DE60227108D1 - Cis-imidazoline als mdm2-hemmer - Google Patents
Cis-imidazoline als mdm2-hemmerInfo
- Publication number
- DE60227108D1 DE60227108D1 DE60227108T DE60227108T DE60227108D1 DE 60227108 D1 DE60227108 D1 DE 60227108D1 DE 60227108 T DE60227108 T DE 60227108T DE 60227108 T DE60227108 T DE 60227108T DE 60227108 D1 DE60227108 D1 DE 60227108D1
- Authority
- DE
- Germany
- Prior art keywords
- hemmer
- mdm2
- imidazoline
- cis
- mdm2 hemmer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34172901P | 2001-12-18 | 2001-12-18 | |
| US39087602P | 2002-06-21 | 2002-06-21 | |
| PCT/EP2002/013905 WO2003051360A1 (en) | 2001-12-18 | 2002-12-09 | Cis-imidazolines as mdm2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60227108D1 true DE60227108D1 (de) | 2008-07-24 |
Family
ID=26992633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60227108T Expired - Lifetime DE60227108D1 (de) | 2001-12-18 | 2002-12-09 | Cis-imidazoline als mdm2-hemmer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6617346B1 (de) |
| EP (1) | EP1463501B1 (de) |
| JP (1) | JP4361798B2 (de) |
| KR (1) | KR100640707B1 (de) |
| CN (1) | CN1604778A (de) |
| AR (1) | AR037882A1 (de) |
| AT (1) | ATE397925T1 (de) |
| AU (1) | AU2002361986B2 (de) |
| BR (1) | BR0215156A (de) |
| CA (1) | CA2468783A1 (de) |
| DE (1) | DE60227108D1 (de) |
| ES (1) | ES2307822T3 (de) |
| MX (1) | MXPA04005880A (de) |
| PA (1) | PA8561801A1 (de) |
| PE (1) | PE20030717A1 (de) |
| PL (1) | PL370909A1 (de) |
| RU (1) | RU2312101C2 (de) |
| TW (1) | TW200301696A (de) |
| UY (1) | UY27586A1 (de) |
| WO (1) | WO2003051360A1 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7132421B2 (en) | 2003-06-17 | 2006-11-07 | Hoffmann-La Roche Inc. | CIS-imidazoles |
| KR100748424B1 (ko) * | 2003-06-17 | 2007-08-10 | 에프. 호프만-라 로슈 아게 | Ｍｄｍ2 억제제로서의 시스-이미다졸린 |
| EP1753727B1 (de) * | 2004-05-18 | 2008-11-19 | F.Hoffmann-La Roche Ag | Neuartige cis-imidazoline |
| EA014729B1 (ru) * | 2004-05-29 | 2011-02-28 | 7ТиЭм ФАРМА А/С | Лиганды crth2 рецептора и их применение |
| US7893278B2 (en) * | 2004-06-17 | 2011-02-22 | Hoffman-La Roche Inc. | CIS-imidazolines |
| CA2598690C (en) | 2005-02-22 | 2011-11-15 | The Regents Of The University Of Michigan | Small molecule inhibitors of mdm2 and uses thereof |
| US7759383B2 (en) | 2005-02-22 | 2010-07-20 | The Regents Of The University Of Michigan | Small molecule inhibitors of MDM2 and the uses thereof |
| KR20100129331A (ko) | 2005-12-01 | 2010-12-08 | 에프. 호프만-라 로슈 아게 | 항암제로서 사용하기 위한 ｐ53 및 ｍｄｍ2 단백질 간 상호작용의 저해제로서의 2,4,5-트리페닐 이미다졸린 유도체 |
| WO2007082805A1 (en) * | 2006-01-18 | 2007-07-26 | F. Hoffmann-La Roche Ag | Cis-4, 5-biaryl-2-heterocyclic-imidazolines as mdm2 inhibitors |
| US8470785B2 (en) | 2006-07-28 | 2013-06-25 | St. Jude Children's Research Hospital | Method for treating ocular cancer |
| WO2008014216A1 (en) | 2006-07-28 | 2008-01-31 | St. Jude Children's Research Hospital | Method for treating ocular cancer |
| US8222288B2 (en) | 2006-08-30 | 2012-07-17 | The Regents Of The University Of Michigan | Small molecule inhibitors of MDM2 and the uses thereof |
| JPWO2008072655A1 (ja) | 2006-12-14 | 2010-04-02 | 第一三共株式会社 | イミダゾチアゾール誘導体 |
| US7625895B2 (en) * | 2007-04-12 | 2009-12-01 | Hoffmann-Le Roche Inc. | Diphenyl-dihydro-imidazopyridinones |
| CN101821251A (zh) * | 2007-10-09 | 2010-09-01 | 霍夫曼-拉罗奇有限公司 | 手性顺式-咪唑啉类 |
| US9539327B2 (en) * | 2007-11-26 | 2017-01-10 | The Research Foundation For The State University Of New York | Small molecule cancer treatments that cause necrosis in cancer cells but do not affect normal cells |
| WO2009151069A1 (ja) | 2008-06-12 | 2009-12-17 | 第一三共株式会社 | ４，７－ジアザスピロ［２．５］オクタン環構造を有するイミダゾチアゾール誘導体 |
| DK2380892T3 (da) | 2009-01-16 | 2014-06-30 | Daiichi Sankyo Co Ltd | Imidazothiazolderivat med prolinringstruktur |
| CA2780547C (en) | 2009-11-12 | 2015-02-03 | The Regents Of The University Of Michigan | Spiro-oxindole mdm2 antagonists |
| US10159669B2 (en) * | 2010-03-02 | 2018-12-25 | Ian H. Chan | Individual and combination of mdivi-1 and nutlin-3 for topical or intravitreal ophthalmic use |
| US20130225603A1 (en) * | 2010-09-27 | 2013-08-29 | Serrata Llc | Mdm2 inhibitors for treatment of ocular conditions |
| WO2012045018A1 (en) | 2010-09-30 | 2012-04-05 | St. Jude Children's Research Hospital | Aryl-substituted imidazoles |
| FR2967072B1 (fr) | 2010-11-05 | 2013-03-29 | Univ Dundee | Procede pour ameliorer la production de virus et semences vaccinales influenza |
| PE20140408A1 (es) | 2010-11-12 | 2014-04-10 | Univ Michigan | Derivados espiro-oxindol como antagonistas de mdm2 |
| PL2684880T3 (pl) | 2011-03-10 | 2018-07-31 | Daiichi Sankyo Company, Limited | Pochodna dispiropirolidyny |
| SG194873A1 (en) | 2011-05-11 | 2013-12-30 | Sanofi Sa | Spiro-oxindole mdm2 antagonists |
| KR101384683B1 (ko) * | 2011-10-27 | 2014-04-11 | 한국생명공학연구원 | ｍｄｍ２－결합 모티프를 포함하는 펩타이드 및 이의 용도 |
| WO2013101436A1 (en) | 2011-12-07 | 2013-07-04 | Duke University | Methods of identifying and using mdm2 inhibitors |
| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| MX2015008196A (es) | 2012-12-20 | 2015-09-16 | Merck Sharp & Dohme | Imidazopiridinas sustituidas como inhibidores de doble minuto 2 humana. |
| WO2015116735A1 (en) | 2014-01-28 | 2015-08-06 | Mayo Foundation For Medical Education And Research | Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders |
| NZ723035A (en) | 2014-01-28 | 2022-07-01 | Buck Inst Res Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
| US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| TWI750129B (zh) * | 2015-08-03 | 2021-12-21 | 瑞士商諾華公司 | 作為血液學毒性生物標記之ｇｄｆ-１５ |
| EP3440082A1 (de) | 2016-04-06 | 2019-02-13 | The Regents of The University of Michigan | Monofunktionelle zwischenprodukte für den ligandenabhängigen zielproteinabbau |
| JP7037500B2 (ja) | 2016-04-06 | 2022-03-16 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | Ｍｄｍ２タンパク質分解剤 |
| ES2858151T3 (es) | 2016-05-20 | 2021-09-29 | Hoffmann La Roche | Conjugados de PROTAC-anticuerpo y procedimientos de uso |
| JP6848055B2 (ja) | 2017-06-16 | 2021-03-24 | ユニティ バイオテクノロジー インコーポレイテッド | 薬学的使用のための鏡像異性的に純粋なシス‐イミダゾリン化合物を生成するための合成方法 |
| AU2019356772A1 (en) | 2018-10-08 | 2021-04-01 | The Regents Of The University Of Michigan | Small molecule MDM2 protein degraders |
| KR20230005160A (ko) | 2020-03-19 | 2023-01-09 | 카이메라 쎄라퓨틱스 인코포레이티드 | Mdm2 분해제 및 이의 용도 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02101065A (ja) * | 1988-10-06 | 1990-04-12 | Tanabe Seiyaku Co Ltd | イミダゾリン誘導体及びその製法 |
| US5474998A (en) | 1990-08-17 | 1995-12-12 | E. I. Du Pont De Nemours And Company | Arthropodicidal pyrazolines, pyrazolidines and hydrazines |
| GB2351082A (en) * | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
-
2002
- 2002-12-09 AT AT02796582T patent/ATE397925T1/de not_active IP Right Cessation
- 2002-12-09 CN CNA028252292A patent/CN1604778A/zh active Pending
- 2002-12-09 DE DE60227108T patent/DE60227108D1/de not_active Expired - Lifetime
- 2002-12-09 ES ES02796582T patent/ES2307822T3/es not_active Expired - Lifetime
- 2002-12-09 JP JP2003552293A patent/JP4361798B2/ja not_active Expired - Fee Related
- 2002-12-09 MX MXPA04005880A patent/MXPA04005880A/es active IP Right Grant
- 2002-12-09 BR BR0215156-1A patent/BR0215156A/pt not_active IP Right Cessation
- 2002-12-09 PL PL02370909A patent/PL370909A1/xx not_active Application Discontinuation
- 2002-12-09 WO PCT/EP2002/013905 patent/WO2003051360A1/en active IP Right Grant
- 2002-12-09 CA CA002468783A patent/CA2468783A1/en not_active Abandoned
- 2002-12-09 KR KR1020047009612A patent/KR100640707B1/ko not_active IP Right Cessation
- 2002-12-09 RU RU2004122404/04A patent/RU2312101C2/ru not_active IP Right Cessation
- 2002-12-09 AU AU2002361986A patent/AU2002361986B2/en not_active Ceased
- 2002-12-09 EP EP02796582A patent/EP1463501B1/de not_active Expired - Lifetime
- 2002-12-11 US US10/316,696 patent/US6617346B1/en not_active Expired - Fee Related
- 2002-12-13 PE PE2002001225A patent/PE20030717A1/es not_active Application Discontinuation
- 2002-12-17 PA PA20028561801A patent/PA8561801A1/es unknown
- 2002-12-17 UY UY27586A patent/UY27586A1/es not_active Application Discontinuation
- 2002-12-17 AR ARP020104913A patent/AR037882A1/es not_active Application Discontinuation
- 2002-12-18 TW TW091136524A patent/TW200301696A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2312101C2 (ru) | 2007-12-10 |
| AR037882A1 (es) | 2004-12-09 |
| BR0215156A (pt) | 2004-10-19 |
| RU2004122404A (ru) | 2005-05-27 |
| JP2005515210A (ja) | 2005-05-26 |
| EP1463501A1 (de) | 2004-10-06 |
| JP4361798B2 (ja) | 2009-11-11 |
| CN1604778A (zh) | 2005-04-06 |
| TW200301696A (en) | 2003-07-16 |
| ES2307822T3 (es) | 2008-12-01 |
| US6617346B1 (en) | 2003-09-09 |
| AU2002361986B2 (en) | 2008-04-10 |
| UY27586A1 (es) | 2003-06-30 |
| KR100640707B1 (ko) | 2006-10-31 |
| PL370909A1 (en) | 2005-05-30 |
| PE20030717A1 (es) | 2003-08-28 |
| CA2468783A1 (en) | 2003-06-26 |
| PA8561801A1 (es) | 2003-07-28 |
| WO2003051360A1 (en) | 2003-06-26 |
| EP1463501B1 (de) | 2008-06-11 |
| MXPA04005880A (es) | 2004-09-13 |
| ATE397925T1 (de) | 2008-07-15 |
| AU2002361986A1 (en) | 2003-06-30 |
| KR20040068289A (ko) | 2004-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |