DE60206154D1 - Bicyclo[3,1,0]hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate - Google Patents

Bicyclo[3,1,0]hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate

Info

Publication number
DE60206154D1
DE60206154D1 DE60206154T DE60206154T DE60206154D1 DE 60206154 D1 DE60206154 D1 DE 60206154D1 DE 60206154 T DE60206154 T DE 60206154T DE 60206154 T DE60206154 T DE 60206154T DE 60206154 D1 DE60206154 D1 DE 60206154D1
Authority
DE
Germany
Prior art keywords
sub
hexane
bicyclo
derivatives
structural element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60206154T
Other languages
English (en)
Other versions
DE60206154T2 (de
Inventor
Yasumichi Fukuda
L Hammond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Merck and Co Inc
Original Assignee
Kyorin Pharmaceutical Co Ltd
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd, Merck and Co Inc filed Critical Kyorin Pharmaceutical Co Ltd
Publication of DE60206154D1 publication Critical patent/DE60206154D1/de
Application granted granted Critical
Publication of DE60206154T2 publication Critical patent/DE60206154T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
DE60206154T 2001-04-17 2002-04-17 Bicyclo[3,1,0]hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate Expired - Fee Related DE60206154T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28395601P 2001-04-17 2001-04-17
US283956P 2001-04-17
US36392802P 2002-03-14 2002-03-14
US363928P 2002-03-14
PCT/US2002/011921 WO2003027083A1 (en) 2001-04-17 2002-04-17 Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof

Publications (2)

Publication Number Publication Date
DE60206154D1 true DE60206154D1 (de) 2005-10-20
DE60206154T2 DE60206154T2 (de) 2006-06-29

Family

ID=30117959

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60206154T Expired - Fee Related DE60206154T2 (de) 2001-04-17 2002-04-17 Bicyclo[3,1,0]hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate

Country Status (9)

Country Link
US (2) US6897230B2 (de)
EP (1) EP1385834B1 (de)
JP (1) JP2005503435A (de)
AT (1) ATE304536T1 (de)
AU (1) AU2002360238B2 (de)
CA (1) CA2443410A1 (de)
DE (1) DE60206154T2 (de)
ES (1) ES2248633T3 (de)
WO (1) WO2003027083A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002360238B2 (en) * 2001-04-17 2007-11-15 Kyorin Pharmaceutical Co., Ltd. Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
ES2310202T3 (es) * 2001-04-26 2009-01-01 EISAI R&D MANAGEMENT CO., LTD. Compuesto ciclico condensado que contiene nitrogeno que tiene un grupo pirazolilo como grupo sustituyente y composicion farmaceutica del mismo.
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
AU2003215861A1 (en) * 2003-04-07 2004-11-01 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2004099199A1 (en) * 2003-05-06 2004-11-18 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
US20070185132A1 (en) * 2003-07-02 2007-08-09 Yasumichi Fukuda Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo
CA2529294A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
DE602004027811D1 (de) 2003-07-02 2010-08-05 Kyorin Seiyaku Kk Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
ZA200510432B (en) * 2003-07-02 2007-03-28 Merck & Co Inc Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
AU2004256084B2 (en) * 2003-07-02 2007-10-18 Kyorin Pharmaceutical Co., Ltd. Oxazolidinone antibiotics and derivatives thereof
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
UA86037C2 (ru) * 2003-10-14 2009-03-25 Пфайзер Продактс Инк. Бициклические [3.1.0] производные, как ингибиторы переносчика глицина
WO2007004032A1 (en) * 2005-07-06 2007-01-11 Pharmacia & Upjohn Company Llc Oxazolidiones containing cyclobutane as antibacterial agents
WO2008126795A1 (ja) * 2007-04-06 2008-10-23 Nippon Soda Co., Ltd. 有害生物防除剤組成物及び有害生物防除方法
KR20120106697A (ko) 2009-06-26 2012-09-26 파나세아 바이오테크 리미티드 신규 아자비시클로헥산
BR112013007566A2 (pt) 2010-09-28 2016-08-02 Panacea Biotec Ltd novos compostos bicíclicos
US9233989B2 (en) * 2011-10-11 2016-01-12 Council Of Scientific & Industrial Research Sila analogs of oxazolidinone derivatives and synthesis thereof
CN107400126A (zh) * 2016-05-19 2017-11-28 陕西合成药业股份有限公司 新型噁唑烷酮类化合物及其制备方法和在医学上的应用
WO2018170664A1 (en) * 2017-03-20 2018-09-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053593A (en) * 1975-11-26 1977-10-11 Lew Frumoff Medical product combining antimicrobial, antiporasitic and vitamin complex
AU667198B2 (en) * 1991-11-01 1996-03-14 Pharmacia & Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
KR100276382B1 (ko) * 1992-12-08 2000-12-15 로렌스 티. 마이젠헬더 트로폰-치환된 페닐옥사졸리디논 항균제
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
US6608081B2 (en) * 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
HUP0301562A2 (hu) * 2000-06-05 2003-12-29 Dong A Pharm. Co., Ltd. Új oxazolidinonszármazékok és eljárás ezek előállítására, ezeket tartalmazó gyógyszerkészítmények
EP1303511A1 (de) * 2000-07-17 2003-04-23 Ranbaxy Laboratories, Ltd. Oxazolidon derivaten als antimikrobieller
AU2002360238B2 (en) * 2001-04-17 2007-11-15 Kyorin Pharmaceutical Co., Ltd. Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
EP1448536A1 (de) * 2001-11-29 2004-08-25 Merck & Co., Inc. Cyclopropyl enthaltende oxazolidinonantibiotika und deren derivate
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
DE602004027811D1 (de) * 2003-07-02 2010-08-05 Kyorin Seiyaku Kk Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
US20070185132A1 (en) * 2003-07-02 2007-08-09 Yasumichi Fukuda Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo
CA2529294A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
AU2004256084B2 (en) * 2003-07-02 2007-10-18 Kyorin Pharmaceutical Co., Ltd. Oxazolidinone antibiotics and derivatives thereof

Also Published As

Publication number Publication date
ATE304536T1 (de) 2005-09-15
WO2003027083A1 (en) 2003-04-03
CA2443410A1 (en) 2003-04-03
EP1385834B1 (de) 2005-09-14
ES2248633T3 (es) 2006-03-16
DE60206154T2 (de) 2006-06-29
JP2005503435A (ja) 2005-02-03
US20050203144A1 (en) 2005-09-15
US6897230B2 (en) 2005-05-24
AU2002360238B2 (en) 2007-11-15
EP1385834A1 (de) 2004-02-04
US20030125367A1 (en) 2003-07-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee