DE60333995D1 - Einrichtugn und verfahren für druckgesteuerten plug-transport und reaktion - Google Patents

Einrichtugn und verfahren für druckgesteuerten plug-transport und reaktion

Info

Publication number
DE60333995D1
DE60333995D1 DE60333995T DE60333995T DE60333995D1 DE 60333995 D1 DE60333995 D1 DE 60333995D1 DE 60333995 T DE60333995 T DE 60333995T DE 60333995 T DE60333995 T DE 60333995T DE 60333995 D1 DE60333995 D1 DE 60333995D1
Authority
DE
Germany
Prior art keywords
reaction
pressure
controlled plug
plug transport
transport
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60333995T
Other languages
English (en)
Inventor
Rustem F Ismagilov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Chicago
Original Assignee
University of Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32179583&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60333995(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Chicago filed Critical University of Chicago
Application granted granted Critical
Publication of DE60333995D1 publication Critical patent/DE60333995D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/45Mixing liquids with liquids; Emulsifying using flow mixing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • B01F33/302Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093Microreactors, e.g. miniaturised or microfabricated reactors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404Handling flow, e.g. hydrodynamic focusing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G01N35/085Flow Injection Analysis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30Injector mixers
    • B01F25/31Injector mixers in conduits or tubes through which the main component flows
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00281Individual reactor vessels
    • B01J2219/00286Reactor vessels with top and bottom openings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • B01J2219/00576Chemical means fluorophore
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/0059Sequential processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00599Solution-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00722Nucleotides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00725Peptides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00736Non-biologic macromolecules, e.g. polymeric compounds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/0074Biological products
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/00756Compositions, e.g. coatings, crystals, formulations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00783Laminate assemblies, i.e. the reactor comprising a stack of plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00819Materials of construction
    • B01J2219/00837Materials of construction comprising coatings other than catalytically active coatings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00851Additional features
    • B01J2219/00858Aspects relating to the size of the reactor
    • B01J2219/0086Dimensions of the flow channels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00851Additional features
    • B01J2219/00867Microreactors placed in series, on the same or on different supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00851Additional features
    • B01J2219/00869Microreactors placed in parallel, on the same or on different supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00889Mixing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00891Feeding or evacuation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/0095Control aspects
    • B01J2219/00952Sensing operations
    • B01J2219/00968Type of sensors
    • B01J2219/0097Optical sensors
    • B01J2219/00975Ultraviolet light
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/0095Control aspects
    • B01J2219/00952Sensing operations
    • B01J2219/00968Type of sensors
    • B01J2219/0097Optical sensors
    • B01J2219/00977Infrared light
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668Trapping microscopic beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0673Handling of plugs of fluid surrounded by immiscible fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883Serpentine channels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424Dielectrophoretic forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B01L2400/0448Marangoni flow; Thermocapillary effect
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404Handling flow, e.g. hydrodynamic focusing
    • G01N15/1409Handling samples, e.g. injecting samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484Optical investigation techniques, e.g. flow cytometry microstructural devices
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/117497Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/12Condition responsive control
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micromachines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Refuse Collection And Transfer (AREA)
  • Control Of Fluid Pressure (AREA)
DE60333995T 2002-05-09 2003-05-09 Einrichtugn und verfahren für druckgesteuerten plug-transport und reaktion Expired - Lifetime DE60333995D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37992702P 2002-05-09 2002-05-09
US39454402P 2002-07-08 2002-07-08
PCT/US2003/014794 WO2004038363A2 (en) 2002-05-09 2003-05-09 Microfluidic device and method for pressure-driven plug transport and reaction

Publications (1)

Publication Number Publication Date
DE60333995D1 true DE60333995D1 (de) 2010-10-14

Family

ID=32179583

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60333995T Expired - Lifetime DE60333995D1 (de) 2002-05-09 2003-05-09 Einrichtugn und verfahren für druckgesteuerten plug-transport und reaktion

Country Status (7)

Country Link
US (11) US7129091B2 (de)
EP (8) EP3290921B1 (de)
JP (9) JP4855680B2 (de)
AT (1) ATE479899T1 (de)
AU (1) AU2003290508A1 (de)
DE (1) DE60333995D1 (de)
WO (1) WO2004038363A2 (de)

Families Citing this family (346)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4855680B2 (ja) * 2002-05-09 2012-01-18 ザ・ユニバーシティ・オブ・シカゴ 圧力駆動プラグによる輸送と反応のための装置および方法
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
JP4346893B2 (ja) * 2002-11-01 2009-10-21 株式会社日立製作所 化学反応装置
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
DK1593091T3 (da) * 2003-01-25 2013-10-28 Seno Medical Instr Inc Optoakustisk afbildning med høj kontrast ved anvendelse af ikke-sfæriske nanopartikler
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
GB0307428D0 (en) * 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
EP3616781A1 (de) 2003-04-10 2020-03-04 President and Fellows of Harvard College Erzeugung und kontrolle von fluiden
US20050031657A1 (en) * 2003-07-18 2005-02-10 Gilson Michael K. Hydrosomes; chemical vessels for laser-guided microfluidics
CN1842368B (zh) 2003-08-27 2014-05-28 哈佛大学 流体物种的电子控制
US7745221B2 (en) 2003-08-28 2010-06-29 Celula, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
US9597644B2 (en) * 2003-09-05 2017-03-21 Stokes Bio Limited Methods for culturing and analyzing cells
WO2005023427A1 (en) 2003-09-05 2005-03-17 Stokes Bio Limited A microfluidic analysis system
US8968659B2 (en) 2003-09-05 2015-03-03 Stokes Bio Limited Sample dispensing
US20060057597A1 (en) * 2003-11-12 2006-03-16 California Institute Of Technology Method and system for processing nanoparticles using a self assembly mechanism to form combined species
US7329391B2 (en) * 2003-12-08 2008-02-12 Applera Corporation Microfluidic device and material manipulating method using same
EP1711263A2 (de) * 2003-12-10 2006-10-18 Northeastern University Verfahren zum effizienten transport kleiner flüssigkeitsvolumina zu, weg von oder innerhalb von mikrofluidischen vorrichtungen
US7416370B2 (en) * 2005-06-15 2008-08-26 Lam Research Corporation Method and apparatus for transporting a substrate using non-Newtonian fluid
US7389879B2 (en) * 2004-01-21 2008-06-24 Hewlett-Packard Development Company, L.P. Sorting particles
US20050178700A1 (en) * 2004-01-21 2005-08-18 David Tyvoll Sorting particles in parallel
PT1776181E (pt) 2004-01-26 2014-01-02 Harvard College Sistema e método para o fornecimento de fluidos
WO2005073410A2 (en) * 2004-01-28 2005-08-11 454 Corporation Nucleic acid amplification with continuous flow emulsion
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
GB0410579D0 (en) * 2004-05-12 2004-06-16 Univ St Andrews Optoelectronic tweezers
US8075863B2 (en) * 2004-05-26 2011-12-13 Massachusetts Institute Of Technology Methods and devices for growth and/or assembly of nanostructures
GB0502398D0 (en) 2005-02-04 2005-03-16 Q Chip Ltd Device and method for producing spherical segmented flow
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
EP1802395B1 (de) * 2004-09-09 2020-01-22 Institut Curie Ein kollineares elektrisches feld verwendende mikrofluidvorrichtung
JP2008513022A (ja) 2004-09-15 2008-05-01 マイクロチップ バイオテクノロジーズ, インコーポレイテッド マイクロ流体デバイス
US7316967B2 (en) * 2004-09-24 2008-01-08 Massachusetts Institute Of Technology Flow method and reactor for manufacturing noncrystals
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US20080095705A1 (en) * 2004-11-09 2008-04-24 Virtanen Jorma A Methods and Devices for Facile Fabrication of Nanoparticles and Their Applications
AU2006208124B2 (en) 2005-01-25 2011-09-15 Massachusetts Institute Of Technology Electrokinetic concentration device and methods of use thereof
DK1859330T3 (da) 2005-01-28 2012-10-15 Univ Duke Apparater og fremgangsmåder til håndtering af små dråber på et trykt kredsløbskort
WO2006096571A2 (en) 2005-03-04 2006-09-14 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
JP2008538077A (ja) * 2005-03-16 2008-10-09 ユニバーシティ オブ シカゴ マイクロフルイディックシステム
AU2006244617B2 (en) 2005-05-09 2013-04-18 Labrador Diagnostics Llc Point-of-care fluidic systems and uses thereof
US8718437B2 (en) 2006-03-07 2014-05-06 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
FR2890578B3 (fr) 2005-09-09 2007-11-30 Rhodia Chimie Sa Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ ou chimique, et son utilisation
WO2007021818A2 (en) * 2005-08-11 2007-02-22 Smithkline Beecham Corporation Flow reactor method and apparatus
US7955864B2 (en) 2005-08-22 2011-06-07 Life Technologies Corporation Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other
US7556776B2 (en) 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
SE529516C2 (sv) * 2005-10-24 2007-09-04 Alfa Laval Corp Ab Universell flödesmodul
US7704457B2 (en) * 2005-11-18 2010-04-27 Patton Charles J Automatic, field portable analyzer using discrete sample aliquots
JP4753367B2 (ja) * 2005-11-25 2011-08-24 日本電子株式会社 有機合成反応装置
GB2433448B (en) * 2005-12-20 2011-03-02 Q Chip Ltd Method for the control of chemical processes
EP3913375A1 (de) * 2006-01-11 2021-11-24 Bio-Rad Laboratories, Inc. Mikrofluidische vorrichtungen und verfahren zur verwendung bei der bildung und steuerung von nanoreaktoren
JP2009528509A (ja) * 2006-01-31 2009-08-06 ユニバーシティ オブ シカゴ 血液凝固をアッセイするための方法及び装置
WO2008030631A2 (en) * 2006-02-03 2008-03-13 Microchip Biotechnologies, Inc. Microfluidic devices
EP1981624B1 (de) 2006-02-07 2011-09-07 Stokes Bio Limited Flüssigkeitsbrückesystem und Verfahren
US8849087B2 (en) 2006-03-07 2014-09-30 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
US9951438B2 (en) 2006-03-07 2018-04-24 Samsung Electronics Co., Ltd. Compositions, optical component, system including an optical component, devices, and other products
US9874674B2 (en) 2006-03-07 2018-01-23 Samsung Electronics Co., Ltd. Compositions, optical component, system including an optical component, devices, and other products
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US20080003142A1 (en) 2006-05-11 2008-01-03 Link Darren R Microfluidic devices
US9562837B2 (en) * 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US20070298486A1 (en) * 2006-06-16 2007-12-27 Velocys Inc. Microchannel Apparatus and Methods Of Conducting Unit Operations With Disrupted Flow
WO2008108798A2 (en) 2006-06-24 2008-09-12 Qd Vision, Inc. Methods for depositing nanomaterial, methods for fabricating a device, and methods for fabricating an array of devices
WO2008105792A2 (en) 2006-06-24 2008-09-04 Qd Vision, Inc. Methods for depositing nanomaterial, methods for fabricating a device, methods for fabricating an array of devices and compositions
WO2008111947A1 (en) 2006-06-24 2008-09-18 Qd Vision, Inc. Methods and articles including nanomaterial
WO2008004550A1 (fr) * 2006-07-05 2008-01-10 Hitachi High-Technologies Corporation analyseur de liquide
JP4933352B2 (ja) * 2006-07-24 2012-05-16 株式会社 Jeol Resonance Nmr装置
EP2077912B1 (de) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
JP4943287B2 (ja) * 2006-09-29 2012-05-30 富士フイルム株式会社 液滴混合方法及び装置
FR2907030B1 (fr) * 2006-10-13 2014-06-06 Rhodia Recherches & Tech Procede et dispositif de gestion de bouchons dans un ecoulement fluidique
US7824736B2 (en) * 2006-12-15 2010-11-02 National Taiwan University Micro patch coating device and method
WO2008079274A1 (en) * 2006-12-19 2008-07-03 University Of Chicago Spacers for microfludic channels
JP4627302B2 (ja) * 2007-01-09 2011-02-09 株式会社神戸製鋼所 微粒子の製造方法及び装置
US20110039303A1 (en) 2007-02-05 2011-02-17 Stevan Bogdan Jovanovich Microfluidic and nanofluidic devices, systems, and applications
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
JP5491203B2 (ja) * 2007-03-05 2014-05-14 アドヴァンスト リキッド ロジック インコーポレイテッド 過酸化水素小滴ベースのアッセイ
US9029085B2 (en) 2007-03-07 2015-05-12 President And Fellows Of Harvard College Assays and other reactions involving droplets
GB2447412A (en) * 2007-03-13 2008-09-17 Shaw Stewart P D Versatile micro-mixing system with chemical and biological applications
EP2136786B8 (de) 2007-03-28 2012-11-14 President and Fellows of Harvard College Vorrichtung zur Formung von Tröpfchen
WO2008121803A1 (en) * 2007-03-30 2008-10-09 Fujifilm Corporation Method of cleaning micro-flow passages
US20090034359A1 (en) * 2007-04-04 2009-02-05 The Regents Of The University Of California Stopped flow, quenched flow and continuous flow reaction method and apparatus
EP2142279A2 (de) * 2007-04-16 2010-01-13 The General Hospital Corporation d/b/a Massachusetts General Hospital Systeme und verfahren zur teilchenfokussierung in mikrokanälen
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
WO2009014590A2 (en) 2007-06-25 2009-01-29 Qd Vision, Inc. Compositions and methods including depositing nanomaterial
JPWO2009008236A1 (ja) * 2007-07-10 2010-09-02 コニカミノルタエムジー株式会社 マイクロ検査チップの液体混合方法および検査装置
WO2009014707A2 (en) 2007-07-23 2009-01-29 Qd Vision, Inc. Quantum dot light enhancement substrate and lighting device including same
US20100227767A1 (en) * 2007-07-26 2010-09-09 Boedicker James Q Stochastic confinement to detect, manipulate, and utilize molecules and organisms
CN101842159B (zh) * 2007-08-09 2014-09-24 赛路拉公司 关联的多参数单细胞测定及残余生物材料回收的方法和装置
WO2009021233A2 (en) 2007-08-09 2009-02-12 Advanced Liquid Logic, Inc. Pcb droplet actuator fabrication
US8128249B2 (en) 2007-08-28 2012-03-06 Qd Vision, Inc. Apparatus for selectively backlighting a material
JP5738597B2 (ja) 2007-12-21 2015-06-24 プレジデント アンド フェローズ オブ ハーバード カレッジ 核酸の配列決定のためのシステムおよび方法
CN101990516B (zh) 2008-01-22 2015-09-09 英特基因有限公司 多用试样准备***及其在集成分析***中的使用
JP5248140B2 (ja) * 2008-02-27 2013-07-31 旭サナック株式会社 混合塗料の供給装置
GB2459085A (en) * 2008-04-07 2009-10-14 Shaw Stewart P D Air-segmented micro-mixing system for chemical and biological applications
US9664619B2 (en) 2008-04-28 2017-05-30 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
EP2297762B1 (de) 2008-05-06 2017-03-15 Samsung Electronics Co., Ltd. Halbleiter-beleuchtungsanordnungen mit quanteneingeschlossenen halbleiternanopartikeln
US9207385B2 (en) 2008-05-06 2015-12-08 Qd Vision, Inc. Lighting systems and devices including same
WO2009137053A1 (en) 2008-05-06 2009-11-12 Qd Vision, Inc. Optical components, systems including an optical component, and devices
EP2291509B1 (de) * 2008-05-16 2023-11-15 Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Mikrofluidische isolierung von tumorzellen oder anderer seltener zellen aus vollblut oder anderen flüssigkeiten
US8622987B2 (en) 2008-06-04 2014-01-07 The University Of Chicago Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
EP2352591A4 (de) * 2008-06-13 2013-01-23 Emerald Biostructures Inc Nanovolumiges mikrokapillarkristallisationssystem
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
WO2011120020A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet transport system for detection
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
WO2011120024A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet generation for droplet-based assays
US11951474B2 (en) 2008-10-22 2024-04-09 Life Technologies Corporation Fluidics systems for sequential delivery of reagents
US8546128B2 (en) 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US8435387B2 (en) * 2008-11-14 2013-05-07 Massachusetts Institute Of Technology Small-scale method and apparatus for separating mixtures
EP3587594B1 (de) 2008-12-19 2022-04-13 President and Fellows of Harvard College Partikelunterstützte nukleinsäuresequenzierung
US8672532B2 (en) 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
US9713802B2 (en) 2009-01-13 2017-07-25 Kobe Steel, Ltd. Method and apparatus for manufacturing liquid microspheres
JP5909095B2 (ja) * 2009-03-13 2016-04-26 プレジデント アンド フェローズ オブ ハーバード カレッジ マイクロ流体デバイスのスケールアップ
JP4706883B2 (ja) * 2009-03-17 2011-06-22 セイコーエプソン株式会社 生体試料定量方法
EP3415235A1 (de) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation von mikrofluidiktröpfchen
WO2010111265A1 (en) 2009-03-24 2010-09-30 University Of Chicago Slip chip device and methods
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
CA2758382C (en) 2009-04-13 2018-01-02 University Of Washington Ensemble-decision aliquot ranking
WO2010129374A2 (en) 2009-04-28 2010-11-11 Qd Vision, Inc. Optical materials, optical components, and methods
US20100300869A1 (en) * 2009-05-29 2010-12-02 Siemens Aktiengesellschaft Micro-fluidic separating device for liquid mixtures
KR20120030130A (ko) 2009-06-02 2012-03-27 인터젠엑스 인크. 다이아프램 밸브를 포함하는 유체 장치
SG176669A1 (en) 2009-06-05 2012-01-30 Integenx Inc Universal sample preparation system and use in an integrated analysis system
DE102009025007A1 (de) 2009-06-11 2011-01-05 Technische Universität Ilmenau Vorrichtung und Verfahren zur Überführung von Fluidproben in regelmäßige Probensequenzen, sowie Verfahren zur Manipulation letzterer
BRPI1011604A2 (pt) * 2009-06-19 2019-05-14 Milestone Dev Services eletropulverização e ionização de nanopulverização de amostras distintas em formato de gotícula
KR101097357B1 (ko) * 2009-07-09 2011-12-23 한국과학기술원 다기능 미세유체 유동 제어 장치 및 다기능 미세유체 유동 제어 방법
