WO2006029153A3 - Monocyclic anilide spirolactam cgrp receptor antagonists - Google Patents

Monocyclic anilide spirolactam cgrp receptor antagonists Download PDF

Info

Publication number
WO2006029153A3
WO2006029153A3 PCT/US2005/031713 US2005031713W WO2006029153A3 WO 2006029153 A3 WO2006029153 A3 WO 2006029153A3 US 2005031713 W US2005031713 W US 2005031713W WO 2006029153 A3 WO2006029153 A3 WO 2006029153A3
Authority
WO
WIPO (PCT)
Prior art keywords
monocyclic
receptor antagonists
cgrp receptor
anilide
compounds
Prior art date
Application number
PCT/US2005/031713
Other languages
French (fr)
Other versions
WO2006029153A2 (en
Inventor
Ian M Bell
Craig A Stump
Original Assignee
Merck & Co Inc
Ian M Bell
Craig A Stump
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Ian M Bell, Craig A Stump filed Critical Merck & Co Inc
Priority to US11/660,821 priority Critical patent/US7659300B2/en
Priority to EP05794099A priority patent/EP1791843B1/en
Priority to JP2007531268A priority patent/JP2008512460A/en
Priority to CN2005800300255A priority patent/CN101014602B/en
Priority to CA002579221A priority patent/CA2579221A1/en
Priority to AU2005282466A priority patent/AU2005282466B2/en
Publication of WO2006029153A2 publication Critical patent/WO2006029153A2/en
Publication of WO2006029153A3 publication Critical patent/WO2006029153A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
PCT/US2005/031713 2004-09-08 2005-09-06 Monocyclic anilide spirolactam cgrp receptor antagonists WO2006029153A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US11/660,821 US7659300B2 (en) 2004-09-08 2005-09-06 Monocyclic anilide spirolactam CGRP receptor antagonists
EP05794099A EP1791843B1 (en) 2004-09-08 2005-09-06 Monocyclic anilide spirolactam cgrp receptor antagonists
JP2007531268A JP2008512460A (en) 2004-09-08 2005-09-06 Monocyclic anilide spirolactam CGRP receptor antagonist
CN2005800300255A CN101014602B (en) 2004-09-08 2005-09-06 Monocyclic anilide spirolactam cgrp receptor antagonists
CA002579221A CA2579221A1 (en) 2004-09-08 2005-09-06 Monocyclic anilide spirolactam cgrp receptor antagonists
AU2005282466A AU2005282466B2 (en) 2004-09-08 2005-09-06 Monocyclic anilide spirolactam CGRP receptor antagonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60787004P 2004-09-08 2004-09-08
US60/607,870 2004-09-08

Publications (2)

Publication Number Publication Date
WO2006029153A2 WO2006029153A2 (en) 2006-03-16
WO2006029153A3 true WO2006029153A3 (en) 2006-05-26

Family

ID=36036946

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/031713 WO2006029153A2 (en) 2004-09-08 2005-09-06 Monocyclic anilide spirolactam cgrp receptor antagonists

Country Status (7)

Country Link
US (1) US7659300B2 (en)
EP (1) EP1791843B1 (en)
JP (1) JP2008512460A (en)
CN (1) CN101014602B (en)
AU (1) AU2005282466B2 (en)
CA (1) CA2579221A1 (en)
WO (1) WO2006029153A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168592B2 (en) 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696192B2 (en) 2004-09-09 2010-04-13 Merck Sharp & Dohme Corp. Tricyclic anilide spirolactam CGRP receptor antagonists
ATE537153T1 (en) 2004-09-09 2011-12-15 Merck Sharp & Dohme ARYLSPIROLACTAM COMPOUNDS AS ANTAGONISTS OF THE CGRP RECEPTOR
CA2579850A1 (en) 2004-09-13 2006-03-23 Merck & Co., Inc. Tricyclic anilide spirohydantoin cgrp receptor antagonists
CN101018781A (en) * 2004-09-13 2007-08-15 默克公司 Bicyclic N-anilide spirolactam CGRP receptor antagonists
AU2006316644B2 (en) 2005-11-18 2011-11-10 Merck Sharp & Dohme Corp. Spirohydantoin tricyclic CGRP receptor antagonists
JP2009515971A (en) 2005-11-18 2009-04-16 メルク エンド カムパニー インコーポレーテッド Spirohydantoin aryl CGRP receptor antagonist
US7947677B2 (en) 2005-11-18 2011-05-24 Merck Sharp & Dohme Corp. Spirolactam tricyclic CGRP receptor antagonists
EP1954135B1 (en) 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Spirolactam aryl cgrp receptor antagonists
EP2024358B1 (en) 2006-05-09 2014-11-05 Merck Sharp & Dohme Corp. Substituted spirocyclic cgrp receptor antagonists
WO2008021422A2 (en) * 2006-08-17 2008-02-21 Wyeth Process for the preparation of indolin-2-one derivatives useful as pr modulators
CA2673108A1 (en) * 2006-12-08 2008-06-19 Merck & Co., Inc. Constrained spirocyclic compounds as cgrp receptor antagonists
WO2008112159A2 (en) * 2007-03-12 2008-09-18 Merck & Co., Inc. Monocyclic anilide spirolactam cgrp receptor antagonists
GB0706914D0 (en) 2007-04-10 2007-05-16 Isis Innovation Novel adenovirus vectors
US8372859B2 (en) * 2007-04-11 2013-02-12 Merck, Sharp & Dohme Corp. CGRP receptor antagonists with tertiary amide, sulfonamide, carbamate and urea end groups
WO2008130524A1 (en) * 2007-04-16 2008-10-30 Merck & Co., Inc. Aryl heterocyclic cgrp receptor antagonists
WO2008130512A1 (en) 2007-04-16 2008-10-30 Merck & Co., Inc. Bicyclic anilide heterocyclic cgrp receptor antagonists
AU2008262403B2 (en) * 2007-06-05 2013-11-14 Merck Sharp & Dohme Llc Carboxamide heterocyclic CGRP receptor antagonists
WO2008153852A1 (en) * 2007-06-07 2008-12-18 Merck & Co., Inc. Tricyclic anilide heterocyclic cgrp receptor antagonists
BRPI0817835A2 (en) 2007-10-18 2015-03-31 Boehringer Ingelheim Int CGRP ANTAGONISTS
AU2009228453A1 (en) * 2008-03-28 2009-10-01 Merck Sharp & Dohme Corp. Monocyclic CGRP receptor antagonists
AU2009288206A1 (en) 2008-09-08 2010-03-11 Merck Sharp & Dohme Corp. Monocyclic amide CGRP receptor antagonists
JP2012504625A (en) * 2008-10-03 2012-02-23 メルク・シャープ・エンド・ドーム・コーポレイション CGRP receptor antagonist
CA2746671A1 (en) * 2008-12-17 2010-07-08 Merck Sharp & Dohme Corp. Imidazolinone derivatives as cgrp receptor antagonists
DE102009028929A1 (en) * 2009-08-27 2011-07-07 Bayer Schering Pharma Aktiengesellschaft, 13353 Heterocyclic-substituted 2-acetamido-5-aryl-1,2,4-triazolones and their use
US8883807B2 (en) * 2010-11-12 2014-11-11 Merck Sharp & Dohme Corp. Piperidinone carboxamide indane CGRP receptor antagonists
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
EP2686324B1 (en) * 2011-03-18 2016-01-06 Merck Sharp & Dohme Corp. Piperidine carboxamide spirohydantoin cgrp receptor antagonists
WO2012129013A1 (en) * 2011-03-18 2012-09-27 Merck Sharp & Dohme Corp. Piperidinone carboxamide spirohydantoin cgrp receptor antagonists
US10202392B2 (en) 2012-04-26 2019-02-12 Francis Xavier Tavares Synthesis of lactams
US9174989B2 (en) * 2012-05-09 2015-11-03 Merck Sharp & Dohme Corp. Process for making CGRP receptor antagonists
FR3030521B1 (en) * 2014-12-23 2019-07-26 Galderma Research & Development NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE AND COSMETICS
WO2018005865A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines
CN106008528A (en) * 2016-07-28 2016-10-12 安徽赛迪生物科技有限公司 Method for synthesizing 4-chlorine-5,7-dihydro-6H-pyrrolo[2,3-D] pyrimidine-6-ketone
GB201704476D0 (en) 2017-03-21 2017-05-03 Antabio Sas Chemical compounds
RU2019142591A (en) 2017-06-29 2021-07-29 Г1 Терапьютикс, Инк. MORPHOLOGICAL FORMS OF G1T38 AND METHODS FOR THEIR PRODUCTION
KR20210049847A (en) 2018-08-24 2021-05-06 쥐원 쎄라퓨틱스, 인크. Improved synthesis of 1,4-diazaspiro[5.5]undecan-3-one
WO2020064175A1 (en) 2018-09-25 2020-04-02 Antabio Sas Indane derivatives for use in the treatment of bacterial infection
EP3628666A1 (en) 2018-09-25 2020-04-01 Antabio SAS Indane derivatives for use in the treatment of bacterial infection
EP3628672A1 (en) 2018-09-25 2020-04-01 Antabio SAS Indane derivatives for use in the treatment of bacterial infection
MA53707A (en) 2018-09-25 2021-12-29 Antabio Sas INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION
US20240016941A1 (en) 2020-03-24 2024-01-18 Antabio Sas Combination therapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5064852A (en) * 1988-12-16 1991-11-12 Pfizer Inc. Indolinone derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993012786A1 (en) * 1986-07-10 1993-07-08 Howard Harry R Jr Indolinone derivatives
DE10211770A1 (en) * 2002-03-14 2003-10-02 Boehringer Ingelheim Pharma Novel substituted piperidines, pharmaceutical compositions containing them and processes for their preparation
CA2519475A1 (en) * 2003-03-14 2004-09-30 Merck & Co., Inc. Bicyclic anilide spirohydantoin cgrp receptor antagonists
AU2004222328B2 (en) * 2003-03-14 2009-10-08 Merck Sharp & Dohme Corp. Aryl spirohydantoin CGRP receptor antagonists
CA2519515A1 (en) * 2003-03-14 2004-10-14 Merck & Co., Inc. Benodiazepine spirohydantoin cgrp receptor antagonists
ATE535514T1 (en) * 2003-03-14 2011-12-15 Merck Sharp & Dohme CARBOXAMIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS
JP4673295B2 (en) * 2003-03-14 2011-04-20 メルク・シャープ・エンド・ドーム・コーポレイション Monocyclic anilide spirohydantoin CGRP receptor antagonist

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5064852A (en) * 1988-12-16 1991-11-12 Pfizer Inc. Indolinone derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1791843A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168592B2 (en) 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates

Also Published As

Publication number Publication date
CN101014602B (en) 2011-08-10
AU2005282466A1 (en) 2006-03-16
US20090054408A1 (en) 2009-02-26
JP2008512460A (en) 2008-04-24
US7659300B2 (en) 2010-02-09
EP1791843A4 (en) 2010-11-10
AU2005282466B2 (en) 2011-03-10
EP1791843B1 (en) 2012-08-29
CN101014602A (en) 2007-08-08
WO2006029153A2 (en) 2006-03-16
CA2579221A1 (en) 2006-03-16
EP1791843A2 (en) 2007-06-06

Similar Documents

Publication Publication Date Title
WO2006029153A3 (en) Monocyclic anilide spirolactam cgrp receptor antagonists
WO2006031610A3 (en) Bicyclic anilide spirolactam cgrp receptor antagonists
WO2006031606A3 (en) Carboxamide spirolactam cgrp receptor antagonists
WO2006031513A3 (en) Aryl spirolactam cgrp receptor antagonists
WO2008112159A3 (en) Monocyclic anilide spirolactam cgrp receptor antagonists
WO2006031491A3 (en) Tricyclic anilide spirolactam cgrp receptor antagonists
WO2006031676A3 (en) Tricyclic anilide spirohydantoin cgrp receptor antagonists
WO2006044504A8 (en) Cgrp receptor antagonists
TW200505903A (en) CGRP receptor antagonists
WO2006099268A3 (en) Cgrp receptor antagonists
WO2004082605A3 (en) Bicyclic anilide spirohydantoin cgrp receptor antagonists
WO2004087649A3 (en) Benodiazepine spirohydantoin cgrp receptor antagonists
WO2006047196A3 (en) Cgrp receptor antagonists
WO2006041830A3 (en) Cgrp receptor antagonists
WO2004082602A3 (en) Carboxamide spirohydantoin cgrp receptor antagonists
EP1606264A4 (en) Monocyclic anilide spirohydantoin cgrp receptor antagonists
WO2004091514A3 (en) Cgrp receptor antagonists
WO2007016087A3 (en) Heterocyclic benzodiazepine cgrp receptor antagonists
WO2005000807A3 (en) Benzodiazepine cgrp receptor antagonists
WO2006078554A3 (en) Cgrp receptor antagonists
WO2006044449A3 (en) Cgrp receptor antagonists

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2005282466

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 11660821

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 1496/DELNP/2007

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2579221

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2005794099

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 200580030025.5

Country of ref document: CN

Ref document number: 2007531268

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2005282466

Country of ref document: AU

Date of ref document: 20050906

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2005282466

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2005794099

Country of ref document: EP