DE60231625D1 - Systeme und verfahren zum screening pharmazeutischer chemikalien - Google Patents
Systeme und verfahren zum screening pharmazeutischer chemikalienInfo
- Publication number
- DE60231625D1 DE60231625D1 DE60231625T DE60231625T DE60231625D1 DE 60231625 D1 DE60231625 D1 DE 60231625D1 DE 60231625 T DE60231625 T DE 60231625T DE 60231625 T DE60231625 T DE 60231625T DE 60231625 D1 DE60231625 D1 DE 60231625D1
- Authority
- DE
- Germany
- Prior art keywords
- systems
- model system
- pharmaceutical chemicals
- activator
- tissue model
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5061—Muscle cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/32—Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces
- G01N3/38—Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces generated by electromagnetic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5064—Endothelial cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0001—Type of application of the stress
- G01N2203/0005—Repeated or cyclic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0014—Type of force applied
- G01N2203/0016—Tensile or compressive
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0058—Kind of property studied
- G01N2203/0069—Fatigue, creep, strain-stress relations or elastic constants
- G01N2203/0073—Fatigue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/02—Details not specific for a particular testing method
- G01N2203/026—Specifications of the specimen
- G01N2203/0262—Shape of the specimen
- G01N2203/0278—Thin specimens
- G01N2203/0282—Two dimensional, e.g. tapes, webs, sheets, strips, disks or membranes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Electromagnetism (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31232201P | 2001-08-14 | 2001-08-14 | |
PCT/US2002/025761 WO2003016860A2 (en) | 2001-08-14 | 2002-08-14 | Systems and methods for screening pharmaceutical chemicals |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60231625D1 true DE60231625D1 (de) | 2009-04-30 |
Family
ID=23210916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60231625T Expired - Lifetime DE60231625D1 (de) | 2001-08-14 | 2002-08-14 | Systeme und verfahren zum screening pharmazeutischer chemikalien |
Country Status (8)
Country | Link |
---|---|
US (2) | US7449306B2 (de) |
EP (2) | EP1425385B1 (de) |
JP (1) | JP4638146B2 (de) |
AT (1) | ATE426015T1 (de) |
AU (1) | AU2002356043A1 (de) |
CA (1) | CA2497343C (de) |
DE (1) | DE60231625D1 (de) |
WO (1) | WO2003016860A2 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8227240B2 (en) | 2001-08-14 | 2012-07-24 | The Washington University | Systems for screening pharmaceutical chemicals |
EP1425385B1 (de) | 2001-08-14 | 2009-03-18 | Washington University in St. Louis | Systeme und verfahren zum screening pharmazeutischer chemikalien |
US7348175B2 (en) * | 2002-03-15 | 2008-03-25 | St3 Development Corporation | Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products |
US7497864B2 (en) * | 2003-04-30 | 2009-03-03 | Marctec, Llc. | Tissue fastener and methods for using same |
EP2578676A1 (de) * | 2003-06-20 | 2013-04-10 | Axiogenesis Ag | Formgebung zu Gewebe in einem embryonischen Stammzellen (ES) System |
US7738682B2 (en) * | 2003-10-22 | 2010-06-15 | Medtrain Technologies, Llc | Tissue engineered construct analytical imaging system and method of obtaining and analyzing images of tissue engineered constructs |
WO2005098425A1 (en) | 2004-04-07 | 2005-10-20 | Axiogenesis Ag | Non-invasive, in vitro functional tissue assay systems |
EP3070174B1 (de) | 2004-05-11 | 2019-11-06 | Ncardia AG | Medikamentenaufspürung auf der basis von in vitro differenzierten zellen |
KR100665299B1 (ko) * | 2004-06-10 | 2007-01-04 | 서울반도체 주식회사 | 발광물질 |
WO2006044997A2 (en) * | 2004-10-15 | 2006-04-27 | The Trustees Of Columbia University In The City Of New York | System and method for localized measurement and imaging of viscosity of tissues |
US8858441B2 (en) * | 2005-05-12 | 2014-10-14 | The Trustees Of Columbia University In The City Of New York | System and method for electromechanical wave imaging of body structures |
