DE69021855T2 - Quinazolinderivate und ihre Herstellung. - Google Patents
Quinazolinderivate und ihre Herstellung.Info
- Publication number
- DE69021855T2 DE69021855T2 DE69021855T DE69021855T DE69021855T2 DE 69021855 T2 DE69021855 T2 DE 69021855T2 DE 69021855 T DE69021855 T DE 69021855T DE 69021855 T DE69021855 T DE 69021855T DE 69021855 T2 DE69021855 T2 DE 69021855T2
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- hydroxy
- protected
- preparation
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909000014A GB9000014D0 (en) | 1990-01-02 | 1990-01-02 | Quinazoline derivatives and their preparation |
GB909025065A GB9025065D0 (en) | 1990-11-19 | 1990-11-19 | Quinazoline derivatives and their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69021855D1 DE69021855D1 (de) | 1995-09-28 |
DE69021855T2 true DE69021855T2 (de) | 1996-02-29 |
Family
ID=26296447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69021855T Expired - Fee Related DE69021855T2 (de) | 1990-01-02 | 1990-12-12 | Quinazolinderivate und ihre Herstellung. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5264438A (de) |
EP (1) | EP0436157B1 (de) |
JP (1) | JPH0578349A (de) |
KR (1) | KR910014368A (de) |
CN (1) | CN1053063A (de) |
AT (1) | ATE126796T1 (de) |
AU (1) | AU635099B2 (de) |
CA (1) | CA2033363A1 (de) |
DE (1) | DE69021855T2 (de) |
HU (1) | HU208131B (de) |
IE (1) | IE904580A1 (de) |
NO (1) | NO905620L (de) |
PT (1) | PT96404A (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5202318A (en) * | 1990-05-14 | 1993-04-13 | Syntex (U.S.A.) Inc. | Tricyclic compounds acting at serotonin receptor subtypes |
CA2117075A1 (en) * | 1991-09-06 | 1993-03-18 | Norihiko Shimazaki | Quinazoline derivatives and their preparation |
GB9127532D0 (en) * | 1991-12-31 | 1992-02-19 | Fujisawa Pharmaceutical Co | A novel use of a quinazoline derivative |
GB9205702D0 (en) * | 1992-03-16 | 1992-04-29 | Fujisawa Pharmaceutical Co | A new use of a quinazoline derivative |
FR2723091B1 (fr) * | 1994-07-29 | 1996-11-08 | Esteve Labor Dr | Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles |
AU1618697A (en) * | 1996-02-06 | 1997-08-28 | Japan Tobacco Inc. | Novel compounds and pharmaceutical use thereof |
AU5679398A (en) * | 1997-01-31 | 1998-08-25 | Kyowa Hakko Kogyo Co. Ltd. | Piperidine derivatives |
US6521630B1 (en) | 1999-08-31 | 2003-02-18 | Pfizer Inc. | Tetrahydroquinazoline-2,4-diones and therapeutic uses thereof |
DE102004020908A1 (de) * | 2004-04-28 | 2005-11-17 | Grünenthal GmbH | Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen |
US20080275058A1 (en) * | 2005-09-15 | 2008-11-06 | Korea Research Institute Of Chemical Technology | N-Substituted-1H-Quinoline-2,4-Diones, Preparation Method Thereof, And Pharmaceutical Composition Containing The Same |
JP2009542628A (ja) * | 2006-07-05 | 2009-12-03 | コーリア リサーチ インスティテュート オブ ケミカル テクノロジー | 新規な置換−1h−キナゾリン−2,4−ジオン誘導体、その製造方法及びそれを含む薬学的組成物 |
BRPI1003506B1 (pt) * | 2010-09-24 | 2019-12-03 | Ache Int Bvi Ltd | composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a |
CN103739596A (zh) * | 2013-12-10 | 2014-04-23 | 刘磊 | 用于心脑血管疾病的喹唑啉衍生物 |
CN106146413B (zh) * | 2015-04-03 | 2019-01-18 | 中南大学 | 2,4-(1h,3h)-喹唑啉二酮衍生物及其合成方法和用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3274194A (en) * | 1963-03-29 | 1966-09-20 | Miles Lab | Quinazolinedione derivatives |
US4684654A (en) * | 1985-08-14 | 1987-08-04 | American Cyanamid Company | 3-heteroalkyl-2,4-quinzaolinediones |
IE913473A1 (en) * | 1990-10-15 | 1992-04-22 | Fujisawa Pharmaceutical Co | Quinazoline derivatives and their preparation |
-
1990
- 1990-12-12 DE DE69021855T patent/DE69021855T2/de not_active Expired - Fee Related
- 1990-12-12 AT AT90123876T patent/ATE126796T1/de not_active IP Right Cessation
- 1990-12-12 EP EP90123876A patent/EP0436157B1/de not_active Expired - Lifetime
- 1990-12-14 US US07/627,417 patent/US5264438A/en not_active Expired - Fee Related
- 1990-12-18 IE IE458090A patent/IE904580A1/en unknown
- 1990-12-18 AU AU68207/90A patent/AU635099B2/en not_active Ceased
- 1990-12-28 CA CA002033363A patent/CA2033363A1/en not_active Abandoned
- 1990-12-28 NO NO90905620A patent/NO905620L/no unknown
- 1990-12-28 JP JP2419312A patent/JPH0578349A/ja active Pending
- 1990-12-28 KR KR1019900022102A patent/KR910014368A/ko not_active Application Discontinuation
- 1990-12-31 PT PT96404A patent/PT96404A/pt not_active Application Discontinuation
- 1990-12-31 CN CN90110247A patent/CN1053063A/zh active Pending
-
1991
- 1991-01-02 HU HU917A patent/HU208131B/hu not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR910014368A (ko) | 1991-08-31 |
AU6820790A (en) | 1991-07-04 |
ATE126796T1 (de) | 1995-09-15 |
NO905620D0 (no) | 1990-12-28 |
DE69021855D1 (de) | 1995-09-28 |
AU635099B2 (en) | 1993-03-11 |
US5264438A (en) | 1993-11-23 |
EP0436157B1 (de) | 1995-08-23 |
EP0436157A1 (de) | 1991-07-10 |
JPH0578349A (ja) | 1993-03-30 |
HUT56089A (en) | 1991-07-29 |
HU208131B (en) | 1993-08-30 |
NO905620L (no) | 1991-07-03 |
IE904580A1 (en) | 1991-07-03 |
CA2033363A1 (en) | 1991-07-03 |
CN1053063A (zh) | 1991-07-17 |
PT96404A (pt) | 1991-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |