 마르, 에스.에이.	코로나바이러스의 치료에 조합하여 사용하기 위한 pld
US20230158102A1 (en) *	2020-03-02	2023-05-25	Pharma Mar, S.A.	Compounds for use in the treatment of coronavirus infection
US20230158104A1 (en) *	2020-03-02	2023-05-25	Pharma Mar, S.A.	Compounds for use in autoimmune conditions
TW202144381A (zh) *	2020-03-02	2021-12-01	西班牙商瑪製藥股份有限公司	用於炎症之化合物
CN115594739A (zh) *	2021-06-28	2023-01-13	浙江珲达生物科技有限公司（Cn）	一种dehydrodidemnin B类化合物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4493796A (en) *	1980-09-12	1985-01-15	Board Of Trustees, Univ. Of Ill.	Didemnins A, B, C, and derivatives thereof, as antiviral agents
US4950649A (en)	1980-09-12	1990-08-21	University Of Illinois	Didemnins and nordidemnins
GB8922026D0 (en)	1989-09-29	1989-11-15	Pharma Mar Sa	Novel anti-viral and cytotoxic agent
TW222637B (de) *	1991-12-12	1994-04-21	Hoechst Ag
US6034058A (en)	1997-04-15	2000-03-07	Rinehart; Kenneth L.	Semi-synthetic alanyl dilemnin analogs
EP0981352B8 (de)	1997-05-07	2009-06-17	Pharma Mar, S.A.	Verwendung von Aplidine zur Behandlung von kardiovaskulären Erkrankungen

1989
- 1989-09-29 GB GB898922026A patent/GB8922026D0/en active Pending
1990
- 1990-10-01 WO PCT/GB1990/001495 patent/WO1991004985A1/en active IP Right Grant
- 1990-10-01 DE DE69024965T patent/DE69024965T2/de not_active Expired - Lifetime
- 1990-10-01 EP EP90914541A patent/EP0493480B1/de not_active Expired - Lifetime
- 1990-10-01 DK DK90914541.9T patent/DK0493480T3/da active
- 1990-10-01 JP JP2513643A patent/JP2919965B2/ja not_active Expired - Lifetime
- 1990-10-01 ES ES90914541T patent/ES2082003T3/es not_active Expired - Lifetime
- 1990-10-01 AU AU64412/90A patent/AU642169B2/en not_active Expired
- 1990-10-01 AT AT90914541T patent/ATE133181T1/de not_active IP Right Cessation
1994
- 1994-07-25 US US08/280,110 patent/US5834586A/en not_active Ceased
1998
- 1998-10-30 US US09/183,024 patent/US6153731A/en not_active Expired - Fee Related
2000
- 2000-07-19 US US09/619,354 patent/US6710029B1/en not_active Expired - Fee Related
2005
- 2005-06-02 US US11/145,507 patent/USRE39887E1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US6710029B1 (en)	2004-03-23
DE69024965T2 (de)	1996-08-22
GB8922026D0 (en)	1989-11-15
JP2919965B2 (ja)	1999-07-19
AU642169B2 (en)	1993-10-14
WO1991004985A1 (en)	1991-04-18
US5834586A (en)	1998-11-10
USRE39887E1 (en)	2007-10-16
DK0493480T3 (da)	1996-05-20
JPH05502441A (ja)	1993-04-28
ATE133181T1 (de)	1996-02-15
ES2082003T3 (es)	1996-03-16
US6153731A (en)	2000-11-28
EP0493480A1 (de)	1992-07-08
EP0493480B1 (de)	1996-01-17
AU6441290A (en)	1991-04-28

Legal Events

Date	Code	Title	Description
1997-02-20	8364	No opposition during term of opposition

Publication	Publication Date	Title
ATE133181T1 (de)	1996-02-15	Dehydrodidemnin b
MY104685A (en)	1994-05-31	Substituted thiazoles and their use as fungicides.
DK0608912T3 (da)	1999-02-15	Synergistiske mikrobicide sammensætninger
DE3884791D1 (de)	1993-11-11	Begasungs-Brutschrank.
NO930615L (no)	1993-02-22	Hypoglykemiske hydroksyurinstoffderivater
ES2054778T3 (es)	1994-08-16	Complejos de 1,2-bis (aminometil) ciclobutano-platino.
ATE265997T1 (de)	2004-05-15	Substituierte tetrahydronaphthalin- und dihydronaphthalin-derivate mit einer retinoiden und/oder retinoid antagonist-ähnlichen biologischen aktivität
DE3867659D1 (de)	1992-02-27	1,5-diphenyl-1h-1,2,4-triazol-3-carboxamid-derivate und diese enthaltende herbizide zusammensetzungen.
ES2099274T3 (es)	1997-05-16	Derivados de estreptolisina o.
ES2066096T3 (es)	1995-03-01	4-bencil-5-fenil-2,4-dihidro-3h-1,2,4-triazol-3-onas y su uso como anticonvulsivos.
FI944563A0 (fi)	1994-09-30	Mikro-organismeja, valmistusmenetelmä ja käyttö
ES2013025A6 (es)	1990-04-16	Un metodo para preparar 24r-escimnol.
DE69016693D1 (de)	1995-03-23	Züchtung von transformierten Mikroorganismen.
ES2098263T3 (es)	1997-05-01	8-alfa-acilamino-ergolinas, su preparacion y su utilizacion como medicamentos.
FI964448A0 (fi)	1996-11-05	Uusi biologisesti aktiivinen peptidi ja sen valmistus
ATE174911T1 (de)	1999-01-15	1-dimethylcarbamoyl-1h-1,2,4-triazole- substituiert in stellungen 3 und 5
ATE204286T1 (de)	2001-09-15	Modifizierte alpha-d-glcp-(1,2)-alpha-d-glcp-(1, 3)-alpha-d-glcp-analoge
ES2181722T3 (es)	2003-03-01	Marcfortinas sustituidas en la posicion 14 y derivados utiles como agentes antiparasitarios.
DE3878988D1 (de)	1993-04-15	1,2-di(4-isobutylphenyl)aethylen, dessen herstellung und verwendung als zwischenprodukt.
ES2052499T3 (es)	1994-07-16	Complejos de (gem-heterociclodimenatamina-n,n') platino.
ES2086449T3 (es)	1996-07-01	2-terbutil-4-cloro-5-(4-ibutilmetilciclohexil)-metiltio-3(h)-piridazinona con actividad acaricida e insecticida.
MX9800306A (es)	1998-03-31	Mezclas fungicidas.
ITFE930013U1 (it)	1995-06-22	Bacchette orientali meccanizzate.
MY128749A (en)	2007-02-28	Fungicidal mixtures
TH5761B (th)	1996-07-09	วิธีการเตรียมชิ้นกล้าสำหรับการเลี้ยงเนื้อเยื่อพืช