DE602005024599D1 - Verbindungen modulierende thrombopoietinaktivität und verfahren - Google Patents

Verbindungen modulierende thrombopoietinaktivität und verfahren

Info

Publication number
DE602005024599D1
DE602005024599D1 DE602005024599T DE602005024599T DE602005024599D1 DE 602005024599 D1 DE602005024599 D1 DE 602005024599D1 DE 602005024599 T DE602005024599 T DE 602005024599T DE 602005024599 T DE602005024599 T DE 602005024599T DE 602005024599 D1 DE602005024599 D1 DE 602005024599D1
Authority
DE
Germany
Prior art keywords
thrombopoietinactivity
compounds modulating
modulating
compounds
modulating thrombopoietinactivity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005024599T
Other languages
English (en)
Inventor
Jyun-Hung Chen
Jackline E Dalgard
Adam E Kallel
Thomas Lau
Matthew H Mcneill
Todd A Miller
Bao N Nguyen
Richard J Penulair
Dean P Phillips
Daniel A Ruppar
Lin Zhi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ligand Pharmaceuticals Inc
Original Assignee
Ligand Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharmaceuticals Inc filed Critical Ligand Pharmaceuticals Inc
Publication of DE602005024599D1 publication Critical patent/DE602005024599D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE602005024599T 2004-10-25 2005-10-21 Verbindungen modulierende thrombopoietinaktivität und verfahren Active DE602005024599D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62187904P 2004-10-25 2004-10-25
US67500105P 2005-04-25 2005-04-25
PCT/US2005/038055 WO2006047344A1 (en) 2004-10-25 2005-10-21 Thrombopoietin activity modulating compounds and methods

Publications (1)

Publication Number Publication Date
DE602005024599D1 true DE602005024599D1 (de) 2010-12-16

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DE602005024599T Active DE602005024599D1 (de) 2004-10-25 2005-10-21 Verbindungen modulierende thrombopoietinaktivität und verfahren

Country Status (15)

Country Link
US (3) US7314887B2 (de)
EP (1) EP1805155B1 (de)
JP (1) JP4728340B2 (de)
KR (1) KR100958337B1 (de)
AR (1) AR051940A1 (de)
AT (1) ATE486859T1 (de)
AU (1) AU2005299720B2 (de)
BR (1) BRPI0516883A (de)
CA (1) CA2583764C (de)
DE (1) DE602005024599D1 (de)
IL (2) IL182763A (de)
MX (1) MX2007004765A (de)
NO (1) NO20072199L (de)
NZ (1) NZ554662A (de)
WO (1) WO2006047344A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
WO2005118551A2 (en) * 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
AU2005299720B2 (en) * 2004-10-25 2010-02-04 Ligand Pharmaceuticals Incorporated Thrombopoietin activity modulating compounds and methods
AU2006318527A1 (en) * 2005-11-23 2007-05-31 Ligand Pharmaceuticals Incorporated Thrombopoietin activity modulating compounds and methods
EP2086551A4 (de) * 2006-12-01 2011-06-08 Stategics Inc Thrombopoietin-mimetika
US20090304634A1 (en) * 2006-12-12 2009-12-10 Smithkline Beecham Corporation Novel Combinations
WO2008074078A1 (en) * 2006-12-19 2008-06-26 University Of Wollongong Selectively deliverable isatin-based cytotoxic agents
UY30915A1 (es) 2007-02-16 2008-09-02 Smithkline Beecham Corp Método de tratamiento de canceres
US20110129550A1 (en) * 2007-02-16 2011-06-02 Connie Erickson-Miller Cancer treatment method
US20110160130A1 (en) * 2007-02-16 2011-06-30 Connie Erickson-Miller Cancer treatment method
MX2010003881A (es) * 2007-10-09 2010-07-28 Univ Pennsylvania El agonista del receptor de trombopoyetina (tpora) destruye las celulas de leucemia mieloide aguda de humano.
WO2009140464A1 (en) * 2008-05-16 2009-11-19 Ligand Pharmaceuticals, Inc. Methods of administration of thrombopoietin mimetic compounds
US8476249B2 (en) 2009-05-07 2013-07-02 Glaxosmithkline Llc Method of treating thrombocytopenia
US8680150B2 (en) * 2009-05-28 2014-03-25 Ligand Pharmaceuticals, Inc. Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors
WO2013074459A1 (en) * 2011-11-14 2013-05-23 Ligand Pharmaceuticals, Inc. Methods and compositions associated with the granulocyte colony-stimulating factor receptor
US9962370B2 (en) 2013-03-15 2018-05-08 Ligand Pharmaceuticals Incorporated Methods of treatment associated with the granulocyte colony-stimulating factor receptor
CA2927806C (en) 2013-11-27 2023-01-10 Redwood Bioscience, Inc. Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
CN106632407A (zh) * 2016-09-30 2017-05-10 陕西科技大学 一种具抗肿瘤活性的不对称双7‑n杂靛红席夫碱类化合物的合成方法
MX2021012679A (es) * 2019-04-17 2021-11-12 Colorado Res Partners Llc Nuevos compuestos y metodos de uso para el tratamiento de enfermedades o trastornos relacionados con la fructosa.

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE653800A (de)
DE193633C (de)
US3148192A (en) * 1961-06-27 1964-09-08 Roussel Uclaf Halogenated 20alpha-yohimbane compounds
DE450819C (de) 1924-12-24 1927-10-20 Chemische Ind Ges Verfahren zur Herstellung von chromhaltigen Azofarbstoffen
GB252957A (en) * 1926-02-19 1926-06-10 Chem Fab Vormals Sandoz Manufacture of diazotizable azo-dyestuffs and intermediate products therefor
GB898706A (en) * 1957-09-20 1962-06-14 Polaroid Corp Azo dyes derived from dihydroxyphenyl ketones and their use in photography
BE594503A (de) * 1959-08-29
GB1080864A (en) 1963-02-26 1967-08-23 Ici Ltd Five membered heterocyclic systems and their use as fungicides
GB1269781A (en) * 1968-11-12 1972-04-06 Ici Ltd Alkanolamine derivatives
US3966900A (en) * 1969-03-12 1976-06-29 Airwick Industries, Inc. Evaporator system comprising a stabilized pesticidal phosphoric acid ester and method for stabilizing such ester enclosed in an evaporator
US3754857A (en) * 1969-08-27 1973-08-28 American Cyanamid Co Polyethylene terephthalate,nylon and organic esters of cellulose dyedwith 5-(2-nitro-pranisylazo) barbituric acid
EP0034725B1 (de) * 1980-02-18 1984-07-25 BASF Aktiengesellschaft Imidazolylmethylgruppen enthaltende Farbstoffe und deren Verwendung
US4322533A (en) * 1980-03-17 1982-03-30 Lesher George Y 1H-Indole-2,3-dione derivatives
DE3329340A1 (de) 1983-08-13 1985-03-07 Basf Ag, 6700 Ludwigshafen Verlackungsmittel enthaltende farbstoffzubereitungen basischer farbstoffe
DE3434379A1 (de) * 1984-09-19 1986-03-20 Basf Farben + Fasern Ag, 2000 Hamburg Pigmentzubereitungen
GB8431426D0 (en) * 1984-12-13 1985-01-23 Glaxo Group Ltd Chemical compounds
DE3743235A1 (de) * 1987-12-19 1989-06-29 Bayer Ag Basische farbstoffe
DE3810958A1 (de) 1988-03-31 1989-10-12 Basf Ag Tinten fuer ink-jet-aufzeichnungsverfahren
GB8816944D0 (en) * 1988-07-15 1988-08-17 Sobio Lab Compounds
JP2683097B2 (ja) 1989-04-28 1997-11-26 キヤノン株式会社 電子写真感光体
US5164404A (en) * 1991-03-15 1992-11-17 Neurosearch A/S Hydrazone derivatives and their use
JP2709750B2 (ja) * 1991-03-27 1998-02-04 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
US5298658A (en) * 1991-12-20 1994-03-29 E. I. Du Pont De Nemours And Company Photographic elements with reduced print-through
DE4335623A1 (de) 1993-10-19 1995-04-20 Henkel Kgaa Indolinon-Derivate zum Färben keratinhaltiger Fasern
US5482546A (en) * 1994-03-30 1996-01-09 Canon Kabushiki Kaisha Dye, ink containing the same, and ink-jet recording method and instrument using the ink
CA2167090C (en) 1994-03-31 2002-05-14 Timothy D. Bartley Compositions and methods for stimulating megakaryocyte growth and differentiation
US6184363B1 (en) * 1997-06-13 2001-02-06 Northwestern University Inhibitors of β-lactamases and uses therefor
US6075044A (en) * 1997-07-21 2000-06-13 The Regents Of The University Of California Heterocyclic derivatives as inhibitors of purine salvage phosphoribosyltransferases
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6649631B1 (en) * 1997-10-23 2003-11-18 The Board Of Regents Of The University Of Texas System Compositions and methods for treating bone deficit conditions
GC0000177A (en) * 1998-12-17 2006-03-29 Smithkline Beecham Thrombopoietin mimetics
JP2000206645A (ja) 1999-01-18 2000-07-28 Fuji Photo Film Co Ltd 画像形成材料および画像形成方法
GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
CN1376150A (zh) * 1999-07-26 2002-10-23 盐野义制药株式会社 具有血栓形成素受体拮抗作用的药物组合物
EP1213965B1 (de) 1999-09-10 2006-01-18 Smithkline Beecham Corporation Thrombopoietin-mimetika
WO2001021180A1 (en) 1999-09-24 2001-03-29 Smithkline Beecham Corporation Thrombopoietin mimetics
US6720345B1 (en) * 1999-11-05 2004-04-13 Smithkline Beecham Corporation Semicarbazone derivatives and their use as thrombopoietin mimetics
JP2001152055A (ja) 1999-11-26 2001-06-05 Fuji Photo Film Co Ltd インクジェット記録用インクおよびそれを用いた画像記録方法
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
JP4359382B2 (ja) 2000-07-11 2009-11-04 富士フイルム株式会社 新規なヒドラゾン色素
US6964977B2 (en) * 2000-09-01 2005-11-15 Smithkline Beecham Corporation Oxindole derivatives
AU2001288374A1 (en) * 2000-09-01 2002-03-22 Glaxo Group Limited Substituted oxindole derivatives as tyrosine kinase inhibitors
US6642265B1 (en) * 2000-09-08 2003-11-04 Smithkline Beecham Corporation Thrombopoietin mimetics
JP2002129073A (ja) 2000-10-20 2002-05-09 Fuji Photo Film Co Ltd 油性インク組成物
JP2002129072A (ja) 2000-10-20 2002-05-09 Fuji Photo Film Co Ltd インクジェット記録用インク及びそれを用いた画像記録方法
AU2002239718A1 (en) * 2000-12-19 2002-07-01 Ligand Pharmaceuticals Thrombopoietin mimetics
ATE384076T1 (de) * 2000-12-21 2008-02-15 Smithkline Beecham Corp Regulierte aktivierung von zellmembranrezeptoren durch metallchelatisierende agonisten
JP4145654B2 (ja) * 2001-01-26 2008-09-03 塩野義製薬株式会社 トロンボポエチン受容体アゴニスト作用を有する環状化合物
US6875786B2 (en) * 2001-03-01 2005-04-05 Smithkline Beecham Corporation Thrombopoietin mimetics
CA2439263C (en) * 2001-03-02 2012-10-23 Frank Becker Three hybrid assay system
GB0106343D0 (en) * 2001-03-14 2001-05-02 Avecia Ltd Compounds compositions and processes
IL160010A0 (en) * 2001-07-23 2004-06-20 Univ Ramot Methods and compositions for treating fungal infections
WO2003011287A1 (en) * 2001-08-03 2003-02-13 Vertex Pharmaceuticals Incorporated Pyrazolon derivatives as inhibitors of gsk-3
JP2003128946A (ja) 2001-10-26 2003-05-08 Fuji Photo Film Co Ltd 新規なアゾ色素、及び該アゾ色素の互変異性体
GB0126036D0 (en) 2001-10-30 2001-12-19 Amedis Pharm Ltd Silicon compounds
SI1466912T1 (sl) * 2002-01-18 2013-08-30 Astellas Pharma Inc. Derivat 2-acilaminotiazola ali njegova sol
US20050049267A1 (en) * 2002-03-01 2005-03-03 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof
CN1652770A (zh) 2002-03-29 2005-08-10 利兰·斯坦福青年大学托管委员会 使用抑制素和其它免疫调节剂治疗自身免疫病
US20030229453A1 (en) * 2002-04-09 2003-12-11 Antonysamy Stephen Suresh Crystals and structures of PAK4KD kinase PAK4KD
JP2003313450A (ja) 2002-04-22 2003-11-06 Fuji Photo Film Co Ltd アゾ色素及びその互変異性体
JP2003335972A (ja) 2002-05-21 2003-11-28 Fuji Photo Film Co Ltd アゾ化合物及びその製造方法
TWI280128B (en) * 2002-05-22 2007-05-01 Smithkline Beecham Corp 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US7414040B2 (en) * 2002-06-06 2008-08-19 Smithkline Beecham Corporation Thrombopoietin mimetics
TWI324593B (en) * 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
JP2004143118A (ja) 2002-10-28 2004-05-20 Fuji Photo Film Co Ltd アゾ化合物及びその互変異性体、並びに、その製造方法
US20060084682A1 (en) * 2002-12-13 2006-04-20 Heerding Dirk A Thrombopoietin mimetics
US20040253178A1 (en) * 2002-12-20 2004-12-16 Shane Atwell Crystals and structures of spleen tyrosine kinase SYKKD
JP4895807B2 (ja) * 2003-04-29 2012-03-14 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 変性疾患／損傷の治療方法
EP1638487A2 (de) * 2003-05-28 2006-03-29 Medcool, Inc. Verfahren und geräte für die wärmeaktivierung einer konsole eines wärmeabgabesystems
UA82695C2 (uk) * 2003-06-06 2008-05-12 Нисан Кемикал Индастриз, Лтд. Гетероароматичні сполуки як активатори рецептора тромбопоетину
EP1755574A4 (de) 2004-04-06 2009-05-13 Semafore Pharmaceuticals Inc Pten-inhibitoren
EP1746887A1 (de) 2004-05-12 2007-01-31 Bayer CropScience GmbH Regulierung des pflanzenwachstums
WO2005118551A2 (en) 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
SE0401790D0 (sv) 2004-07-07 2004-07-07 Forskarpatent I Syd Ab Tamoxifen response in pre- and postmenopausal breast cancer patients
AU2005299720B2 (en) 2004-10-25 2010-02-04 Ligand Pharmaceuticals Incorporated Thrombopoietin activity modulating compounds and methods
GT200500321A (es) 2004-11-09 2006-09-04 Compuestos y composiciones como inhibidores de proteina kinase.
US7563781B2 (en) 2005-01-14 2009-07-21 Janssen Pharmaceutica Nv Triazolopyrimidine derivatives
AU2006318527A1 (en) 2005-11-23 2007-05-31 Ligand Pharmaceuticals Incorporated Thrombopoietin activity modulating compounds and methods
WO2007114972A2 (en) 2006-01-11 2007-10-11 Elifecare Enterprises, Inc Toolbar user interface for information system

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JP4728340B2 (ja) 2011-07-20
JP2008517932A (ja) 2008-05-29
IL191542A0 (en) 2008-11-03
KR100958337B1 (ko) 2010-05-17
ATE486859T1 (de) 2010-11-15
CA2583764C (en) 2009-06-09
US7314887B2 (en) 2008-01-01
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US20060116417A1 (en) 2006-06-01
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EP1805155A1 (de) 2007-07-11
US20080146594A1 (en) 2008-06-19
EP1805155B1 (de) 2010-11-03
IL182763A0 (en) 2007-07-24
US7691895B2 (en) 2010-04-06
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CA2583764A1 (en) 2006-05-04
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