DE602005016272D1 - 2-phenylpyridinderivat - Google Patents
2-phenylpyridinderivatInfo
- Publication number
- DE602005016272D1 DE602005016272D1 DE602005016272T DE602005016272T DE602005016272D1 DE 602005016272 D1 DE602005016272 D1 DE 602005016272D1 DE 602005016272 T DE602005016272 T DE 602005016272T DE 602005016272 T DE602005016272 T DE 602005016272T DE 602005016272 D1 DE602005016272 D1 DE 602005016272D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- electron
- compound
- phenylpyridine derivative
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004249275 | 2004-08-27 | ||
| JP2005078222 | 2005-03-17 | ||
| PCT/JP2005/015549 WO2006022374A1 (ja) | 2004-08-27 | 2005-08-26 | ２－フェニルピリジン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005016272D1 true DE602005016272D1 (de) | 2009-10-08 |
Family
ID=35967576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005016272T Active DE602005016272D1 (de) | 2004-08-27 | 2005-08-26 | 2-phenylpyridinderivat |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7820700B2 (de) |
| EP (1) | EP1783116B1 (de) |
| JP (1) | JP4894517B2 (de) |
| KR (1) | KR20070045272A (de) |
| AT (1) | ATE440820T1 (de) |
| CA (1) | CA2578168A1 (de) |
| DE (1) | DE602005016272D1 (de) |
| ES (1) | ES2331579T3 (de) |
| MX (1) | MX2007002160A (de) |
| WO (1) | WO2006022374A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7816558B2 (en) | 2005-10-07 | 2010-10-19 | Astellas Pharma Inc. | Triarylcarboxylic acid derivative |
| CN101389352B (zh) * | 2006-02-24 | 2012-09-19 | 安斯泰来制药株式会社 | 治疗或预防消化道溃疡的药物 |
| EP2128136A4 (de) * | 2006-12-12 | 2012-01-04 | Nippon Zoki Pharmaceutical Co | 2-phenylnicotinsäurederivat |
| US8536186B2 (en) | 2008-08-04 | 2013-09-17 | Chdi Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| JP5580204B2 (ja) * | 2008-10-15 | 2014-08-27 | キッセイ薬品工業株式会社 | ビアリールイソニコチン酸誘導体及びその医薬用途 |
| JP5563985B2 (ja) * | 2008-10-15 | 2014-07-30 | キッセイ薬品工業株式会社 | フェニルイソニコチン酸誘導体及びその医薬用途 |
| KR101639834B1 (ko) | 2009-02-27 | 2016-07-14 | 데이진 화-마 가부시키가이샤 | 천이 금속 촉매를 사용한 커플링법에 의한 페닐 치환 복소 고리 유도체의 제조법 |
| US8883785B2 (en) | 2010-01-25 | 2014-11-11 | Chdi Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| CN103153955A (zh) | 2010-09-17 | 2013-06-12 | 普渡制药公司 | 吡啶化合物及其用途 |
| CN103889989B (zh) * | 2011-08-24 | 2016-01-20 | 橘生药品工业株式会社 | 稠合杂环衍生物及其制药用途 |
| KR20140072037A (ko) | 2011-08-30 | 2014-06-12 | 씨에이치디아이 파운데이션, 인코포레이티드 | 키뉴레닌-3-모노옥시게나제 억제제, 약학적 조성물 및 이의 사용 방법 |
| PT2750677T (pt) | 2011-08-30 | 2017-07-03 | Chdi Foundation Inc | Inibidores de quinurenina-3-monooxigenase, composições farmacêuticas e métodos de utilização dos mesmos |
| CN103848798B (zh) | 2012-11-30 | 2016-01-06 | 镇江新元素医药科技有限公司 | 2-芳基硒唑化合物及其药物组合物 |
| US9493449B2 (en) | 2013-03-15 | 2016-11-15 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
| EP3039019B1 (de) | 2013-08-26 | 2020-04-22 | Purdue Pharma L.P. | Azaspiro[4.5]decan-derivate und verwendung davon |
| KR20170026633A (ko) | 2014-07-17 | 2017-03-08 | 씨에이치디아이 파운데이션, 인코포레이티드 | Hiv-관련 장애의 치료 방법 및 치료용 조성물 |