CA2767056C (en) 2009-09-02 2018-12-04 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
EP2473263B1 (de) 2009-09-02 2022-11-02 President and Fellows of Harvard College Mehrere mithilfe von strahl- und anderen technologien hergestellte emulsionen
WO2011031876A1 (en) 2009-09-09 2011-03-17 Qd Vision, Inc. Formulations including nanoparticles
CN102482457B (zh) 2009-09-09 2015-04-15 Qd视光有限公司 包含纳米颗粒的颗粒、其应用和方法
US8207651B2 (en) 2009-09-16 2012-06-26 Tyco Healthcare Group Lp Low energy or minimum disturbance method for measuring frequency response functions of ultrasonic surgical devices in determining optimum operating point
EP2486409A1 (de) 2009-10-09 2012-08-15 Universite De Strasbourg Markiertes nanomaterial auf siliziumbasis mit verbesserten eigenschaften und seine verwendung
WO2011050105A1 (en) * 2009-10-21 2011-04-28 Sanford-Burnham Medical Research Institute Compositions of nanoparticles and methods of making the same
US10207240B2 (en) 2009-11-03 2019-02-19 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
US9216414B2 (en) * 2009-11-25 2015-12-22 Gen9, Inc. Microfluidic devices and methods for gene synthesis
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
JP4973721B2 (ja) * 2009-12-07 2012-07-11 東ソー株式会社 微小粒子構造体およびそれを用いた微小粒子の製造方法
US20120258053A1 (en) * 2009-12-21 2012-10-11 Colgate-Palmolive Company Oral care compositions for use with an oral light device
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US20110165037A1 (en) * 2010-01-07 2011-07-07 Ismagilov Rustem F Interfaces that eliminate non-specific adsorption, and introduce specific interactions
US20130157251A1 (en) * 2010-01-13 2013-06-20 John Gerard Quinn In situ-dilution method and system for measuring molecular and chemical interactions
JP2013527022A (ja) * 2010-01-24 2013-06-27 インスチチュート・ケミィ・フィジズネジ・ポルスキージ・アカデミィ・ナウク 液体混合物の自動形成及び操作システムと方法。
EP3392349A1 (de) 2010-02-12 2018-10-24 Raindance Technologies, Inc. Digitale analyse von analyten
US9399797B2 (en) * 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
JP5691195B2 (ja) * 2010-03-01 2015-04-01 ソニー株式会社 マイクロチップ及び微小粒子分析装置
US8399198B2 (en) 2010-03-02 2013-03-19 Bio-Rad Laboratories, Inc. Assays with droplets transformed into capsules
JP2013524169A (ja) 2010-03-25 2013-06-17 クァンタライフ・インコーポレーテッド 液滴によるアッセイ用の検出システム
JP5550014B2 (ja) * 2010-04-19 2014-07-16 国立大学法人 筑波大学 マイクロポンプおよび送液制御装置
US9228785B2 (en) 2010-05-04 2016-01-05 Alexander Poltorak Fractal heat transfer device
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
GB201011019D0 (en) 2010-07-01 2010-08-18 Weston Richard Ionisation mass spectrometry
US8465707B2 (en) 2010-07-22 2013-06-18 Gencell Biosystems Ltd. Composite liquid cells
US8748191B2 (en) * 2010-08-02 2014-06-10 Ecolab Usa Inc. Stop-flow analytical systems and methods
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
US8486703B2 (en) 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
EP2622103B2 (de) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwichassays in tröpfchen
CA3140602C (en) 2010-11-01 2023-10-03 Bio-Rad Laboratories, Inc. System for forming emulsions
EP3859011A1 (de) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Verfahren zur bildung gemischter tröpfchen
EP2675819B1 (de) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Zusammensetzungen und verfahren für molekulare etikettierung
JP2014509865A (ja) 2011-03-18 2014-04-24 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド シグナルの組合せ使用による多重化デジタルアッセイ
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
WO2012134629A1 (en) 2011-04-01 2012-10-04 Qd Vision, Inc. Quantum dots, method, and devices
CN103733074B (zh) * 2011-04-08 2016-06-15 斯多克斯生物有限公司 用于连续流动式pcr***的***及方法
EP3395957B1 (de) 2011-04-25 2020-08-12 Bio-Rad Laboratories, Inc. Verfahren und zusammensetzungen zur nukleinsäureanalyse
KR20140034242A (ko) 2011-05-23 2014-03-19 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 다중 에멀젼을 포함하는 에멀젼의 제어
GB201109203D0 (en) * 2011-06-01 2011-07-13 Carclo Technical Plastics Ltd Fluid flow control
DE202012013668U1 (de) 2011-06-02 2019-04-18 Raindance Technologies, Inc. Enzymquantifizierung
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
JP5749987B2 (ja) * 2011-06-22 2015-07-15 株式会社神戸製鋼所 液体混合方法及び装置
JP2014522718A (ja) 2011-07-06 2014-09-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 多相エマルションおよび多相エマルション形成法
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013019751A1 (en) 2011-07-29 2013-02-07 Bio-Rad Laboratories, Inc., Library characterization by digital assay
US8932543B2 (en) * 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
SG11201401810QA (en) * 2011-09-28 2014-10-30 Harvard College Systems and methods for droplet production and/or fluidic manipulation
JP5908244B2 (ja) * 2011-09-29 2016-04-26 デクセリアルズ株式会社 マイクロリアクタ及び反応生成物の製造方法
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
JP5800195B2 (ja) * 2011-11-25 2015-10-28 国立研究開発法人産業技術総合研究所 結晶成長用容器、液滴調製器具および結晶取得方法
EP2872523B1 (de) 2011-12-30 2018-01-17 Abbott Molecular Inc. Mikroorganismus-nukleinsäurereinigung von wirtsproben
KR102028225B1 (ko) 2012-01-25 2019-10-02 젠셀 바이오시스템즈 리미티드 생체분자 분리
CN104203456B (zh) * 2012-03-16 2017-09-26 M技术株式会社 固体金镍合金纳米粒子及其制造方法
WO2013155531A2 (en) 2012-04-13 2013-10-17 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
WO2013159116A1 (en) 2012-04-20 2013-10-24 University Of Chicago Fluidic devices for biospecimen preservation
EP2839260B1 (de) 2012-04-20 2018-07-18 Talis Biomedical Corporation Fluidische vorrichtungen und systeme zur herstellung oder autonomen analyse einer probe
US9803237B2 (en) 2012-04-24 2017-10-31 California Institute Of Technology Slip-induced compartmentalization
US9929325B2 (en) 2012-06-05 2018-03-27 Samsung Electronics Co., Ltd. Lighting device including quantum dots
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4397767A3 (de) 2012-08-14 2024-07-31 10X Genomics, Inc. Mikrokapselzusammensetzungen und verfahren
FR2996545B1 (fr) 2012-10-08 2016-03-25 Ecole Polytech Procede microfluidique de traitement et d'analyse d'une solution contenant un materiel biologique, et circuit microfluidique correspondant.
US9990464B1 (en) 2012-10-09 2018-06-05 Pall Corporation Label-free biomolecular interaction analysis using a rapid analyte dispersion injection method
CA2888042A1 (en) 2012-11-27 2014-06-05 Gencell Biosystems Ltd. Handling liquid samples
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2014108323A1 (en) * 2013-01-10 2014-07-17 Eth Zurich Method and apparatus for depositing droplets onto a substrate
EP3998342A1 (de) 2013-02-08 2022-05-18 10X Genomics, Inc. Partitionierung und verarbeitung von analyten und andere arten
WO2014158367A1 (en) 2013-03-13 2014-10-02 Opko Diagnostics, Llc Mixing of fluids in fluidic systems
US9693958B2 (en) * 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
EP3017308A4 (de) 2013-07-05 2017-04-26 University Of Washington Through Its Center For Commercialization Verfahren, zusammensetzungen und systeme für mikrofluidische assays
GB2516684A (en) * 2013-07-30 2015-02-04 Sphere Fluidics Ltd Microfluidic devices and systems
GB201313583D0 (en) 2013-07-30 2013-09-11 Sphere Fluidics Ltd Emulsion
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9562914B2 (en) * 2013-10-16 2017-02-07 President And Fellows Of Harvard College Microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation
CN110560187B (zh) 2013-11-18 2022-01-11 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
GB201321433D0 (en) * 2013-12-04 2014-01-15 Isis Innovation Controling fluid micro compartments
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
US10060939B2 (en) 2014-01-31 2018-08-28 Carnegie Mellon University Device and method for clinical data sampling and specimen banking
US10384187B2 (en) 2014-02-10 2019-08-20 Gencell Biosystems Ltd Composite liquid cell (CLC) mediated nucleic acid library preparation device, and methods for using the same
BR112016023625A2 (pt) 2014-04-10 2018-06-26 10X Genomics, Inc. dispositivos fluídicos, sistemas e métodos para encapsular e particionar reagentes, e aplicações dos mesmos
JP6366988B2 (ja) * 2014-04-25 2018-08-01 国立研究開発法人産業技術総合研究所 長さの揃った金又は銀ナノロッドの製造方法
GB2544198B (en) 2014-05-21 2021-01-13 Integenx Inc Fluidic cartridge with valve mechanism
US9757727B2 (en) * 2014-05-29 2017-09-12 Massachusetts Institute Of Technology Hydrodynamic trap array
WO2015200893A2 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
JP2017526046A (ja) 2014-06-26 2017-09-07 10エックス ゲノミクス,インコーポレイテッド 核酸配列アセンブルのプロセス及びシステム
GB201414177D0 (en) 2014-08-11 2014-09-24 Sphere Fluidics Ltd Droplet Sorting
JP2017532024A (ja) 2014-09-09 2017-11-02 ザ・ブロード・インスティテュート・インコーポレイテッド コンポジット単一細胞核酸分析のための液滴ベースの方法および機器
CN104237186B (zh) * 2014-09-15 2017-01-25 华中科技大学 一种荧光成像装置及方法
CN113092563B (zh) 2014-10-22 2024-06-07 尹特根埃克斯有限公司 用于样品制备、处理和分析的***和方法
AU2015339148B2 (en) 2014-10-29 2022-03-10 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
US10258986B2 (en) 2014-11-12 2019-04-16 University Of New Hampshire Viscoelastic fluid drop production
TWI728963B (zh) 2014-12-12 2021-06-01 美商Opko診斷法有限責任公司 包含培養通道之流體系統,包括成型而成的流體系統及與其相關聯之方法
KR102321863B1 (ko) 2015-01-12 2021-11-08 10엑스 제노믹스, 인크. 핵산 시퀀싱 라이브러리의 제조 방법 및 시스템 및 이를 이용하여 제조한 라이브러리
KR20170106979A (ko) 2015-01-13 2017-09-22 10엑스 제노믹스, 인크. 구조 변이 및 위상 조정 정보를 시각화하기 위한 시스템 및 방법
US20160238506A1 (en) * 2015-02-02 2016-08-18 Derek Oberreit Ice nucleii counter technology
WO2016127073A1 (en) * 2015-02-06 2016-08-11 The Regents Of The University Of Michigan Controlled coalescence of gas phase segmented droplets
CN107208156B (zh) 2015-02-09 2021-10-08 10X基因组学有限公司 用于使用变异识别数据来确定结构变异和定相的***和方法
US10639631B2 (en) 2015-02-13 2020-05-05 International Business Machines Corporation Microfluidic probe head for processing a sequence of liquid volumes separated by spacers
US10391488B2 (en) * 2015-02-13 2019-08-27 International Business Machines Corporation Microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers
AU2016222719B2 (en) 2015-02-24 2022-03-31 10X Genomics, Inc. Methods for targeted nucleic acid sequence coverage
EP4286516A3 (de) 2015-02-24 2024-03-06 10X Genomics, Inc. Partitionsverarbeitungsverfahren und -systeme
CN107614700A (zh) 2015-03-11 2018-01-19 布罗德研究所有限公司 基因型和表型偶联
US10632465B2 (en) 2015-04-22 2020-04-28 Stilla Technologies Contact-less priming method for loading a solution in a microfluidic device and associated system
WO2017004250A1 (en) 2015-06-29 2017-01-05 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Systems and methods for continuous flow digital droplet polymerase chain reaction bioanalysis
EP3112869A1 (de) * 2015-06-30 2017-01-04 IMEC vzw Sensorvorrichtung
EP3339841B1 (de) * 2015-08-21 2021-11-10 Hitachi, Ltd. Lichtdetektionsvorrichtung
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
GB201614150D0 (en) * 2016-08-18 2016-10-05 Univ Oxford Innovation Ltd Microfluidic arrangements
EP3362177A1 (de) 2015-10-16 2018-08-22 Oxford University Innovation Limited Mikrofluidische anordnungen
CN105289385A (zh) * 2015-10-22 2016-02-03 上海交通大学 基于增强弯道二次流效应的扭曲弧形微混合器
US11092607B2 (en) 2015-10-28 2021-08-17 The Board Institute, Inc. Multiplex analysis of single cell constituents
WO2017075297A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. High-throughput dynamic reagent delivery system
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
DK3882357T3 (da) 2015-12-04 2022-08-29 10X Genomics Inc Fremgangsmåder og sammensætninger til analyse af nukleinsyrer
WO2017138984A1 (en) 2016-02-11 2017-08-17 10X Genomics, Inc. Systems, methods, and media for de novo assembly of whole genome sequence data
US10688493B2 (en) * 2016-03-09 2020-06-23 Texas Tech University System Integrated microfluidic rectifier for various bioanalytical applications
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
WO2018011809A1 (en) 2016-07-12 2018-01-18 Micro Green Technologies Ltd. Compositions comprising microalgae and methods of producing and using same
EP3485215B1 (de) 2016-07-12 2023-06-07 Alexander Poltorak System und verfahren zur bewahrung der effizienz eines kühlkörpers
US11029293B2 (en) 2016-10-18 2021-06-08 Institut National D'optique Method and system for the detection of a chemical species in solution
CN110740813B (zh) 2016-11-28 2022-06-03 亚利桑那州立大学董事会 涉及连续流动液滴反应的***和方法
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4029939B1 (de) 2017-01-30 2023-06-28 10X Genomics, Inc. Verfahren und systeme für eine einzelzellbarcodierung auf tröpfchenbasis
US10995333B2 (en) 2017-02-06 2021-05-04 10X Genomics, Inc. Systems and methods for nucleic acid preparation
TWI774752B (zh) * 2017-04-13 2022-08-21 國立大學法人北海道大學 流路構造體及使用該流路構造體之脂質粒子至微胞的形成方法
EP3615220A4 (de) 2017-04-28 2020-12-30 Neofluidics, LLC Fluidische vorrichtungen mit reaktionsvertiefungen und ihre verwendungen
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers
CN110870018A (zh) 2017-05-19 2020-03-06 10X基因组学有限公司 用于分析数据集的***和方法
SG11201901822QA (en) 2017-05-26 2019-03-28 10X Genomics Inc Single cell analysis of transposase accessible chromatin
US20180340169A1 (en) 2017-05-26 2018-11-29 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
WO2019032690A1 (en) 2017-08-09 2019-02-14 Neofluidics, Llc DEVICES AND METHODS FOR BIOLOGICAL TESTING
US10837047B2 (en) 2017-10-04 2020-11-17 10X Genomics, Inc. Compositions, methods, and systems for bead formation using improved polymers
WO2019084043A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS
EP3700672B1 (de) 2017-10-27 2022-12-28 10X Genomics, Inc. Verfahren zur probenvorbereitung und -analyse
US11305279B2 (en) 2017-11-10 2022-04-19 Neofluidics, Llc Integrated fluidic circuit and device for droplet manipulation and methods thereof
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019108851A1 (en) 2017-11-30 2019-06-06 10X Genomics, Inc. Systems and methods for nucleic acid preparation and analysis
JP7218558B2 (ja) * 2017-12-19 2023-02-07 東ソー株式会社 核酸増幅法および核酸増幅試薬
CN111699255B (zh) * 2018-02-09 2024-03-08 首尔大学校产学协力团 基于生物反应器的生物样品分析方法、分析芯片及分析***
SG11202007686VA (en) 2018-02-12 2020-09-29 10X Genomics Inc Methods characterizing multiple analytes from individual cells or cell populations
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
EP3533519B1 (de) * 2018-02-28 2020-09-30 Paris Sciences et Lettres - Quartier Latin Biphasischer plasmamikroreaktor und verfahren zur verwendung davon
EP3774005A4 (de) 2018-04-02 2022-04-20 Dropworks, Inc. Systeme und verfahren für serielle fliessemulsionsverfahren
US11485944B2 (en) * 2018-04-04 2022-11-01 Hewlett-Packard Development Company, L.P. Microfluidic cellular membrane modification devices
SG11202009889VA (en) 2018-04-06 2020-11-27 10X Genomics Inc Systems and methods for quality control in single cell processing
CN111989158B (zh) * 2018-04-15 2022-08-12 奥普图弗卢迪克生物鉴定有限责任公司 压差辅助排水***
CN112399882B (zh) 2018-04-16 2023-08-01 派特恩生物技术有限公司 用于形成二维微滴阵列的方法和设备
US11673107B2 (en) * 2018-05-01 2023-06-13 Hewlett-Packard Development Company, L.P. Sequential encapsulation of reagents
US11932899B2 (en) 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
AU2019283225B2 (en) 2018-06-07 2022-02-10 Yokogawa Electric Corporation Optical analysis system and optical analysis method
FR3082440B1 (fr) * 2018-06-14 2020-12-11 Paris Sciences Lettres Quartier Latin Methode de transfert de matiere dans un dispositif microfluidique ou millifluidique
US11703427B2 (en) 2018-06-25 2023-07-18 10X Genomics, Inc. Methods and systems for cell and bead processing
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
US11752175B2 (en) 2018-09-21 2023-09-12 Cornell University Compositions and methods for glaucoma
US11137493B2 (en) * 2018-10-15 2021-10-05 GM Global Technology Operations LLC System and method for detecting precipitation using radar
US10486155B1 (en) 2018-10-22 2019-11-26 Klaris Corporation Vacuum-loaded, droplet-generating microfluidic chips and related methods
WO2020087032A2 (en) 2018-10-26 2020-04-30 Neofluidics, Llc Fluidic devices with reaction wells and constriction channels and uses thereof
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
US11845983B1 (en) 2019-01-09 2023-12-19 10X Genomics, Inc. Methods and systems for multiplexing of droplet based assays
US11584953B2 (en) 2019-02-12 2023-02-21 10X Genomics, Inc. Methods for processing nucleic acid molecules
US11851683B1 (en) 2019-02-12 2023-12-26 10X Genomics, Inc. Methods and systems for selective analysis of cellular samples
US11467153B2 (en) 2019-02-12 2022-10-11 10X Genomics, Inc. Methods for processing nucleic acid molecules
US11655499B1 (en) 2019-02-25 2023-05-23 10X Genomics, Inc. Detection of sequence elements in nucleic acid molecules
SG11202111242PA (en) 2019-03-11 2021-11-29 10X Genomics Inc Systems and methods for processing optically tagged beads
EP3747541B1 (de) * 2019-06-03 2024-02-07 Cellular Highways Ltd. Vorrichtung zum sortieren von mikrofluidischen partikeln
CN110560188B (zh) * 2019-09-19 2021-09-28 济南大学 一种合成Ag/Ag2S/CdS异质结的多级进样微流控芯片的制备方法
WO2021059628A1 (ja) * 2019-09-24 2021-04-01 富士フイルム株式会社 スラグ流の形成方法、有機化合物の製造方法、粒子の製造方法、及び抽出方法
AU2020361681A1 (en) 2019-10-10 2022-05-05 1859, Inc. Methods and systems for microfluidic screening
CN111289469B (zh) * 2020-02-28 2021-03-23 浙江大学 一种icf靶丸内冰层折射率分布的测量装置和方法
US11242558B2 (en) 2020-04-15 2022-02-08 Enumerix, Inc. Systems and methods for generation of emulsions with suitable clarity with applications of use
WO2021216036A1 (en) * 2020-04-20 2021-10-28 Hewlett-Packard Development Company, L.P. Fluid dispenser frequencies
US10953404B1 (en) 2020-04-24 2021-03-23 Pattern Bioscience, Inc. Apparatuses for contactless loading and imaging of microfluidic chips and related methods
US11686730B2 (en) 2020-04-30 2023-06-27 Quanterix Corporation Quantitative antibody test
GB202006525D0 (en) 2020-05-04 2020-06-17 Sphere Fluidics Ltd Surfactant
US20210354144A1 (en) * 2020-05-12 2021-11-18 The Texas A&M University System Microfluidic platform for evaluation of liquid interfaces
US11851700B1 (en) 2020-05-13 2023-12-26 10X Genomics, Inc. Methods, kits, and compositions for processing extracellular molecules
JP7522444B2 (ja) 2020-09-09 2024-07-25 株式会社チップトン テイラー反応装置
CN112354573B (zh) 2020-10-26 2022-01-04 深圳亘流科技有限公司 阶跃式惯性聚焦微流控芯片
AU2022227563A1 (en) 2021-02-23 2023-08-24 10X Genomics, Inc. Probe-based analysis of nucleic acids and proteins
EP4323117A1 (de) 2021-04-15 2024-02-21 ScreenSYS GmbH Verfahren zur entwicklung und/oder umprogrammierung von zellulären pflanzenobjekten
CN114534652B (zh) * 2022-02-08 2024-07-19 上海天泽云泰生物医药有限公司 波形微结构混合单元及其用途
CN114398378B (zh) * 2022-03-25 2022-11-01 北京奥星贝斯科技有限公司 确定索引代价的方法和装置
CN115069134B (zh) * 2022-07-07 2023-09-05 山东省科学院能源研究所 一种基于迪恩涡流的微流体高效混合器
DE102022124200A1 (de) * 2022-09-21 2024-03-21 Asepto GmbH Aseptische Verfahrenstechnik und Automation Verfahren zum Herstellen zumindest eines pflanzenbasierten Getränkes und Vorrichtung zum Herstellen zumindest eines pflanzenbasierten Getränkes
WO2024091930A1 (en) * 2022-10-24 2024-05-02 1859, Inc. Miniaturized methods and systems for sample screening
US20240198336A1 (en) * 2022-12-19 2024-06-20 Anchorline Biolabs, Inc. Capillary partitioning microfluidics

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3479141A (en) * 1967-05-17 1969-11-18 Technicon Corp Method and apparatus for analysis
US3960187A (en) 1974-07-23 1976-06-01 Usm Corporation Method and device for metering and dispersing fluid materials
GB2097692B (en) * 1981-01-10 1985-05-22 Shaw Stewart P D Combining chemical reagents
US4853336A (en) * 1982-11-15 1989-08-01 Technicon Instruments Corporation Single channel continuous flow system
CA1238900A (en) * 1982-11-15 1988-07-05 Stephen Saros Single channel continuous slug flow mixing of discrete fluid components
JPS61238330A (ja) * 1985-04-12 1986-10-23 Mitsui Petrochem Ind Ltd 乳化装置
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US5185099A (en) * 1988-04-20 1993-02-09 Institut National De Recherche Chimique Appliquee Visco-elastic, isotropic materials based on water, fluorinate sufactants and fluorinated oils, process for their preparation, and their use in various fields, such as optics, pharmacology and electrodynamics
JP3512186B2 (ja) * 1993-03-19 2004-03-29 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 化学処理及び製造のための一体構造及び方法、並びにその使用方法及び製造方法
MY110990A (en) * 1993-06-03 1999-07-31 Atomaer Pty Ltd Multiphase staged passive reactor
EP0636413B1 (de) * 1993-07-28 2001-11-14 PE Corporation (NY) Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5595712A (en) * 1994-07-25 1997-01-21 E. I. Du Pont De Nemours And Company Chemical mixing and reaction apparatus
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
AU708165B2 (en) 1995-06-06 1999-07-29 Interpore International Inc. Wound sealant preparation and application device and method
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US6132580A (en) * 1995-09-28 2000-10-17 The Regents Of The University Of California Miniature reaction chamber and devices incorporating same
WO1997029508A2 (en) * 1996-02-08 1997-08-14 Perseptive Biosystems, Inc. Interface between liquid flow and mass spectrometer
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
WO1997039359A1 (en) * 1996-04-15 1997-10-23 Dade International Inc. Apparatus and method for analysis
NZ333346A (en) * 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
BR9710052A (pt) * 1996-06-28 2000-01-11 Caliper Techn Corp Sistema microfluido com compensação para polarização eletroforética, eletropipetador, processos para introduzir materiais a partir de uma série de fontes em um sistema microfluido, para distribuir de maneira controlável uma corrente de fluido e para transportar amostras de fluido, sistema de amostragem, emprego de um substrato, emprego de um sistema microfluido, e, substrato.
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
AU4114397A (en) * 1996-07-15 1998-02-09 Kemgas Limited Production of powders
US6140053A (en) * 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
US5993750A (en) * 1997-04-11 1999-11-30 Eastman Kodak Company Integrated ceramic micro-chemical plant
DE19717085C2 (de) * 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
KR100351531B1 (ko) * 1997-04-25 2002-09-11 캘리퍼 테크놀로지스 코포레이션 기하형상이 개선된 채널을 채용하는 미소 유체 장치
DE69823347T2 (de) * 1997-05-16 2005-05-12 Alberta Research Council, Edmonton Mikrofluidisches system und verfahren zu dessen betrieb
JP2843319B1 (ja) 1997-06-27 1999-01-06 科学技術振興事業団 マイクロストリップガスチャンバー高速データ収集システム及びそれを用いた試料の測定方法
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
FR2769215B1 (fr) * 1997-10-03 1999-12-24 Oreal Composition de teinture des fibres keratiniques et procede de teinture mettant en oeuvre cette composition
US5997636A (en) 1998-05-01 1999-12-07 Instrumentation Technology Associates, Inc. Method and apparatus for growing crystals
US6149787A (en) * 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6569631B1 (en) 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
US20030069601A1 (en) 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US6605475B1 (en) * 1999-04-16 2003-08-12 Perspective Biosystems, Inc. Apparatus and method for sample delivery
US6630006B2 (en) 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US6296673B1 (en) 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US7195670B2 (en) 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
JP2001088098A (ja) * 1999-09-14 2001-04-03 Kawamura Inst Of Chem Res 減圧送液機構を有する微小ケミカルデバイス
JP2001088096A (ja) * 1999-09-14 2001-04-03 Kawamura Inst Of Chem Res 吸収式送液機構を有する微小ケミカルデバイス
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
JP2001145486A (ja) * 1999-11-19 2001-05-29 Natl Inst Of Advanced Industrial Science & Technology Meti 多試料用の微小容量化学反応装置
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
JP2001194373A (ja) * 2000-01-06 2001-07-19 Olympus Optical Co Ltd 超小型化学操作装置
WO2001051918A1 (en) 2000-01-12 2001-07-19 Ut-Battelle, Llc A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
AU2001234997B2 (en) * 2000-02-11 2006-07-27 Monogram Biosciences, Inc. Microfluid device with sample injector and method of use
EP1272768A4 (de) 2000-02-23 2005-09-07 Zyomyx Inc Mikrofluidische einrichtungen und verfahren
GB2359765B (en) 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
US20020012971A1 (en) * 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
JP4927287B2 (ja) 2000-03-31 2012-05-09 マイクロニックス、インコーポレーテッド タンパク質の結晶化のマイクロ流動体装置
AU2001250058A1 (en) * 2000-04-06 2001-10-23 Caliper Technologies Corp. Methods and devices for achieving long incubation times in high-throughput systems
EP1286913A2 (de) 2000-05-24 2003-03-05 Micronics, Inc. Mikrofluidischer kreislauf mit konzentrationsgradienten
US20010048637A1 (en) * 2000-05-24 2001-12-06 Weigl Bernhard H. Microfluidic system and method
JP2002031638A (ja) * 2000-07-17 2002-01-31 Mitsubishi Chemicals Corp 生体試料検出用チップ及び生体試料検出方法
US7004184B2 (en) * 2000-07-24 2006-02-28 The Reagents Of The University Of Michigan Compositions and methods for liquid metering in microchannels
DE60121604T2 (de) * 2000-08-04 2007-06-21 Caliper Life Sciences, Inc., Mountain View Steuerung von betriebsbedingungen in fluidischen systemen
US20040005582A1 (en) 2000-08-10 2004-01-08 Nanobiodynamics, Incorporated Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
WO2002025243A1 (en) * 2000-09-21 2002-03-28 Dna Sciences, Inc. Sample injector system and method
EP1330306A2 (de) * 2000-10-10 2003-07-30 BioTrove, Inc. Vorrichtung zum testen, synthese und lagerung sowie verfahren zur herstellung, verwendung und handhabung
JP2004526949A (ja) 2000-10-19 2004-09-02 ストラクチュラル ジェノミックス,インコーポレーテッド その場x線回折による結晶識別のための装置および方法
CN2482070Y (zh) 2001-01-02 2002-03-13 大连市临床检验中心 血液促凝球
CA2450676C (en) * 2001-03-09 2010-03-30 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US20030064414A1 (en) 2001-03-30 2003-04-03 Benecky Michael J. Rapid assessment of coagulation activity in whole blood
US20020148992A1 (en) 2001-04-03 2002-10-17 Hayenga Jon W. Pneumatic valve interface for use in microfluidic structures
US6797056B2 (en) 2001-06-08 2004-09-28 Syrrx, Inc. Microfluidic method employing delivery of plural different fluids to same lumen
US6719840B2 (en) 2001-06-08 2004-04-13 Syrrx, Inc. In situ crystal growth and crystallization
US6656267B2 (en) 2001-07-10 2003-12-02 Structural Genomix, Inc. Tray for macromolecule crystallization and method of using the same
US6766817B2 (en) 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
WO2003044221A1 (en) * 2001-10-19 2003-05-30 West Virginia University Research Corporation Microfluidic system for proteome analysis
US6783647B2 (en) 2001-10-19 2004-08-31 Ut-Battelle, Llc Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate
CA2477702A1 (en) 2002-03-05 2003-09-18 Caliper Life Sciences, Inc. Mixed mode microfluidic systems abstract of the disclosure
US7101467B2 (en) 2002-03-05 2006-09-05 Caliper Life Sciences, Inc. Mixed mode microfluidic systems
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
JP4855680B2 (ja) * 2002-05-09 2012-01-18 ザ・ユニバーシティ・オブ・シカゴ 圧力駆動プラグによる輸送と反応のための装置および方法
US7901939B2 (en) * 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP3883060B2 (ja) 2002-06-17 2007-02-21 株式会社リガク 結晶評価装置
JP2004016925A (ja) * 2002-06-17 2004-01-22 Taisei Corp 管内面ライニング装置
US20040136497A1 (en) 2002-10-30 2004-07-15 Meldrum Deirdre R Preparation of samples and sample evaluation
KR20050088476A (ko) 2002-12-30 2005-09-06 더 리전트 오브 더 유니버시티 오브 캘리포니아 병원균 검출과 분석을 위한 방법과 기구
EP1605817A2 (de) 2003-02-25 2005-12-21 Inlight Solutions, Inc. Bestimmung des ph-werts mit hämoglobin-korrektur
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US7262059B2 (en) 2003-05-06 2007-08-28 Thrombodyne, Inc. Systems and methods for measuring fluid properties
JP4466991B2 (ja) 2003-05-22 2010-05-26 英明 森山 結晶成長装置及び方法
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
CN101163800B (zh) 2005-02-18 2013-04-17 佳能美国生命科学公司 鉴定生物的基因组dna的装置和方法
CN101223268A (zh) 2005-05-18 2008-07-16 康奈尔研究基金会(有限公司) 具有生物屏障的基于药代动力学的培养***
US20070026439A1 (en) 2005-07-15 2007-02-01 Applera Corporation Fluid processing device and method
AU2008265610B2 (en) 2007-06-21 2012-08-23 Gen-Probe Incorporated Instrument and receptacles for performing processes
US8622987B2 (en) 2008-06-04 2014-01-07 The University Of Chicago Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution

Also Published As

Publication number Publication date
EP1508044A4 (de) 2008-09-10
WO2004038363A2 (en) 2004-05-06
EP2283917B1 (de) 2021-12-15
EP2283918A2 (de) 2011-02-16
WO2004038363A3 (en) 2004-12-09
JP2021119004A (ja) 2021-08-12
US20170361321A1 (en) 2017-12-21
EP2302389A1 (de) 2011-03-30
EP2278337B1 (de) 2019-06-26
JP2006504512A (ja) 2006-02-09
ATE479899T1 (de) 2010-09-15
US9889446B2 (en) 2018-02-13
US7129091B2 (en) 2006-10-31
JP2015024406A (ja) 2015-02-05
EP3290921A1 (de) 2018-03-07
EP2283917A2 (de) 2011-02-16
EP1508044B1 (de) 2010-09-01
JP2017159297A (ja) 2017-09-14
JP5859393B2 (ja) 2016-02-10
EP2278338B1 (de) 2020-08-26
US10668471B2 (en) 2020-06-02
US10562028B2 (en) 2020-02-18
US8889083B2 (en) 2014-11-18
JP2009291788A (ja) 2009-12-17
US20170232440A1 (en) 2017-08-17
US20200360928A1 (en) 2020-11-19
EP2283918B1 (de) 2022-10-05
US20180193838A1 (en) 2018-07-12
EP2282214A2 (de) 2011-02-09
JP2012254452A (ja) 2012-12-27
JP6270278B2 (ja) 2018-01-31
EP2278337A3 (de) 2012-09-26
EP2278338A3 (de) 2012-09-26
EP2282214B1 (de) 2022-10-05
US20050272159A1 (en) 2005-12-08
JP4855680B2 (ja) 2012-01-18
US9579622B2 (en) 2017-02-28
US20160051960A1 (en) 2016-02-25
US20070172954A1 (en) 2007-07-26
US20180193837A1 (en) 2018-07-12
US10118174B2 (en) 2018-11-06
US9968933B2 (en) 2018-05-15
US20180154362A1 (en) 2018-06-07
US10105703B2 (en) 2018-10-23
JP2019141841A (ja) 2019-08-29
JP2011212679A (ja) 2011-10-27
JP2017104863A (ja) 2017-06-15
AU2003290508A8 (en) 2004-05-13
JP5519975B2 (ja) 2014-06-11
EP3290921B1 (de) 2022-06-15
EP2283917A3 (de) 2012-08-01
EP2278338A2 (de) 2011-01-26
EP2302389B1 (de) 2018-01-24
EP1508044A2 (de) 2005-02-23
EP2283918A3 (de) 2012-08-01
US9839893B2 (en) 2017-12-12
EP2278337A2 (de) 2011-01-26
US20150099264A1 (en) 2015-04-09
AU2003290508A1 (en) 2004-05-13
EP2282214A3 (de) 2012-08-01
US20170368551A1 (en) 2017-12-28

Similar Documents

Publication Publication Date Title
DE60333995D1 (de) Einrichtugn und verfahren für druckgesteuerten plug-transport und reaktion
DE60308971D1 (de) Verfahren und Vorrichtung für sichere Datenkommunikationsverbindungen
DE60235698D1 (de) System zur schmierung und zur reduzierung von hydraten und verfahren für ein fluidströmungssystem
DE60232129D1 (de) Rechtwinklige Anschlussvorrichtung für Leiterplatte, Verfahren und hergestellte Gegenstände
DE60227021D1 (de) Verfahren und Einrichtung zur lokalen Generierung von Medieninhalten für wartende Anrufer
DE60302275D1 (de) Verfahren und Vorrichtung zum mischen von Gasen
DE60312689D1 (de) Verfahren und vorrichtung zur verminderung von übertragungsfehlern
DE60324868D1 (de) Träger für elektronische Vorrichtungen, dessen Verfahren zur Herstellung, und elektronische Vorrichtung
DE10291574D2 (de) Vorrichtung und Verfahren zum katalytischen Reformieren von Kohlenwasserstoffen oder Alkoholen
ATE467301T1 (de) Verfahren und vorrichtung für gleichrangigen diensten
DE10391476D2 (de) Verfahren und Vorrichtung zum Auftragen von Fluiden
DE60301087D1 (de) Basisstation und Verfahren zur Regelung der Übertragungsleistung
DE60221158D1 (de) Vorrichtung und verfahren für oberflächeneigenschaften
DE60306222D1 (de) Gerät und Verfahren für chemische Analysen
ATE320983T1 (de) Hermetische umhüllung für nahrungsmittel, entsprechendes verfahren und entsprechende vorrichtung
DE60311941D1 (de) Behälter für die polymerasekettenreaktion und verfahren zu dessen herstellung
DE60314160D1 (de) Verfahren und vorrichtung zum austausch von unterirdischen rohren
DE50302347D1 (de) Verfahren und einrichtung zum verarbeiten von flachen sendungen
DE60328788D1 (de) Verfahren und einrichtung zum verknüpfen von multimedia-daten
DE60229325D1 (de) Verfahren und Vorrichtung zum Aufkohlen
DE50212087D1 (de) Abgasanlage und verfahren zu deren betrieb
DE50212310D1 (de) Verfahren und Einrichtung für den Transfer von Werkstücken
DE60312964D1 (de) Vorrichtung und verfahren für geplante wellenlängehinzufügung und -abbau
DE602004011045D1 (de) Vorrichtung und verfahren zur versorgung mit ammoniakgas
DE602004010604D1 (de) Vorrichtung und Verfahren zur Prüfung von Datenübertragung