DE602007011409D1 - Verfahren für verbesserte zellproliferation von pankreas-vorläuferzellen in einer pankreaszellkultur - Google Patents

Verfahren für verbesserte zellproliferation von pankreas-vorläuferzellen in einer pankreaszellkultur

Info

Publication number
DE602007011409D1
DE602007011409D1 DE602007011409T DE602007011409T DE602007011409D1 DE 602007011409 D1 DE602007011409 D1 DE 602007011409D1 DE 602007011409 T DE602007011409 T DE 602007011409T DE 602007011409 T DE602007011409 T DE 602007011409T DE 602007011409 D1 DE602007011409 D1 DE 602007011409D1
Authority
DE
Germany
Prior art keywords
pancreas
cells
propulation
clearer
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007011409T
Other languages
English (en)
Inventor
Monica Florio
Aleksandar Francki
Wen-Ghih Tsang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reneuron Inc USA
Original Assignee
Reneuron Inc USA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reneuron Inc USA filed Critical Reneuron Inc USA
Publication of DE602007011409D1 publication Critical patent/DE602007011409D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/48—Regulators of apoptosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/32—Polylysine, polyornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate
DE602007011409T 2006-01-20 2007-01-18 Verfahren für verbesserte zellproliferation von pankreas-vorläuferzellen in einer pankreaszellkultur Active DE602007011409D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76044506P 2006-01-20 2006-01-20
PCT/US2007/001555 WO2007084730A2 (en) 2006-01-20 2007-01-18 Method of improving cell proliferation of pancreatic progenitor cells in a pancreatic cell culture

Publications (1)

Publication Number Publication Date
DE602007011409D1 true DE602007011409D1 (de) 2011-02-03

Family

ID=38288290

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007011409T Active DE602007011409D1 (de) 2006-01-20 2007-01-18 Verfahren für verbesserte zellproliferation von pankreas-vorläuferzellen in einer pankreaszellkultur

Country Status (8)

Country Link
US (1) US9745554B2 (de)
EP (1) EP1994140B1 (de)
JP (1) JP5459823B2 (de)
AT (1) ATE492629T1 (de)
AU (1) AU2007207434B2 (de)
CA (1) CA2637843C (de)
DE (1) DE602007011409D1 (de)
WO (1) WO2007084730A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2923160B1 (fr) * 2007-11-02 2013-07-26 Pasteur Institut Composes destines a prevenir ou traiter une infection virale.
CN103827303B (zh) 2011-09-26 2021-10-22 普瑞阿那利提克斯有限公司 细胞外核酸的稳定化和分离
US11021733B2 (en) 2011-09-26 2021-06-01 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
CN102589955A (zh) * 2012-01-15 2012-07-18 中国人民解放军第四军医大学 一种检测体液细胞中结核杆菌的染色试剂盒
CA2884915C (en) 2012-09-25 2022-05-17 Qiagen Gmbh Stabilisation of biological samples
US20150361400A1 (en) * 2013-01-25 2015-12-17 Wake Forest University Health Sciences Compositions and methods for maintaining and improving pancreatic islet cell function and stability
US11525155B2 (en) 2013-03-18 2022-12-13 Qiagen Gmbh Stabilisation of biological samples
US20160281133A1 (en) 2013-03-18 2016-09-29 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
DE202014011287U1 (de) 2013-06-11 2019-02-06 The President And Fellows Of Harvard College SC-ß Zellen und Zusammensetzungen zur Erzeugung der Zellen
WO2016021734A1 (ja) * 2014-08-04 2016-02-11 武田薬品工業株式会社 膵前駆細胞の増殖方法
EP3234110B1 (de) 2014-12-18 2024-02-28 President and Fellows of Harvard College Verfahren zur generierung von stammzell-abgeleiteten beta-zellen und verwendungen davon
CN107614678B (zh) 2014-12-18 2021-04-30 哈佛学院校长同事会 干细胞来源的β细胞的产生方法及其使用方法
WO2016100898A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof
CA3005694A1 (en) * 2015-11-20 2017-05-26 Qiagen Gmbh Method of preparing sterilized compositions for stabilization of extracellular nucleic acids
AU2018370029A1 (en) 2017-11-15 2020-07-02 Vertex Pharmaceuticals Incorporated Islet cell manufacturing compositions and methods of use
WO2020033879A1 (en) 2018-08-10 2020-02-13 Semma Therapeutics, Inc. Stem cell derived islet differentiation
JP2023520460A (ja) * 2020-03-30 2023-05-17 ザ ジョンズ ホプキンズ ユニヴァーシティー 損傷修復の強化ならびに細菌およびウイルス感染の治療のためのカスパーゼ阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562620B2 (en) * 1997-09-19 2003-05-13 Mcgill University Medium to promote islet cell survival
AU2005221095A1 (en) * 2004-03-09 2005-09-22 John J. O'neil Methods for generating insulin-producing cells
US7807459B2 (en) * 2005-09-27 2010-10-05 Reneuron, Inc. EphA4-positive human adult pancreatic endocrine progenitor cells
US7875451B2 (en) * 2006-01-19 2011-01-25 The University Of Washington Formulation to improve survival of transplanted cells

Also Published As

Publication number Publication date
JP2009523449A (ja) 2009-06-25
WO2007084730A3 (en) 2007-12-27
US9745554B2 (en) 2017-08-29
EP1994140B1 (de) 2010-12-22
AU2007207434B2 (en) 2012-04-05
ATE492629T1 (de) 2011-01-15
CA2637843A1 (en) 2007-07-26
CA2637843C (en) 2014-12-30
EP1994140A2 (de) 2008-11-26
AU2007207434A1 (en) 2007-07-26
JP5459823B2 (ja) 2014-04-02
WO2007084730A2 (en) 2007-07-26
EP1994140A4 (de) 2009-04-08
US20100311166A1 (en) 2010-12-09

Similar Documents

Publication Publication Date Title
DE602007011409D1 (de) Verfahren für verbesserte zellproliferation von pankreas-vorläuferzellen in einer pankreaszellkultur
MX2019015525A (es) Modificacion genetica de ratas.
ATE480615T1 (de) Verfahren zur proliferation von stammzellen
GB2451523B (en) Pluripotent cells from rat and other species
IN2014DN10053A (de)
CL2009000782A1 (es) Metodo que comprende un compuesto derivado de oximetilen-arilo sustituido, inhibidores de dpp-iv; y su uso en el tratamiento de la diabetes y disminucion de trigliceridos, entre otras enfermedades.
WO2007134294A3 (en) Novel chlorella species and uses therefor
GB2452456A (en) Cell growth medium
UY31222A1 (es) Modificación enzimática del aceite
EP2344632A4 (de) Verfahren zur herbeiführung von pluripotenzen in zellen
WO2010033906A3 (en) Efficient induction of pluripotent stem cells using small molecule compounds
MX2008011838A (es) Propagacion de celulas primarias.
GB2458863A (en) Improved culture of stem cells
MY157524A (en) Culturing embryonic stem cells, embryonic stem-like cells, or induced pluripotent stem cells with a muc1 or muc1* ligand
WO2009126251A3 (en) Reprogramming a cell by inducing a pluripotent gene through use of an hdac modulator
ATE500327T1 (de) Verfahren und zusammensetzungen für ethanolproduzierende cyanobakterien
SG137782A1 (en) Membrane surface modification by radiation-induced polymerization
MX2010000348A (es) Cultivo de celulas madre pluripotentes individuales.
MX2010002426A (es) Agente para promover la adhesion de las celulas del endotelio corneal.
NZ594516A (en) Apolipoprotein a-i mimics
ATE477714T1 (de) Verfahren zur behandlung von pflanzlichem material mit einem enzym
EP2444527A3 (de) Blechplattierungslösung
WO2012162518A3 (en) Method for the remediation of water generated from natural resource production operations
UA107325C2 (uk) Спосіб обробки декоративних рослин
WO2012102527A3 (ko) 조절자 Ｔ 세포에 특이적으로 존재하는 새로운 표면단백질 Ｌｒｉｇ-1의 용도