DE60328376D1 - Verfahren zur herstellung eines thiazolderivats und zwischenprodukte für dessen herstellung - Google Patents

Verfahren zur herstellung eines thiazolderivats und zwischenprodukte für dessen herstellung

Info

Publication number
DE60328376D1
DE60328376D1 DE60328376T DE60328376T DE60328376D1 DE 60328376 D1 DE60328376 D1 DE 60328376D1 DE 60328376 T DE60328376 T DE 60328376T DE 60328376 T DE60328376 T DE 60328376T DE 60328376 D1 DE60328376 D1 DE 60328376D1
Authority
DE
Germany
Prior art keywords
thiazone
derivative
producing
production
intermediate products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60328376T
Other languages
English (en)
Inventor
Heonjoong Kang
Jungyeob Ham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seoul National University Industry Foundation
Original Assignee
Seoul National University Industry Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seoul National University Industry Foundation filed Critical Seoul National University Industry Foundation
Application granted granted Critical
Publication of DE60328376D1 publication Critical patent/DE60328376D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60328376T 2002-05-04 2003-05-01 Verfahren zur herstellung eines thiazolderivats und zwischenprodukte für dessen herstellung Expired - Lifetime DE60328376D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2002-0024595A KR100474202B1 (ko) 2002-05-04 2002-05-04 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체
PCT/KR2003/000877 WO2003106442A1 (en) 2002-05-04 2003-05-01 Process for preparing thiazole derivative and the intermediate compounds for preparing the same

Publications (1)

Publication Number Publication Date
DE60328376D1 true DE60328376D1 (de) 2009-08-27

Family

ID=29728605

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60328376T Expired - Lifetime DE60328376D1 (de) 2002-05-04 2003-05-01 Verfahren zur herstellung eines thiazolderivats und zwischenprodukte für dessen herstellung

Country Status (8)

Country Link
US (2) US7241901B2 (de)
EP (1) EP1501811B1 (de)
JP (1) JP2005536480A (de)
KR (1) KR100474202B1 (de)
CN (1) CN100457744C (de)
DE (1) DE60328376D1 (de)
ES (1) ES2330095T3 (de)
WO (1) WO2003106442A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE539066T1 (de) * 2004-12-31 2012-01-15 Seoul Nat Univ Ind Foundation Organoselenhaltige verbindungen und deren verwendung
RU2371437C2 (ru) * 2004-12-31 2009-10-27 Сеул Нэшнл Юниверсити Индастри Фаундейшн Селенорганические соединения и их применение
EP1856072A4 (de) * 2005-02-25 2009-10-21 Seoul Nat Univ Ind Foundation Thiazolderivate als ppar-delta-liganden und verfahren zu ihrer herstellung
RU2392274C2 (ru) * 2005-02-25 2010-06-20 Сеул Нэшнл Юниверсити Индастри Фаундейшн Тиазольные производные в качестве лигандов ppar-дельта и способ их получения
US7982050B2 (en) 2005-05-07 2011-07-19 Seoul National University Industry Foundation Process for preparing ligands of PPARdelta and the intermediate compounds for preparing the same
CN101400663A (zh) * 2006-01-10 2009-04-01 史密丝克莱恩比彻姆公司 {2-甲基-4-[4-甲基-2-(4-三氟甲基苯基)噻唑-5-基甲硫基]苯氧基}-乙酸的多晶型
KR101005020B1 (ko) 2006-12-13 2010-12-30 대전대학교 산학협력단 신규 쿠마린 유도체 및 이를 함유하는 항염증, 항알러지용조성물
EP2104666A4 (de) 2007-01-08 2011-05-25 Seoul Nat Univ Ind Foundation Thiazolverbindung (als ppar-delta-ligand) sowie pharmazeutisches, kosmetisches und gesundes nahrungsmittel daraus
CN107879994A (zh) * 2017-10-31 2018-04-06 广西师范大学 一种噻唑类化合物的合成方法
CN109897013B (zh) * 2019-03-31 2023-04-07 无锡科华生物科技有限公司 一种选择性PPARδ激动剂GW501516的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727187A (en) * 1984-06-15 1988-02-23 Ciba-Geigy Corporation Process for the preparation of α, α-difluoroalkyl phenyl ether derivatives
JPH06306005A (ja) * 1993-04-23 1994-11-01 Nippon Kayaku Co Ltd エーテル系化合物及びその製法
AU740444B2 (en) * 1996-08-19 2001-11-01 Japan Tobacco Inc. Propionic acid derivatives and use thereof
AU3275999A (en) * 1998-03-10 1999-09-27 Ono Pharmaceutical Co. Ltd. Carboxylic acid derivatives and drugs containing the same as the active ingredient
GB9817118D0 (en) * 1998-08-07 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
GB9914977D0 (en) * 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
PE20011010A1 (es) * 1999-12-02 2001-10-18 Glaxo Group Ltd Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
JP2001354671A (ja) * 2000-04-14 2001-12-25 Nippon Chemiphar Co Ltd ペルオキシソーム増殖剤応答性受容体δの活性化剤
WO2002014291A1 (en) * 2000-08-11 2002-02-21 Nippon Chemiphar Co.,Ltd. PPARδ ACTIVATORS
EP1345916A1 (de) 2000-12-20 2003-09-24 Glaxo Group Limited Substituierte oxazole und thiazole als hppar alpha agonisten
WO2002070011A2 (en) * 2001-02-02 2002-09-12 Smithkline Beecham Corporation Treatment of ppar mediated diseases
EP1478630A2 (de) * 2002-02-28 2004-11-24 SmithKline Beecham Corporation Verfahren und zwischenprodukte zur herstellung von phenylthiomethyl-thiazolen und -oxazolen

Also Published As

Publication number Publication date
ES2330095T3 (es) 2009-12-04
EP1501811A1 (de) 2005-02-02
KR20030086373A (ko) 2003-11-10
EP1501811B1 (de) 2009-07-15
CN1649854A (zh) 2005-08-03
WO2003106442A1 (en) 2003-12-24
KR100474202B1 (ko) 2005-03-08
CN100457744C (zh) 2009-02-04
US20050176785A1 (en) 2005-08-11
JP2005536480A (ja) 2005-12-02
EP1501811A4 (de) 2006-02-08
US7241901B2 (en) 2007-07-10
US20070179300A1 (en) 2007-08-02

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