DE60328376D1 - Verfahren zur herstellung eines thiazolderivats und zwischenprodukte für dessen herstellung - Google Patents
Verfahren zur herstellung eines thiazolderivats und zwischenprodukte für dessen herstellungInfo
- Publication number
- DE60328376D1 DE60328376D1 DE60328376T DE60328376T DE60328376D1 DE 60328376 D1 DE60328376 D1 DE 60328376D1 DE 60328376 T DE60328376 T DE 60328376T DE 60328376 T DE60328376 T DE 60328376T DE 60328376 D1 DE60328376 D1 DE 60328376D1
- Authority
- DE
- Germany
- Prior art keywords
- thiazone
- derivative
- producing
- production
- intermediate products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2002-0024595A KR100474202B1 (ko) | 2002-05-04 | 2002-05-04 | 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체 |
PCT/KR2003/000877 WO2003106442A1 (en) | 2002-05-04 | 2003-05-01 | Process for preparing thiazole derivative and the intermediate compounds for preparing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60328376D1 true DE60328376D1 (de) | 2009-08-27 |
Family
ID=29728605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60328376T Expired - Lifetime DE60328376D1 (de) | 2002-05-04 | 2003-05-01 | Verfahren zur herstellung eines thiazolderivats und zwischenprodukte für dessen herstellung |
Country Status (8)
Country | Link |
---|---|
US (2) | US7241901B2 (de) |
EP (1) | EP1501811B1 (de) |
JP (1) | JP2005536480A (de) |
KR (1) | KR100474202B1 (de) |
CN (1) | CN100457744C (de) |
DE (1) | DE60328376D1 (de) |
ES (1) | ES2330095T3 (de) |
WO (1) | WO2003106442A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE539066T1 (de) * | 2004-12-31 | 2012-01-15 | Seoul Nat Univ Ind Foundation | Organoselenhaltige verbindungen und deren verwendung |
RU2371437C2 (ru) * | 2004-12-31 | 2009-10-27 | Сеул Нэшнл Юниверсити Индастри Фаундейшн | Селенорганические соединения и их применение |
EP1856072A4 (de) * | 2005-02-25 | 2009-10-21 | Seoul Nat Univ Ind Foundation | Thiazolderivate als ppar-delta-liganden und verfahren zu ihrer herstellung |
RU2392274C2 (ru) * | 2005-02-25 | 2010-06-20 | Сеул Нэшнл Юниверсити Индастри Фаундейшн | Тиазольные производные в качестве лигандов ppar-дельта и способ их получения |
US7982050B2 (en) | 2005-05-07 | 2011-07-19 | Seoul National University Industry Foundation | Process for preparing ligands of PPARdelta and the intermediate compounds for preparing the same |
CN101400663A (zh) * | 2006-01-10 | 2009-04-01 | 史密丝克莱恩比彻姆公司 | {2-甲基-4-[4-甲基-2-(4-三氟甲基苯基)噻唑-5-基甲硫基]苯氧基}-乙酸的多晶型 |
KR101005020B1 (ko) | 2006-12-13 | 2010-12-30 | 대전대학교 산학협력단 | 신규 쿠마린 유도체 및 이를 함유하는 항염증, 항알러지용조성물 |
EP2104666A4 (de) | 2007-01-08 | 2011-05-25 | Seoul Nat Univ Ind Foundation | Thiazolverbindung (als ppar-delta-ligand) sowie pharmazeutisches, kosmetisches und gesundes nahrungsmittel daraus |
CN107879994A (zh) * | 2017-10-31 | 2018-04-06 | 广西师范大学 | 一种噻唑类化合物的合成方法 |
CN109897013B (zh) * | 2019-03-31 | 2023-04-07 | 无锡科华生物科技有限公司 | 一种选择性PPARδ激动剂GW501516的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4727187A (en) * | 1984-06-15 | 1988-02-23 | Ciba-Geigy Corporation | Process for the preparation of α, α-difluoroalkyl phenyl ether derivatives |
JPH06306005A (ja) * | 1993-04-23 | 1994-11-01 | Nippon Kayaku Co Ltd | エーテル系化合物及びその製法 |
AU740444B2 (en) * | 1996-08-19 | 2001-11-01 | Japan Tobacco Inc. | Propionic acid derivatives and use thereof |
AU3275999A (en) * | 1998-03-10 | 1999-09-27 | Ono Pharmaceutical Co. Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
GB9817118D0 (en) * | 1998-08-07 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
GB9914977D0 (en) * | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
PE20011010A1 (es) * | 1999-12-02 | 2001-10-18 | Glaxo Group Ltd | Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano |
JP2001354671A (ja) * | 2000-04-14 | 2001-12-25 | Nippon Chemiphar Co Ltd | ペルオキシソーム増殖剤応答性受容体δの活性化剤 |
WO2002014291A1 (en) * | 2000-08-11 | 2002-02-21 | Nippon Chemiphar Co.,Ltd. | PPARδ ACTIVATORS |
EP1345916A1 (de) | 2000-12-20 | 2003-09-24 | Glaxo Group Limited | Substituierte oxazole und thiazole als hppar alpha agonisten |
WO2002070011A2 (en) * | 2001-02-02 | 2002-09-12 | Smithkline Beecham Corporation | Treatment of ppar mediated diseases |
EP1478630A2 (de) * | 2002-02-28 | 2004-11-24 | SmithKline Beecham Corporation | Verfahren und zwischenprodukte zur herstellung von phenylthiomethyl-thiazolen und -oxazolen |
-
2002
- 2002-05-04 KR KR10-2002-0024595A patent/KR100474202B1/ko not_active IP Right Cessation
-
2003
- 2003-05-01 ES ES03721130T patent/ES2330095T3/es not_active Expired - Lifetime
- 2003-05-01 EP EP03721130A patent/EP1501811B1/de not_active Expired - Lifetime
- 2003-05-01 DE DE60328376T patent/DE60328376D1/de not_active Expired - Lifetime
- 2003-05-01 CN CNB038100819A patent/CN100457744C/zh not_active Expired - Fee Related
- 2003-05-01 WO PCT/KR2003/000877 patent/WO2003106442A1/en active Application Filing
- 2003-05-01 JP JP2004513274A patent/JP2005536480A/ja active Pending
- 2003-05-01 US US10/513,408 patent/US7241901B2/en not_active Expired - Lifetime
-
2007
- 2007-04-03 US US11/730,658 patent/US20070179300A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2330095T3 (es) | 2009-12-04 |
EP1501811A1 (de) | 2005-02-02 |
KR20030086373A (ko) | 2003-11-10 |
EP1501811B1 (de) | 2009-07-15 |
CN1649854A (zh) | 2005-08-03 |
WO2003106442A1 (en) | 2003-12-24 |
KR100474202B1 (ko) | 2005-03-08 |
CN100457744C (zh) | 2009-02-04 |
US20050176785A1 (en) | 2005-08-11 |
JP2005536480A (ja) | 2005-12-02 |
EP1501811A4 (de) | 2006-02-08 |
US7241901B2 (en) | 2007-07-10 |
US20070179300A1 (en) | 2007-08-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |