DE60326894D1 - 1,4-Diazabicycloalkanderivate, deren Herstellung und Verwendung - Google Patents
1,4-Diazabicycloalkanderivate, deren Herstellung und VerwendungInfo
- Publication number
- DE60326894D1 DE60326894D1 DE60326894T DE60326894T DE60326894D1 DE 60326894 D1 DE60326894 D1 DE 60326894D1 DE 60326894 T DE60326894 T DE 60326894T DE 60326894 T DE60326894 T DE 60326894T DE 60326894 D1 DE60326894 D1 DE 60326894D1
- Authority
- DE
- Germany
- Prior art keywords
- diseases
- disorders
- compounds
- nervous system
- disorders related
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200201456 | 2002-09-30 | ||
DKPA200201738 | 2002-11-11 | ||
US42636802P | 2002-11-15 | 2002-11-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60326894D1 true DE60326894D1 (de) | 2009-05-07 |
Family
ID=32045613
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60311853T Expired - Lifetime DE60311853T2 (de) | 2002-09-30 | 2003-09-29 | Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung |
DE60326894T Expired - Lifetime DE60326894D1 (de) | 2002-09-30 | 2003-09-29 | 1,4-Diazabicycloalkanderivate, deren Herstellung und Verwendung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60311853T Expired - Lifetime DE60311853T2 (de) | 2002-09-30 | 2003-09-29 | Neue 1,4-diazabicycloalkanderivate, deren herstellung und verwendung |
Country Status (11)
Country | Link |
---|---|
US (1) | US7220741B2 (de) |
EP (2) | EP1551835B1 (de) |
AT (2) | ATE353899T1 (de) |
AU (1) | AU2003266222B2 (de) |
CA (1) | CA2496585C (de) |
DE (2) | DE60311853T2 (de) |
DK (1) | DK1551835T3 (de) |
ES (1) | ES2280836T3 (de) |
NZ (1) | NZ538512A (de) |
PL (1) | PL375025A1 (de) |
WO (1) | WO2004029053A1 (de) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0218876D0 (en) * | 2002-08-13 | 2002-09-25 | Merck Sharp & Dohme | Therapeutic agents |
US7223753B2 (en) | 2002-11-11 | 2007-05-29 | Neurosearch A/S | Diazabicyclic biaryl derivatives |
MXPA05006861A (es) | 2003-02-27 | 2005-12-12 | Neurosearch As | Derivados arildiazabiciclicos novedosos. |
BRPI0506890A (pt) | 2004-02-04 | 2007-07-17 | Neurosearch As | derivado de arila diazabicìclica, composição farmacêutica, uso de um derivado de arila diazabicìclica, e, método de tratamento, prevenção ou alìvio de uma doença, distúrbio ou condição de um corpo de animal vivo |
JP4931823B2 (ja) * | 2004-10-18 | 2012-05-16 | アムジエン・インコーポレーテツド | チアジアゾール化合物及び使用方法 |
AU2005317235A1 (en) * | 2004-12-16 | 2006-06-22 | Astrazeneca Ab | Nicotinic acetycholine receptor ligands |
JP2008525524A (ja) * | 2004-12-28 | 2008-07-17 | アストラゼネカ・アクチエボラーグ | アリールスルホンアミドモジュレーター |
DE602006019561D1 (de) | 2005-02-16 | 2011-02-24 | Neurosearch As | Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin-acetylcholin-rezeptoren |
ATE481407T1 (de) | 2005-02-16 | 2010-10-15 | Neurosearch As | Neue diazabicyclische arylderivate und medizinische verwendung dafür |
CA2653769A1 (en) * | 2006-05-30 | 2007-12-06 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use |
TW200811155A (en) * | 2006-05-30 | 2008-03-01 | Glaxo Group Ltd | Compounds |
MX2008014890A (es) * | 2006-05-30 | 2008-12-05 | Neurosearch As | Nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil pirimidinilo y su uso medico. |
MX2008016338A (es) | 2006-06-27 | 2009-01-16 | Abbott Lab | Derivados de pirrol y sus metodos de uso. |
JP2009544580A (ja) | 2006-06-27 | 2009-12-17 | アボット・ラボラトリーズ | チアゾリンおよびオキサゾリン誘導体ならびにそれらの使用方法 |
WO2008016123A1 (fr) | 2006-08-03 | 2008-02-07 | Takeda Pharmaceutical Company Limited | INHIBITEUR DE LA GSK-3β |
UY30916A1 (es) * | 2007-02-15 | 2008-09-30 | Argenta Discovery Ltd | Derivados del 1-[sustituido]--3-[sustituido]-1-azona-biciclo[2,2,2]octano y sus enantiomeros |
MX2010001638A (es) * | 2007-08-17 | 2010-03-15 | Neurosearch As | Derivados de 1,4-diaza-biciclo(3.2.2)nonilpirimidinil utiles como ligandos del receptor acetilcolina nicotinico. |
EP2190847A1 (de) * | 2007-08-17 | 2010-06-02 | Neurosearch A/S | Als nikotin-actelcholin-rezeptor-liganden geeignete neuartige 1,4-diaza-bicyclo-[3,2,2,]-nonyl-oxadiazolyl-derivate |
JP2010536726A (ja) | 2007-08-17 | 2010-12-02 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体リガンドとして有用な新規1,4−ジアザ−ビシクロ〔3.2.2〕ノニルヘテロアリール誘導体 |
DE102007053771A1 (de) * | 2007-11-12 | 2009-05-14 | Merck Patent Gmbh | Organische Elektrolumineszenzvorrichtungen |
WO2009062989A1 (en) * | 2007-11-14 | 2009-05-22 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use |
CN101855223A (zh) * | 2007-11-14 | 2010-10-06 | 神经研究公司 | 新的1,4-二氮杂-二环[3.2.2]壬基嘧啶衍生物及它们的医药应用 |
GB0723719D0 (en) * | 2007-12-04 | 2008-01-16 | Glaxo Group Ltd | Compounds |
GB0723815D0 (en) * | 2007-12-05 | 2008-01-16 | Glaxo Group Ltd | Compounds |
GB0723814D0 (en) * | 2007-12-05 | 2008-01-16 | Glaxo Group Ltd | Compounds |
US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
EP2250162B1 (de) | 2008-02-07 | 2014-03-19 | AbbVie Inc. | Amidderivate als positive allostere modulatoren und verfahren zu deren anwendung |
CA2718194A1 (en) * | 2008-03-11 | 2009-09-17 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as modulator of nicotinic acetylcholine receptors |
US7786171B2 (en) | 2008-04-04 | 2010-08-31 | Abbott Laboratories | Amide derivatives as positive allosteric modulators and methods of use thereof |
US20110112078A1 (en) * | 2008-06-10 | 2011-05-12 | Neurosearch A/S | Novel oxadiazolyl-diazabicyclononane derivatives and their medical use |
WO2010018352A1 (en) * | 2008-08-12 | 2010-02-18 | Argenta Discovery Limited | Heterocyclic compounds used in the treatment of diseases where enhanced m3 receptor activation is implicated |
WO2010043539A1 (en) * | 2008-10-13 | 2010-04-22 | Neurosearch A/S | Novel oxadiazolyl-diazabicyclononane derivatives and their medical use |
WO2010063784A1 (en) * | 2008-12-04 | 2010-06-10 | Neurosearch A/S | Novel diaza-bicyclononyl-phenyl derivatives and their medical use |
US20120004214A1 (en) | 2009-01-21 | 2012-01-05 | Neurosearch A/S | N-oxides of 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives useful as nicotinic acetylcholine receptor ligands |
US20120028967A1 (en) | 2009-01-21 | 2012-02-02 | Neurosearch A/S | Novel diaza-bicyclononyl-pyrimidinyl derivatives and their medical use |
MX2011007510A (es) * | 2009-01-26 | 2011-11-04 | Neurosearch As | N-oxidos de derivados de diazabiciclononil pirimidina y su uso medico. |
US8778928B2 (en) * | 2009-01-26 | 2014-07-15 | Danpet Ab | Indolyl-oxadiazolyl-diazabicyclononane derivatives and their medical and diagnostical use |
US20120238553A1 (en) | 2009-01-27 | 2012-09-20 | Neurosearch A/S | Novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
US20110319397A1 (en) | 2009-01-27 | 2011-12-29 | Neurosearch A/S | Novel n-oxides of furanyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
WO2010086279A1 (en) | 2009-01-27 | 2010-08-05 | Neurosearch A/S | Novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
US20120071469A1 (en) * | 2009-05-14 | 2012-03-22 | Neurosearch A/S | Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators |
EP2498826A1 (de) | 2009-11-11 | 2012-09-19 | NeuroSearch AS | Markierte pyrrolyl-oxadiazolyl-diazabicyclononanderivative und ihre verwendung für diagnoseverfahren |
WO2011073296A1 (en) | 2009-12-18 | 2011-06-23 | Neurosearch A/S | Diazabicyclononyl oxadiazole compounds and their use as nicotinic acetylcholine receptor modulators |
WO2012139925A1 (en) | 2011-04-15 | 2012-10-18 | Neurosearch A/S | Labelled and un-labelled methyl-pyrrolyl-oxadiazolyl-diazabicyclononane derivatives and their medical use |
WO2014060381A1 (de) | 2012-10-18 | 2014-04-24 | Bayer Cropscience Ag | Heterocyclische verbindungen als schädlingsbekämpfungsmittel |
CN105037343B (zh) * | 2015-05-27 | 2018-02-02 | 山东师范大学 | 有机配体和Cu(I)双金属硫杂冠醚大环的合成方法 |
ES2879995T3 (es) | 2015-12-10 | 2021-11-23 | Ptc Therapeutics Inc | Métodos para el tratamiento de la enfermedad de Huntington |
AU2018282154B2 (en) | 2017-06-05 | 2022-04-07 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
WO2019005980A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | METHODS OF TREATING HUNTINGTON'S DISEASE |
BR112019027719A2 (pt) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics, Inc. | métodos para tratar a doença de huntington |
GB2587457B (en) | 2017-08-04 | 2022-06-01 | Skyhawk Therapeutics Inc | Methods and compositions for modulating splicing |
KR20210005559A (ko) | 2018-03-27 | 2021-01-14 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료 화합물 |
AU2019294478B2 (en) | 2018-06-27 | 2023-03-23 | Ptc Therapeutics, Inc. | Heterocyclic and heteroaryl compounds for treating Huntington's disease |
US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
KR20210135241A (ko) | 2019-02-05 | 2021-11-12 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
EP3920928A4 (de) | 2019-02-06 | 2022-09-28 | Skyhawk Therapeutics, Inc. | Verfahren und zusammensetzungen zur modulierung von spleissung |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ226000A (en) * | 1987-09-10 | 1991-06-25 | Merck Sharp & Dohme | Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions |
US5478939A (en) * | 1994-07-20 | 1995-12-26 | American Cyanamid Company | (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives |
FR2786770B1 (fr) | 1998-12-04 | 2001-01-19 | Synthelabo | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique |
FR2804430B1 (fr) | 2000-01-28 | 2002-03-22 | Sanofi Synthelabo | Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
FR2809731B1 (fr) | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique |
FR2809732B1 (fr) * | 2000-05-31 | 2002-07-19 | Sanofi Synthelabo | DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE |
US20020086871A1 (en) | 2000-12-29 | 2002-07-04 | O'neill Brian Thomas | Pharmaceutical composition for the treatment of CNS and other disorders |
FR2832713B1 (fr) * | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
FR2832714B1 (fr) | 2001-11-23 | 2004-07-16 | Sanofi Synthelabo | Derives de 4-(oxazolopyridin-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
FR2832712B1 (fr) | 2001-11-23 | 2004-02-13 | Sanofi Synthelabo | Derives de 4-(oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]nonane, leur preparation et leur application en therapeutique |
-
2003
- 2003-09-29 DE DE60311853T patent/DE60311853T2/de not_active Expired - Lifetime
- 2003-09-29 AU AU2003266222A patent/AU2003266222B2/en not_active Ceased
- 2003-09-29 DE DE60326894T patent/DE60326894D1/de not_active Expired - Lifetime
- 2003-09-29 AT AT03798094T patent/ATE353899T1/de active
- 2003-09-29 CA CA2496585A patent/CA2496585C/en not_active Expired - Fee Related
- 2003-09-29 EP EP03798094A patent/EP1551835B1/de not_active Expired - Lifetime
- 2003-09-29 ES ES03798094T patent/ES2280836T3/es not_active Expired - Lifetime
- 2003-09-29 WO PCT/DK2003/000639 patent/WO2004029053A1/en active IP Right Grant
- 2003-09-29 NZ NZ538512A patent/NZ538512A/en not_active IP Right Cessation
- 2003-09-29 AT AT07101576T patent/ATE426602T1/de not_active IP Right Cessation
- 2003-09-29 EP EP07101576A patent/EP1785425B1/de not_active Expired - Lifetime
- 2003-09-29 PL PL03375025A patent/PL375025A1/xx not_active Application Discontinuation
- 2003-09-29 DK DK03798094T patent/DK1551835T3/da active
- 2003-09-29 US US10/528,361 patent/US7220741B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE353899T1 (de) | 2007-03-15 |
ES2280836T3 (es) | 2007-09-16 |
EP1785425B1 (de) | 2009-03-25 |
CA2496585A1 (en) | 2004-04-08 |
EP1785425A2 (de) | 2007-05-16 |
NZ538512A (en) | 2006-12-22 |
AU2003266222B2 (en) | 2009-10-01 |
US20060122172A1 (en) | 2006-06-08 |
CA2496585C (en) | 2012-05-29 |
DE60311853D1 (de) | 2007-03-29 |
DE60311853T2 (de) | 2007-06-21 |
EP1785425A3 (de) | 2007-06-06 |
WO2004029053A1 (en) | 2004-04-08 |
US7220741B2 (en) | 2007-05-22 |
EP1551835A1 (de) | 2005-07-13 |
EP1551835B1 (de) | 2007-02-14 |
DK1551835T3 (da) | 2007-06-04 |
AU2003266222A1 (en) | 2004-04-19 |
PL375025A1 (en) | 2005-11-14 |
ATE426602T1 (de) | 2009-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |