DE60323060D1 - Thiazol- und oxazolderivaten als ppar modulatoren - Google Patents

Thiazol- und oxazolderivaten als ppar modulatoren

Info

Publication number
DE60323060D1
DE60323060D1 DE60323060T DE60323060T DE60323060D1 DE 60323060 D1 DE60323060 D1 DE 60323060D1 DE 60323060 T DE60323060 T DE 60323060T DE 60323060 T DE60323060 T DE 60323060T DE 60323060 D1 DE60323060 D1 DE 60323060D1
Authority
DE
Germany
Prior art keywords
thiazol
oxazole derivatives
ppar modulators
ppar
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60323060T
Other languages
English (en)
Inventor
Xue-Min Cheng
Noe Ouano Erasga
Gary F Filzen
Andrew G Geyer
Chitase Lee
Bharat K Trivedi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of DE60323060D1 publication Critical patent/DE60323060D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60323060T 2002-03-07 2003-02-24 Thiazol- und oxazolderivaten als ppar modulatoren Expired - Fee Related DE60323060D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36240202P 2002-03-07 2002-03-07
PCT/IB2003/000708 WO2003074050A1 (en) 2002-03-07 2003-02-24 Thiazole and oxazole derivatives which modulate ppar activity

Publications (1)

Publication Number Publication Date
DE60323060D1 true DE60323060D1 (de) 2008-10-02

Family

ID=27789157

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60323060T Expired - Fee Related DE60323060D1 (de) 2002-03-07 2003-02-24 Thiazol- und oxazolderivaten als ppar modulatoren

Country Status (29)

Country Link
US (1) US20030207924A1 (de)
EP (1) EP1482935B1 (de)
JP (1) JP2005528348A (de)
KR (1) KR20040091693A (de)
AP (1) AP2004003124A0 (de)
AR (1) AR038881A1 (de)
AT (1) ATE405260T1 (de)
AU (1) AU2003206059A1 (de)
BR (1) BR0308277A (de)
CA (1) CA2478520A1 (de)
CO (1) CO5601012A2 (de)
DE (1) DE60323060D1 (de)
EA (1) EA200400943A1 (de)
EC (1) ECSP045285A (de)
ES (1) ES2310650T3 (de)
HN (1) HN2003000090A (de)
IS (1) IS7377A (de)
MA (1) MA27181A1 (de)
MX (1) MXPA04007564A (de)
NO (1) NO20044242L (de)
OA (1) OA12780A (de)
PA (1) PA8567801A1 (de)
PE (1) PE20030989A1 (de)
PL (1) PL372969A1 (de)
TN (1) TNSN04168A1 (de)
TW (1) TW200305403A (de)
UY (1) UY27695A1 (de)
WO (1) WO2003074050A1 (de)
ZA (1) ZA200406068B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6833380B2 (en) 2002-03-07 2004-12-21 Warner-Lambert Company, Llc Compounds that modulate PPAR activity and methods of preparation
US6875780B2 (en) * 2002-04-05 2005-04-05 Warner-Lambert Company Compounds that modulate PPAR activity and methods for their preparation
US7244763B2 (en) * 2003-04-17 2007-07-17 Warner Lambert Company Llc Compounds that modulate PPAR activity and methods of preparation
ATE537825T1 (de) * 2003-05-19 2012-01-15 Irm Llc Immunosuppressive verbindungen und zusammensetzungen
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
EP1737809B1 (de) 2004-02-27 2013-09-18 Amgen, Inc Verbindungen, pharmazeutische zusammensetzungen und verfahren zur verwendung bei der behandlung von stoffwechselstörungen
EP1745003B1 (de) 2004-05-05 2010-10-27 High Point Pharmaceuticals, LLC Neue verbindungen, ihre herstellung und verwendung
EP1745014B1 (de) 2004-05-05 2011-07-06 High Point Pharmaceuticals, LLC Neue verbindungen, deren herstellung und verwendung
US7456164B2 (en) 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
AU2012200214B2 (en) * 2004-05-14 2013-10-24 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US20060014785A1 (en) * 2004-05-25 2006-01-19 Metabolex, Inc. Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation
ZA200610650B (en) * 2004-05-25 2009-04-29 Metabolex Inc Substituted triazoles as modulators of PPAR and methods of their preparation
CN101193876B (zh) * 2005-05-07 2011-05-11 财团法人首尔大学校产学协力财团 制备PPARδ的配体的方法和用于制备该配体的中间化合物
US7465804B2 (en) * 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
CA2613365C (en) 2005-06-30 2013-08-13 Novo-Nordisk A/S Phenoxy acetic acids as ppar delta activators
US8153694B2 (en) * 2005-07-29 2012-04-10 Takeda Pharmaceutical Company Limited Cyclopropanecarboxylic acid compound
WO2007033002A1 (en) 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
JP5054028B2 (ja) 2005-12-22 2012-10-24 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー 新規化合物、それらの製造および使用
JP2009132620A (ja) * 2006-03-07 2009-06-18 Astellas Pharma Inc フェニルチアゾール誘導体
JP2009529512A (ja) 2006-03-09 2009-08-20 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー 新規な化合物、それらの製造法、及び使用法
AU2007292816B2 (en) 2006-09-07 2011-11-17 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
EP2064193A1 (de) 2006-09-07 2009-06-03 Amgen, Inc Heterozyklische gpr40-modulatoren
EP2139843B1 (de) 2007-04-16 2013-12-25 Amgen, Inc Substituierte biphenyl phenoxy-, thiophenyl- und aminophenylpropansäure als gpr40-modulatoren
CA2702047C (en) 2007-10-10 2012-04-17 Amgen Inc. Substituted biphenyl gpr40 modulators
CA2708391A1 (en) * 2007-12-13 2009-06-25 Sri International Ppar-delta ligands and methods of their use
EP2234954B1 (de) 2007-12-20 2015-02-18 Envivo Pharmaceuticals, Inc. Tetrasubstituierte benzole
CA2716352C (en) 2008-03-06 2013-05-28 Amgen Inc. Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
JP5551707B2 (ja) 2008-10-15 2014-07-16 アムジエン・インコーポレーテツド スピロ環ｇｐｒ４０調節因子
AU2010347183A1 (en) * 2010-02-25 2012-09-06 Snu R&Db Foundation Selenalzole derivative having ligand which activates peroxisome proliferator activated receptor (PPAR), preparing method thereof and usage of the chemical compounds
US9487493B2 (en) 2013-09-09 2016-11-08 Vtv Therapeutics Llc Use of a PPAR-delta agonist for treating muscle atrophy
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859051A (en) * 1996-02-02 1999-01-12 Merck & Co., Inc. Antidiabetic agents
NZ334738A (en) * 1996-08-19 2001-01-26 Japan Tobacco Inc Pyridinyl or oxazolyl substituted phenyl-propionic acid derivatives
GB9914977D0 (en) * 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
JP2004517100A (ja) * 2000-12-20 2004-06-10 グラクソ　グループ　リミテッド ｈＰＰＡＲアルファアゴニストとしての置換オキサゾールおよびチアゾール
GB0031107D0 (en) * 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
GB0111523D0 (en) * 2001-05-11 2001-07-04 Glaxo Group Ltd Chemical compounds
KR20040030658A (ko) * 2001-06-07 2004-04-09 일라이 릴리 앤드 캄파니 페록시좀 증식제 활성화 수용체의 조절제

Also Published As

Publication number Publication date
EP1482935B1 (de) 2008-08-20
ECSP045285A (es) 2004-10-26
OA12780A (en) 2006-07-07
JP2005528348A (ja) 2005-09-22
WO2003074050A1 (en) 2003-09-12
IS7377A (is) 2004-07-29
US20030207924A1 (en) 2003-11-06
ES2310650T3 (es) 2009-01-16
EA200400943A1 (ru) 2005-02-24
AP2004003124A0 (en) 2004-09-30
CA2478520A1 (en) 2003-09-12
TW200305403A (en) 2003-11-01
ZA200406068B (en) 2005-09-06
PL372969A1 (en) 2005-08-08
MXPA04007564A (es) 2004-11-10
HN2003000090A (es) 2004-05-05
NO20044242L (no) 2004-10-06
EP1482935A1 (de) 2004-12-08
AR038881A1 (es) 2005-02-02
AU2003206059A1 (en) 2003-09-16
MA27181A1 (fr) 2005-01-03
KR20040091693A (ko) 2004-10-28
PE20030989A1 (es) 2003-11-29
BR0308277A (pt) 2004-12-28
TNSN04168A1 (fr) 2007-03-12
CO5601012A2 (es) 2006-01-31
PA8567801A1 (es) 2003-11-12
UY27695A1 (es) 2003-10-31
ATE405260T1 (de) 2008-09-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee