DE674771C - Sterilization process - Google Patents
Sterilization processInfo
- Publication number
- DE674771C DE674771C DEW96018D DEW0096018D DE674771C DE 674771 C DE674771 C DE 674771C DE W96018 D DEW96018 D DE W96018D DE W0096018 D DEW0096018 D DE W0096018D DE 674771 C DE674771 C DE 674771C
- Authority
- DE
- Germany
- Prior art keywords
- chlorine
- sterilization
- solution
- water
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000001954 sterilising effect Effects 0.000 title claims description 16
- 238000004659 sterilization and disinfection Methods 0.000 title claims description 15
- 238000000034 method Methods 0.000 title claims description 9
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 13
- 239000000460 chlorine Substances 0.000 claims description 13
- 229910052801 chlorine Inorganic materials 0.000 claims description 13
- 239000000243 solution Substances 0.000 claims description 10
- 229910019142 PO4 Inorganic materials 0.000 claims description 6
- 235000021317 phosphate Nutrition 0.000 claims description 6
- 239000003206 sterilizing agent Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 3
- 239000003223 protective agent Substances 0.000 claims description 3
- 150000004760 silicates Chemical class 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- -1 dichloro compound Chemical class 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000008267 milk Substances 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 229910001369 Brass Inorganic materials 0.000 description 1
- 238000009631 Broth culture Methods 0.000 description 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000010951 brass Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- QEHKBHWEUPXBCW-UHFFFAOYSA-N nitrogen trichloride Chemical compound ClN(Cl)Cl QEHKBHWEUPXBCW-UHFFFAOYSA-N 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/72—Treatment of water, waste water, or sewage by oxidation
- C02F1/76—Treatment of water, waste water, or sewage by oxidation with halogens or compounds of halogens
Description
Sterilisationsverfahren . Die Erfindung betrifft ein Sterilisationsverfahren, das sich auf zahlreiche keimfrei zu machende Stoffe anwenden läßt, und zwar vorzugsweise ,auf leicht oxydierbare,organische Stoffe. Die zu sterilisierenden Stoffe können flüssig oder fest sein, wie z. B. Wasser, Milch, Serum, infizierte bzw. keimfrei zu machende Gegenstände us-,v.Sterilization process. The invention relates to a sterilization process, that can be applied to numerous sterile substances, preferably , on easily oxidizable, organic substances. The substances to be sterilized can be liquid or solid, such as B. water, milk, serum, infected or germ-free objects to be made us-, v.
Gemäß der Erfindung sollen die zu sterilisierenden Stoffe mit einem N-Cblorderivat behandelt werden, das die Strukturformel: aufweist, wobei zwei oder drei Wasserstoffatome durch Chlorersetzt sind.According to the invention, the substances to be sterilized are to be treated with an N-Cblorderivat which has the structural formula: having two or three hydrogen atoms replaced by chlorine.
Das wichtigste dieser N-Chlorderivate ist hinsichtlich seiner Herstellung und seiner Eigentümlichkeiten im Patent 657378 beschrieben, nämlich das N N'-Dichlor.azodicarb@ainidn mit der empirischen Formel C2 N6 H4 Ch . Diese Verbindung, bei der zwei Wasserstoffatome durch Chlor ersetzt sind, zeichnet sich außer durch ihre Sterilisationswirkung auch durch vorzügliche Beständigkeit aus. Wenn man bei der Herstellung der Dichlorverbindu ng mit einem überschuß an Chlorgas bzw. unterchlorig@er Säure,-wie sie sich beim Einleiten von Chlor in Wasser bildet, arbeitet, so entsteht Aals amorpher orangefarbener Niederschlag die Trichlorverbindung, die zwar weniger beständig als die Dichlorverbindung ist, dieser aber in ihren Sterilisationseigenschaften entspricht.The most important of these N-chlorine derivatives is described with regard to its preparation and its peculiarities in the patent 657378 , namely the N N'-dichlor.azodicarb@ainidn with the empirical formula C2 N6 H4 Ch. This compound, in which two hydrogen atoms have been replaced by chlorine, is not only characterized by its sterilizing effect but also by its excellent resistance. If you work with an excess of chlorine gas or hypochlorous acid, as it forms when chlorine is introduced into water, in the preparation of the dichloro compound, the trichloro compound is formed as an amorphous orange precipitate, which is less stable than the dichloro compound is, but this corresponds in its sterilization properties.
Die Trichlorverbind@un,g läßt sich beispielsweise wie folgt gewinnen: i kg Hydrazodicarbonamidinhydrochlorid wird in i oe 1 Wasser aufgelöst. Dann wird langsam Chlör durchgeleitet, bis der entstandene rötlichbraun gefärbte Niederschlag an Menge nicht mehr zwvmmt und die Überstehende Flüssigkeit farblos geworden ist bzw. lediglich die schwach gelbgrüne Farbe des Chlors aufweist. Man kann dann i kg der Trichlorverbindung (87% Ausbeute) abfiltrieren.The trichloro compound @ un, g can be obtained, for example, as follows: 1 kg of hydrazodicarbonamidine hydrochloride is dissolved in 1 oe of water. Then it will be slowly passed through chlorine until the resulting reddish-brown colored precipitate the amount is no longer tweaked and the supernatant liquid has become colorless or only has the pale yellow-green color of chlorine. One can then i Filter off kg of the trichloro compound (87% yield).
Die für das neue Sterilisationsverfahren wertvollste Eigenschaft der beiden Produkte, der Dichlorverbindung und der Trichlorverbin.dung, ist die, daß beide in ihrer Desinfektionswirkung durch Serum oder organische Stoffe anderer Art nur wenig beeinflußt werden. Sie haben daher eine auswählende. Sterilisationswirkung, da sie Bakterien abtöten, ohne mit sonst ,anwesenden oxydwerbaren organischen Stoffen bemerkenswert zu reagieren. Die keimtöteaade Wirkung ist infolgedessen. überraschend günstig, und man kommt mithin für denselben Sterilisationserfolg mit wesentlich kleineren Mengen von diesen. N-Chlorderivaten aus, ,als sie bei N-ChlordeTivaten: anderer Art gebraucht werden. Die nach der Erfindung anzuwendenden Körper wirken ,auch sicherer -und schneller als Hypochlorite.The most valuable property of the for the new sterilization process both products, the dichloro compound and the Trichlorverbin.dung, is that that both in their disinfecting effect through serum or other organic substances are only slightly influenced. You therefore have a selective one. Sterilization effect, because they kill bacteria without any oxidizable organic substances that are otherwise present respond remarkably. The germ-killing effect is as a result. surprised cheap, and you therefore get the same sterilization success with essential smaller amounts of these. N-chlorine derivatives, when they were with N-chlorine derivatives: used in a different way. The body to be used according to the invention act , also safer and faster than hypochlorite.
Während die Trichlorverbindung als amorpher orangefarbener Niederschlag anfällt, bildet die Dichlorverbindung nadelähnliche gelbliche Kristalle. Sie färbt Wasser, in. dem sie gelöst ist, sogar bei nur Zoo Teilen NN'-Dichlorazodicarbamidin auf i Million Teile Wasser (gesättigte Lösung bei o° C) stark gelb, und diese Farbe ist ,auch bei viel geringeren Konzentrationen noch deutlich wahrnehmbar. Die kennzeichnende gelbe Farbe der Lösung verschwindet, wenn das verfügbare Chlor aus ihr verbraucht ist. Diese Eigenschaft erweist sich bei dem neuen Sterilisationsverfahren deshalb als überaus wertvoll, weil man aus einer Lösung des NN'-Dichlorazodicarbamidin und entsprechend auch bei der Trichlorverbindung an der Farbe bzw. dem Farbton erkennen kann, ob die Lösung noch eine genügende Menge der Verbindung enthält, um die gewünschte keimtötende Wirkung ausüben zu können..While the trichloro compound as an amorphous orange precipitate is obtained, the dichloro compound forms needle-like yellowish crystals. She colors Water in which it is dissolved, even with only zoo parts of NN'-dichlorazodicarbamidine on one million parts of water (saturated solution at 0 ° C) strongly yellow, and this color is still clearly perceptible, even at much lower concentrations. The distinctive yellow color of the solution disappears when the available chlorine from it is consumed is. This property therefore proves itself in the new sterilization process as extremely valuable because you can get from a solution of NN'-dichlorazodicarbamidine and can also be recognized by the color or shade of the trichloro compound can determine whether the solution still contains a sufficient amount of the compound to achieve the desired to be able to exert a germicidal effect ..
Obgleich die erfindungsgemäß anzuwendenden N-Chlorderivate praktisch- frei vom Chlorgeruch und unfähig sind, aus neutralem Kaliumjodid Jod freizusetzen, zeichnen sie sich doch durch einen viel größeren Gehalt an verfügbarem Chlor aus, als er bei anderen chlorhaltigen Sterilisationsmitteln vorhanden ist.Although the N-chlorine derivatives to be used according to the invention are practically are free from the smell of chlorine and incapable of releasing iodine from neutral potassium iodide, they are characterized by a much higher content of available chlorine, than is the case with other chlorine-containing sterilizing agents.
Das NN'-Dichlorazodicarbiamidin ist bei 2o° C bis zu ungefähr 26o Teilen in i Million Teilen. Wasser löslich. Die Anwendung der Verbindungen in wässeriger Lösung ist die bequemste. Man kann jedoch auch organische Lösungsmittel, beispielsweise Alkohol, benutzen.The NN'-dichloroazodicarbiamidine is up to about 26o at 20 ° C Share in a million pieces. Water soluble. Application of the compounds in aqueous Solution is the most convenient. However, you can also use organic solvents, for example Alcohol, use.
Die Wasserlöslichkeit ist für die Herstellung von keimtötenden Lösungen zum Gebrauch in Molkereien, bei der Bereitung kohlensaurer Wässer usw., wo namentlich auch Geräte, Behälter u. dgl. sterilisiert werden sollen, sehr wertvoll. Zwecks Herstellung der Lösung kann man durch eine Schicht der festen Verbindungen langsam Wasser hindurchsickern lassen und dann die so erhaltene gesättigte Lösung gewünschtenfalls verdünnen. Sollen die Lösungen nicht sofort benutzt werden; so sind sie vor Licht zu schützen.The water solubility is essential for the preparation of germicidal solutions for use in dairies, in the preparation of carbonated water, etc., where specifically Devices, containers and the like are also to be sterilized, very valuable. For the purpose of Preparing the solution can be done slowly through a layer of solid compounds Let water seep through and then the resulting saturated solution if desired dilute. Should the solutions not be used immediately; so are they with light to protect.
Durch Versuche wurde festgestellt, daß im allgemeinen 25 bis 25o Teile NN'-Dichlorazodica.rbamidin: je i Million Teile wässeriger Flüssigkeit genügen, um alle Bakterien, die in dem Wasser vorhanden sind oder sich auf den, in das Wasser getauchten Gegenständen befinden, in weniger als 5 Minuten zu töten, selbst wenn die Flüssigkeit, wie z. B. Milch oder Serum, andere organische Stoffe enthält. Soll die N-Dichlorazoverbindung lediglich als Schutzmittel benutzt werden, so sind auch niedrigere Konzentrationen wirksam.Experiments have shown that generally 25 to 25o parts NN'-Dichlorazodica.rbamidine: per million parts of aqueous liquid are sufficient, to remove any bacteria that are present in the water or that are on the in the water submerged objects kill in less than 5 minutes, even if the liquid, such as B. milk or serum, contains other organic substances. Intended to the N-dichlorazo compound are only used as a protective agent, so are lower concentrations effective.
Die erfindungsgemäß anzuwendenden N-Chlorderivate lassen sich nicht nur allein, sondern auch unter Beimischung anderer Stoffe benutzen, die auch selbst Sterilisationsmittel sein können. Als beizumischende Nichtsterili,-sationsmittel kommen in Betracht: insbesondere kolloidale Schutzmittel, Phosphate oder Silikate.The N-chlorine derivatives to be used according to the invention cannot be used only use it alone, but also with the admixture of other substances, which also Can be sterilizing agents. As a non-sterile agent to be mixed in The following can be considered: especially colloidal protective agents, phosphates or silicates.
Folgende Zahlentafel veranschaulicht die Wirkung der N-Chlorazodicarbamidine:
Bacterium Coli 12,5 Teile Milch verdünnt mit 87,5 Teilen Wasser. 0,5 ccm
24stündige Fleischbrühekultur auf iooccm Desinfektionsmittel-Milch-Mischung (infizierte
Mischung = 7900000 Keime pro ccm).
Die N-Chlorderivate des Azodicarbamidins greifen Messing oder Kupfer nicht an, wie es die Lösungen des Chlors oder des Stickstofftrichlorids tun. Eisen und Aluminium werden jedoch angegriffen. Diese Wirkung kann ohne n en11enswerten. Verlust a#n Sterilisationsvermögen dadurch stark abgeschwächt oder verhindert werden, daß dem Sterilisationsmittel Trülatriumphosphat (Na" P04), Dinatriumphosphat (Na. HPO,i), Natriumsilikat (Na2 Si03) oder überhaupt Salzmischungen, die Phosphate oder Silikate enthalten, zugesetzt werden. Die Menge des Phosphates oder Silikates muß ausreichen, um den Gehalt ain Chlor im trockenen Gemisch auf nicht mehr als ungefähr 5 o,ö herabzudrücken. Da NN'-Diclilorazodicarbamidin ungefähr 39% verfügbares Chlor enthält, muß also das Verhältnis des Phosphates oder Silikates zur N-Dichlorverbindung mindestens 7 : 1 sein.The N-chlorine derivatives of azodicarbamidine attack brass or copper not like the solutions of chlorine or nitrogen trichloride do. iron and aluminum, however, are attacked. This effect can be significant without any cost. Loss of sterilization capacity can be greatly weakened or prevented as a result, that the sterilizing agent tresodium phosphate (Na "P04), disodium phosphate (Na. HPO, i), sodium silicate (Na2 Si03) or any salt mixtures, the phosphates or Contain silicates, are added. The amount of phosphate or silicate must be sufficient to keep the chlorine content in the dry mixture to no more than approximately 5 to push down o, ö. As NN'-diclilorazodicarbamidine approximately 39% available chlorine contains the ratio of the phosphate or silicate to the N-dichloro compound be at least 7: 1.
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US421006XA | 1932-09-08 | 1932-09-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE674771C true DE674771C (en) | 1939-04-21 |
Family
ID=21920047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEW96018D Expired DE674771C (en) | 1932-09-08 | 1933-09-05 | Sterilization process |
Country Status (4)
Country | Link |
---|---|
CH (1) | CH181651A (en) |
DE (1) | DE674771C (en) |
FR (1) | FR765611A (en) |
GB (1) | GB421006A (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2903361A (en) * | 1956-01-12 | 1959-09-08 | Wallace & Tiernan Inc | Procedures and compositions for the treatment of flour |
WO1991007876A1 (en) * | 1989-12-06 | 1991-06-13 | Previsan S.A. | Active agent against retrovirus group viruses, compositions containing same and their use |
US6123973A (en) * | 1993-07-30 | 2000-09-26 | Tillin, Inc. | Methods of preparation and using antimicrobial products |
US5858447A (en) * | 1993-07-30 | 1999-01-12 | Tillin, Inc. | Mold inhibitors |
-
1933
- 1933-09-01 GB GB24294/33A patent/GB421006A/en not_active Expired
- 1933-09-04 FR FR765611D patent/FR765611A/en not_active Expired
- 1933-09-05 DE DEW96018D patent/DE674771C/en not_active Expired
- 1933-09-07 CH CH181651D patent/CH181651A/en unknown
Also Published As
Publication number | Publication date |
---|---|
FR765611A (en) | 1934-06-13 |
CH181651A (en) | 1935-12-31 |
GB421006A (en) | 1934-12-12 |
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