| CN114805192B (zh) * | 2022-03-30 | 2023-05-23 | 华南理工大学 | 一种含2-羟基苯甲酸的三环类xor/urat1双重抑制剂及其制备方法与应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3655679A (en) * | 1969-06-25 | 1972-04-11 | Merck & Co Inc | Certain aryl pyridine carboxylic acid derivatives |
| US3703582A (en) | 1970-04-20 | 1972-11-21 | Merck & Co Inc | Aryl pyridine carboxylic acids in the treatment of inflammation |
| US4346094A (en) * | 1980-09-22 | 1982-08-24 | Eli Lilly And Company | 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels |
| US4544752A (en) | 1980-09-22 | 1985-10-01 | Eli Lilly And Company | 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels |
| US4495195A (en) | 1982-11-01 | 1985-01-22 | Eli Lilly And Company | Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use |
| WO1992009279A1 (en) | 1990-11-30 | 1992-06-11 | Teijin Limited | 2-arylthiazole derivative and pharmaceutical composition containing the same |
| JP3399559B2 (ja) * | 1992-08-12 | 2003-04-21 | 帝人株式会社 | ２−フェニル複素環式化合物 |
| JP3113110B2 (ja) * | 1993-01-19 | 2000-11-27 | 帝人株式会社 | イソキサゾールおよびイソチアゾール誘導体 |
| KR100308332B1 (ko) | 1995-04-07 | 2002-09-17 | 데이진 가부시키가이샤 | 기관또는조직보호제 |
| ID21775A (id) | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
| JPH10310578A (ja) * | 1996-11-13 | 1998-11-24 | Yoshitomi Pharmaceut Ind Ltd | ３−フェニルピラゾール化合物 |
| JP2000001431A (ja) | 1998-06-15 | 2000-01-07 | Kotobuki Seiyaku Kk | 尿酸***剤 |
| JP2002105067A (ja) * | 2000-09-28 | 2002-04-10 | Teijin Ltd | ２−フェニルチアゾール誘導体、およびそれを有効成分とする医薬組成物 |
| JPWO2002098840A1 (ja) * | 2001-06-04 | 2004-09-16 | エーザイ株式会社 | カルボン酸誘導体及びその塩もしくはそのエステルからなる医薬 |
| US6867221B2 (en) * | 2001-08-30 | 2005-03-15 | Kowa Co., Ltd. | Cyclic amine compounds and pharmaceutical composition containing the same |
| US6395753B1 (en) * | 2001-08-30 | 2002-05-28 | Kowa Co., Ltd. | Cyclic amine compounds and pharmaceutical composition containing the same |
-
2005
- 2005-08-26 EP EP05781016A patent/EP1783116B1/de not_active Not-in-force
- 2005-08-26 MX MX2007002160A patent/MX2007002160A/es not_active Application Discontinuation
- 2005-08-26 ES ES05781016T patent/ES2331579T3/es active Active
- 2005-08-26 DE DE602005016272T patent/DE602005016272D1/de active Active
- 2005-08-26 JP JP2006532626A patent/JP4894517B2/ja not_active Expired - Fee Related
- 2005-08-26 US US11/661,284 patent/US7820700B2/en not_active Expired - Fee Related
- 2005-08-26 WO PCT/JP2005/015549 patent/WO2006022374A1/ja active Application Filing
- 2005-08-26 KR KR1020077004183A patent/KR20070045272A/ko not_active Application Discontinuation
- 2005-08-26 AT AT05781016T patent/ATE440820T1/de not_active IP Right Cessation
- 2005-08-26 CA CA002578168A patent/CA2578168A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP4894517B2 (ja) | 2012-03-14 |
| KR20070045272A (ko) | 2007-05-02 |
| ES2331579T3 (es) | 2010-01-08 |
| EP1783116B1 (de) | 2009-08-26 |
| CA2578168A1 (en) | 2006-03-02 |
| US20070275950A1 (en) | 2007-11-29 |
| EP1783116A1 (de) | 2007-05-09 |
| ATE440820T1 (de) | 2009-09-15 |
| EP1783116A4 (de) | 2008-03-05 |
| US7820700B2 (en) | 2010-10-26 |
| WO2006022374A1 (ja) | 2006-03-02 |
| MX2007002160A (es) | 2007-05-10 |
| JPWO2006022374A1 (ja) | 2008-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |