DE60312998D1 - 1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten - Google Patents
1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und hustenInfo
- Publication number
- DE60312998D1 DE60312998D1 DE60312998T DE60312998T DE60312998D1 DE 60312998 D1 DE60312998 D1 DE 60312998D1 DE 60312998 T DE60312998 T DE 60312998T DE 60312998 T DE60312998 T DE 60312998T DE 60312998 D1 DE60312998 D1 DE 60312998D1
- Authority
- DE
- Germany
- Prior art keywords
- husten
- antagonsists
- anxieties
- neurokinin
- benzyloxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/98—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
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- C—CHEMISTRY; METALLURGY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39370802P | 2002-07-03 | 2002-07-03 | |
US393708P | 2002-07-03 | ||
PCT/US2003/020783 WO2004004722A1 (en) | 2002-07-03 | 2003-07-02 | 1-amido-4-phenyl-4-benzyloxymethyl-piperidine derivatives and related compounds as neurokinin-1(nk-1) antagonists for the treatment of emesis, depression, anxiety and cough |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60312998D1 true DE60312998D1 (de) | 2007-05-16 |
DE60312998T2 DE60312998T2 (de) | 2007-12-13 |
Family
ID=30115630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60312998T Expired - Lifetime DE60312998T2 (de) | 2002-07-03 | 2003-07-02 | 1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten |
Country Status (12)
Country | Link |
---|---|
US (2) | US7041682B2 (de) |
EP (1) | EP1536797B1 (de) |
JP (1) | JP4592077B2 (de) |
CN (1) | CN1678317B (de) |
AT (1) | ATE358482T1 (de) |
AU (1) | AU2003281213A1 (de) |
CA (1) | CA2490463A1 (de) |
DE (1) | DE60312998T2 (de) |
ES (1) | ES2285151T3 (de) |
HK (1) | HK1072006A1 (de) |
MX (1) | MXPA05000196A (de) |
WO (1) | WO2004004722A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20030762A1 (es) | 2001-12-18 | 2003-09-05 | Schering Corp | Compuestos heterociclicos como antagonistas nk1 |
US8084610B2 (en) * | 2006-06-07 | 2011-12-27 | James Edward Summerton | Compositions and methods for detecting and treating tumors containing acidic areas |
US20070249607A1 (en) | 2006-04-17 | 2007-10-25 | Bristol-Myers Squibb Company | Nk-1 and serotonin transporter inhibitors |
JP2009535364A (ja) * | 2006-05-03 | 2009-10-01 | シーエヌエスバイオ ピーティーワイ リミテッド | 炎症性疼痛の治療のための方法および組成物 |
BRPI0714615A2 (pt) * | 2006-07-27 | 2013-06-18 | Bristol-Myers Squibb Company | Éteres heterocÍclicos substituÍdos e sua utilizaÇço em distérbios do cns |
US8071778B2 (en) | 2006-07-27 | 2011-12-06 | Bristol-Myers Squibb Company | Substituted heterocyclic ethers and their use in CNS disorders |
EP2125750B1 (de) | 2007-02-26 | 2014-05-21 | Vitae Pharmaceuticals, Inc. | Zyklische harnstoff- und carbamat-hemmer aus 11-beta-hydroxysteroid-dehydrogenase 1 |
AR066191A1 (es) | 2007-03-22 | 2009-08-05 | Schering Corp | Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona |
WO2009000038A1 (en) * | 2007-06-28 | 2008-12-31 | Cnsbio Pty Ltd | Combination methods and compositions for treatment of neuropathic pain |
US20090018163A1 (en) * | 2007-07-11 | 2009-01-15 | Bristol-Myers Squibb Company | Substituted Heterocyclic Ethers and Their Use in CNS Disorders |
US8026257B2 (en) * | 2007-07-11 | 2011-09-27 | Bristol-Myers Squibb Company | Substituted heterocyclic ethers and their use in CNS disorders |
ES2395081T3 (es) | 2007-07-26 | 2013-02-08 | Vitae Pharmaceuticals, Inc. | Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1 |
AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
US7632861B2 (en) | 2007-11-13 | 2009-12-15 | Bristol-Myers Squibb Company | Substituted heterocyclic ethers and their use in CNS disorders |
US8440658B2 (en) | 2007-12-11 | 2013-05-14 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
EP2252601B1 (de) | 2008-01-24 | 2012-12-19 | Vitae Pharmaceuticals, Inc. | Cyclische carbazate und semicarbazide als inhibitoren von 11beta-hydroxysteroiddehydrogenase 1 |
CA2714532A1 (en) | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
WO2009102460A2 (en) | 2008-02-15 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
ES2421537T3 (es) | 2008-05-01 | 2013-09-03 | Vitae Pharmaceuticals Inc | Inhibidores cíclicos de la 11beta-hidroxiesteroide deshidrogenasa 1 |
US8569292B2 (en) | 2008-05-01 | 2013-10-29 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
JP5538365B2 (ja) | 2008-05-01 | 2014-07-02 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤 |
US8242111B2 (en) | 2008-05-01 | 2012-08-14 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
PL2324018T3 (pl) | 2008-07-25 | 2014-02-28 | Boehringer Ingelheim Int | Cykliczne inhibitory dehydrogenazy 11 beta-hydroksysteroidowej typu 1 |
JP5777030B2 (ja) | 2008-07-25 | 2015-09-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤 |
EP2393807B1 (de) | 2009-02-04 | 2013-08-14 | Boehringer Ingelheim International GmbH | Zyklische 11beta-hydroxysteroid-dehydrogenase-1-hemmer |
UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
WO2010128418A1 (en) * | 2009-05-08 | 2010-11-11 | Koninklijke Philips Electronics N.V. | Arrangement and method for heating of a magnetic material |
JP5656986B2 (ja) | 2009-06-11 | 2015-01-21 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 1,3−オキサジナン−2−オン構造に基づく11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤 |
EP2448928B1 (de) | 2009-07-01 | 2014-08-13 | Vitae Pharmaceuticals, Inc. | CYCLISCHE 11ß-HYDROXYSTEROID-DEHYDROGENASE-1-HEMMER |
EP3143996A1 (de) * | 2009-08-14 | 2017-03-22 | OPKO Health, Inc. | Intravenöse formulierungen von neurokinin-1-antagonisten |
EP2582698B1 (de) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituierte 5-,6- und 7-gliedrige heterocyclen, medikamente mit derartigen verbindungen und ihre verwendung |
JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための11−β−HSD1のインヒビターとしてのアザスピロヘキサノン |
CA2813671A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
CN104803914B (zh) * | 2015-03-05 | 2017-11-14 | 成都理工大学 | 作为Rho激酶抑制剂的六氢氮杂卓氧基苯甲酰胺类化合物 |
BR112017024852B1 (pt) * | 2015-05-18 | 2023-10-31 | KaNDy Therapeutics Limited | Usos de um composto antagonista do receptor nk-1/nk-3 duplo e de uma composição farmacêutica compreendendo dito composto para o tratamento de sintomas vasomotores associados com menopausa |
CN106008403B (zh) * | 2016-05-28 | 2018-06-26 | 复旦大学 | 一种(E)-β-三氟甲基-烯烃磺酰胺类化合物的制备方法 |
BR112021026554A2 (pt) * | 2019-06-28 | 2022-05-24 | Jiangsu Hengrui Medicine Co | Antagonista de neurocinina-1 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3217008A (en) * | 1962-01-22 | 1965-11-09 | Searle & Co | 4-alkoxycarbonyl-1-amino-4-phenyl-piperidines, derivatives thereof and intermediates thereto |
ATE188472T1 (de) * | 1992-10-28 | 2000-01-15 | Merck Sharp & Dohme | 4-arylmethyloxymethyl piperidine als tachykinin antagonisten |
AU685212B2 (en) * | 1994-01-13 | 1998-01-15 | Merck Sharp & Dohme Limited | Gem-disubstituted azacyclic tachykinin antagonists |
AU2097601A (en) * | 1999-12-17 | 2001-06-25 | Schering Corporation | Selective neurokinin antagonists |
PE20030762A1 (es) * | 2001-12-18 | 2003-09-05 | Schering Corp | Compuestos heterociclicos como antagonistas nk1 |
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2003
- 2003-07-02 JP JP2004519752A patent/JP4592077B2/ja not_active Expired - Fee Related
- 2003-07-02 MX MXPA05000196A patent/MXPA05000196A/es active IP Right Grant
- 2003-07-02 AU AU2003281213A patent/AU2003281213A1/en not_active Abandoned
- 2003-07-02 DE DE60312998T patent/DE60312998T2/de not_active Expired - Lifetime
- 2003-07-02 EP EP03742381A patent/EP1536797B1/de not_active Expired - Lifetime
- 2003-07-02 US US10/612,176 patent/US7041682B2/en not_active Expired - Fee Related
- 2003-07-02 CA CA002490463A patent/CA2490463A1/en not_active Abandoned
- 2003-07-02 WO PCT/US2003/020783 patent/WO2004004722A1/en active IP Right Grant
- 2003-07-02 AT AT03742381T patent/ATE358482T1/de not_active IP Right Cessation
- 2003-07-02 CN CN038204037A patent/CN1678317B/zh not_active Expired - Fee Related
- 2003-07-02 ES ES03742381T patent/ES2285151T3/es not_active Expired - Lifetime
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2005
- 2005-06-09 HK HK05104894A patent/HK1072006A1/xx not_active IP Right Cessation
- 2005-12-15 US US11/300,848 patent/US20060094720A1/en not_active Abandoned
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CA2490463A1 (en) | 2004-01-15 |
ATE358482T1 (de) | 2007-04-15 |
HK1072006A1 (en) | 2005-08-12 |
CN1678317B (zh) | 2010-10-27 |
JP2005535659A (ja) | 2005-11-24 |
JP4592077B2 (ja) | 2010-12-01 |
US7041682B2 (en) | 2006-05-09 |
MXPA05000196A (es) | 2005-06-06 |
EP1536797A1 (de) | 2005-06-08 |
US20040072867A1 (en) | 2004-04-15 |
AU2003281213A1 (en) | 2004-01-23 |
EP1536797B1 (de) | 2007-04-04 |
ES2285151T3 (es) | 2007-11-16 |
WO2004004722A1 (en) | 2004-01-15 |
DE60312998T2 (de) | 2007-12-13 |
US20060094720A1 (en) | 2006-05-04 |
CN1678317A (zh) | 2005-10-05 |
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