DE60336727D1 - Vorrichtung mit kontrollierter abgabe und verfahren - Google Patents

Vorrichtung mit kontrollierter abgabe und verfahren

Info

Publication number
DE60336727D1
DE60336727D1 DE60336727T DE60336727T DE60336727D1 DE 60336727 D1 DE60336727 D1 DE 60336727D1 DE 60336727 T DE60336727 T DE 60336727T DE 60336727 T DE60336727 T DE 60336727T DE 60336727 D1 DE60336727 D1 DE 60336727D1
Authority
DE
Germany
Prior art keywords
reservoir
caps
reservoirs
contents
substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60336727T
Other languages
English (en)
Inventor
Scott A Uhland
Benjamin F Polito
John M Maloney
Norman F Sheppard
Stephen J Herman
Barry M Yomtov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dare MB inc
Original Assignee
Microchips Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microchips Inc filed Critical Microchips Inc
Application granted granted Critical
Publication of DE60336727D1 publication Critical patent/DE60336727D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
    • A61B5/283—Invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A61M2005/1726—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure the body parameters being measured at, or proximate to, the infusion site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/123—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/0069—Tip not integral with tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
DE60336727T 2002-08-16 2003-08-15 Vorrichtung mit kontrollierter abgabe und verfahren Expired - Lifetime DE60336727D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40419602P 2002-08-16 2002-08-16
US46386503P 2003-04-18 2003-04-18
PCT/US2003/025774 WO2004071487A2 (en) 2002-08-16 2003-08-15 Controlled release device and method

Publications (1)

Publication Number Publication Date
DE60336727D1 true DE60336727D1 (de) 2011-05-26

Family

ID=32871667

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60336727T Expired - Lifetime DE60336727D1 (de) 2002-08-16 2003-08-15 Vorrichtung mit kontrollierter abgabe und verfahren

Country Status (10)

Country Link
US (4) US7510551B2 (de)
EP (1) EP1528940B1 (de)
JP (2) JP4436258B2 (de)
KR (1) KR100725973B1 (de)
CN (1) CN100594892C (de)
AT (1) ATE505224T1 (de)
AU (1) AU2003303288B2 (de)
CA (1) CA2495327C (de)
DE (1) DE60336727D1 (de)
WO (1) WO2004071487A2 (de)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070590B1 (en) 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
EP1261427B1 (de) * 2000-03-02 2011-03-02 Microchips, Inc. Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien
DE60139705D1 (de) * 2000-11-09 2009-10-08 Sicel Technologies Inc In-vivo detektion von biomolekülekonzentrationen mittels fluoreszenzmarker
US9107605B2 (en) * 2000-11-17 2015-08-18 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Device for in vivo delivery of bioactive agents and method of manufacture thereof
JP4657577B2 (ja) 2001-01-09 2011-03-23 マイクロチップス・インコーポレーテッド 眼への適用および他への適用のための可撓性マイクロチップデバイス
DE10234589A1 (de) * 2002-07-30 2004-02-12 Robert Bosch Gmbh Schichtsystem mit einer Siliziumschicht und einer Passivierschicht, Verfahren zur Erzeugung einer Passivierschicht auf einer Siliziumschicht und deren Verwendung
EP1528940B1 (de) * 2002-08-16 2011-04-13 Microchips, Inc. Vorrichtung mit kontrollierter abgabe und verfahren
US7497855B2 (en) * 2002-09-04 2009-03-03 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
EP1551505B1 (de) * 2002-10-04 2010-02-24 Microchips, Inc. Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation
IL152629A (en) * 2002-11-04 2010-12-30 Innoventions Ltd Implantable medical device for controlled release of a substance
WO2005010240A2 (en) * 2003-07-17 2005-02-03 Microchips, Inc. Low temperature methods for hermetically sealing reservoir devices
WO2005016558A2 (en) * 2003-08-04 2005-02-24 Microchips, Inc. Methods for accelerated release of material from a reservoir device
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
AU2004285603A1 (en) * 2003-11-03 2005-05-12 Microchips, Inc. Medical device for sensing glucose
AU2005327211A1 (en) * 2004-06-01 2006-08-17 Microchips, Inc. Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant
US20070036835A1 (en) * 2004-07-19 2007-02-15 Microchips, Inc. Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents
US7537590B2 (en) * 2004-07-30 2009-05-26 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
CN100488635C (zh) * 2004-09-01 2009-05-20 微芯片公司 用于控制释放或者暴露储库内容物的多盖储库装置
US7350479B2 (en) * 2004-09-10 2008-04-01 United States Of America As Represented By The Secretary Of The Army System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp
US7156049B2 (en) * 2004-09-10 2007-01-02 The United States Of America As Represented By The Secretary Of The Army Release mechanism to interact with biota, in particular fauna that may outgrow available habitat
GB2418144A (en) * 2004-09-17 2006-03-22 Psimedica Ltd Medical device for delivery of beneficial substance
CA2583911A1 (en) * 2004-10-28 2006-05-11 Microchips, Inc. Orthopedic and dental implant devices providing controlled drug delivery
CA2584851C (en) * 2004-11-04 2015-04-07 Microchips, Inc. Compression and cold weld sealing methods and devices
US7413846B2 (en) 2004-11-15 2008-08-19 Microchips, Inc. Fabrication methods and structures for micro-reservoir devices
WO2006081279A2 (en) * 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments
US9095722B2 (en) * 2005-02-01 2015-08-04 Second Sight Medical Products, Inc. Micro-miniature implantable coated device
US8314024B2 (en) 2008-12-19 2012-11-20 Unity Semiconductor Corporation Device fabrication
WO2007001624A2 (en) * 2005-06-28 2007-01-04 Microchips, Inc. Medical and dental implant devices for controlled drug delivery
US20080208174A1 (en) 2005-07-05 2008-08-28 Koninklijke Philips Electronics, N.V. Device for the Controlled Release of a Predefined Quantity of a Substance
WO2007004171A1 (en) 2005-07-05 2007-01-11 Koninklijke Philips Electronics N.V. Device for the controlled release of a predefined quantity of a substance
US20070228606A1 (en) * 2005-07-07 2007-10-04 Specialty Coating Systems, Inc. Nanoscale structures and methods of preparation
US7387813B2 (en) * 2005-07-07 2008-06-17 Specialty Coating Systems, Inc. Methods of preparation of hollow microstructures and nanostructures
US20080228044A1 (en) * 2005-10-11 2008-09-18 Koninklijke Philips Electronics, N.V. Individually Activated Sensors for Implantable Sensors
US8083710B2 (en) 2006-03-09 2011-12-27 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US20070106277A1 (en) * 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Remote controller for substance delivery system
US8998886B2 (en) * 2005-12-13 2015-04-07 The Invention Science Fund I, Llc Remote control of osmotic pump device
US8273071B2 (en) 2006-01-18 2012-09-25 The Invention Science Fund I, Llc Remote controller for substance delivery system
US8882747B2 (en) 2005-11-09 2014-11-11 The Invention Science Fund I, Llc Substance delivery system
US8992511B2 (en) 2005-11-09 2015-03-31 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US9067047B2 (en) * 2005-11-09 2015-06-30 The Invention Science Fund I, Llc Injectable controlled release fluid delivery system
US8936590B2 (en) * 2005-11-09 2015-01-20 The Invention Science Fund I, Llc Acoustically controlled reaction device
US9254256B2 (en) * 2005-11-09 2016-02-09 The Invention Science Fund I, Llc Remote controlled in vivo reaction method
US20070148390A1 (en) * 2005-12-27 2007-06-28 Specialty Coating Systems, Inc. Fluorinated coatings
US20070191816A1 (en) * 2006-02-13 2007-08-16 Boston Scientific Scimed, Inc. Radio frequency induced drug elution
US20080140057A1 (en) * 2006-03-09 2008-06-12 Searete Llc, A Limited Liability Corporation Of State Of The Delaware Injectable controlled release fluid delivery system
US8642059B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
JP2009536064A (ja) * 2006-05-05 2009-10-08 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 所定量の物質の制御放出のための装置および方法
EP2037999B1 (de) 2006-07-07 2016-12-28 Proteus Digital Health, Inc. Intelligentes parenterales verabreichungssystem
WO2008008845A2 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
US20080033260A1 (en) * 2006-08-03 2008-02-07 Microchips, Inc. Cardiac Biosensor Devices and Methods
EP2063953A2 (de) * 2006-09-08 2009-06-03 Koninklijke Philips Electronics N.V. Vorrichtung zur kontrollierten freigabe einer vordefinierten menge einer substanz
US8138588B2 (en) * 2006-12-21 2012-03-20 Texas Instruments Incorporated Package stiffener and a packaged device using the same
US7998110B2 (en) * 2007-04-25 2011-08-16 Hong Kong Polytechnic University Medical device for delivering drug and/or performing physical therapy
EP2157907B1 (de) 2007-06-07 2013-03-27 MicroCHIPS, Inc. Elektrochemische biosensoren und anordnungen
US8706211B2 (en) 2007-08-17 2014-04-22 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having self-cleaning surfaces
US8366652B2 (en) 2007-08-17 2013-02-05 The Invention Science Fund I, Llc Systems, devices, and methods including infection-fighting and monitoring shunts
US8734718B2 (en) 2007-08-17 2014-05-27 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component
US8753304B2 (en) 2007-08-17 2014-06-17 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having acoustically actuatable waveguide components for delivering a sterilizing stimulus to a region proximate a surface of the catheter
US8702640B2 (en) 2007-08-17 2014-04-22 The Invention Science Fund I, Llc System, devices, and methods including catheters configured to monitor and inhibit biofilm formation
US9005263B2 (en) 2007-08-17 2015-04-14 The Invention Science Fund I, Llc System, devices, and methods including actively-controllable sterilizing excitation delivery implants
WO2009055733A1 (en) * 2007-10-25 2009-04-30 Proteus Biomedical, Inc. Fluid transfer port information system
US8419638B2 (en) * 2007-11-19 2013-04-16 Proteus Digital Health, Inc. Body-associated fluid transport structure evaluation devices
US7833266B2 (en) * 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
DE102008024447A1 (de) 2008-05-20 2009-11-26 Biotronik Crm Patent Ag Implantierbare Schockelektrodenleitung und implantierbare Defibrillationsanordnung
US8961498B2 (en) * 2008-06-25 2015-02-24 Medimetrics Personalized Drug Delivery Electronic pill comprising a plurality of medicine reservoirs
US7951193B2 (en) * 2008-07-23 2011-05-31 Boston Scientific Scimed, Inc. Drug-eluting stent
US20100028403A1 (en) * 2008-07-31 2010-02-04 Boston Scientific Scimed, Inc. Medical devices for therapeutic agent delivery
US9474831B2 (en) 2008-12-04 2016-10-25 Gearbox, Llc Systems, devices, and methods including implantable devices with anti-microbial properties
US20110208023A1 (en) * 2008-12-04 2011-08-25 Goodall Eleanor V Systems, devices, and methods including implantable devices with anti-microbial properties
US8285387B2 (en) 2008-12-12 2012-10-09 Microchips, Inc. Wireless communication with a medical implant
US8126736B2 (en) 2009-01-23 2012-02-28 Warsaw Orthopedic, Inc. Methods and systems for diagnosing, treating, or tracking spinal disorders
US8685093B2 (en) 2009-01-23 2014-04-01 Warsaw Orthopedic, Inc. Methods and systems for diagnosing, treating, or tracking spinal disorders
GR1007310B (el) 2009-03-09 2011-06-10 Αχιλλεας Τσουκαλης Εμφυτευσιμος βιοαισθητηρας με αυτοματη βαθμονομηση
WO2010116312A1 (en) * 2009-04-07 2010-10-14 Koninklijke Philips Electronics N.V. Modular ingestible drug delivery capsule
TW201043224A (en) * 2009-06-06 2010-12-16 Univ Nat Taiwan Drug delivery chip and fabricating method thereof
US9283305B2 (en) 2009-07-09 2016-03-15 Medtronic Vascular, Inc. Hollow tubular drug eluting medical devices
CA2770246A1 (en) * 2009-08-08 2011-02-17 Sanofi-Aventis Deutschland Gmbh Implantable sensor device and medical delivery device connectable to such a sensor device
US20110070358A1 (en) 2009-09-20 2011-03-24 Medtronic Vascular, Inc. Method of forming hollow tubular drug eluting medical devices
EP2496936B1 (de) * 2009-10-16 2018-02-21 Microchips Biotech, Inc. Mehrkanal-potentiostat für eine biosensoranordnung und verwendungsverfahren
US8696740B2 (en) * 2010-01-05 2014-04-15 The Johns Hopkins University Implantable pressure-actuated drug delivery systems and methods of manufacture and use
SG189763A1 (en) 2010-02-01 2013-05-31 Proteus Digital Health Inc Two-wrist data gathering system
WO2011094606A2 (en) 2010-02-01 2011-08-04 Proteus Biomedical, Inc. Data gathering system
US10408040B2 (en) 2010-02-12 2019-09-10 Fluidion Sas Passive micro-vessel and sensor
WO2011100509A2 (en) * 2010-02-12 2011-08-18 Dan Angelescu Passive micro-vessel and sensor
US9389158B2 (en) 2010-02-12 2016-07-12 Dan Angelescu Passive micro-vessel and sensor
US9869613B2 (en) 2010-02-12 2018-01-16 Fluidion Sas Passive micro-vessel and sensor
US9772261B2 (en) 2010-02-12 2017-09-26 Fluidion Sas Passive micro-vessel and sensor
EP2600761A4 (de) 2010-08-06 2014-08-13 Microchips Inc Biosensormembranzusammensetzung, biosensor und herstellungsverfahren dafür
EP2608715B1 (de) * 2010-08-24 2016-06-22 Microchips, Inc. Implantierbare biosensorvorrichtung und verfahren zu ihrer verwendung
WO2012035429A2 (en) 2010-09-13 2012-03-22 The University Of British Columbia Remotely controlled drug delivery systems
PT2747642T (pt) 2011-08-25 2021-07-27 Microchips Biotech Inc Dispositivos de contenção eficientes em termos de espaço e método de criação dos mesmos
US10427153B2 (en) 2011-08-25 2019-10-01 Microchips Biotech, Inc. Systems and methods for sealing a plurality of reservoirs of a microchip element with a sealing grid
US9048505B2 (en) 2011-11-03 2015-06-02 Robert Bosch Gmbh Lithium-ion battery with life extension additive
SG11201403931YA (en) 2012-02-22 2014-08-28 Duchesnay Inc Formulation of doxylamine and pyridoxine and/or metabolites or salts thereof
JP6403939B2 (ja) * 2012-02-29 2018-10-10 ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッドＪｏｈｎｓｏｎ ＆ Ｊｏｈｎｓｏｎ Ｖｉｓｉｏｎ Ｃａｒｅ， Ｉｎｃ． 電圧が印加される収容アレイを有する涙点プラグ
CA2895235C (en) * 2012-12-21 2020-12-29 Microchips Biotech, Inc. Implantable medical device for minimally-invasive insertion
EP2953677B1 (de) 2013-02-06 2017-12-20 Dan Angelescu Passives mikrogefäss und sensor zur bestimmung der viscosität
WO2014124184A1 (en) 2013-02-06 2014-08-14 California Institute Of Technology Miniaturized implantable electrochemical sensor devices
MY175542A (en) 2013-02-28 2020-07-01 Microchips Biotech Inc Implantable medical device for minimally-invasive insertion
WO2014151906A1 (en) 2013-03-14 2014-09-25 Medtronic Vascular Inc. Method for manufacturing a stent and stent manufactured thereby
CN105228675B (zh) * 2013-05-31 2018-04-27 瓦莱里塔斯公司 具有可***式预填充筒的流体输送装置
ES2670619T3 (es) 2013-07-22 2018-05-31 Duchesnay Inc. Composición para la gestión de náuseas y vómitos
DK3030286T3 (da) 2013-08-05 2019-11-11 Cam Med Llc Komfortabel patch-pumpe
EP3168595B1 (de) 2014-04-03 2020-10-07 Fluidion System und verfahren zur probennahme in einem flüssigkeitskörper
AU2015249716A1 (en) * 2014-04-25 2016-11-03 Johnson & Johnson Vision Care, Inc. Method and ophthalmic device with active agent release system
US10350349B2 (en) 2014-05-20 2019-07-16 Cequr Sa Medicine delivery device with restricted access filling port
US10244951B2 (en) * 2014-06-10 2019-04-02 Acist Medical Systems, Inc. Physiological sensor delivery device and method
US9937124B2 (en) 2014-09-11 2018-04-10 International Business Machines Corporation Microchip substance delivery devices having low-power electromechanical release mechanisms
US9808608B2 (en) * 2014-11-16 2017-11-07 International Business Machines Corporation Helical coil delivery device for active agent
US10368788B2 (en) * 2015-07-23 2019-08-06 California Institute Of Technology System and methods for wireless drug delivery on command
US10881788B2 (en) 2015-10-30 2021-01-05 International Business Machines Corporation Delivery device including reactive material for programmable discrete delivery of a substance
US9672393B1 (en) * 2016-02-01 2017-06-06 Verily Life Sciences, LLC Phase controlled array for wirelessly powering implantable devices
US10286198B2 (en) 2016-04-08 2019-05-14 International Business Machines Corporation Microchip medical substance delivery devices
WO2017195060A1 (en) * 2016-05-09 2017-11-16 King Abdullah University Of Science & Technology Wearable personalized medicinal platform
US10620151B2 (en) 2016-08-30 2020-04-14 Analog Devices Global Electrochemical sensor, and a method of forming an electrochemical sensor
US11268927B2 (en) 2016-08-30 2022-03-08 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
US10784877B2 (en) 2016-12-21 2020-09-22 Johnson & Johnson Vision Care, Inc. Extended period timer circuits for ophthalmic devices
US10737090B2 (en) 2017-07-11 2020-08-11 Medtronic, Inc. External defibrillation electrode conductive electrolyte dispersal pad
US10508755B2 (en) * 2017-07-21 2019-12-17 International Business Machines Corporation Fluid delivery device with hydrophobic surface
WO2019138108A1 (en) 2018-01-15 2019-07-18 Fluidion Passive micro-vessel and sensor
US11022579B2 (en) 2018-02-05 2021-06-01 Analog Devices International Unlimited Company Retaining cap
WO2020061573A1 (en) * 2018-09-23 2020-03-26 Metcalf Douglas Systems and methods to administer pharmaceuticals
JP7465271B2 (ja) 2019-01-09 2024-04-10 トゥウェンティ トゥウェンティ セラピューティクス エルエルシー 治療剤放出のための眼球装着装置
WO2020146358A1 (en) 2019-01-09 2020-07-16 Verily Life Sciences Llc Programmable therapeutic agent delivery from eye mounted device
US11406299B2 (en) * 2019-02-22 2022-08-09 International Business Machines Corporation Biosensors with programmable sensing cavities
KR20220091506A (ko) 2019-11-01 2022-06-30 데어 엠비 아이엔씨. 2단계 마이크로칩 약물 전달 장치 및 방법
EP4275593A1 (de) * 2022-05-09 2023-11-15 Wellspect AB Medizinische wegwerfvorrichtungsanordnung mit sensor
CN117228133A (zh) * 2022-06-15 2023-12-15 珠海纳思达信息技术有限公司 包装件、包装组件和数据存储部的升级方法

Family Cites Families (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692027A (en) * 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
DE2505186C3 (de) * 1974-02-15 1979-07-12 N.V. Philips' Gloeilampenfabrieken, Eindhoven (Niederlande) Programmierbarer Lesespeicher
US4146029A (en) * 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US4003379A (en) * 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US4089734A (en) * 1974-09-16 1978-05-16 Raytheon Company Integrated circuit fusing technique
US3952741A (en) * 1975-01-09 1976-04-27 Bend Research Inc. Controlled release delivery system by an osmotic bursting mechanism
US4209894A (en) * 1978-04-27 1980-07-01 Texas Instruments Incorporated Fusible-link semiconductor memory
US4345981A (en) * 1978-11-24 1982-08-24 Diamond Shamrock Corporation Anodically polarized surface for biofouling and scale control
US4360019A (en) * 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
GB8422876D0 (en) * 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
US4585652A (en) * 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
US5252294A (en) * 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5041107A (en) * 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5167625A (en) * 1990-10-09 1992-12-01 Sarcos Group Multiple vesicle implantable drug delivery system
US5493177A (en) * 1990-12-03 1996-02-20 The Regents Of The University Of California Sealed micromachined vacuum and gas filled devices
US5254081A (en) * 1991-02-01 1993-10-19 Empi, Inc. Multiple site drug iontophoresis electronic device and method
US5391164A (en) * 1991-05-03 1995-02-21 Giampapa; Vincent C. Subcutaneous implantable multiple-agent delivery system
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
CA2123428A1 (en) * 1991-11-13 1993-05-27 John Corish Drug delivery device
US5756117A (en) * 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
US5304293A (en) * 1992-05-11 1994-04-19 Teknekron Sensor Development Corporation Microsensors for gaseous and vaporous species
US5380272A (en) * 1993-01-28 1995-01-10 Scientific Innovations Ltd. Transcutaneous drug delivery applicator
US5368588A (en) * 1993-02-26 1994-11-29 Bettinger; David S. Parenteral fluid medication reservoir pump
US5366454A (en) * 1993-03-17 1994-11-22 La Corporation De L'ecole Polytechnique Implantable medication dispensing device
US5368704A (en) * 1993-08-06 1994-11-29 Teknekron Corporation Micro-electrochemical valves and method
US6180239B1 (en) * 1993-10-04 2001-01-30 President And Fellows Of Harvard College Microcontact printing on surfaces and derivative articles
JP3488465B2 (ja) 1993-10-28 2004-01-19 ヒューストン・アドバンスド・リサーチ・センター 結合反応を別々に検出する微細加工フロースルー多孔性装置
US6129685A (en) * 1994-02-09 2000-10-10 The University Of Iowa Research Foundation Stereotactic hypothalamic obesity probe
US5660680A (en) * 1994-03-07 1997-08-26 The Regents Of The University Of California Method for fabrication of high vertical aspect ratio thin film structures
US5770076A (en) * 1994-03-07 1998-06-23 The Regents Of The University Of California Micromachined capsules having porous membranes and bulk supports
US5985328A (en) * 1994-03-07 1999-11-16 Regents Of The University Of California Micromachined porous membranes with bulk support
US5971931A (en) * 1994-03-29 1999-10-26 Raff; Gilbert Lewis Biologic micromonitoring methods and systems
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5504026A (en) * 1995-04-14 1996-04-02 Analog Devices, Inc. Methods for planarization and encapsulation of micromechanical devices in semiconductor processes
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US5992769A (en) * 1995-06-09 1999-11-30 The Regents Of The University Of Michigan Microchannel system for fluid delivery
SE9502258D0 (sv) * 1995-06-21 1995-06-21 Pharmacia Biotech Ab Method for the manufacture of a membrane-containing microstructure
US6518168B1 (en) * 1995-08-18 2003-02-11 President And Fellows Of Harvard College Self-assembled monolayer directed patterning of surfaces
US5662689A (en) * 1995-09-08 1997-09-02 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain
US6051017A (en) * 1996-02-20 2000-04-18 Advanced Bionics Corporation Implantable microstimulator and systems employing the same
DE19610293C1 (de) * 1996-03-15 1997-07-31 Fraunhofer Ges Forschung Vorrichtung zur gekapselten Aufnahme eines Materials
US5951881A (en) * 1996-07-22 1999-09-14 President And Fellows Of Harvard College Fabrication of small-scale cylindrical articles
US5824204A (en) * 1996-06-27 1998-10-20 Ic Sensors, Inc. Micromachined capillary electrophoresis device
US7070590B1 (en) * 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US6136212A (en) * 1996-08-12 2000-10-24 The Regents Of The University Of Michigan Polymer-based micromachining for microfluidic devices
IN184589B (de) * 1996-10-16 2000-09-09 Alza Corp
US6326204B1 (en) * 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
DE19716683C1 (de) * 1997-04-21 1998-06-04 Fraunhofer Ges Forschung Vorrichtung zur getrennten, gekapselten Aufnahme einer Mehrzahl gleicher oder unterschiedlicher Stoffe
WO1998049548A1 (en) * 1997-04-25 1998-11-05 Caliper Technologies Corporation Microfluidic devices incorporating improved channel geometries
IL121286A0 (en) * 1997-07-11 1998-01-04 Pets N People Ltd Apparatus and methods for dispensing pet care substances
US5949187A (en) * 1997-07-29 1999-09-07 Motorola, Inc. Organic electroluminescent device with plural microcavities
US5961492A (en) * 1997-08-27 1999-10-05 Science Incorporated Fluid delivery device with temperature controlled energy source
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US6081736A (en) * 1997-10-20 2000-06-27 Alfred E. Mann Foundation Implantable enzyme-based monitoring systems adapted for long term use
US6475170B1 (en) 1997-12-30 2002-11-05 Remon Medical Technologies Ltd Acoustic biosensor for monitoring physiological conditions in a body implantation site
US6140740A (en) * 1997-12-30 2000-10-31 Remon Medical Technologies, Ltd. Piezoelectric transducer
US6237398B1 (en) * 1997-12-30 2001-05-29 Remon Medical Technologies, Ltd. System and method for monitoring pressure, flow and constriction parameters of plumbing and blood vessels
US6486588B2 (en) 1997-12-30 2002-11-26 Remon Medical Technologies Ltd Acoustic biosensor for monitoring physiological conditions in a body implantation site
US6001090A (en) 1998-02-09 1999-12-14 Lenhart; Douglas Thermal pharmaceutical delivery system
US6027695A (en) * 1998-04-01 2000-02-22 Dupont Pharmaceuticals Company Apparatus for holding small volumes of liquids
US6757560B1 (en) * 1999-04-09 2004-06-29 Novosis Pharma Ag Transdermal delivery system (TDS) with electrode network
US6161047A (en) 1998-04-30 2000-12-12 Medtronic Inc. Apparatus and method for expanding a stimulation lead body in situ
US6319241B1 (en) 1998-04-30 2001-11-20 Medtronic, Inc. Techniques for positioning therapy delivery elements within a spinal cord or a brain
US6062461A (en) * 1998-06-03 2000-05-16 Delphi Technologies, Inc. Process for bonding micromachined wafers using solder
US6058752A (en) * 1998-06-10 2000-05-09 Feder; George N. Pick-resistant lock system and method
US6941171B2 (en) * 1998-07-06 2005-09-06 Advanced Bionics Corporation Implantable stimulator methods for treatment of incontinence and pain
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6201980B1 (en) * 1998-10-05 2001-03-13 The Regents Of The University Of California Implantable medical sensor system
US6232150B1 (en) * 1998-12-03 2001-05-15 The Regents Of The University Of Michigan Process for making microstructures and microstructures made thereby
US6289237B1 (en) * 1998-12-22 2001-09-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Apparatus for energizing a remote station and related method
US6171850B1 (en) * 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
US6178349B1 (en) * 1999-04-15 2001-01-23 Medtronic, Inc. Drug delivery neural stimulation device for treatment of cardiovascular disorders
US6923784B2 (en) * 1999-04-30 2005-08-02 Medtronic, Inc. Therapeutic treatment of disorders based on timing information
US6669663B1 (en) * 1999-04-30 2003-12-30 Medtronic, Inc. Closed loop medicament pump
US6683615B1 (en) * 1999-06-09 2004-01-27 3Dlabs Inc., Ltd. Doubly-virtualized texture memory
US6587719B1 (en) * 1999-07-01 2003-07-01 Cyberonics, Inc. Treatment of obesity by bilateral vagus nerve stimulation
US6804558B2 (en) * 1999-07-07 2004-10-12 Medtronic, Inc. System and method of communicating between an implantable medical device and a remote computer system or health care provider
US6334859B1 (en) * 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
EP1210064B1 (de) * 1999-08-18 2005-03-09 Microchips, Inc. Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien
AU770395B2 (en) * 1999-11-17 2004-02-19 Boston Scientific Limited Microfabricated devices for the delivery of molecules into a carrier fluid
JP2003516343A (ja) * 1999-12-10 2003-05-13 マサチューセッツ インスティテュート オブ テクノロジー 分子を送達するマイクロチップ素子およびその製作方法
CN2414777Y (zh) * 1999-12-14 2001-01-17 陈刚 透皮渗药仪
US6384353B1 (en) * 2000-02-01 2002-05-07 Motorola, Inc. Micro-electromechanical system device
EP1261427B1 (de) * 2000-03-02 2011-03-02 Microchips, Inc. Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien
WO2001091902A2 (en) 2000-05-30 2001-12-06 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
CN2460122Y (zh) * 2000-06-19 2001-11-21 翁春晓 一种超声电导透皮给药装置的治疗头
AU2001283358A1 (en) * 2000-08-14 2002-02-25 Pharmacia Corporation Drug delivery system with burst electrode
US6403403B1 (en) * 2000-09-12 2002-06-11 The Aerospace Corporation Diode isolated thin film fuel cell array addressing method
US6437640B1 (en) * 2000-09-12 2002-08-20 The Aerospace Corporation Addressable diode isolated thin film array
DE60116520T2 (de) 2000-10-10 2006-08-31 Microchips, Inc., Bedford Microchip-reservoir-vorrichtungen mit drahtloser übertragung von energie und daten
WO2002030401A2 (en) * 2000-10-11 2002-04-18 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
WO2002034330A2 (en) * 2000-10-26 2002-05-02 Medtronic, Inc. Method and apparatus to minimize the effects of a cardiac insult
WO2002034327A2 (en) * 2000-10-26 2002-05-02 Medtronic, Inc. Method and apparatus to minimize the effects of a cardiac insult
EP1331965B1 (de) * 2000-10-26 2008-07-16 Medtronic, Inc. Vorrichtung zur elektrischen stimulation des nervensystems zur therapie ventrikulärer fehlfunktionen, herzversagen und anderer kardialer zustände
US6378292B1 (en) * 2000-11-10 2002-04-30 Honeywell International Inc. MEMS microthruster array
DE10061057A1 (de) * 2000-12-08 2002-06-13 Pharmed Holding Gmbh Chip-Systeme zur kontrollierten Emission chemosensorisch wirkender Stoffe
DE10063612C2 (de) 2000-12-20 2002-11-07 Fraunhofer Ges Forschung Mikrosystem zur Kontrolle der Wirkstoffabgabe aus einem Wirkstoffreservoir sowie Implantat mit Mikrosystem
JP4657577B2 (ja) 2001-01-09 2011-03-23 マイクロチップス・インコーポレーテッド 眼への適用および他への適用のための可撓性マイクロチップデバイス
AU2002245291A1 (en) * 2001-01-22 2002-07-30 Integrated Sensing Systems, Inc. Sensing catheter system and method of fabrication
DE10102817B4 (de) 2001-01-23 2006-01-12 Lts Lohmann Therapie-Systeme Ag Vorrichtung und Verfahren zur Hitzepulsgestützten transdermalen Applikation von Wirkstoffen
US6571125B2 (en) * 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
US7181287B2 (en) 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6858220B2 (en) * 2001-02-28 2005-02-22 Second Sight Medical Products, Inc. Implantable microfluidic delivery system using ultra-nanocrystalline diamond coating
US20020144548A1 (en) * 2001-04-06 2002-10-10 Cohn Michael B. High precision accelerometer
WO2002089767A1 (en) * 2001-05-03 2002-11-14 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
US6733485B1 (en) * 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
CA2447643A1 (en) * 2001-05-29 2002-12-05 Medtronic, Inc. Closed-loop neuromodulation for prevention and treatment of cardiac conditions
WO2002096389A1 (en) 2001-05-30 2002-12-05 Microchips, Inc. Conformal coated microchip reservoir devices
WO2002099457A1 (en) 2001-05-31 2002-12-12 Massachusetts Inst Technology Microchip devices with improved reservoir opening
CA2451953A1 (en) 2001-06-28 2003-04-24 Microchips, Inc. Methods for hermetically sealing microchip reservoir devices
WO2003002710A2 (en) * 2001-06-29 2003-01-09 The Board Of Trustees Of Leland Stanford Jr. University Artificial synapse chip interface for electronic prosthetic retina
US6663615B1 (en) 2001-09-04 2003-12-16 The Ohio State University Dual stage microvalve and method of use
US7097775B2 (en) * 2001-10-26 2006-08-29 Second Sight Medical Products, Inc. Coated microfluidic delivery system
EP1528940B1 (de) * 2002-08-16 2011-04-13 Microchips, Inc. Vorrichtung mit kontrollierter abgabe und verfahren
US7497855B2 (en) * 2002-09-04 2009-03-03 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
EP1551505B1 (de) * 2002-10-04 2010-02-24 Microchips, Inc. Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation
EP1551499A1 (de) * 2002-10-04 2005-07-13 Microchips, Inc. Medizinische vorrichtung zur nervenstimulation und kontrollierten verabreichung von medikamenten
ATE494885T1 (de) * 2003-04-25 2011-01-15 Boston Scient Scimed Inc Feste arzneimittelformulierung und vorrichtung zu ihrer aufbewahrung und kontrollierten abgabe
CN1905835B (zh) * 2003-09-11 2011-11-30 赛拉诺斯股份有限公司 分析物监测和药物递送的医疗装置

Also Published As

Publication number Publication date
JP2006515860A (ja) 2006-06-08
US20090030404A1 (en) 2009-01-29
WO2004071487A2 (en) 2004-08-26
CA2495327C (en) 2008-10-21
US7510551B2 (en) 2009-03-31
EP1528940B1 (de) 2011-04-13
CN1681542A (zh) 2005-10-12
CN100594892C (zh) 2010-03-24
US7910151B2 (en) 2011-03-22
WO2004071487A3 (en) 2004-09-30
US20060100608A1 (en) 2006-05-11
JP5313756B2 (ja) 2013-10-09
US20080168921A1 (en) 2008-07-17
JP4436258B2 (ja) 2010-03-24
JP2009195721A (ja) 2009-09-03
CA2495327A1 (en) 2004-08-26
AU2003303288A1 (en) 2004-09-06
US7455667B2 (en) 2008-11-25
US20040121486A1 (en) 2004-06-24
US8211092B2 (en) 2012-07-03
EP1528940A2 (de) 2005-05-11
AU2003303288B2 (en) 2006-12-07
KR100725973B1 (ko) 2007-06-11
ATE505224T1 (de) 2011-04-15
KR20050035277A (ko) 2005-04-15

Similar Documents

Publication Publication Date Title
DE60336727D1 (de) Vorrichtung mit kontrollierter abgabe und verfahren
ATE367184T1 (de) Wundheilungsfördernde vorrichtung
DE602005025048D1 (de) Film beschichtete elektrische Vorrichtung mit Druckentlastungsöffnung
AU2002345104A1 (en) Enhancement electrode configuration for electrically controlled light modulators
US9755185B2 (en) OLED device and manufacture thereof
TW337035B (en) Semiconductor device and method of manufacturing the same
TW200734737A (en) Liquid crystal device and electronic apparatus
TW200618363A (en) Light emitting element and light emitting device using the same
WO2006050079A3 (en) Electronic components associated and apparatus for deionization and electrochemical purification and regeneration of electrodes
TW200603367A (en) Semiconductor device and the fabricating method of the same
RU2525672C2 (ru) Электролюминесцентное устройство
HK1087245A1 (en) A method for preparing a plurality of connected optoelectronic devices and corresponding optoelectronic devices
EP1427007A3 (de) Anschlüsse für Halbleiterbauelement und Verfahren zu deren Herstellung
TW200620620A (en) Fuse structure with charge protection circuit
TW200711194A (en) Organic based device and method for manufacture thereof
TW200950147A (en) Method of manufacturing addressable and static electronic displays, power generating or other electronic apparatus
WO2009028807A3 (en) Light emitting device package and method for fabricating the same
TW200703621A (en) Resistive memory device with improved data retention and reduced power
DE602006015937D1 (de) Vorrichtung zur elektrischen Feldsteuerung
ATE300093T1 (de) Aktor mit einer elektrode, einer schwammartigen perkolierenden schicht, einem elektrolyten und einem mittel zum anlegen einer spannung
WO2018114684A1 (en) Multi-phase busbar for conducting electric energy and method of manufacturing the same
US20150236292A1 (en) Organic electroluminescent element and illuminating apparatus
CN109920828A (zh) 一种oled基板及其制备方法
US9606285B1 (en) LED lighting apparatus having electrically conductive sheets coupled to LEDs on an LED carrier
US10168038B1 (en) Solid state lighting (SSL) apparatus having electrically conductive sheets coupled to solid state lighting on an SSL element carrier