DE60333995D1 - Einrichtugn und verfahren für druckgesteuerten plug-transport und reaktion - Google Patents
Einrichtugn und verfahren für druckgesteuerten plug-transport und reaktionInfo
- Publication number
- DE60333995D1 DE60333995D1 DE60333995T DE60333995T DE60333995D1 DE 60333995 D1 DE60333995 D1 DE 60333995D1 DE 60333995 T DE60333995 T DE 60333995T DE 60333995 T DE60333995 T DE 60333995T DE 60333995 D1 DE60333995 D1 DE 60333995D1
- Authority
- DE
- Germany
- Prior art keywords
- reaction
- pressure
- controlled plug
- plug transport
- transport
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006243 chemical reaction Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 1
Classifications
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Families Citing this family (346)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4855680B2 (ja) * | 2002-05-09 | 2012-01-18 | ザ・ユニバーシティ・オブ・シカゴ | 圧力駆動プラグによる輸送と反応のための装置および方法 |
US7901939B2 (en) | 2002-05-09 | 2011-03-08 | University Of Chicago | Method for performing crystallization and reactions in pressure-driven fluid plugs |
JP2006507921A (ja) | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
US6911132B2 (en) | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
US7329545B2 (en) | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
JP4346893B2 (ja) * | 2002-11-01 | 2009-10-21 | 株式会社日立製作所 | 化学反応装置 |
GB2395196B (en) * | 2002-11-14 | 2006-12-27 | Univ Cardiff | Microfluidic device and methods for construction and application |
DK1593091T3 (da) * | 2003-01-25 | 2013-10-28 | Seno Medical Instr Inc | Optoakustisk afbildning med høj kontrast ved anvendelse af ikke-sfæriske nanopartikler |
US20100022414A1 (en) | 2008-07-18 | 2010-01-28 | Raindance Technologies, Inc. | Droplet Libraries |
US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
GB0307428D0 (en) * | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
EP3616781A1 (de) | 2003-04-10 | 2020-03-04 | President and Fellows of Harvard College | Erzeugung und kontrolle von fluiden |
US20050031657A1 (en) * | 2003-07-18 | 2005-02-10 | Gilson Michael K. | Hydrosomes; chemical vessels for laser-guided microfluidics |
CN1842368B (zh) | 2003-08-27 | 2014-05-28 | 哈佛大学 | 流体物种的电子控制 |
US7745221B2 (en) | 2003-08-28 | 2010-06-29 | Celula, Inc. | Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network |
US9597644B2 (en) * | 2003-09-05 | 2017-03-21 | Stokes Bio Limited | Methods for culturing and analyzing cells |
WO2005023427A1 (en) | 2003-09-05 | 2005-03-17 | Stokes Bio Limited | A microfluidic analysis system |
US8968659B2 (en) | 2003-09-05 | 2015-03-03 | Stokes Bio Limited | Sample dispensing |
US20060057597A1 (en) * | 2003-11-12 | 2006-03-16 | California Institute Of Technology | Method and system for processing nanoparticles using a self assembly mechanism to form combined species |
US7329391B2 (en) * | 2003-12-08 | 2008-02-12 | Applera Corporation | Microfluidic device and material manipulating method using same |
EP1711263A2 (de) * | 2003-12-10 | 2006-10-18 | Northeastern University | Verfahren zum effizienten transport kleiner flüssigkeitsvolumina zu, weg von oder innerhalb von mikrofluidischen vorrichtungen |
US7416370B2 (en) * | 2005-06-15 | 2008-08-26 | Lam Research Corporation | Method and apparatus for transporting a substrate using non-Newtonian fluid |
US7389879B2 (en) * | 2004-01-21 | 2008-06-24 | Hewlett-Packard Development Company, L.P. | Sorting particles |
US20050178700A1 (en) * | 2004-01-21 | 2005-08-18 | David Tyvoll | Sorting particles in parallel |
PT1776181E (pt) | 2004-01-26 | 2014-01-02 | Harvard College | Sistema e método para o fornecimento de fluidos |
WO2005073410A2 (en) * | 2004-01-28 | 2005-08-11 | 454 Corporation | Nucleic acid amplification with continuous flow emulsion |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
GB0410579D0 (en) * | 2004-05-12 | 2004-06-16 | Univ St Andrews | Optoelectronic tweezers |
US8075863B2 (en) * | 2004-05-26 | 2011-12-13 | Massachusetts Institute Of Technology | Methods and devices for growth and/or assembly of nanostructures |
GB0502398D0 (en) | 2005-02-04 | 2005-03-16 | Q Chip Ltd | Device and method for producing spherical segmented flow |
US9477233B2 (en) | 2004-07-02 | 2016-10-25 | The University Of Chicago | Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets |
EP1802395B1 (de) * | 2004-09-09 | 2020-01-22 | Institut Curie | Ein kollineares elektrisches feld verwendende mikrofluidvorrichtung |
JP2008513022A (ja) | 2004-09-15 | 2008-05-01 | マイクロチップ バイオテクノロジーズ, インコーポレイテッド | マイクロ流体デバイス |
US7316967B2 (en) * | 2004-09-24 | 2008-01-08 | Massachusetts Institute Of Technology | Flow method and reactor for manufacturing noncrystals |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
US20080095705A1 (en) * | 2004-11-09 | 2008-04-24 | Virtanen Jorma A | Methods and Devices for Facile Fabrication of Nanoparticles and Their Applications |
AU2006208124B2 (en) | 2005-01-25 | 2011-09-15 | Massachusetts Institute Of Technology | Electrokinetic concentration device and methods of use thereof |
DK1859330T3 (da) | 2005-01-28 | 2012-10-15 | Univ Duke | Apparater og fremgangsmåder til håndtering af små dråber på et trykt kredsløbskort |
WO2006096571A2 (en) | 2005-03-04 | 2006-09-14 | President And Fellows Of Harvard College | Method and apparatus for forming multiple emulsions |
JP2008538077A (ja) * | 2005-03-16 | 2008-10-09 | ユニバーシティ オブ シカゴ | マイクロフルイディックシステム |
AU2006244617B2 (en) | 2005-05-09 | 2013-04-18 | Labrador Diagnostics Llc | Point-of-care fluidic systems and uses thereof |
US8718437B2 (en) | 2006-03-07 | 2014-05-06 | Qd Vision, Inc. | Compositions, optical component, system including an optical component, devices, and other products |
US20060280029A1 (en) * | 2005-06-13 | 2006-12-14 | President And Fellows Of Harvard College | Microfluidic mixer |
FR2890578B3 (fr) | 2005-09-09 | 2007-11-30 | Rhodia Chimie Sa | Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ ou chimique, et son utilisation |
WO2007021818A2 (en) * | 2005-08-11 | 2007-02-22 | Smithkline Beecham Corporation | Flow reactor method and apparatus |
US7955864B2 (en) | 2005-08-22 | 2011-06-07 | Life Technologies Corporation | Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other |
US7556776B2 (en) | 2005-09-08 | 2009-07-07 | President And Fellows Of Harvard College | Microfluidic manipulation of fluids and reactions |
SE529516C2 (sv) * | 2005-10-24 | 2007-09-04 | Alfa Laval Corp Ab | Universell flödesmodul |
US7704457B2 (en) * | 2005-11-18 | 2010-04-27 | Patton Charles J | Automatic, field portable analyzer using discrete sample aliquots |
JP4753367B2 (ja) * | 2005-11-25 | 2011-08-24 | 日本電子株式会社 | 有機合成反応装置 |
GB2433448B (en) * | 2005-12-20 | 2011-03-02 | Q Chip Ltd | Method for the control of chemical processes |
EP3913375A1 (de) * | 2006-01-11 | 2021-11-24 | Bio-Rad Laboratories, Inc. | Mikrofluidische vorrichtungen und verfahren zur verwendung bei der bildung und steuerung von nanoreaktoren |
JP2009528509A (ja) * | 2006-01-31 | 2009-08-06 | ユニバーシティ オブ シカゴ | 血液凝固をアッセイするための方法及び装置 |
WO2008030631A2 (en) * | 2006-02-03 | 2008-03-13 | Microchip Biotechnologies, Inc. | Microfluidic devices |
EP1981624B1 (de) | 2006-02-07 | 2011-09-07 | Stokes Bio Limited | Flüssigkeitsbrückesystem und Verfahren |
US8849087B2 (en) | 2006-03-07 | 2014-09-30 | Qd Vision, Inc. | Compositions, optical component, system including an optical component, devices, and other products |
US9951438B2 (en) | 2006-03-07 | 2018-04-24 | Samsung Electronics Co., Ltd. | Compositions, optical component, system including an optical component, devices, and other products |
US9874674B2 (en) | 2006-03-07 | 2018-01-23 | Samsung Electronics Co., Ltd. | Compositions, optical component, system including an optical component, devices, and other products |
US11287421B2 (en) | 2006-03-24 | 2022-03-29 | Labrador Diagnostics Llc | Systems and methods of sample processing and fluid control in a fluidic system |
US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
US7439014B2 (en) | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
US20080003142A1 (en) | 2006-05-11 | 2008-01-03 | Link Darren R | Microfluidic devices |
US9562837B2 (en) * | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
US20070298486A1 (en) * | 2006-06-16 | 2007-12-27 | Velocys Inc. | Microchannel Apparatus and Methods Of Conducting Unit Operations With Disrupted Flow |
WO2008108798A2 (en) | 2006-06-24 | 2008-09-12 | Qd Vision, Inc. | Methods for depositing nanomaterial, methods for fabricating a device, and methods for fabricating an array of devices |
WO2008105792A2 (en) | 2006-06-24 | 2008-09-04 | Qd Vision, Inc. | Methods for depositing nanomaterial, methods for fabricating a device, methods for fabricating an array of devices and compositions |
WO2008111947A1 (en) | 2006-06-24 | 2008-09-18 | Qd Vision, Inc. | Methods and articles including nanomaterial |
WO2008004550A1 (fr) * | 2006-07-05 | 2008-01-10 | Hitachi High-Technologies Corporation | analyseur de liquide |
JP4933352B2 (ja) * | 2006-07-24 | 2012-05-16 | 株式会社 Jeol Resonance | Nmr装置 |
EP2077912B1 (de) | 2006-08-07 | 2019-03-27 | The President and Fellows of Harvard College | Fluorkohlenstoffemulsionsstabilisierende tenside |
JP4943287B2 (ja) * | 2006-09-29 | 2012-05-30 | 富士フイルム株式会社 | 液滴混合方法及び装置 |
FR2907030B1 (fr) * | 2006-10-13 | 2014-06-06 | Rhodia Recherches & Tech | Procede et dispositif de gestion de bouchons dans un ecoulement fluidique |
US7824736B2 (en) * | 2006-12-15 | 2010-11-02 | National Taiwan University | Micro patch coating device and method |
WO2008079274A1 (en) * | 2006-12-19 | 2008-07-03 | University Of Chicago | Spacers for microfludic channels |
JP4627302B2 (ja) * | 2007-01-09 | 2011-02-09 | 株式会社神戸製鋼所 | 微粒子の製造方法及び装置 |
US20110039303A1 (en) | 2007-02-05 | 2011-02-17 | Stevan Bogdan Jovanovich | Microfluidic and nanofluidic devices, systems, and applications |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
JP5491203B2 (ja) * | 2007-03-05 | 2014-05-14 | アドヴァンスト リキッド ロジック インコーポレイテッド | 過酸化水素小滴ベースのアッセイ |
US9029085B2 (en) | 2007-03-07 | 2015-05-12 | President And Fellows Of Harvard College | Assays and other reactions involving droplets |
GB2447412A (en) * | 2007-03-13 | 2008-09-17 | Shaw Stewart P D | Versatile micro-mixing system with chemical and biological applications |
EP2136786B8 (de) | 2007-03-28 | 2012-11-14 | President and Fellows of Harvard College | Vorrichtung zur Formung von Tröpfchen |
WO2008121803A1 (en) * | 2007-03-30 | 2008-10-09 | Fujifilm Corporation | Method of cleaning micro-flow passages |
US20090034359A1 (en) * | 2007-04-04 | 2009-02-05 | The Regents Of The University Of California | Stopped flow, quenched flow and continuous flow reaction method and apparatus |
EP2142279A2 (de) * | 2007-04-16 | 2010-01-13 | The General Hospital Corporation d/b/a Massachusetts General Hospital | Systeme und verfahren zur teilchenfokussierung in mikrokanälen |
WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
US8691164B2 (en) * | 2007-04-20 | 2014-04-08 | Celula, Inc. | Cell sorting system and methods |
WO2009014590A2 (en) | 2007-06-25 | 2009-01-29 | Qd Vision, Inc. | Compositions and methods including depositing nanomaterial |
JPWO2009008236A1 (ja) * | 2007-07-10 | 2010-09-02 | コニカミノルタエムジー株式会社 | マイクロ検査チップの液体混合方法および検査装置 |
WO2009014707A2 (en) | 2007-07-23 | 2009-01-29 | Qd Vision, Inc. | Quantum dot light enhancement substrate and lighting device including same |
US20100227767A1 (en) * | 2007-07-26 | 2010-09-09 | Boedicker James Q | Stochastic confinement to detect, manipulate, and utilize molecules and organisms |
CN101842159B (zh) * | 2007-08-09 | 2014-09-24 | 赛路拉公司 | 关联的多参数单细胞测定及残余生物材料回收的方法和装置 |
WO2009021233A2 (en) | 2007-08-09 | 2009-02-12 | Advanced Liquid Logic, Inc. | Pcb droplet actuator fabrication |
US8128249B2 (en) | 2007-08-28 | 2012-03-06 | Qd Vision, Inc. | Apparatus for selectively backlighting a material |
JP5738597B2 (ja) | 2007-12-21 | 2015-06-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 核酸の配列決定のためのシステムおよび方法 |
CN101990516B (zh) | 2008-01-22 | 2015-09-09 | 英特基因有限公司 | 多用试样准备***及其在集成分析***中的使用 |
JP5248140B2 (ja) * | 2008-02-27 | 2013-07-31 | 旭サナック株式会社 | 混合塗料の供給装置 |
GB2459085A (en) * | 2008-04-07 | 2009-10-14 | Shaw Stewart P D | Air-segmented micro-mixing system for chemical and biological applications |
US9664619B2 (en) | 2008-04-28 | 2017-05-30 | President And Fellows Of Harvard College | Microfluidic device for storage and well-defined arrangement of droplets |
EP2297762B1 (de) | 2008-05-06 | 2017-03-15 | Samsung Electronics Co., Ltd. | Halbleiter-beleuchtungsanordnungen mit quanteneingeschlossenen halbleiternanopartikeln |
US9207385B2 (en) | 2008-05-06 | 2015-12-08 | Qd Vision, Inc. | Lighting systems and devices including same |
WO2009137053A1 (en) | 2008-05-06 | 2009-11-12 | Qd Vision, Inc. | Optical components, systems including an optical component, and devices |
EP2291509B1 (de) * | 2008-05-16 | 2023-11-15 | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College | Mikrofluidische isolierung von tumorzellen oder anderer seltener zellen aus vollblut oder anderen flüssigkeiten |
US8622987B2 (en) | 2008-06-04 | 2014-01-07 | The University Of Chicago | Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution |
