DE68915165T2 - Schimärische glykoproteine enthaltende immunogenische abschnitte von menschlichem parainfluenzavirus typ 3. - Google Patents
Schimärische glykoproteine enthaltende immunogenische abschnitte von menschlichem parainfluenzavirus typ 3.Info
- Publication number
- DE68915165T2 DE68915165T2 DE68915165T DE68915165T DE68915165T2 DE 68915165 T2 DE68915165 T2 DE 68915165T2 DE 68915165 T DE68915165 T DE 68915165T DE 68915165 T DE68915165 T DE 68915165T DE 68915165 T2 DE68915165 T2 DE 68915165T2
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- Prior art keywords
- gene
- glycoprotein
- fragment
- plasmid
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Claims (10)
1.
Polypeptid, enthaltend mindestens ein immunogenes
Fragment von den beiden Glycoproteinen F und HN des
humanen Parainfluenza-Virus vom Typ 3.
2. Polypeptid nach Anspruch 1, das zusätzlich eine
Signalsequenz enthält.
3. Polypeptid nach Anspruch 2, das, beginnend mit dem N-
terminalen Ende, die Signalsequenz des Glycoproteins F,
ein immunogenes Fragment des Glycoproteins F und ein
immunogenes Fragment des Glycoproteins HN enthält.
4. Humanvaccine, enthaltend ein Polypeptid nach einem der
voranstehenden Ansprüche.
5. Verwendung eines Polypeptids nach einem der
voranstehenden Ansprüche für die Herstellung eines Impfstoffs
für den Gebrauch zum Schutz von Menschen vor dem humanen
Parainfluenza-Virus vom Typ 3.
6. Expressionssystem, umfassend einen geeigneten Wirt,
welches eine DNA-Sequenz enthält, das in der Lage ist,
ein Polypeptid nach einem der Ansprüche 1 - 3 zu
exprimieren.
7. Expressionssystem nach Anspruch 6, worin der Wirt unter
Bakterienzellen, Hefezellen, Säugerzellen und
Insektenzellen, z. B. E. coli-Bakterien,
Ovariumzellen des chinesischen Hamsters, von der Maus
stammenden C127-Zellen oder S. frugiperda-Zellen
ausgewählt ist.
8. Expressionssystem nach Anspruch 6 oder 7, worin der Wirt
in der Lage ist, das Polypeptid zu sezernieren.
9. Expressionssystem nach einem der Ansprüche 6 bis 8, worin
die DNA-Sequenz in einem Plasmid enthalten ist, das sich
unter der Kontrolle eines Cytomegalovirus-Promotors,
oder, in einem eukaryontischen Wirt, von
Rinder-Papillomavirus-DNA-Sequenzen befindet.
10. Expressionssystem nach einem der Ansprüche 6 bis 8,
worin die DNA-Sequenz in einem rekombinanten Virus der
Baculovirus-Familie, z. B. Autographa californica
Kernpolyhedrosis-Virus, enthalten ist.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18464888A | 1988-04-22 | 1988-04-22 | |
PCT/US1989/000814 WO1989010405A1 (en) | 1988-04-22 | 1989-03-03 | Chimeric glycoproteins containig immunogenic segments of human parainfluenza virus type 3 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68915165D1 DE68915165D1 (de) | 1994-06-09 |
DE68915165T2 true DE68915165T2 (de) | 1994-09-08 |
Family
ID=22677770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68915165T Expired - Lifetime DE68915165T2 (de) | 1988-04-22 | 1989-03-03 | Schimärische glykoproteine enthaltende immunogenische abschnitte von menschlichem parainfluenzavirus typ 3. |
Country Status (12)
Country | Link |
---|---|
US (2) | US5169628A (de) |
EP (1) | EP0413695B1 (de) |
KR (1) | KR970009347B1 (de) |
AT (1) | ATE105334T1 (de) |
AU (1) | AU611784B2 (de) |
CA (1) | CA1306709C (de) |
DE (1) | DE68915165T2 (de) |
DK (1) | DK172635B1 (de) |
FI (1) | FI102616B (de) |
HK (1) | HK37397A (de) |
NO (1) | NO303499B1 (de) |
WO (1) | WO1989010405A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5486599A (en) * | 1989-03-29 | 1996-01-23 | The Board Of Trustees Of The Leland Stanford Junior University | Construction and use of synthetic constructs encoding syndecan |
GB8914968D0 (en) * | 1989-06-29 | 1989-08-23 | Connaught Lab | Production of virus and purification of viral envelope proteins for vaccine use |
JP2649285B2 (ja) * | 1990-11-29 | 1997-09-03 | 藤倉化成株式会社 | ヒトパラインフルエンザ4a型ウイルスフュージョンプロテイン遺伝子及び該遺伝子を含む物質 |
GB9120221D0 (en) * | 1991-09-23 | 1991-11-06 | Smithkline Beecham Biolog | Novel compounds |
GB9200117D0 (en) * | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
US6479055B1 (en) * | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
US5550017A (en) * | 1993-10-12 | 1996-08-27 | Emory University | Anti-paramyxovirus screening method and vaccine |
DE69534077T2 (de) * | 1994-01-14 | 2005-08-11 | Rath, Matthias, Dr.med. | Verwendung von methoden zur identifizierung von hydrophilen signal-oligopeptiden |
US7300918B2 (en) | 1994-01-14 | 2007-11-27 | Matthias Rath | Method of producing vaccines from protein signal oligopeptides |
US5869036A (en) * | 1995-12-08 | 1999-02-09 | St. Louis University | Live attenuated vaccines based on CP45 HPIV-3 strain and method to ensure attenuation in such vaccine |
EP1019435A4 (de) * | 1996-01-29 | 2001-12-12 | Univ Georgetown | Amplifizierung der wirksamkeit exprimierter rekombinanter proteine |
FR2751229B1 (fr) * | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique notamment contre la pathologie respiratoire des bovins |
US6060308A (en) | 1997-09-04 | 2000-05-09 | Connaught Laboratories Limited | RNA respiratory syncytial virus vaccines |
AU749345B2 (en) | 1997-11-14 | 2002-06-27 | Connaught Laboratories Limited | Alphavirus vectors for paramyxovirus vaccines |
DE60041183D1 (de) | 1999-05-06 | 2009-02-05 | Univ Wake Forest | Zusammensetzungen und methoden zur identifikation von antigenen, die eine immunantwort hervorrufen |
US6764685B1 (en) | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
KR100964413B1 (ko) | 2001-01-19 | 2010-06-15 | 비로노바티브 비.브이. | 감응성 포유류에서 호흡계 질환을 유발하는 바이러스 |
US8715922B2 (en) | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
EP2327418A1 (de) | 2002-02-21 | 2011-06-01 | MedImmune, LLC | Rekombinante Parainfluenza Virus basierte Expressions Systeme und Impfstoffe, die heterologe Antigene von anderen Viren enthalten |
EP2494986A1 (de) | 2003-04-25 | 2012-09-05 | MedImmune Vaccines, Inc. | Metapneumovirusstämme und deren Verwendung in Impfstoffformulierungen und als Vektoren für die Expression antigener Sequenzen und Verfahren zur Ausbreitung des Virus |
MXPA05012542A (es) * | 2003-06-05 | 2006-02-08 | Wyeth Corp | Composiciones inmunogenicas que comprenden vectores de replicon del virus de la encefalitis equina venezolana y antigenos de la proteina del paramixovirus. |
EP4349404A3 (de) | 2015-10-22 | 2024-06-19 | ModernaTX, Inc. | Impfstoffe gegen respiratorische viren |
MA50335A (fr) | 2016-12-08 | 2020-08-19 | Modernatx Inc | Vaccins à acide nucléique contre des virus respiratoires |
US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
US20230036213A1 (en) * | 2019-12-10 | 2023-02-02 | Children's National Medical Center | T-cell epitopes of human parainfluenza virus 3 for adoptive t-cell immunotherapy |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4743553A (en) * | 1984-07-18 | 1988-05-10 | W. R. Grace & Co. | Synthetic genes for bovine parainfluenza virus |
JP2564268B2 (ja) * | 1985-08-28 | 1996-12-18 | 協和醗酵工業株式会社 | 融合抗原ポリペプチド |
US4790987A (en) * | 1985-11-15 | 1988-12-13 | Research Corporation | Viral glycoprotein subunit vaccine |
NZ230425A (en) * | 1988-09-02 | 1992-07-28 | Molecular Eng Ass | Production of paramyxovirus fusion (f) protein using recombinant baculovirus expression vector |
-
1989
- 1989-03-03 AU AU31975/89A patent/AU611784B2/en not_active Expired
- 1989-03-03 EP EP89903005A patent/EP0413695B1/de not_active Expired - Lifetime
- 1989-03-03 WO PCT/US1989/000814 patent/WO1989010405A1/en active IP Right Grant
- 1989-03-03 DE DE68915165T patent/DE68915165T2/de not_active Expired - Lifetime
- 1989-03-03 US US07/582,891 patent/US5169628A/en not_active Expired - Lifetime
- 1989-03-03 AT AT8989903005T patent/ATE105334T1/de not_active IP Right Cessation
- 1989-03-13 CA CA000593516A patent/CA1306709C/en not_active Expired - Lifetime
- 1989-12-21 KR KR89702416A patent/KR970009347B1/ko not_active IP Right Cessation
-
1990
- 1990-10-18 DK DK199002518A patent/DK172635B1/da not_active IP Right Cessation
- 1990-10-19 NO NO904538A patent/NO303499B1/no not_active IP Right Cessation
- 1990-10-19 FI FI905184A patent/FI102616B/fi not_active IP Right Cessation
-
1992
- 1992-09-04 US US07/941,027 patent/US5284764A/en not_active Expired - Lifetime
-
1997
- 1997-03-27 HK HK37397A patent/HK37397A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0413695B1 (de) | 1994-05-04 |
CA1306709C (en) | 1992-08-25 |
DK172635B1 (da) | 1999-03-22 |
AU611784B2 (en) | 1991-06-20 |
FI905184A0 (fi) | 1990-10-19 |
JPH03503760A (ja) | 1991-08-22 |
NO904538D0 (no) | 1990-10-19 |
FI102616B1 (fi) | 1999-01-15 |
US5169628A (en) | 1992-12-08 |
ATE105334T1 (de) | 1994-05-15 |
NO904538L (no) | 1990-12-27 |
FI102616B (fi) | 1999-01-15 |
NO303499B1 (no) | 1998-07-20 |
KR970009347B1 (en) | 1997-06-10 |
DK251890A (da) | 1990-10-18 |
KR900700613A (ko) | 1990-08-16 |
US5284764A (en) | 1994-02-08 |
DK251890D0 (da) | 1990-10-18 |
WO1989010405A1 (en) | 1989-11-02 |
EP0413695A1 (de) | 1991-02-27 |
DE68915165D1 (de) | 1994-06-09 |
HK37397A (en) | 1997-04-04 |
AU3197589A (en) | 1989-11-24 |
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Owner name: PHARMACIA & UPJOHN CO., KALAMAZOO, MICH., US |