US10687785B2 (en) | 2005-05-12 | 2020-06-23 | The Trustees Of Columbia Univeristy In The City Of New York | System and method for electromechanical activation of arrhythmias |
US20080025917A1 (en) * | 2006-04-10 | 2008-01-31 | Malcolm Whitman | Methods for modulating formation and progression of cellulite |
WO2008027520A2 (en) * | 2006-08-30 | 2008-03-06 | The Trustees Of Columbia University In The City Of New York | Systems and methods for composite elastography and wave imaging |
JP4931017B2 (ja) * | 2008-01-10 | 2012-05-16 | 国立大学法人山口大学 | 細胞への伸展刺激負荷デバイス |
WO2011035312A1 (en) | 2009-09-21 | 2011-03-24 | The Trustees Of Culumbia University In The City Of New York | Systems and methods for opening of a tissue barrier |
CN107267384B (zh) * | 2008-06-05 | 2020-11-27 | 因维沃科学有限公司 | 用于高通量试验的三维组织 |
WO2010014977A1 (en) * | 2008-08-01 | 2010-02-04 | The Trustees Of Columbia University In The City Of New York | Systems and methods for matching and imaging tissue characteristics |
AU2009282480B2 (en) | 2008-08-11 | 2015-05-07 | Children's Medical Center Corporation | Halofuginone analogs for inhibition of tRNA synthetases and uses thereof |
WO2010030819A1 (en) | 2008-09-10 | 2010-03-18 | The Trustees Of Columbia University In The City Of New York | Systems and methods for opening a tissue |
JP2015037381A (ja) * | 2009-03-18 | 2015-02-26 | 株式会社豊田中央研究所 | 筋細胞の出力装置及び筋細胞の出力評価方法 |
WO2011137210A2 (en) * | 2010-04-30 | 2011-11-03 | The Regents Of The University Of California | Modulating compliance of trabecular meshwork |
JP5549547B2 (ja) * | 2010-11-04 | 2014-07-16 | 株式会社豊田中央研究所 | 筋細胞の出力装置及び筋細胞の出力評価方法 |
US9320491B2 (en) | 2011-04-18 | 2016-04-26 | The Trustees Of Columbia University In The City Of New York | Ultrasound devices methods and systems |
WO2012162664A1 (en) | 2011-05-26 | 2012-11-29 | The Trustees Of Columbia University In The City Of New York | Systems and methods for opening of a tissue barrier in primates |
WO2012170490A2 (en) | 2011-06-06 | 2012-12-13 | Invivosciences, Llc | Engineered cardiac tissues and methods of using them |
JP2015506363A (ja) | 2012-01-13 | 2015-03-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ハロフジノール誘導体、および化粧料組成物および医薬組成物におけるその使用 |
WO2014059170A1 (en) | 2012-10-10 | 2014-04-17 | The Trustees Of Columbia University In The City Of New York | Systems and methods for mechanical mapping of cardiac rhythm |
US9247921B2 (en) | 2013-06-07 | 2016-02-02 | The Trustees Of Columbia University In The City Of New York | Systems and methods of high frame rate streaming for treatment monitoring |
US10322178B2 (en) | 2013-08-09 | 2019-06-18 | The Trustees Of Columbia University In The City Of New York | Systems and methods for targeted drug delivery |
US10028723B2 (en) | 2013-09-03 | 2018-07-24 | The Trustees Of Columbia University In The City Of New York | Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening |
EP3063262A4 (de) * | 2013-10-30 | 2017-07-19 | Miklas, Jason | Vorrichtungen und verfahren für eine dreidimensionale gewebekultur |
AU2016331079B2 (en) * | 2015-10-02 | 2022-07-14 | Wake Forest University Health Sciences | Spontaneously beating cardiac organoid constructs and integrated body-on-chip apparatus containing the same |
DE102016110328B3 (de) * | 2016-06-03 | 2017-09-07 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Lochplatte |
FR3064359B1 (fr) * | 2017-03-21 | 2021-04-16 | Centre Nat Rech Scient | Dispositif pour la caracterisation mecanique d'un element d'interet par exemple un ovocyte |
US20180372724A1 (en) * | 2017-06-26 | 2018-12-27 | The Regents Of The University Of California | Methods and apparatuses for prediction of mechanism of activity of compounds |
WO2019237125A1 (en) | 2018-06-08 | 2019-12-12 | The General Hospital Corporation | Inhibitors of prolyl-trna-synthetase |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US526357A (en) * | 1894-09-18 | Antirust-ware | ||
US4593042A (en) * | 1985-10-18 | 1986-06-03 | G. D. Searle & Co. | Bicyclo-substituted phenylacetonitrile derivatives |
US4705785A (en) * | 1986-04-09 | 1987-11-10 | Ortho Pharmaceutical Corporation | Substituted thiacycloalkeno (3,2-b) pyridines and pharmaceutical compositions and method of use |
US4839280A (en) * | 1987-05-04 | 1989-06-13 | Banes Albert J | Apparatus for applying stress to cell cultures |
US5038795A (en) * | 1987-08-05 | 1991-08-13 | Roush Elsie S | Muscle tonometer apparatus and method |
US5464853A (en) * | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US5122470A (en) * | 1988-07-05 | 1992-06-16 | Banes Albert J | Floating cell culture device and method |
US4940853A (en) * | 1988-07-22 | 1990-07-10 | Vandenburgh Herman H | Method for growing tissue specimens in vitro |
US4940856A (en) * | 1989-06-26 | 1990-07-10 | Burndy Corporation | Electrical connector |
US5326357A (en) * | 1992-03-18 | 1994-07-05 | Mount Sinai Hospital Corporation | Reconstituted cartridge tissue |
US5486457A (en) * | 1993-08-25 | 1996-01-23 | Children's Medical Center Corporation | Method and system for measurement of mechanical properties of molecules and cells |
US5571083A (en) * | 1994-02-18 | 1996-11-05 | Lemelson; Jerome H. | Method and system for cell transplantation |
DE19500498C2 (de) | 1995-01-10 | 1997-05-07 | Thomas Dr Med Eschenhagen | Matrixkörper für die Messung isometrischer Kraftparameter von Zellgewebe, Verfahren zum Herstellen des Matrixkörpers, Set für dieses Verfahren und Verwendung des Matrixkörpers zum Kultivieren von Kardiomyozyten |
AU7377396A (en) * | 1995-09-27 | 1997-04-17 | Artann Laboratories | Measuring anisotropic mechanical properties of tissue |
US5665391A (en) * | 1995-10-12 | 1997-09-09 | Spectral Diagnostics Inc. | Cultured, full-thickness integument substitutes based on three-dimensional matrix membranes |
US20060105357A1 (en) * | 1998-02-18 | 2006-05-18 | Myomics, Inc. | Tissue sensor and uses thereof |
DE69903800T2 (de) * | 1998-03-18 | 2003-10-02 | Massachusetts Inst Technology | Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane |
CA2306275C (en) * | 1999-04-23 | 2009-11-03 | Bio Syntech Canada Inc. | Universal mechanical testing device |
AU783432B2 (en) | 1999-06-25 | 2005-10-27 | Genetronics, Inc. | High efficiency transfection based on low electric field strength, long pulse length |
DE10003521A1 (de) * | 2000-01-27 | 2001-08-09 | Medigene Ag | Vorrichtung zum Herstellen eines dreidimensionalen Matrixkörpers, Multi-Well-Platte, Lösung zum Kultivieren von Säugerkardiomyocyten, Verfahren zum Kultivieren einer Zellkultur, Vorrichtung für die Messung isometrischer Kraftparameter von Zellkulturen sowie Verfahren zum meßbaren Verfolgen von Kontraktionen eines in eine Trägersubstanz eingelagerten Zellgewebes |
US8227240B2 (en) * | 2001-08-14 | 2012-07-24 | The Washington University | Systems for screening pharmaceutical chemicals |
EP1425385B1 (de) * | 2001-08-14 | 2009-03-18 | Washington University in St. Louis | Systeme und verfahren zum screening pharmazeutischer chemikalien |
-
2002
- 2002-08-14 EP EP02752832A patent/EP1425385B1/de not_active Expired - Lifetime
- 2002-08-14 US US10/219,097 patent/US7449306B2/en not_active Expired - Lifetime
- 2002-08-14 AU AU2002356043A patent/AU2002356043A1/en not_active Abandoned
- 2002-08-14 DE DE60231625T patent/DE60231625D1/de not_active Expired - Lifetime
- 2002-08-14 AT AT02752832T patent/ATE426015T1/de not_active IP Right Cessation
- 2002-08-14 CA CA2497343A patent/CA2497343C/en not_active Expired - Lifetime
- 2002-08-14 EP EP08009189A patent/EP1983043A1/de not_active Ceased
- 2002-08-14 WO PCT/US2002/025761 patent/WO2003016860A2/en active Application Filing
- 2002-08-14 JP JP2003521318A patent/JP4638146B2/ja not_active Expired - Lifetime
-
2008
- 2008-11-11 US US12/268,783 patent/US8071381B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1983043A1 (de) | 2008-10-22 |
US8071381B2 (en) | 2011-12-06 |
JP4638146B2 (ja) | 2011-02-23 |
EP1425385B1 (de) | 2009-03-18 |
US7449306B2 (en) | 2008-11-11 |
EP1425385A4 (de) | 2005-04-06 |
US20090068701A1 (en) | 2009-03-12 |
WO2003016860A3 (en) | 2003-06-12 |
CA2497343C (en) | 2013-04-02 |
AU2002356043A1 (en) | 2003-03-03 |
EP1425385A2 (de) | 2004-06-09 |
CA2497343A1 (en) | 2003-02-27 |
WO2003016860A2 (en) | 2003-02-27 |
ATE426015T1 (de) | 2009-04-15 |
JP2005523417A (ja) | 2005-08-04 |
US20030064358A1 (en) | 2003-04-03 |
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