EP2352591A4 (de) * | 2008-06-13 | 2013-01-23 | Emerald Biostructures Inc | Nanovolumiges mikrokapillarkristallisationssystem |
US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
US8633015B2 (en) | 2008-09-23 | 2014-01-21 | Bio-Rad Laboratories, Inc. | Flow-based thermocycling system with thermoelectric cooler |
US8709762B2 (en) | 2010-03-02 | 2014-04-29 | Bio-Rad Laboratories, Inc. | System for hot-start amplification via a multiple emulsion |
US9417190B2 (en) | 2008-09-23 | 2016-08-16 | Bio-Rad Laboratories, Inc. | Calibrations and controls for droplet-based assays |
US9764322B2 (en) | 2008-09-23 | 2017-09-19 | Bio-Rad Laboratories, Inc. | System for generating droplets with pressure monitoring |
US9132394B2 (en) | 2008-09-23 | 2015-09-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
WO2011120020A1 (en) | 2010-03-25 | 2011-09-29 | Quantalife, Inc. | Droplet transport system for detection |
US9492797B2 (en) | 2008-09-23 | 2016-11-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
WO2011120024A1 (en) | 2010-03-25 | 2011-09-29 | Quantalife, Inc. | Droplet generation for droplet-based assays |
US11951474B2 (en) | 2008-10-22 | 2024-04-09 | Life Technologies Corporation | Fluidics systems for sequential delivery of reagents |
US8546128B2 (en) | 2008-10-22 | 2013-10-01 | Life Technologies Corporation | Fluidics system for sequential delivery of reagents |
US8435387B2 (en) * | 2008-11-14 | 2013-05-07 | Massachusetts Institute Of Technology | Small-scale method and apparatus for separating mixtures |
EP3587594B1 (de) | 2008-12-19 | 2022-04-13 | President and Fellows of Harvard College | Partikelunterstützte nukleinsäuresequenzierung |
US8672532B2 (en) | 2008-12-31 | 2014-03-18 | Integenx Inc. | Microfluidic methods |
US9713802B2 (en) | 2009-01-13 | 2017-07-25 | Kobe Steel, Ltd. | Method and apparatus for manufacturing liquid microspheres |
JP5909095B2 (ja) * | 2009-03-13 | 2016-04-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | マイクロ流体デバイスのスケールアップ |
JP4706883B2 (ja) * | 2009-03-17 | 2011-06-22 | セイコーエプソン株式会社 | 生体試料定量方法 |
EP3415235A1 (de) | 2009-03-23 | 2018-12-19 | Raindance Technologies Inc. | Manipulation von mikrofluidiktröpfchen |
WO2010111265A1 (en) | 2009-03-24 | 2010-09-30 | University Of Chicago | Slip chip device and methods |
US9464319B2 (en) | 2009-03-24 | 2016-10-11 | California Institute Of Technology | Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes |
US10196700B2 (en) | 2009-03-24 | 2019-02-05 | University Of Chicago | Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes |
US9447461B2 (en) | 2009-03-24 | 2016-09-20 | California Institute Of Technology | Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes |
CA2758382C (en) | 2009-04-13 | 2018-01-02 | University Of Washington | Ensemble-decision aliquot ranking |
WO2010129374A2 (en) | 2009-04-28 | 2010-11-11 | Qd Vision, Inc. | Optical materials, optical components, and methods |
US20100300869A1 (en) * | 2009-05-29 | 2010-12-02 | Siemens Aktiengesellschaft | Micro-fluidic separating device for liquid mixtures |
KR20120030130A (ko) | 2009-06-02 | 2012-03-27 | 인터젠엑스 인크. | 다이아프램 밸브를 포함하는 유체 장치 |
SG176669A1 (en) | 2009-06-05 | 2012-01-30 | Integenx Inc | Universal sample preparation system and use in an integrated analysis system |
DE102009025007A1 (de) | 2009-06-11 | 2011-01-05 | Technische Universität Ilmenau | Vorrichtung und Verfahren zur Überführung von Fluidproben in regelmäßige Probensequenzen, sowie Verfahren zur Manipulation letzterer |
BRPI1011604A2 (pt) * | 2009-06-19 | 2019-05-14 | Milestone Dev Services | eletropulverização e ionização de nanopulverização de amostras distintas em formato de gotícula |
KR101097357B1 (ko) * | 2009-07-09 | 2011-12-23 | 한국과학기술원 | 다기능 미세유체 유동 제어 장치 및 다기능 미세유체 유동 제어 방법 |
CA2767056C (en) | 2009-09-02 | 2018-12-04 | Bio-Rad Laboratories, Inc. | System for mixing fluids by coalescence of multiple emulsions |
EP2473263B1 (de) | 2009-09-02 | 2022-11-02 | President and Fellows of Harvard College | Mehrere mithilfe von strahl- und anderen technologien hergestellte emulsionen |
WO2011031876A1 (en) | 2009-09-09 | 2011-03-17 | Qd Vision, Inc. | Formulations including nanoparticles |
CN102482457B (zh) | 2009-09-09 | 2015-04-15 | Qd视光有限公司 | 包含纳米颗粒的颗粒、其应用和方法 |
US8207651B2 (en) | 2009-09-16 | 2012-06-26 | Tyco Healthcare Group Lp | Low energy or minimum disturbance method for measuring frequency response functions of ultrasonic surgical devices in determining optimum operating point |
EP2486409A1 (de) | 2009-10-09 | 2012-08-15 | Universite De Strasbourg | Markiertes nanomaterial auf siliziumbasis mit verbesserten eigenschaften und seine verwendung |
WO2011050105A1 (en) * | 2009-10-21 | 2011-04-28 | Sanford-Burnham Medical Research Institute | Compositions of nanoparticles and methods of making the same |
US10207240B2 (en) | 2009-11-03 | 2019-02-19 | Gen9, Inc. | Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly |
US9216414B2 (en) * | 2009-11-25 | 2015-12-22 | Gen9, Inc. | Microfluidic devices and methods for gene synthesis |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
JP4973721B2 (ja) * | 2009-12-07 | 2012-07-11 | 東ソー株式会社 | 微小粒子構造体およびそれを用いた微小粒子の製造方法 |
US20120258053A1 (en) * | 2009-12-21 | 2012-10-11 | Colgate-Palmolive Company | Oral care compositions for use with an oral light device |
US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
US20110165037A1 (en) * | 2010-01-07 | 2011-07-07 | Ismagilov Rustem F | Interfaces that eliminate non-specific adsorption, and introduce specific interactions |
US20130157251A1 (en) * | 2010-01-13 | 2013-06-20 | John Gerard Quinn | In situ-dilution method and system for measuring molecular and chemical interactions |
JP2013527022A (ja) * | 2010-01-24 | 2013-06-27 | インスチチュート・ケミィ・フィジズネジ・ポルスキージ・アカデミィ・ナウク | 液体混合物の自動形成及び操作システムと方法。 |
EP3392349A1 (de) | 2010-02-12 | 2018-10-24 | Raindance Technologies, Inc. | Digitale analyse von analyten |
US9399797B2 (en) * | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
JP5691195B2 (ja) * | 2010-03-01 | 2015-04-01 | ソニー株式会社 | マイクロチップ及び微小粒子分析装置 |
US8399198B2 (en) | 2010-03-02 | 2013-03-19 | Bio-Rad Laboratories, Inc. | Assays with droplets transformed into capsules |
JP2013524169A (ja) | 2010-03-25 | 2013-06-17 | クァンタライフ・インコーポレーテッド | 液滴によるアッセイ用の検出システム |
JP5550014B2 (ja) * | 2010-04-19 | 2014-07-16 | 国立大学法人 筑波大学 | マイクロポンプおよび送液制御装置 |
US9228785B2 (en) | 2010-05-04 | 2016-01-05 | Alexander Poltorak | Fractal heat transfer device |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
GB201011019D0 (en) | 2010-07-01 | 2010-08-18 | Weston Richard | Ionisation mass spectrometry |
US8465707B2 (en) | 2010-07-22 | 2013-06-18 | Gencell Biosystems Ltd. | Composite liquid cells |
US8748191B2 (en) * | 2010-08-02 | 2014-06-10 | Ecolab Usa Inc. | Stop-flow analytical systems and methods |
US8763642B2 (en) | 2010-08-20 | 2014-07-01 | Integenx Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
US9121058B2 (en) | 2010-08-20 | 2015-09-01 | Integenx Inc. | Linear valve arrays |
US8486703B2 (en) | 2010-09-30 | 2013-07-16 | Ut-Battelle, Llc | Surface sampling concentration and reaction probe |
EP2622103B2 (de) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Sandwichassays in tröpfchen |
CA3140602C (en) | 2010-11-01 | 2023-10-03 | Bio-Rad Laboratories, Inc. | System for forming emulsions |
EP3859011A1 (de) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Verfahren zur bildung gemischter tröpfchen |
EP2675819B1 (de) | 2011-02-18 | 2020-04-08 | Bio-Rad Laboratories, Inc. | Zusammensetzungen und verfahren für molekulare etikettierung |
JP2014509865A (ja) | 2011-03-18 | 2014-04-24 | バイオ−ラッド・ラボラトリーズ・インコーポレーテッド | シグナルの組合せ使用による多重化デジタルアッセイ |
US9260753B2 (en) | 2011-03-24 | 2016-02-16 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
WO2012134629A1 (en) | 2011-04-01 | 2012-10-04 | Qd Vision, Inc. | Quantum dots, method, and devices |
CN103733074B (zh) * | 2011-04-08 | 2016-06-15 | 斯多克斯生物有限公司 | 用于连续流动式pcr***的***及方法 |
EP3395957B1 (de) | 2011-04-25 | 2020-08-12 | Bio-Rad Laboratories, Inc. | Verfahren und zusammensetzungen zur nukleinsäureanalyse |
KR20140034242A (ko) | 2011-05-23 | 2014-03-19 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 다중 에멀젼을 포함하는 에멀젼의 제어 |
GB201109203D0 (en) * | 2011-06-01 | 2011-07-13 | Carclo Technical Plastics Ltd | Fluid flow control |
DE202012013668U1 (de) | 2011-06-02 | 2019-04-18 | Raindance Technologies, Inc. | Enzymquantifizierung |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
JP5749987B2 (ja) * | 2011-06-22 | 2015-07-15 | 株式会社神戸製鋼所 | 液体混合方法及び装置 |
JP2014522718A (ja) | 2011-07-06 | 2014-09-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 多相エマルションおよび多相エマルション形成法 |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
WO2013019751A1 (en) | 2011-07-29 | 2013-02-07 | Bio-Rad Laboratories, Inc., | Library characterization by digital assay |
US8932543B2 (en) * | 2011-09-21 | 2015-01-13 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
SG11201401810QA (en) * | 2011-09-28 | 2014-10-30 | Harvard College | Systems and methods for droplet production and/or fluidic manipulation |
JP5908244B2 (ja) * | 2011-09-29 | 2016-04-26 | デクセリアルズ株式会社 | マイクロリアクタ及び反応生成物の製造方法 |
US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
JP5800195B2 (ja) * | 2011-11-25 | 2015-10-28 | 国立研究開発法人産業技術総合研究所 | 結晶成長用容器、液滴調製器具および結晶取得方法 |
EP2872523B1 (de) | 2011-12-30 | 2018-01-17 | Abbott Molecular Inc. | Mikroorganismus-nukleinsäurereinigung von wirtsproben |
KR102028225B1 (ko) | 2012-01-25 | 2019-10-02 | 젠셀 바이오시스템즈 리미티드 | 생체분자 분리 |
CN104203456B (zh) * | 2012-03-16 | 2017-09-26 | M技术株式会社 | 固体金镍合金纳米粒子及其制造方法 |
WO2013155531A2 (en) | 2012-04-13 | 2013-10-17 | Bio-Rad Laboratories, Inc. | Sample holder with a well having a wicking promoter |
WO2013159116A1 (en) | 2012-04-20 | 2013-10-24 | University Of Chicago | Fluidic devices for biospecimen preservation |
EP2839260B1 (de) | 2012-04-20 | 2018-07-18 | Talis Biomedical Corporation | Fluidische vorrichtungen und systeme zur herstellung oder autonomen analyse einer probe |
US9803237B2 (en) | 2012-04-24 | 2017-10-31 | California Institute Of Technology | Slip-induced compartmentalization |
US9929325B2 (en) | 2012-06-05 | 2018-03-27 | Samsung Electronics Co., Ltd. | Lighting device including quantum dots |
US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US10400280B2 (en) | 2012-08-14 | 2019-09-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
EP4397767A3 (de) | 2012-08-14 | 2024-07-31 | 10X Genomics, Inc. | Mikrokapselzusammensetzungen und verfahren |
FR2996545B1 (fr) | 2012-10-08 | 2016-03-25 | Ecole Polytech | Procede microfluidique de traitement et d'analyse d'une solution contenant un materiel biologique, et circuit microfluidique correspondant. |
US9990464B1 (en) | 2012-10-09 | 2018-06-05 | Pall Corporation | Label-free biomolecular interaction analysis using a rapid analyte dispersion injection method |
CA2888042A1 (en) | 2012-11-27 | 2014-06-05 | Gencell Biosystems Ltd. | Handling liquid samples |
CA2894694C (en) | 2012-12-14 | 2023-04-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
WO2014108323A1 (en) * | 2013-01-10 | 2014-07-17 | Eth Zurich | Method and apparatus for depositing droplets onto a substrate |
EP3998342A1 (de) | 2013-02-08 | 2022-05-18 | 10X Genomics, Inc. | Partitionierung und verarbeitung von analyten und andere arten |
WO2014158367A1 (en) | 2013-03-13 | 2014-10-02 | Opko Diagnostics, Llc | Mixing of fluids in fluidic systems |
US9693958B2 (en) * | 2013-03-15 | 2017-07-04 | Cureport, Inc. | Methods and devices for preparation of lipid nanoparticles |
EP3017308A4 (de) | 2013-07-05 | 2017-04-26 | University Of Washington Through Its Center For Commercialization | Verfahren, zusammensetzungen und systeme für mikrofluidische assays |
GB2516684A (en) * | 2013-07-30 | 2015-02-04 | Sphere Fluidics Ltd | Microfluidic devices and systems |
GB201313583D0 (en) | 2013-07-30 | 2013-09-11 | Sphere Fluidics Ltd | Emulsion |
US10395758B2 (en) | 2013-08-30 | 2019-08-27 | 10X Genomics, Inc. | Sequencing methods |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US9562914B2 (en) * | 2013-10-16 | 2017-02-07 | President And Fellows Of Harvard College | Microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation |
CN110560187B (zh) | 2013-11-18 | 2022-01-11 | 尹特根埃克斯有限公司 | 用于样本分析的卡盒和仪器 |
GB201321433D0 (en) * | 2013-12-04 | 2014-01-15 | Isis Innovation | Controling fluid micro compartments |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
US9824068B2 (en) | 2013-12-16 | 2017-11-21 | 10X Genomics, Inc. | Methods and apparatus for sorting data |
US11193176B2 (en) | 2013-12-31 | 2021-12-07 | Bio-Rad Laboratories, Inc. | Method for detecting and quantifying latent retroviral RNA species |
US10060939B2 (en) | 2014-01-31 | 2018-08-28 | Carnegie Mellon University | Device and method for clinical data sampling and specimen banking |
US10384187B2 (en) | 2014-02-10 | 2019-08-20 | Gencell Biosystems Ltd | Composite liquid cell (CLC) mediated nucleic acid library preparation device, and methods for using the same |
BR112016023625A2 (pt) | 2014-04-10 | 2018-06-26 | 10X Genomics, Inc. | dispositivos fluídicos, sistemas e métodos para encapsular e particionar reagentes, e aplicações dos mesmos |
JP6366988B2 (ja) * | 2014-04-25 | 2018-08-01 | 国立研究開発法人産業技術総合研究所 | 長さの揃った金又は銀ナノロッドの製造方法 |
GB2544198B (en) | 2014-05-21 | 2021-01-13 | Integenx Inc | Fluidic cartridge with valve mechanism |
US9757727B2 (en) * | 2014-05-29 | 2017-09-12 | Massachusetts Institute Of Technology | Hydrodynamic trap array |
WO2015200893A2 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
JP2017526046A (ja) | 2014-06-26 | 2017-09-07 | 10エックス ゲノミクス,インコーポレイテッド | 核酸配列アセンブルのプロセス及びシステム |
GB201414177D0 (en) | 2014-08-11 | 2014-09-24 | Sphere Fluidics Ltd | Droplet Sorting |
JP2017532024A (ja) | 2014-09-09 | 2017-11-02 | ザ・ブロード・インスティテュート・インコーポレイテッド | コンポジット単一細胞核酸分析のための液滴ベースの方法および機器 |
CN104237186B (zh) * | 2014-09-15 | 2017-01-25 | 华中科技大学 | 一种荧光成像装置及方法 |
CN113092563B (zh) | 2014-10-22 | 2024-06-07 | 尹特根埃克斯有限公司 | 用于样品制备、处理和分析的***和方法 |
AU2015339148B2 (en) | 2014-10-29 | 2022-03-10 | 10X Genomics, Inc. | Methods and compositions for targeted nucleic acid sequencing |
US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
US10258986B2 (en) | 2014-11-12 | 2019-04-16 | University Of New Hampshire | Viscoelastic fluid drop production |
TWI728963B (zh) | 2014-12-12 | 2021-06-01 | 美商Opko診斷法有限責任公司 | 包含培養通道之流體系統,包括成型而成的流體系統及與其相關聯之方法 |
KR102321863B1 (ko) | 2015-01-12 | 2021-11-08 | 10엑스 제노믹스, 인크. | 핵산 시퀀싱 라이브러리의 제조 방법 및 시스템 및 이를 이용하여 제조한 라이브러리 |
KR20170106979A (ko) | 2015-01-13 | 2017-09-22 | 10엑스 제노믹스, 인크. | 구조 변이 및 위상 조정 정보를 시각화하기 위한 시스템 및 방법 |
US20160238506A1 (en) * | 2015-02-02 | 2016-08-18 | Derek Oberreit | Ice nucleii counter technology |
WO2016127073A1 (en) * | 2015-02-06 | 2016-08-11 | The Regents Of The University Of Michigan | Controlled coalescence of gas phase segmented droplets |
CN107208156B (zh) | 2015-02-09 | 2021-10-08 | 10X基因组学有限公司 | 用于使用变异识别数据来确定结构变异和定相的***和方法 |
US10639631B2 (en) | 2015-02-13 | 2020-05-05 | International Business Machines Corporation | Microfluidic probe head for processing a sequence of liquid volumes separated by spacers |
US10391488B2 (en) * | 2015-02-13 | 2019-08-27 | International Business Machines Corporation | Microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers |
AU2016222719B2 (en) | 2015-02-24 | 2022-03-31 | 10X Genomics, Inc. | Methods for targeted nucleic acid sequence coverage |
EP4286516A3 (de) | 2015-02-24 | 2024-03-06 | 10X Genomics, Inc. | Partitionsverarbeitungsverfahren und -systeme |
CN107614700A (zh) | 2015-03-11 | 2018-01-19 | 布罗德研究所有限公司 | 基因型和表型偶联 |
US10632465B2 (en) | 2015-04-22 | 2020-04-28 | Stilla Technologies | Contact-less priming method for loading a solution in a microfluidic device and associated system |
WO2017004250A1 (en) | 2015-06-29 | 2017-01-05 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Systems and methods for continuous flow digital droplet polymerase chain reaction bioanalysis |
EP3112869A1 (de) * | 2015-06-30 | 2017-01-04 | IMEC vzw | Sensorvorrichtung |
EP3339841B1 (de) * | 2015-08-21 | 2021-11-10 | Hitachi, Ltd. | Lichtdetektionsvorrichtung |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
GB201614150D0 (en) * | 2016-08-18 | 2016-10-05 | Univ Oxford Innovation Ltd | Microfluidic arrangements |
EP3362177A1 (de) | 2015-10-16 | 2018-08-22 | Oxford University Innovation Limited | Mikrofluidische anordnungen |
CN105289385A (zh) * | 2015-10-22 | 2016-02-03 | 上海交通大学 | 基于增强弯道二次流效应的扭曲弧形微混合器 |
US11092607B2 (en) | 2015-10-28 | 2021-08-17 | The Board Institute, Inc. | Multiplex analysis of single cell constituents |
WO2017075297A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | High-throughput dynamic reagent delivery system |
US11371094B2 (en) | 2015-11-19 | 2022-06-28 | 10X Genomics, Inc. | Systems and methods for nucleic acid processing using degenerate nucleotides |
DK3882357T3 (da) | 2015-12-04 | 2022-08-29 | 10X Genomics Inc | Fremgangsmåder og sammensætninger til analyse af nukleinsyrer |
WO2017138984A1 (en) | 2016-02-11 | 2017-08-17 | 10X Genomics, Inc. | Systems, methods, and media for de novo assembly of whole genome sequence data |
US10688493B2 (en) * | 2016-03-09 | 2020-06-23 | Texas Tech University System | Integrated microfluidic rectifier for various bioanalytical applications |
WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
WO2018011809A1 (en) | 2016-07-12 | 2018-01-18 | Micro Green Technologies Ltd. | Compositions comprising microalgae and methods of producing and using same |
EP3485215B1 (de) | 2016-07-12 | 2023-06-07 | Alexander Poltorak | System und verfahren zur bewahrung der effizienz eines kühlkörpers |
US11029293B2 (en) | 2016-10-18 | 2021-06-08 | Institut National D'optique | Method and system for the detection of a chemical species in solution |
CN110740813B (zh) | 2016-11-28 | 2022-06-03 | 亚利桑那州立大学董事会 | 涉及连续流动液滴反应的***和方法 |
US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
EP4029939B1 (de) | 2017-01-30 | 2023-06-28 | 10X Genomics, Inc. | Verfahren und systeme für eine einzelzellbarcodierung auf tröpfchenbasis |
US10995333B2 (en) | 2017-02-06 | 2021-05-04 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation |
TWI774752B (zh) * | 2017-04-13 | 2022-08-21 | 國立大學法人北海道大學 | 流路構造體及使用該流路構造體之脂質粒子至微胞的形成方法 |
EP3615220A4 (de) | 2017-04-28 | 2020-12-30 | Neofluidics, LLC | Fluidische vorrichtungen mit reaktionsvertiefungen und ihre verwendungen |
US11072816B2 (en) | 2017-05-03 | 2021-07-27 | The Broad Institute, Inc. | Single-cell proteomic assay using aptamers |
CN110870018A (zh) | 2017-05-19 | 2020-03-06 | 10X基因组学有限公司 | 用于分析数据集的***和方法 |
SG11201901822QA (en) | 2017-05-26 | 2019-03-28 | 10X Genomics Inc | Single cell analysis of transposase accessible chromatin |
US20180340169A1 (en) | 2017-05-26 | 2018-11-29 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
WO2019032690A1 (en) | 2017-08-09 | 2019-02-14 | Neofluidics, Llc | DEVICES AND METHODS FOR BIOLOGICAL TESTING |
US10837047B2 (en) | 2017-10-04 | 2020-11-17 | 10X Genomics, Inc. | Compositions, methods, and systems for bead formation using improved polymers |
WO2019084043A1 (en) | 2017-10-26 | 2019-05-02 | 10X Genomics, Inc. | METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS |
EP3700672B1 (de) | 2017-10-27 | 2022-12-28 | 10X Genomics, Inc. | Verfahren zur probenvorbereitung und -analyse |
US11305279B2 (en) | 2017-11-10 | 2022-04-19 | Neofluidics, Llc | Integrated fluidic circuit and device for droplet manipulation and methods thereof |
SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
WO2019108851A1 (en) | 2017-11-30 | 2019-06-06 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation and analysis |
JP7218558B2 (ja) * | 2017-12-19 | 2023-02-07 | 東ソー株式会社 | 核酸増幅法および核酸増幅試薬 |
CN111699255B (zh) * | 2018-02-09 | 2024-03-08 | 首尔大学校产学协力团 | 基于生物反应器的生物样品分析方法、分析芯片及分析*** |
SG11202007686VA (en) | 2018-02-12 | 2020-09-29 | 10X Genomics Inc | Methods characterizing multiple analytes from individual cells or cell populations |
US11639928B2 (en) | 2018-02-22 | 2023-05-02 | 10X Genomics, Inc. | Methods and systems for characterizing analytes from individual cells or cell populations |
EP3533519B1 (de) * | 2018-02-28 | 2020-09-30 | Paris Sciences et Lettres - Quartier Latin | Biphasischer plasmamikroreaktor und verfahren zur verwendung davon |
EP3774005A4 (de) | 2018-04-02 | 2022-04-20 | Dropworks, Inc. | Systeme und verfahren für serielle fliessemulsionsverfahren |
US11485944B2 (en) * | 2018-04-04 | 2022-11-01 | Hewlett-Packard Development Company, L.P. | Microfluidic cellular membrane modification devices |
SG11202009889VA (en) | 2018-04-06 | 2020-11-27 | 10X Genomics Inc | Systems and methods for quality control in single cell processing |
CN111989158B (zh) * | 2018-04-15 | 2022-08-12 | 奥普图弗卢迪克生物鉴定有限责任公司 | 压差辅助排水*** |
CN112399882B (zh) | 2018-04-16 | 2023-08-01 | 派特恩生物技术有限公司 | 用于形成二维微滴阵列的方法和设备 |
US11673107B2 (en) * | 2018-05-01 | 2023-06-13 | Hewlett-Packard Development Company, L.P. | Sequential encapsulation of reagents |
US11932899B2 (en) | 2018-06-07 | 2024-03-19 | 10X Genomics, Inc. | Methods and systems for characterizing nucleic acid molecules |
AU2019283225B2 (en) | 2018-06-07 | 2022-02-10 | Yokogawa Electric Corporation | Optical analysis system and optical analysis method |
FR3082440B1 (fr) * | 2018-06-14 | 2020-12-11 | Paris Sciences Lettres Quartier Latin | Methode de transfert de matiere dans un dispositif microfluidique ou millifluidique |
US11703427B2 (en) | 2018-06-25 | 2023-07-18 | 10X Genomics, Inc. | Methods and systems for cell and bead processing |
US20200032335A1 (en) | 2018-07-27 | 2020-01-30 | 10X Genomics, Inc. | Systems and methods for metabolome analysis |
US11752175B2 (en) | 2018-09-21 | 2023-09-12 | Cornell University | Compositions and methods for glaucoma |
US11137493B2 (en) * | 2018-10-15 | 2021-10-05 | GM Global Technology Operations LLC | System and method for detecting precipitation using radar |
US10486155B1 (en) | 2018-10-22 | 2019-11-26 | Klaris Corporation | Vacuum-loaded, droplet-generating microfluidic chips and related methods |
WO2020087032A2 (en) | 2018-10-26 | 2020-04-30 | Neofluidics, Llc | Fluidic devices with reaction wells and constriction channels and uses thereof |
US11459607B1 (en) | 2018-12-10 | 2022-10-04 | 10X Genomics, Inc. | Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes |
US11845983B1 (en) | 2019-01-09 | 2023-12-19 | 10X Genomics, Inc. | Methods and systems for multiplexing of droplet based assays |
US11584953B2 (en) | 2019-02-12 | 2023-02-21 | 10X Genomics, Inc. | Methods for processing nucleic acid molecules |
US11851683B1 (en) | 2019-02-12 | 2023-12-26 | 10X Genomics, Inc. | Methods and systems for selective analysis of cellular samples |
US11467153B2 (en) | 2019-02-12 | 2022-10-11 | 10X Genomics, Inc. | Methods for processing nucleic acid molecules |
US11655499B1 (en) | 2019-02-25 | 2023-05-23 | 10X Genomics, Inc. | Detection of sequence elements in nucleic acid molecules |
SG11202111242PA (en) | 2019-03-11 | 2021-11-29 | 10X Genomics Inc | Systems and methods for processing optically tagged beads |
EP3747541B1 (de) * | 2019-06-03 | 2024-02-07 | Cellular Highways Ltd. | Vorrichtung zum sortieren von mikrofluidischen partikeln |
CN110560188B (zh) * | 2019-09-19 | 2021-09-28 | 济南大学 | 一种合成Ag/Ag2S/CdS异质结的多级进样微流控芯片的制备方法 |
WO2021059628A1 (ja) * | 2019-09-24 | 2021-04-01 | 富士フイルム株式会社 | スラグ流の形成方法、有機化合物の製造方法、粒子の製造方法、及び抽出方法 |
AU2020361681A1 (en) | 2019-10-10 | 2022-05-05 | 1859, Inc. | Methods and systems for microfluidic screening |
CN111289469B (zh) * | 2020-02-28 | 2021-03-23 | 浙江大学 | 一种icf靶丸内冰层折射率分布的测量装置和方法 |
US11242558B2 (en) | 2020-04-15 | 2022-02-08 | Enumerix, Inc. | Systems and methods for generation of emulsions with suitable clarity with applications of use |
WO2021216036A1 (en) * | 2020-04-20 | 2021-10-28 | Hewlett-Packard Development Company, L.P. | Fluid dispenser frequencies |
US10953404B1 (en) | 2020-04-24 | 2021-03-23 | Pattern Bioscience, Inc. | Apparatuses for contactless loading and imaging of microfluidic chips and related methods |
US11686730B2 (en) | 2020-04-30 | 2023-06-27 | Quanterix Corporation | Quantitative antibody test |
GB202006525D0 (en) | 2020-05-04 | 2020-06-17 | Sphere Fluidics Ltd | Surfactant |
US20210354144A1 (en) * | 2020-05-12 | 2021-11-18 | The Texas A&M University System | Microfluidic platform for evaluation of liquid interfaces |
US11851700B1 (en) | 2020-05-13 | 2023-12-26 | 10X Genomics, Inc. | Methods, kits, and compositions for processing extracellular molecules |
JP7522444B2 (ja) | 2020-09-09 | 2024-07-25 | 株式会社チップトン | テイラー反応装置 |
CN112354573B (zh) | 2020-10-26 | 2022-01-04 | 深圳亘流科技有限公司 | 阶跃式惯性聚焦微流控芯片 |
AU2022227563A1 (en) | 2021-02-23 | 2023-08-24 | 10X Genomics, Inc. | Probe-based analysis of nucleic acids and proteins |
EP4323117A1 (de) | 2021-04-15 | 2024-02-21 | ScreenSYS GmbH | Verfahren zur entwicklung und/oder umprogrammierung von zellulären pflanzenobjekten |
CN114534652B (zh) * | 2022-02-08 | 2024-07-19 | 上海天泽云泰生物医药有限公司 | 波形微结构混合单元及其用途 |
CN114398378B (zh) * | 2022-03-25 | 2022-11-01 | 北京奥星贝斯科技有限公司 | 确定索引代价的方法和装置 |
CN115069134B (zh) * | 2022-07-07 | 2023-09-05 | 山东省科学院能源研究所 | 一种基于迪恩涡流的微流体高效混合器 |
DE102022124200A1 (de) * | 2022-09-21 | 2024-03-21 | Asepto GmbH Aseptische Verfahrenstechnik und Automation | Verfahren zum Herstellen zumindest eines pflanzenbasierten Getränkes und Vorrichtung zum Herstellen zumindest eines pflanzenbasierten Getränkes |
WO2024091930A1 (en) * | 2022-10-24 | 2024-05-02 | 1859, Inc. | Miniaturized methods and systems for sample screening |
US20240198336A1 (en) * | 2022-12-19 | 2024-06-20 | Anchorline Biolabs, Inc. | Capillary partitioning microfluidics |
Family Cites Families (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3479141A (en) * | 1967-05-17 | 1969-11-18 | Technicon Corp | Method and apparatus for analysis |
US3960187A (en) | 1974-07-23 | 1976-06-01 | Usm Corporation | Method and device for metering and dispersing fluid materials |
GB2097692B (en) * | 1981-01-10 | 1985-05-22 | Shaw Stewart P D | Combining chemical reagents |
US4853336A (en) * | 1982-11-15 | 1989-08-01 | Technicon Instruments Corporation | Single channel continuous flow system |
CA1238900A (en) * | 1982-11-15 | 1988-07-05 | Stephen Saros | Single channel continuous slug flow mixing of discrete fluid components |
JPS61238330A (ja) * | 1985-04-12 | 1986-10-23 | Mitsui Petrochem Ind Ltd | 乳化装置 |
US4963498A (en) | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
US5185099A (en) * | 1988-04-20 | 1993-02-09 | Institut National De Recherche Chimique Appliquee | Visco-elastic, isotropic materials based on water, fluorinate sufactants and fluorinated oils, process for their preparation, and their use in various fields, such as optics, pharmacology and electrodynamics |
JP3512186B2 (ja) * | 1993-03-19 | 2004-03-29 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | 化学処理及び製造のための一体構造及び方法、並びにその使用方法及び製造方法 |
MY110990A (en) * | 1993-06-03 | 1999-07-31 | Atomaer Pty Ltd | Multiphase staged passive reactor |
EP0636413B1 (de) * | 1993-07-28 | 2001-11-14 | PE Corporation (NY) | Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung |
US5580523A (en) * | 1994-04-01 | 1996-12-03 | Bard; Allen J. | Integrated chemical synthesizers |
US5595712A (en) * | 1994-07-25 | 1997-01-21 | E. I. Du Pont De Nemours And Company | Chemical mixing and reaction apparatus |
US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
AU708165B2 (en) | 1995-06-06 | 1999-07-29 | Interpore International Inc. | Wound sealant preparation and application device and method |
US20020022261A1 (en) * | 1995-06-29 | 2002-02-21 | Anderson Rolfe C. | Miniaturized genetic analysis systems and methods |
US5872010A (en) | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
US6132580A (en) * | 1995-09-28 | 2000-10-17 | The Regents Of The University Of California | Miniature reaction chamber and devices incorporating same |
WO1997029508A2 (en) * | 1996-02-08 | 1997-08-14 | Perseptive Biosystems, Inc. | Interface between liquid flow and mass spectrometer |
US5948684A (en) * | 1997-03-31 | 1999-09-07 | University Of Washington | Simultaneous analyte determination and reference balancing in reference T-sensor devices |
WO1997039359A1 (en) * | 1996-04-15 | 1997-10-23 | Dade International Inc. | Apparatus and method for analysis |
NZ333346A (en) * | 1996-06-28 | 2000-03-27 | Caliper Techn Corp | High-throughput screening assay systems in microscale fluidic devices |
BR9710052A (pt) * | 1996-06-28 | 2000-01-11 | Caliper Techn Corp | Sistema microfluido com compensação para polarização eletroforética, eletropipetador, processos para introduzir materiais a partir de uma série de fontes em um sistema microfluido, para distribuir de maneira controlável uma corrente de fluido e para transportar amostras de fluido, sistema de amostragem, emprego de um substrato, emprego de um sistema microfluido, e, substrato. |
US5800690A (en) * | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces |
AU4114397A (en) * | 1996-07-15 | 1998-02-09 | Kemgas Limited | Production of powders |
US6140053A (en) * | 1996-11-06 | 2000-10-31 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
US5993750A (en) * | 1997-04-11 | 1999-11-30 | Eastman Kodak Company | Integrated ceramic micro-chemical plant |
DE19717085C2 (de) * | 1997-04-23 | 1999-06-17 | Bruker Daltonik Gmbh | Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR) |
KR100351531B1 (ko) * | 1997-04-25 | 2002-09-11 | 캘리퍼 테크놀로지스 코포레이션 | 기하형상이 개선된 채널을 채용하는 미소 유체 장치 |
DE69823347T2 (de) * | 1997-05-16 | 2005-05-12 | Alberta Research Council, Edmonton | Mikrofluidisches system und verfahren zu dessen betrieb |
JP2843319B1 (ja) | 1997-06-27 | 1999-01-06 | 科学技術振興事業団 | マイクロストリップガスチャンバー高速データ収集システム及びそれを用いた試料の測定方法 |
US5876675A (en) * | 1997-08-05 | 1999-03-02 | Caliper Technologies Corp. | Microfluidic devices and systems |
US7214298B2 (en) * | 1997-09-23 | 2007-05-08 | California Institute Of Technology | Microfabricated cell sorter |
FR2769215B1 (fr) * | 1997-10-03 | 1999-12-24 | Oreal | Composition de teinture des fibres keratiniques et procede de teinture mettant en oeuvre cette composition |
US5997636A (en) | 1998-05-01 | 1999-12-07 | Instrumentation Technology Associates, Inc. | Method and apparatus for growing crystals |
US6149787A (en) * | 1998-10-14 | 2000-11-21 | Caliper Technologies Corp. | External material accession systems and methods |
US6569631B1 (en) | 1998-11-12 | 2003-05-27 | 3-Dimensional Pharmaceuticals, Inc. | Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes |
US20030069601A1 (en) | 1998-12-15 | 2003-04-10 | Closys Corporation | Clotting cascade initiating apparatus and methods of use |
US7615373B2 (en) | 1999-02-25 | 2009-11-10 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen and tissue engineering |
US6605475B1 (en) * | 1999-04-16 | 2003-08-12 | Perspective Biosystems, Inc. | Apparatus and method for sample delivery |
US6630006B2 (en) | 1999-06-18 | 2003-10-07 | The Regents Of The University Of California | Method for screening microcrystallizations for crystal formation |
US6296673B1 (en) | 1999-06-18 | 2001-10-02 | The Regents Of The University Of California | Methods and apparatus for performing array microcrystallizations |
US7195670B2 (en) | 2000-06-27 | 2007-03-27 | California Institute Of Technology | High throughput screening of crystallization of materials |
US6524456B1 (en) | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
JP2001088098A (ja) * | 1999-09-14 | 2001-04-03 | Kawamura Inst Of Chem Res | 減圧送液機構を有する微小ケミカルデバイス |
JP2001088096A (ja) * | 1999-09-14 | 2001-04-03 | Kawamura Inst Of Chem Res | 吸収式送液機構を有する微小ケミカルデバイス |
US6361958B1 (en) * | 1999-11-12 | 2002-03-26 | Motorola, Inc. | Biochannel assay for hybridization with biomaterial |
JP2001145486A (ja) * | 1999-11-19 | 2001-05-29 | Natl Inst Of Advanced Industrial Science & Technology Meti | 多試料用の微小容量化学反応装置 |
US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
JP2001194373A (ja) * | 2000-01-06 | 2001-07-19 | Olympus Optical Co Ltd | 超小型化学操作装置 |
WO2001051918A1 (en) | 2000-01-12 | 2001-07-19 | Ut-Battelle, Llc | A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream |
AU2001234997B2 (en) * | 2000-02-11 | 2006-07-27 | Monogram Biosciences, Inc. | Microfluid device with sample injector and method of use |
EP1272768A4 (de) | 2000-02-23 | 2005-09-07 | Zyomyx Inc | Mikrofluidische einrichtungen und verfahren |
GB2359765B (en) | 2000-03-02 | 2003-03-05 | Univ Newcastle | Capillary reactor distribution device and method |
US20020012971A1 (en) * | 2000-03-20 | 2002-01-31 | Mehta Tammy Burd | PCR compatible nucleic acid sieving medium |
JP4927287B2 (ja) | 2000-03-31 | 2012-05-09 | マイクロニックス、インコーポレーテッド | タンパク質の結晶化のマイクロ流動体装置 |
AU2001250058A1 (en) * | 2000-04-06 | 2001-10-23 | Caliper Technologies Corp. | Methods and devices for achieving long incubation times in high-throughput systems |
EP1286913A2 (de) | 2000-05-24 | 2003-03-05 | Micronics, Inc. | Mikrofluidischer kreislauf mit konzentrationsgradienten |
US20010048637A1 (en) * | 2000-05-24 | 2001-12-06 | Weigl Bernhard H. | Microfluidic system and method |
JP2002031638A (ja) * | 2000-07-17 | 2002-01-31 | Mitsubishi Chemicals Corp | 生体試料検出用チップ及び生体試料検出方法 |
US7004184B2 (en) * | 2000-07-24 | 2006-02-28 | The Reagents Of The University Of Michigan | Compositions and methods for liquid metering in microchannels |
DE60121604T2 (de) * | 2000-08-04 | 2007-06-21 | Caliper Life Sciences, Inc., Mountain View | Steuerung von betriebsbedingungen in fluidischen systemen |
US20040005582A1 (en) | 2000-08-10 | 2004-01-08 | Nanobiodynamics, Incorporated | Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators |
AU2001290879A1 (en) | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
WO2002025243A1 (en) * | 2000-09-21 | 2002-03-28 | Dna Sciences, Inc. | Sample injector system and method |
EP1330306A2 (de) * | 2000-10-10 | 2003-07-30 | BioTrove, Inc. | Vorrichtung zum testen, synthese und lagerung sowie verfahren zur herstellung, verwendung und handhabung |
JP2004526949A (ja) | 2000-10-19 | 2004-09-02 | ストラクチュラル ジェノミックス,インコーポレーテッド | その場x線回折による結晶識別のための装置および方法 |
CN2482070Y (zh) | 2001-01-02 | 2002-03-13 | 大连市临床检验中心 | 血液促凝球 |
CA2450676C (en) * | 2001-03-09 | 2010-03-30 | Biomicro Systems, Inc. | Method and system for microfluidic interfacing to arrays |
US20030064414A1 (en) | 2001-03-30 | 2003-04-03 | Benecky Michael J. | Rapid assessment of coagulation activity in whole blood |
US20020148992A1 (en) | 2001-04-03 | 2002-10-17 | Hayenga Jon W. | Pneumatic valve interface for use in microfluidic structures |
US6797056B2 (en) | 2001-06-08 | 2004-09-28 | Syrrx, Inc. | Microfluidic method employing delivery of plural different fluids to same lumen |
US6719840B2 (en) | 2001-06-08 | 2004-04-13 | Syrrx, Inc. | In situ crystal growth and crystallization |
US6656267B2 (en) | 2001-07-10 | 2003-12-02 | Structural Genomix, Inc. | Tray for macromolecule crystallization and method of using the same |
US6766817B2 (en) | 2001-07-25 | 2004-07-27 | Tubarc Technologies, Llc | Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action |
WO2003044221A1 (en) * | 2001-10-19 | 2003-05-30 | West Virginia University Research Corporation | Microfluidic system for proteome analysis |
US6783647B2 (en) | 2001-10-19 | 2004-08-31 | Ut-Battelle, Llc | Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate |
CA2477702A1 (en) | 2002-03-05 | 2003-09-18 | Caliper Life Sciences, Inc. | Mixed mode microfluidic systems abstract of the disclosure |
US7101467B2 (en) | 2002-03-05 | 2006-09-05 | Caliper Life Sciences, Inc. | Mixed mode microfluidic systems |
US7312085B2 (en) | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
JP4855680B2 (ja) * | 2002-05-09 | 2012-01-18 | ザ・ユニバーシティ・オブ・シカゴ | 圧力駆動プラグによる輸送と反応のための装置および方法 |
US7901939B2 (en) * | 2002-05-09 | 2011-03-08 | University Of Chicago | Method for performing crystallization and reactions in pressure-driven fluid plugs |
JP3883060B2 (ja) | 2002-06-17 | 2007-02-21 | 株式会社リガク | 結晶評価装置 |
JP2004016925A (ja) * | 2002-06-17 | 2004-01-22 | Taisei Corp | 管内面ライニング装置 |
US20040136497A1 (en) | 2002-10-30 | 2004-07-15 | Meldrum Deirdre R | Preparation of samples and sample evaluation |
KR20050088476A (ko) | 2002-12-30 | 2005-09-06 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 병원균 검출과 분석을 위한 방법과 기구 |
EP1605817A2 (de) | 2003-02-25 | 2005-12-21 | Inlight Solutions, Inc. | Bestimmung des ph-werts mit hämoglobin-korrektur |
US20100022414A1 (en) | 2008-07-18 | 2010-01-28 | Raindance Technologies, Inc. | Droplet Libraries |
US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
US7262059B2 (en) | 2003-05-06 | 2007-08-28 | Thrombodyne, Inc. | Systems and methods for measuring fluid properties |
JP4466991B2 (ja) | 2003-05-22 | 2010-05-26 | 英明 森山 | 結晶成長装置及び方法 |
US7655470B2 (en) | 2004-10-29 | 2010-02-02 | University Of Chicago | Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems |
CN101163800B (zh) | 2005-02-18 | 2013-04-17 | 佳能美国生命科学公司 | 鉴定生物的基因组dna的装置和方法 |
CN101223268A (zh) | 2005-05-18 | 2008-07-16 | 康奈尔研究基金会(有限公司) | 具有生物屏障的基于药代动力学的培养*** |
US20070026439A1 (en) | 2005-07-15 | 2007-02-01 | Applera Corporation | Fluid processing device and method |
AU2008265610B2 (en) | 2007-06-21 | 2012-08-23 | Gen-Probe Incorporated | Instrument and receptacles for performing processes |
US8622987B2 (en) | 2008-06-04 | 2014-01-07 | The University Of Chicago | Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution |
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2003
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- 2003-05-09 EP EP17186748.4A patent/EP3290921B1/de not_active Expired - Lifetime
- 2003-05-09 US US10/434,970 patent/US7129091B2/en not_active Expired - Lifetime
- 2003-05-09 DE DE60333995T patent/DE60333995D1/de not_active Expired - Lifetime
- 2003-05-09 EP EP03783044A patent/EP1508044B1/de not_active Expired - Lifetime
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- 2003-05-09 EP EP10183101.4A patent/EP2282214B1/de not_active Expired - Lifetime
- 2003-05-09 EP EP10174433.2A patent/EP2278337B1/de not_active Expired - Lifetime
- 2003-05-09 EP EP10185097.2A patent/EP2283918B1/de not_active Expired - Lifetime
- 2003-05-09 AU AU2003290508A patent/AU2003290508A1/en not_active Abandoned
- 2003-05-09 EP EP10183131.1A patent/EP2283917B1/de not_active Expired - Lifetime
- 2003-05-09 WO PCT/US2003/014794 patent/WO2004038363A2/en active Application Filing
- 2003-05-09 EP EP10174436.5A patent/EP2278338B1/de not_active Expired - Lifetime
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2006
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2009
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2011
- 2011-07-07 JP JP2011151228A patent/JP2011212679A/ja active Pending
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2012
- 2012-07-05 JP JP2012151353A patent/JP5859393B2/ja not_active Expired - Lifetime
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2014
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- 2014-10-07 US US14/507,938 patent/US9579622B2/en not_active Expired - Lifetime
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2015
- 2015-08-26 US US14/836,432 patent/US9839893B2/en not_active Expired - Lifetime
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2016
- 2016-12-19 JP JP2016245154A patent/JP2017104863A/ja active Pending
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2017
- 2017-03-28 JP JP2017063059A patent/JP2017159297A/ja not_active Withdrawn
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2018
- 2018-01-03 US US15/861,225 patent/US10105703B2/en not_active Expired - Lifetime
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2019
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2020
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