DE602006015861D1 - Antivirale verbindungen - Google Patents
Antivirale verbindungenInfo
- Publication number
- DE602006015861D1 DE602006015861D1 DE602006015861T DE602006015861T DE602006015861D1 DE 602006015861 D1 DE602006015861 D1 DE 602006015861D1 DE 602006015861 T DE602006015861 T DE 602006015861T DE 602006015861 T DE602006015861 T DE 602006015861T DE 602006015861 D1 DE602006015861 D1 DE 602006015861D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- antiviral
- connections
- hcv
- viral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75247305P | 2005-12-21 | 2005-12-21 | |
| PCT/US2006/049080 WO2007076035A2 (en) | 2005-12-21 | 2006-12-20 | Anti-viral compounds |
| US11/613,836 US7763731B2 (en) | 2005-12-21 | 2006-12-20 | Anti-viral compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602006015861D1 true DE602006015861D1 (de) | 2010-09-09 |
Family
ID=38069383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602006015861T Active DE602006015861D1 (de) | 2005-12-21 | 2006-12-20 | Antivirale verbindungen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7763731B2 (de) |
| EP (1) | EP1979349B1 (de) |
| JP (1) | JP2009521480A (de) |
| CN (1) | CN102702194A (de) |
| AT (1) | ATE475660T1 (de) |
| CA (1) | CA2633760A1 (de) |
| DE (1) | DE602006015861D1 (de) |
| HK (1) | HK1122292A1 (de) |
| RU (1) | RU2467007C2 (de) |
| WO (1) | WO2007076035A2 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
| DE602006015861D1 (de) | 2005-12-21 | 2010-09-09 | Abbott Lab | Antivirale verbindungen |
| AU2006330924B2 (en) | 2005-12-21 | 2012-03-15 | Abbvie Inc. | Anti-viral compounds |
| US8236950B2 (en) * | 2006-12-20 | 2012-08-07 | Abbott Laboratories | Anti-viral compounds |
| CA2711500A1 (en) * | 2008-01-07 | 2009-07-16 | Huanming Chen | Novel hiv integrase inhibitors and methods of use |
| US8344018B2 (en) | 2008-07-14 | 2013-01-01 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
| CN102264737A (zh) | 2008-12-23 | 2011-11-30 | 雅培制药有限公司 | 抗病毒化合物 |
| CA2740195A1 (en) * | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
| US20100222381A1 (en) | 2009-02-27 | 2010-09-02 | Hariprasad Vankayalapati | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors |
| RU2541571C2 (ru) * | 2009-04-15 | 2015-02-20 | Эббви Инк. | Противовирусные соединения |
| BRPI1010884A2 (pt) | 2009-06-08 | 2016-03-15 | Gilead Sciences Inc | composto inibidores hdac de alcanoilamino benzamida anilina |
| NZ596783A (en) | 2009-06-08 | 2014-01-31 | Gilead Sciences Inc | Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| DK2455376T3 (en) * | 2009-06-11 | 2015-03-02 | Abbvie Bahamas Ltd | Heterocyclic compounds as inhibitors of hepatitis C virus (HCV) |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US20110137633A1 (en) * | 2009-12-03 | 2011-06-09 | Abbott Laboratories | Anti-viral compounds and methods of identifying the same |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| CA2818853A1 (en) | 2010-11-30 | 2012-06-07 | Gilead Pharmasset Llc | 2'-spirocyclo-nucleosides for use in therapy of hcv or dengue virus |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| MX354958B (es) | 2011-09-16 | 2018-03-27 | Gilead Pharmasset Llc | Metodos para el tratamiento de vhc. |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
| EP2861590B1 (de) * | 2012-06-15 | 2017-10-25 | Curegenix Inc. | Verbindung als wnt-signalübertragungshemmer, zusammensetzung und verwendung davon |
| JP5922791B2 (ja) | 2012-10-29 | 2016-05-24 | 京セラ株式会社 | 弾性表面波センサ |
| CA2890009C (en) | 2012-11-08 | 2017-11-28 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| PL2950786T3 (pl) | 2013-01-31 | 2020-05-18 | Gilead Pharmasset Llc | Formulacja skojarzona dwóch związków przeciwwirusowych |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| EP3089757A1 (de) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Feste antivirale darreichungsformen |
| US9868744B2 (en) | 2014-04-25 | 2018-01-16 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine D1 ligands |
| CN104086543A (zh) * | 2014-06-19 | 2014-10-08 | 湖南华腾制药有限公司 | 一种制备4-氯-1,8-二氮萘的方法 |
| CN106458908B (zh) | 2014-06-27 | 2018-11-06 | 阿格罗－金正株式会社 | 2-氨基-6-甲基烟酸的制造方法 |
| US10131683B2 (en) | 2014-07-17 | 2018-11-20 | Molecular Templates, Inc. | TH-302 solid forms and methods related thereto |
| EP3277380B1 (de) * | 2015-03-10 | 2020-09-16 | Obi Pharma, Inc. | Dna-alkylierungsmittel |
| KR102276681B1 (ko) | 2015-04-02 | 2021-07-13 | 아센타위츠 파마슈티컬즈 리미티드 | 항암제의 나이트로벤질 유도체 |
| TWI772263B (zh) | 2015-06-24 | 2022-08-01 | 美商免疫原公司 | 含有ｄｎａ烷化劑之氮丙啶 |
| EP3325482B1 (de) * | 2015-07-21 | 2020-06-24 | ImmunoGen, Inc. | Verfahren zur herstellung von zytotoxischen benzodiazepinderivaten |
| US20190112317A1 (en) | 2015-10-05 | 2019-04-18 | The Trustees Of Columbia University In The City Of New York | Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies |
| CN105461582A (zh) * | 2015-11-18 | 2016-04-06 | 浙江汇能生物股份有限公司 | 一种碘醚柳胺的制备方法 |
| US10239875B2 (en) | 2017-06-16 | 2019-03-26 | King Saud University | Naphthyridinyl hydrazine derivatives as potent peripheral analgesic agents |
| EP3594205A1 (de) | 2018-07-09 | 2020-01-15 | Abivax | Phenyl-n-aryl-derivate zur behandlung einer rna-virusinfektion |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034393A (en) | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
| GB9127252D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
| DE4308014A1 (de) * | 1993-03-13 | 1994-09-15 | Hoechst Schering Agrevo Gmbh | Kondensierte Stickstoffheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
| GB9312891D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US5679683A (en) | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| DK0831829T3 (da) | 1995-06-07 | 2003-12-15 | Pfizer | Heterocykliske, ringkondenserede pyrimidinderivater |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| US6130217A (en) | 1995-09-20 | 2000-10-10 | Pfizer Inc | Compounds enhancing antitumor activity of other cytotoxic agents |
| AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| ID19430A (id) | 1996-07-13 | 1998-07-09 | Glaxo Group Ltd | Senyawa senyawa heterosiklik |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| FR2751330B1 (fr) | 1996-07-16 | 1998-10-30 | Pernod Ricard | Procede de production de derivees de diol-1,3 naturels et de derives de 1,3-dioxane naturels correspondants |
| DE69719193T2 (de) | 1996-08-06 | 2003-09-25 | Pfizer | Substituierte pyrido- oder pyrimidogruppen enthaltende 6,6- oder 6,7-bicyclische derivate |
| TW477787B (en) | 1996-08-27 | 2002-03-01 | Pfizer | Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same |
| CN1252054C (zh) * | 1996-09-25 | 2006-04-19 | 曾尼卡有限公司 | 抑制生长因子的作用的喹啉衍生物 |
| DE19647317A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Schering Agrevo Gmbh | Substituierte Stickstoff-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| DE19647413A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Schering Agrevo Gmbh | Substituierte Stickstoff-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| KR20000057228A (ko) | 1996-11-27 | 2000-09-15 | 디. 제이. 우드, 스피겔 알렌 제이 | 축합된 비사이클릭 피리미딘 유도체 |
| IL138037A0 (en) | 1998-02-25 | 2001-10-31 | Univ Emory | 2'-fluoronucleosides |
| KR20010025055A (ko) | 1998-05-20 | 2001-03-26 | 피터 지. 스트링거 | 항바이러스 화합물 |
| US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| UA71945C2 (en) | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
| GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
| EP1230225A2 (de) | 1999-11-01 | 2002-08-14 | Eli Lilly And Company | Pharmazeutisch wirksame 4-substituierte pyrimidine derivate |
| CA2389745C (en) | 1999-11-04 | 2010-03-23 | Shire Biochem Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
| ITMI992711A1 (it) | 1999-12-27 | 2001-06-27 | Novartis Ag | Composti organici |
| CA2363274A1 (en) | 1999-12-27 | 2001-07-05 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs for hepatitis c |
| WO2001057040A1 (en) | 2000-02-03 | 2001-08-09 | Abbott Laboratories | 6,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
| PL364995A1 (en) | 2000-02-18 | 2004-12-27 | Shire Biochem Inc. | Method for the treatment or prevention of flavivirus |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| MXPA03003263A (es) * | 2000-10-12 | 2003-06-06 | Merck & Co Inc | Aza y poliaza naftalenil carboxamidas utiles como inhibidores de la integrasa del virus de inmunodeficiencia humana. |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| WO2002089731A2 (en) | 2001-05-03 | 2002-11-14 | Stanford University | Agents for treatment of hcv and methods of use |
| US20030158195A1 (en) * | 2001-12-21 | 2003-08-21 | Cywin Charles L. | 1,6 naphthyridines useful as inhibitors of SYK kinase |
| US7037913B2 (en) | 2002-05-01 | 2006-05-02 | Bristol-Myers Squibb Company | Bicyclo 4.4.0 antiviral derivatives |
| AU2003261434A1 (en) | 2002-08-12 | 2004-02-25 | Bristol-Myers Squibb Company | Iminothiazolidinones as inhibitors of hcv replication |
| EP1541558B1 (de) | 2002-08-13 | 2008-08-13 | Shionogi & Co., Ltd. | Heterocyclische verbindungen mit hiv-integrase-hemmender wirkung |
| US20050075331A1 (en) | 2003-10-06 | 2005-04-07 | Pratt John K. | Anti-infective agents |
| US20040138188A1 (en) | 2002-11-22 | 2004-07-15 | Higgins Linda S. | Use of TGF-beta inhibitors to counteract pathologic changes in the level or function of steroid/thyroid receptors |
| WO2004055003A1 (en) | 2002-12-13 | 2004-07-01 | Neurogen Corporation | 2-substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators |
| WO2004065392A1 (en) | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands |
| WO2004087056A2 (en) | 2003-03-28 | 2004-10-14 | Scios Inc. | BI-CYCLIC PYRIMIDINE INHIBITORS OF TGFβ |
| MXPA05012839A (es) | 2003-05-27 | 2006-05-17 | Pfizer Prod Inc | Quinazolinas y pirido[3,4-d] pirimidinas como inhibidores de receptores tirosina quinasa. |
| TW200510373A (en) * | 2003-07-14 | 2005-03-16 | Neurogen Corp | Substituted quinolin-4-ylamine analogues |
| US7378414B2 (en) | 2003-08-25 | 2008-05-27 | Abbott Laboratories | Anti-infective agents |
| GB0326168D0 (en) * | 2003-11-10 | 2003-12-17 | Arrow Therapeutics Ltd | Chemical compounds |
| JP2007534735A (ja) | 2004-04-28 | 2007-11-29 | アロウ セラピューティクス リミテッド | 抗ウイルス剤として使用するためのモルホリニルアニリノキナゾリン誘導体 |
| WO2006012333A1 (en) | 2004-06-30 | 2006-02-02 | Merck & Co., Inc. | Estrogen receptor modulators |
| BRPI0516751A (pt) | 2004-09-30 | 2008-09-16 | Tibotec Pharm Ltd | pirimidinas bicìclicas que inibem hcv |
| GB0421908D0 (en) | 2004-10-01 | 2004-11-03 | Angeletti P Ist Richerche Bio | New uses |
| TW200716631A (en) | 2005-05-12 | 2007-05-01 | Tibotec Pharm Ltd | Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and methods for the preparation thereof |
| AR056347A1 (es) | 2005-05-12 | 2007-10-03 | Tibotec Pharm Ltd | Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas |
| DE602005018972D1 (de) | 2005-09-23 | 2010-03-04 | Equispharm Co Ltd | 5,6-dimethylthienoä2,3-diüpyrimidinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung für die bekämpfung von viren |
| WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
| DE602006015861D1 (de) | 2005-12-21 | 2010-09-09 | Abbott Lab | Antivirale verbindungen |
-
2006
- 2006-12-20 DE DE602006015861T patent/DE602006015861D1/de active Active
- 2006-12-20 WO PCT/US2006/049080 patent/WO2007076035A2/en active Application Filing
- 2006-12-20 US US11/613,836 patent/US7763731B2/en active Active
- 2006-12-20 JP JP2008547625A patent/JP2009521480A/ja active Pending
- 2006-12-20 CA CA002633760A patent/CA2633760A1/en not_active Abandoned
- 2006-12-20 CN CN2012101601285A patent/CN102702194A/zh active Pending
- 2006-12-20 AT AT06848056T patent/ATE475660T1/de not_active IP Right Cessation
- 2006-12-20 RU RU2008129807/04A patent/RU2467007C2/ru not_active IP Right Cessation
- 2006-12-20 EP EP06848056A patent/EP1979349B1/de active Active
-
2009
- 2009-02-11 HK HK09101289.9A patent/HK1122292A1/xx not_active IP Right Cessation
-
2010
- 2010-06-17 US US12/817,808 patent/US8338605B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2633760A1 (en) | 2007-07-05 |
| RU2008129807A (ru) | 2010-02-20 |
| HK1122292A1 (en) | 2009-05-15 |
| JP2009521480A (ja) | 2009-06-04 |
| US8338605B2 (en) | 2012-12-25 |
| ATE475660T1 (de) | 2010-08-15 |
| WO2007076035A3 (en) | 2007-10-04 |
| US20100256139A1 (en) | 2010-10-07 |
| CN102702194A (zh) | 2012-10-03 |
| EP1979349A2 (de) | 2008-10-15 |
| EP1979349B1 (de) | 2010-07-28 |
| WO2007076035A2 (en) | 2007-07-05 |
| US7763731B2 (en) | 2010-07-27 |
| RU2467007C2 (ru) | 2012-11-20 |
| US20070232645A1 (en) | 2007-10-04 |
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