DE602005020472D1 - Tricyclische anilid-spirohydantoin-cgrp-rezeptorantagonisten - Google Patents
Tricyclische anilid-spirohydantoin-cgrp-rezeptorantagonistenInfo
- Publication number
- DE602005020472D1 DE602005020472D1 DE602005020472T DE602005020472T DE602005020472D1 DE 602005020472 D1 DE602005020472 D1 DE 602005020472D1 DE 602005020472 T DE602005020472 T DE 602005020472T DE 602005020472 T DE602005020472 T DE 602005020472T DE 602005020472 D1 DE602005020472 D1 DE 602005020472D1
- Authority
- DE
- Germany
- Prior art keywords
- anilid
- tricyclic
- receptor antagonists
- cgrp receptor
- spirohydantoin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60829404P | 2004-09-09 | 2004-09-09 | |
| PCT/US2005/031617 WO2006031491A2 (en) | 2004-09-09 | 2005-09-06 | Tricyclic anilide spirolactam cgrp receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005020472D1 true DE602005020472D1 (de) | 2010-05-20 |
Family
ID=36060520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005020472T Active DE602005020472D1 (de) | 2004-09-09 | 2005-09-06 | Tricyclische anilid-spirohydantoin-cgrp-rezeptorantagonisten |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7696192B2 (de) |
| EP (1) | EP1793827B1 (de) |
| JP (1) | JP2008512456A (de) |
| CN (1) | CN101014345A (de) |
| AT (1) | ATE463245T1 (de) |
| AU (1) | AU2005285270B2 (de) |
| CA (1) | CA2579717A1 (de) |
| DE (1) | DE602005020472D1 (de) |
| WO (1) | WO2006031491A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2580020A1 (en) * | 2004-09-09 | 2006-03-23 | Ian M. Bell | Aryl spirolactam cgrp receptor antagonists |
| US7696192B2 (en) * | 2004-09-09 | 2010-04-13 | Merck Sharp & Dohme Corp. | Tricyclic anilide spirolactam CGRP receptor antagonists |
| US7750010B2 (en) | 2004-09-13 | 2010-07-06 | Merck Sharp & Dohme Corp. | Tricyclic anilide spirohydantion CGRP receptor antagonists |
| US8003792B2 (en) * | 2004-09-13 | 2011-08-23 | Merck Sharp & Dohme Corp. | Bicyclic anilide spirolactam CGRP receptor antagonists |
| EP1954135B1 (de) | 2005-11-18 | 2012-10-10 | Merck Sharp & Dohme Corp. | Spirolactam-aryl cgrp-rezeptor-antagonisten |
| AU2006316644B2 (en) * | 2005-11-18 | 2011-11-10 | Merck Sharp & Dohme Corp. | Spirohydantoin tricyclic CGRP receptor antagonists |
| AU2006316642A1 (en) | 2005-11-18 | 2007-05-31 | Merck Sharp & Dohme Corp. | Spirolactam tricyclic CGRP receptor antagonists |
| US8071770B2 (en) | 2005-11-18 | 2011-12-06 | Merck Sharp & Dohme Corp. | Spirohydantoin aryl CGRP receptor antagonists |
| TW200732302A (en) * | 2005-12-13 | 2007-09-01 | Daicel Chem | Indoline derivative |
| EP2024358B1 (de) * | 2006-05-09 | 2014-11-05 | Merck Sharp & Dohme Corp. | Substituierte spirocyclische cgrp-rezeptorantagonisten |
| CA2673108A1 (en) * | 2006-12-08 | 2008-06-19 | Merck & Co., Inc. | Constrained spirocyclic compounds as cgrp receptor antagonists |
| AU2008239754A1 (en) * | 2007-04-11 | 2008-10-23 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists with tertiary amide, sulfonamide, carbamate and urea end groups |
| CA2683745A1 (en) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Bicyclic anilide heterocyclic cgrp receptor antagonists |
| WO2008130524A1 (en) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Aryl heterocyclic cgrp receptor antagonists |
| JP5511657B2 (ja) * | 2007-06-05 | 2014-06-04 | メルク・シャープ・アンド・ドーム・コーポレーション | カルボキサミドヘテロ環式ｃｇｒｐ受容体アンタゴニスト |
| JP2010529120A (ja) * | 2007-06-07 | 2010-08-26 | メルク・シャープ・エンド・ドーム・コーポレイション | 三環式アニリド複素環ｃｇｒｐ受容体アンタゴニスト |
| JP2011523958A (ja) * | 2008-06-12 | 2011-08-25 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｃｇｒｐ受容体アンタゴニストとしての分岐状３−及び６−置換キノリン |
| US8362005B2 (en) * | 2008-09-08 | 2013-01-29 | Merk. Sharp & Dohme Corp. | Monocyclic amide CGRP receptor antagonists |
| US20110306626A1 (en) * | 2008-12-17 | 2011-12-15 | Selnick Harold G | Imidazolinone derivatives as cgrp receptor antagonists |
| EP2471776A1 (de) | 2010-12-28 | 2012-07-04 | Bayer CropScience AG | Pyridin-2-ylpropandinitrile und deren Verwendung als Herbizide |
| US9174989B2 (en) | 2012-05-09 | 2015-11-03 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CA3028752A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines |
| CN106008528A (zh) * | 2016-07-28 | 2016-10-12 | 安徽赛迪生物科技有限公司 | 一种合成4-氯-5,7-二氢-6h-吡咯并[2,3-d]嘧啶-6-酮的方法 |
| AU2018291026B2 (en) | 2017-06-29 | 2022-09-01 | G1 Therapeutics, Inc. | Morphic forms of GIT38 and methods of manufacture thereof |
| US20210130445A1 (en) * | 2019-07-05 | 2021-05-06 | Allergan Pharmaceuticals International Limited | CGRP Antagonists and Botulinum Toxins for the Treatment of Inflammatory and Neurologic Disorders |
| WO2021005494A1 (en) * | 2019-07-05 | 2021-01-14 | Allergan Pharmaceuticals International Limited | Cgrp antagonists and clostridial derivatives for the treatment of neuropsychiatric and neurological disorders |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MC1999A1 (fr) * | 1987-12-18 | 1990-01-26 | Hoffmann La Roche | Composes tricycliques |
| WO1989008654A1 (en) * | 1988-03-11 | 1989-09-21 | Pfizer Inc. | Pyrroloquinoline and pyrrolophenothiazine carboxamides and related compounds |
| US4906655A (en) * | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
| AUPN449295A0 (en) | 1995-07-28 | 1995-08-24 | Inner And Eastern Health Care Network, The | Radioprotectors |
| EP0851759A4 (de) * | 1995-09-05 | 2000-12-06 | Smithkline Beecham Corp | Verbindungen und verfahren dazu |
| DE19963868A1 (de) * | 1999-12-30 | 2001-07-12 | Boehringer Ingelheim Pharma | Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE60113247T2 (de) | 2000-05-03 | 2006-06-22 | F. Hoffmann-La Roche Ag | Hydantoin-enthaltende glucokinase aktivatoren |
| EP1399160A4 (de) * | 2001-06-12 | 2004-08-25 | Merck & Co Inc | Nr2b-rezeptor-antagonisten zur behandlung oder prävention von migräne |
| BRPI0311812B8 (pt) * | 2002-06-05 | 2021-05-25 | Bristol Myers Squibb Co | antagonistas de receptor de peptídeo relacionado com o gene de calcitonina, composição farmacêutica e seu uso |
| ATE556060T1 (de) * | 2003-03-14 | 2012-05-15 | Merck Sharp & Dohme | Monocyclische anilidspirohydantoine als cgrp- rezeptorantagonisten |
| AU2005282466B2 (en) | 2004-09-08 | 2011-03-10 | Merck Sharp & Dohme Corp. | Monocyclic anilide spirolactam CGRP receptor antagonists |
| US7696192B2 (en) * | 2004-09-09 | 2010-04-13 | Merck Sharp & Dohme Corp. | Tricyclic anilide spirolactam CGRP receptor antagonists |
-
2005
- 2005-09-06 US US11/662,246 patent/US7696192B2/en active Active
- 2005-09-06 AT AT05796847T patent/ATE463245T1/de not_active IP Right Cessation
- 2005-09-06 DE DE602005020472T patent/DE602005020472D1/de active Active
- 2005-09-06 AU AU2005285270A patent/AU2005285270B2/en not_active Ceased
- 2005-09-06 CA CA002579717A patent/CA2579717A1/en not_active Abandoned
- 2005-09-06 EP EP05796847A patent/EP1793827B1/de active Active
- 2005-09-06 WO PCT/US2005/031617 patent/WO2006031491A2/en active Application Filing
- 2005-09-06 JP JP2007531249A patent/JP2008512456A/ja active Pending
- 2005-09-06 CN CNA2005800299915A patent/CN101014345A/zh active Pending
-
2010
- 2010-03-05 US US12/718,386 patent/US8133891B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20080214511A1 (en) | 2008-09-04 |
| AU2005285270A1 (en) | 2006-03-23 |
| US20100160334A1 (en) | 2010-06-24 |
| EP1793827B1 (de) | 2010-04-07 |
| WO2006031491A2 (en) | 2006-03-23 |
| CA2579717A1 (en) | 2006-03-23 |
| JP2008512456A (ja) | 2008-04-24 |
| US8133891B2 (en) | 2012-03-13 |
| AU2005285270B2 (en) | 2011-04-21 |
| CN101014345A (zh) | 2007-08-08 |
| EP1793827A4 (de) | 2009-07-29 |
| EP1793827A2 (de) | 2007-06-13 |
| WO2006031491A3 (en) | 2006-11-09 |
| US7696192B2 (en) | 2010-04-13 |
| ATE463245T1 (de) | 2010-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| R081 | Change of applicant/patentee |
Ref document number: 1793827 Country of ref document: EP Owner name: SCHERING CORPORATION, US Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., RAHWAY, US Effective date: 20121213 |
|
| R082 | Change of representative |
Ref document number: 1793827 Country of ref document: EP Representative=s name: ABITZ & PARTNER, DE Effective date: 20121213 |