DE602006009845D1 - Verfahren zur herstellung von zwischenprodukten für die herstellung von ezetimibe - Google Patents

Verfahren zur herstellung von zwischenprodukten für die herstellung von ezetimibe

Info

Publication number
DE602006009845D1
DE602006009845D1 DE602006009845T DE602006009845T DE602006009845D1 DE 602006009845 D1 DE602006009845 D1 DE 602006009845D1 DE 602006009845 T DE602006009845 T DE 602006009845T DE 602006009845 T DE602006009845 T DE 602006009845T DE 602006009845 D1 DE602006009845 D1 DE 602006009845D1
Authority
DE
Germany
Prior art keywords
ezetimibe
production
intermediate products
preparing intermediate
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602006009845T
Other languages
English (en)
Inventor
I Escude Ana Gavalda
I Llado Jordi Bosch
I Ferran Anton Vidal
Garcia Eva Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem SA filed Critical Medichem SA
Publication of DE602006009845D1 publication Critical patent/DE602006009845D1/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE602006009845T 2005-12-22 2006-12-22 Verfahren zur herstellung von zwischenprodukten für die herstellung von ezetimibe Expired - Fee Related DE602006009845D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75258905P 2005-12-22 2005-12-22
PCT/IB2006/004107 WO2007119106A2 (en) 2005-12-22 2006-12-22 Processes for preparing intermediate compounds useful for the preparation of ezetimibe

Publications (1)

Publication Number Publication Date
DE602006009845D1 true DE602006009845D1 (de) 2009-11-26

Family

ID=38609864

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006009845T Expired - Fee Related DE602006009845D1 (de) 2005-12-22 2006-12-22 Verfahren zur herstellung von zwischenprodukten für die herstellung von ezetimibe

Country Status (8)

Country Link
US (1) US20090227786A1 (de)
EP (1) EP1971573B1 (de)
AR (1) AR058754A1 (de)
AT (1) ATE445596T1 (de)
CA (1) CA2634648A1 (de)
DE (1) DE602006009845D1 (de)
IL (1) IL192362A0 (de)
WO (1) WO2007119106A2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2008102236A (ru) * 2005-06-22 2009-07-27 РЕДДИ Манне САТЬЯНАРАЯНА (IN) Улучшенный способ получения эзетимиб
US20070259845A1 (en) * 2005-09-08 2007-11-08 Kansal Vinod K Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe
HU0501164D0 (en) * 2005-12-20 2006-02-28 Richter Gedeon Vegyeszet New industrial process for the production of ezetimibe
CA2647902A1 (en) * 2006-03-29 2007-12-21 Medichem S.A. Processes for preparing ezetimibe and intermediate compounds useful for the preparation thereof
EP2004639A2 (de) * 2006-04-10 2008-12-24 Teva Pharmaceutical Industries Ltd Verfahren zur synthese von azetinidon
WO2008027081A1 (en) * 2006-08-29 2008-03-06 Teva Pharmaceutical Industries Ltd. Processes for the purification of (3r,4s)-4-(4-hydroxy-protected-phenyl)-1-(4-fluorophenyl)-3-(4-fluorophenyl)-3-oxopropyl] azetidin-2-one
CZ302395B6 (cs) * 2007-03-02 2011-04-27 Zentiva, A. S. Zpusob výroby (3R,4S)-1-(4-fluorfenyl)-3-[(3S)-3-(4-fluorfenyl)-3-hydroxypropyl)]-4-(4-hydroxyfenyl)-2-azetidinonu
US8013189B2 (en) * 2007-09-21 2011-09-06 Basf Se Accelerated amide and ester reductions with amine boranes and additives
CZ2007843A3 (cs) * 2007-11-30 2009-06-10 Zentiva, A. S. Zpusob výroby (3R,4S)-1-(4-fluorfenyl)-3-[(3S)-3-(4-fluorfenyl)-3-hydroxypropyl)]-4-(4-hydroxyfenyl)-2-azetidinonu a jeho meziprodukty
CZ305066B6 (cs) * 2008-02-25 2015-04-22 Zentiva, K.S. Způsob výroby (3R,4S)-1-(4-fluorfenyl)-3-[(3S)-3-(4-fluorfenyl)-3-hydroxypropyl)]-4-(4-hydroxyfenyl)-2-azetidinonu
EP2414326B1 (de) 2009-03-31 2017-12-20 Lupin Limited Zwischenprodukte für die herstellung von 1,4-diphenylazetidinon
US9388440B2 (en) 2009-04-01 2016-07-12 Mylan Laboratories Limited Enzymatic process for the preparation of (S)-5-(4-fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one, an intermediate of Ezetimibe and further conversion to Ezetimibe
US9040262B2 (en) 2010-05-04 2015-05-26 Codexis, Inc. Biocatalysts for ezetimibe synthesis
ES2372460B1 (es) 2010-07-09 2012-11-16 Moehs Ibérica S.L. Nuevo método para la preparación de ezetimiba.
WO2012076030A1 (en) * 2010-12-10 2012-06-14 Pharmathen S.A. Process for the preparation of intermediate compounds useful in the preparation of ezetimibe
CN102731489B (zh) * 2011-04-11 2016-10-26 天津药物研究院有限公司 一种依折麦布关键中间体的制备方法
CN103159751A (zh) * 2011-12-13 2013-06-19 重庆华邦胜凯制药有限公司 苯酮酸酰胺缩酮衍生物的制备方法
CN104744331B (zh) * 2013-12-31 2018-05-15 浙江九洲药业股份有限公司 一种依泽替米贝中间体的合成工艺
CN104447473B (zh) * 2014-11-06 2016-11-16 成都森科制药有限公司 依折麦布中间体的制备方法
CN105439929B (zh) * 2015-12-16 2018-08-21 江苏恒盛药业有限公司 一种依泽麦布中间体的合成工艺
CN106966942B (zh) * 2017-04-07 2018-07-24 四川智强医药科技开发有限公司 一种依折麦布的制备方法
CN107652214A (zh) * 2017-11-07 2018-02-02 河南师范大学 一种高血脂治疗药依折麦布的制备方法
CN107793339A (zh) * 2017-11-07 2018-03-13 河南师范大学 一种高血脂治疗药依折麦布的制备方法
CN107903200A (zh) * 2017-11-07 2018-04-13 河南师范大学 一种高血脂治疗药依折麦布的制备方法
CN107991410A (zh) * 2017-11-24 2018-05-04 中山奕安泰医药科技有限公司 一种依替米贝中间体的检测方法
CN116283948A (zh) * 2023-02-24 2023-06-23 江苏阿尔法药业股份有限公司 一种依折麦布中间体的合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
AU7472896A (en) * 1995-11-02 1997-05-22 Schering Corporation Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-({phenyl or 4-fluorophenyl})-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinon
US5739321A (en) * 1996-05-31 1998-04-14 Schering Corporation 3-hydroxy γ-lactone based enantionselective synthesis of azetidinones
US5886171A (en) * 1996-05-31 1999-03-23 Schering Corporation 3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones
RU2008102236A (ru) * 2005-06-22 2009-07-27 РЕДДИ Манне САТЬЯНАРАЯНА (IN) Улучшенный способ получения эзетимиб
US20070259845A1 (en) * 2005-09-08 2007-11-08 Kansal Vinod K Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe
HU0501164D0 (en) * 2005-12-20 2006-02-28 Richter Gedeon Vegyeszet New industrial process for the production of ezetimibe
CA2647902A1 (en) * 2006-03-29 2007-12-21 Medichem S.A. Processes for preparing ezetimibe and intermediate compounds useful for the preparation thereof
EP2004639A2 (de) * 2006-04-10 2008-12-24 Teva Pharmaceutical Industries Ltd Verfahren zur synthese von azetinidon
WO2008027081A1 (en) * 2006-08-29 2008-03-06 Teva Pharmaceutical Industries Ltd. Processes for the purification of (3r,4s)-4-(4-hydroxy-protected-phenyl)-1-(4-fluorophenyl)-3-(4-fluorophenyl)-3-oxopropyl] azetidin-2-one
JP2010529148A (ja) * 2007-06-07 2010-08-26 テバ ファーマシューティカル インダストリーズ リミティド エゼチミブ製造のための還元方法
US20080318920A1 (en) * 2007-06-19 2008-12-25 Protia, Llc Deuterium-enriched ezetimibe
US20090093627A1 (en) * 2007-08-30 2009-04-09 Lorand Szabo Process for preparing intermediates of ezetimibe by microbial reduction
CZ305066B6 (cs) * 2008-02-25 2015-04-22 Zentiva, K.S. Způsob výroby (3R,4S)-1-(4-fluorfenyl)-3-[(3S)-3-(4-fluorfenyl)-3-hydroxypropyl)]-4-(4-hydroxyfenyl)-2-azetidinonu

Also Published As

Publication number Publication date
US20090227786A1 (en) 2009-09-10
ATE445596T1 (de) 2009-10-15
EP1971573B1 (de) 2009-10-14
CA2634648A1 (en) 2007-10-25
EP1971573A2 (de) 2008-09-24
AR058754A1 (es) 2008-02-20
IL192362A0 (en) 2009-08-03
WO2007119106A2 (en) 2007-10-25
WO2007119106A3 (en) 2008-01-31

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee