CY1105789T1 - Νεα μεθοδος για τη συνθεση πepιντοπριλ και των φαρμακευτικως αποδεκτων αλατων αυτου - Google Patents
Νεα μεθοδος για τη συνθεση πepιντοπριλ και των φαρμακευτικως αποδεκτων αλατων αυτουInfo
- Publication number
- CY1105789T1 CY1105789T1 CY20061101671T CY061101671T CY1105789T1 CY 1105789 T1 CY1105789 T1 CY 1105789T1 CY 20061101671 T CY20061101671 T CY 20061101671T CY 061101671 T CY061101671 T CY 061101671T CY 1105789 T1 CY1105789 T1 CY 1105789T1
- Authority
- CY
- Cyprus
- Prior art keywords
- synthesis
- pepidopril
- pharmaceutically acceptable
- acceptable salts
- new method
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Μέθοδος σύνθεσης παραγώγων του τύπου (Ι):
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291930A EP1367062B1 (fr) | 2003-07-31 | 2003-07-31 | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1105789T1 true CY1105789T1 (el) | 2011-02-02 |
Family
ID=29414889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20061101671T CY1105789T1 (el) | 2003-07-31 | 2006-11-16 | Νεα μεθοδος για τη συνθεση πepιντοπριλ και των φαρμακευτικως αποδεκτων αλατων αυτου |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7368580B2 (el) |
| EP (1) | EP1367062B1 (el) |
| JP (1) | JP4263744B2 (el) |
| CN (1) | CN100439392C (el) |
| AR (1) | AR045150A1 (el) |
| AT (1) | ATE338058T1 (el) |
| AU (1) | AU2004261440B2 (el) |
| CY (1) | CY1105789T1 (el) |
| DE (1) | DE60307925T2 (el) |
| DK (1) | DK1367062T3 (el) |
| EA (1) | EA008644B1 (el) |
| ES (1) | ES2271497T3 (el) |
| HK (1) | HK1096407A1 (el) |
| MY (1) | MY139098A (el) |
| NZ (1) | NZ544880A (el) |
| PL (1) | PL211802B1 (el) |
| PT (1) | PT1367062E (el) |
| SI (1) | SI1367062T1 (el) |
| WO (1) | WO2005012328A2 (el) |
| ZA (1) | ZA200600480B (el) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8604144A1 (es) * | 1984-11-21 | 1986-01-16 | Farmhispania | Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico |
| FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| DK1319668T3 (da) * | 2003-03-12 | 2005-02-14 | Servier Lab | Fremgangsmåde til syntese af (2S, 3aS, 7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese af perindopril |
| EP1321471B1 (fr) * | 2003-03-12 | 2005-05-04 | Les Laboratoires Servier | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
-
2003
- 2003-07-31 DE DE60307925T patent/DE60307925T2/de not_active Expired - Lifetime
- 2003-07-31 AT AT03291930T patent/ATE338058T1/de active
- 2003-07-31 PT PT03291930T patent/PT1367062E/pt unknown
- 2003-07-31 SI SI200330449T patent/SI1367062T1/sl unknown
- 2003-07-31 ES ES03291930T patent/ES2271497T3/es not_active Expired - Lifetime
- 2003-07-31 EP EP03291930A patent/EP1367062B1/fr not_active Expired - Lifetime
- 2003-07-31 DK DK03291930T patent/DK1367062T3/da active
-
2004
- 2004-07-29 CN CNB2004800212086A patent/CN100439392C/zh not_active Expired - Fee Related
- 2004-07-29 JP JP2006521622A patent/JP4263744B2/ja not_active Expired - Fee Related
- 2004-07-29 NZ NZ544880A patent/NZ544880A/en not_active IP Right Cessation
- 2004-07-29 EA EA200600249A patent/EA008644B1/ru not_active IP Right Cessation
- 2004-07-29 US US10/566,558 patent/US7368580B2/en not_active Expired - Fee Related
- 2004-07-29 AR ARP040102692A patent/AR045150A1/es not_active Application Discontinuation
- 2004-07-29 WO PCT/FR2004/002036 patent/WO2005012328A2/fr active Application Filing
- 2004-07-29 ZA ZA200600480A patent/ZA200600480B/en unknown
- 2004-07-29 MY MYPI20043052A patent/MY139098A/en unknown
- 2004-07-29 AU AU2004261440A patent/AU2004261440B2/en not_active Ceased
- 2004-07-29 PL PL379625A patent/PL211802B1/pl unknown
-
2006
- 2006-11-16 CY CY20061101671T patent/CY1105789T1/el unknown
-
2007
- 2007-02-01 HK HK07101183.8A patent/HK1096407A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4263744B2 (ja) | 2009-05-13 |
| EA200600249A1 (ru) | 2006-06-30 |
| DE60307925D1 (de) | 2006-10-12 |
| SI1367062T1 (sl) | 2006-12-31 |
| AR045150A1 (es) | 2005-10-19 |
| AU2004261440A1 (en) | 2005-02-10 |
| ZA200600480B (en) | 2007-05-30 |
| WO2005012328A3 (fr) | 2005-03-24 |
| US7368580B2 (en) | 2008-05-06 |
| EP1367062B1 (fr) | 2006-08-30 |
| JP2006528653A (ja) | 2006-12-21 |
| MY139098A (en) | 2009-08-28 |
| NZ544880A (en) | 2009-03-31 |
| DE60307925T2 (de) | 2007-05-24 |
| EP1367062A1 (fr) | 2003-12-03 |
| CN100439392C (zh) | 2008-12-03 |
| DK1367062T3 (da) | 2007-01-02 |
| AU2004261440B2 (en) | 2008-07-31 |
| ATE338058T1 (de) | 2006-09-15 |
| HK1096407A1 (en) | 2007-06-01 |
| PT1367062E (pt) | 2006-12-29 |
| CN1826351A (zh) | 2006-08-30 |
| US20060189813A1 (en) | 2006-08-24 |
| EA008644B1 (ru) | 2007-06-29 |
| PL211802B1 (pl) | 2012-06-29 |
| WO2005012328A2 (fr) | 2005-02-10 |
| ES2271497T3 (es) | 2007-04-16 |
| PL379625A1 (pl) | 2006-10-30 |
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