DE60233420D1 - Fumagillolderivate und verfahren zu deren herstellung - Google Patents
Fumagillolderivate und verfahren zu deren herstellungInfo
- Publication number
- DE60233420D1 DE60233420D1 DE60233420T DE60233420T DE60233420D1 DE 60233420 D1 DE60233420 D1 DE 60233420D1 DE 60233420 T DE60233420 T DE 60233420T DE 60233420 T DE60233420 T DE 60233420T DE 60233420 D1 DE60233420 D1 DE 60233420D1
- Authority
- DE
- Germany
- Prior art keywords
- angiogenesis
- preparation
- fumagillol derivatives
- fumagillol
- psoriasis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2001-0060017A KR100455900B1 (ko) | 2001-09-27 | 2001-09-27 | 새로운 푸마질롤 유도체 및 그의 제조방법 |
| KR10-2002-0029915A KR100483836B1 (ko) | 2002-05-29 | 2002-05-29 | 푸마질롤 유도체 및 그의 제조방법 |
| PCT/KR2002/001102 WO2003027104A1 (en) | 2001-09-27 | 2002-06-11 | Fumagillol derivatives and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60233420D1 true DE60233420D1 (de) | 2009-10-01 |
Family
ID=26639368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60233420T Expired - Lifetime DE60233420D1 (de) | 2001-09-27 | 2002-06-11 | Fumagillolderivate und verfahren zu deren herstellung |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US7087768B2 (de) |
| EP (1) | EP1436286B1 (de) |
| AT (1) | ATE440094T1 (de) |
| DE (1) | DE60233420D1 (de) |
| WO (1) | WO2003027104A1 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7087768B2 (en) * | 2001-09-27 | 2006-08-08 | Equispharm Co., Ltd. | Fumagillol derivatives and preparing method thereof |
| KR100552043B1 (ko) * | 2004-02-28 | 2006-02-20 | 주식회사종근당 | 푸마질롤 유도체를 포함하는 비만치료용 조성물 |
| JP2008528574A (ja) * | 2005-01-26 | 2008-07-31 | チョン クン ダン ファーマシューティカル コープ． | フマギロール誘導体またはフマギロール誘導体の製造方法およびこれを含む医薬用組成物 |
| WO2009003110A2 (en) | 2007-06-26 | 2008-12-31 | Children's Medical Center Corporation | Metap-2 inhibitor polymersomes for therapeutic administration |
| MX2010005857A (es) * | 2007-11-28 | 2010-11-22 | Mersana Therapeutics Inc | Conjugados de analogos de fumagillina biodegradables biocompatibles. |
| AU2009270799B2 (en) | 2008-07-18 | 2016-05-19 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
| US8642650B2 (en) | 2008-12-04 | 2014-02-04 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
| US20120004162A1 (en) | 2008-12-04 | 2012-01-05 | Vath James E | Methods of Treating an Overweight or Obese Subject |
| AU2010303270A1 (en) | 2009-10-09 | 2012-05-03 | Zafgen Corporation | Sulphone compounds for use in the treatment of obesity |
| AU2011204267B2 (en) | 2010-01-08 | 2015-12-03 | Zafgen Corporation | Fumagillol type compounds and methods of making and using same |
| US8815309B2 (en) | 2010-01-08 | 2014-08-26 | Zafgen, Inc. | Methods of treating a subject with benign prostate hyperplasia |
| US20130266578A1 (en) | 2010-04-07 | 2013-10-10 | Thomas E. Hughes | Methods of treating an overweight subject |
| US9895449B2 (en) | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
| WO2011150022A2 (en) * | 2010-05-25 | 2011-12-01 | Syndevrx, Inc. | Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof |
| KR20130043207A (ko) | 2010-07-22 | 2013-04-29 | 자프겐 인크. | 트리시클릭 화합물 및 이의 제조 및 사용 방법 |
| NZ610569A (en) | 2010-11-09 | 2015-06-26 | Zafgen Inc | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
| BR112013013411A2 (pt) | 2010-11-29 | 2016-09-13 | Zafgen Inc | tratamento de obesidade usando administração não diária de 6-0-(4-dimetilaminoetxi) cinamoil fumagilol |
| JP6058557B2 (ja) | 2011-01-26 | 2017-01-11 | ザフゲン，インコーポレイテッド | テトラゾール化合物ならびにその作製方法および使用方法 |
| WO2012122264A1 (en) | 2011-03-08 | 2012-09-13 | Zafgen Corporation | Oxaspiro [2.5] octane derivatives and analogs |
| FR2973376B1 (fr) * | 2011-03-28 | 2013-05-10 | Atlanthera | Derives utiles dans le traitement ou la prevention de tumeurs osseuses |
| BR112013028534A2 (pt) | 2011-05-06 | 2016-09-06 | Zafgen Inc | compostos tricíclicos parcialmente saturados e métodos para produção e utilização dos mesmos |
| BR112013028665A2 (pt) | 2011-05-06 | 2016-09-06 | Zafgen Inc | compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos |
| BR112013028666A2 (pt) | 2011-05-06 | 2017-08-08 | Zafgen Inc | compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo |
| EP2763671A2 (de) | 2011-10-03 | 2014-08-13 | Zafgen, Inc. | Verfahren zur behandlung von altersbedingten erkrankungen |
| EP2804856B1 (de) | 2012-01-18 | 2017-03-15 | Zafgen, Inc. | Tricyclische sulfonverbindungen sowie verfahren zur herstellung und verwendung davon |
| JP6035347B2 (ja) | 2012-01-18 | 2016-11-30 | ザフゲン，インコーポレイテッド | 三環式スルホンアミド化合物ならびにその作製および使用方法 |
| KR20150016303A (ko) | 2012-05-07 | 2015-02-11 | 자프겐 인크. | 6-o-(4-디메틸아미노에톡시) 신나모일 푸마지롤의 옥살레이트 염의 다형체 염 및 이의 제조 및 사용 방법 |
| CA2872876A1 (en) | 2012-05-08 | 2013-11-14 | Zafgen, Inc. | Treating hypothalamic obesity with metap2 inhibitors |
| EP2850079B1 (de) | 2012-05-09 | 2018-05-02 | Zafgen, Inc. | Fumigillol derivate,verfahren zu deren herstellung und deren verwendung |
| CN104918615B (zh) | 2012-11-05 | 2018-10-12 | 扎夫根股份有限公司 | 治疗肝病的方法 |
| CA2890342A1 (en) | 2012-11-05 | 2014-05-08 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
| EP2925737B1 (de) | 2012-11-05 | 2017-06-14 | Zafgen, Inc. | Tricyclische verbindungen zur verwendung bei der behandlung und/oder kontrolle von adipositas |
| EP2968250B1 (de) | 2013-03-14 | 2019-06-19 | Zafgen, Inc. | Verfahren zur behandlung von nierenerkrankungen und anderen störungen |
| DK2984085T3 (da) | 2013-04-10 | 2019-10-21 | Syndevrx Inc | Modificerede eller polymerkonjugerede fumagillol metap2-hæmmere til anvendelse i behandling af fedme |
| TW201636342A (zh) | 2014-12-19 | 2016-10-16 | 武田藥品工業有限公司 | 煙黴醇衍生物 |
| CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
| KR20180093995A (ko) | 2015-12-10 | 2018-08-22 | 신데브알엑스, 인크. | 푸마길롤 유도체 및 그의 다형체 |
| US10646463B2 (en) | 2016-01-11 | 2020-05-12 | Syndevrx, Inc. | Treatment for tumors driven by metabolic dysfunction |
| CN113453721A (zh) | 2018-10-26 | 2021-09-28 | 辛德弗雷克斯公司 | Metap2抑制剂的生物标志物及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164410A (en) * | 1988-01-09 | 1992-11-17 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
| US5166172A (en) * | 1988-09-01 | 1992-11-24 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
| US5180738A (en) * | 1988-09-01 | 1993-01-19 | Takeda Chemical Industries | Fumagillol derivatives and pharmaceutical compositions thereof |
| ES2053890T3 (es) | 1988-09-01 | 1994-08-01 | Takeda Chemical Industries Ltd | Agente inhibidor de la angiogenesis. |
| EP0359036B1 (de) * | 1988-09-01 | 1997-03-26 | Takeda Chemical Industries, Ltd. | Fumagillol-Derivate |
| DE69001187T2 (de) | 1989-03-06 | 1993-07-08 | Takeda Chemical Industries Ltd | 6-epifumagillole, ihre herstellung und ihre verwendung. |
| US5290807A (en) * | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
| EP0415294A3 (en) * | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
| TW282399B (de) | 1990-05-25 | 1996-08-01 | Takeda Pharm Industry Co Ltd | |
| EP0799616A1 (de) * | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Orale Zubereitung enthaltend ein Fumagillolderivat |
| DE19653036A1 (de) | 1996-12-19 | 1998-06-25 | Merck Patent Gmbh | Cyclopeptidderivate |
| WO1998056372A1 (en) * | 1997-06-09 | 1998-12-17 | Massachusetts Institute Of Technology | TYPE 2 METHIONINE AMINOPEPTIDASE (MetAP2) INHIBITORS AND USES THEROF |
| KR100357541B1 (ko) * | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 5-데메톡시 푸마질롤 유도체 및 그 제조방법 |
| YU9602A (sh) | 1999-08-12 | 2004-11-25 | Pharmacia Italia S.P.A. | Derivati 3(5)-amino-pirazola, postupak za njihovu izradu i njihova upotreba kao antitumornih agenasa |
| US6114365A (en) | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
| US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
| US7087768B2 (en) * | 2001-09-27 | 2006-08-08 | Equispharm Co., Ltd. | Fumagillol derivatives and preparing method thereof |
| WO2003037330A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | Sulfonyl-and sulfonylheteroaryl-pyrazoles with a hydrazinyl or nitrogen oxide substituent at the 5-position for use as cyclooxygenase inhibitors |
-
2002
- 2002-06-11 US US10/490,588 patent/US7087768B2/en not_active Expired - Fee Related
- 2002-06-11 EP EP02738910A patent/EP1436286B1/de not_active Expired - Lifetime
- 2002-06-11 DE DE60233420T patent/DE60233420D1/de not_active Expired - Lifetime
- 2002-06-11 AT AT02738910T patent/ATE440094T1/de not_active IP Right Cessation
- 2002-06-11 WO PCT/KR2002/001102 patent/WO2003027104A1/en not_active Application Discontinuation
-
2006
- 2006-07-26 US US11/494,026 patent/US20060276512A1/en not_active Abandoned
- 2006-11-21 US US11/603,688 patent/US20070149613A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003027104A1 (en) | 2003-04-03 |
| EP1436286A4 (de) | 2004-12-15 |
| US20070149613A1 (en) | 2007-06-28 |
| EP1436286A1 (de) | 2004-07-14 |
| ATE440094T1 (de) | 2009-09-15 |
| US7087768B2 (en) | 2006-08-08 |
| US20040242681A1 (en) | 2004-12-02 |
| EP1436286B1 (de) | 2009-08-19 |
| US20060276512A1 (en) | 2006-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |