DE602005012483D1 - Verfahren zum nachweis einer methyltransferaseaktivität sowie verfahren zum screening auf modulatoren der methyltransferaseaktivität - Google Patents

Verfahren zum nachweis einer methyltransferaseaktivität sowie verfahren zum screening auf modulatoren der methyltransferaseaktivität

Info

Publication number
DE602005012483D1
DE602005012483D1 DE602005012483T DE602005012483T DE602005012483D1 DE 602005012483 D1 DE602005012483 D1 DE 602005012483D1 DE 602005012483 T DE602005012483 T DE 602005012483T DE 602005012483 T DE602005012483 T DE 602005012483T DE 602005012483 D1 DE602005012483 D1 DE 602005012483D1
Authority
DE
Germany
Prior art keywords
methyltransferase activity
modulators
screening
detecting
transferase activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005012483T
Other languages
English (en)
Inventor
Yusuke Nakamura
Yoichi Furukawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncotherapy Science Inc
Original Assignee
Oncotherapy Science Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncotherapy Science Inc filed Critical Oncotherapy Science Inc
Publication of DE602005012483D1 publication Critical patent/DE602005012483D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57419Specifically defined cancers of colon
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57438Specifically defined cancers of liver, pancreas or kidney
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/91005Transferases (2.) transferring one-carbon groups (2.1)
    • G01N2333/91011Methyltransferases (general) (2.1.1.)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE602005012483T 2004-01-23 2005-01-21 Verfahren zum nachweis einer methyltransferaseaktivität sowie verfahren zum screening auf modulatoren der methyltransferaseaktivität Active DE602005012483D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53865804P 2004-01-23 2004-01-23
PCT/JP2005/001172 WO2005071102A2 (en) 2004-01-23 2005-01-21 Methods of detecting methyl transferase activity and methods of screening for methyl transferase activity modulators

Publications (1)

Publication Number Publication Date
DE602005012483D1 true DE602005012483D1 (de) 2009-03-12

Family

ID=34807204

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005012483T Active DE602005012483D1 (de) 2004-01-23 2005-01-21 Verfahren zum nachweis einer methyltransferaseaktivität sowie verfahren zum screening auf modulatoren der methyltransferaseaktivität

Country Status (11)

Country Link
US (1) US8221993B2 (de)
EP (1) EP1718761B1 (de)
JP (1) JP4614954B2 (de)
KR (1) KR20060129025A (de)
CN (1) CN1954082B (de)
AT (1) ATE421596T1 (de)
CA (1) CA2554053A1 (de)
DE (1) DE602005012483D1 (de)
ES (1) ES2321527T3 (de)
TW (1) TWI350373B (de)
WO (1) WO2005071102A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE356223T1 (de) * 2001-09-25 2007-03-15 Japan President Univ Tokyo Gen und protein mit bezug zu hepatozellulärem karzinom
CA2399569A1 (en) * 2001-09-25 2003-03-25 Yusuke Nakamura Diagnostic markers and drug targets for treatment of cancer
JP4851451B2 (ja) * 2005-02-28 2012-01-11 オンコセラピー・サイエンス株式会社 乳癌関連遺伝子znfn3a1
TW200741009A (en) 2005-07-01 2007-11-01 Oncotherapy Science Inc Methods of modulating SMYD3 for treatment of cancer
WO2008152816A1 (en) * 2007-06-14 2008-12-18 Oncotherapy Science, Inc. Methods of identifying agents that modulate methylation of vegfr1 by smyd3
CN101928749A (zh) * 2010-06-11 2010-12-29 济南大学 一种S-腺苷甲硫氨酸(AdoMet)依赖的甲基转移酶的检测方法
US20130210664A1 (en) * 2010-08-05 2013-08-15 Cellzome Ag Methods for the Identification of Methyltransferase Interacting Molecules and for the Purification of Methyltransferase Proteins
KR101217866B1 (ko) * 2010-08-18 2013-01-03 한국원자력의학원 혈관신생 억제용 약학 조성물 및 혈관신생 억제용 활성물질을 스크리닝하는 방법
WO2012154858A1 (en) * 2011-05-09 2012-11-15 Whitehead Institute For Biomedical Research Chaperone interaction assays and uses thereof
JP6051373B2 (ja) 2011-12-02 2016-12-27 オンコセラピー・サイエンス株式会社 癌の治療および診断の標的遺伝子としてのsmyd2
CN102590509A (zh) * 2012-03-20 2012-07-18 湖南大学 基于无修饰抗体介导纳米金组装检测组蛋白修饰酶活性及筛选其抑制剂的生物传感方法
CN104990973B (zh) * 2015-07-06 2017-12-15 济南大学 一种固载甲基转移酶电极传感器的制备及应用
MX2018003903A (es) 2015-09-29 2018-09-21 Oncotherapy Science Inc Compuesto biciclico y uso del mismo para inhibicion de suv39h2.

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133437A (en) * 1997-02-13 2000-10-17 Apoptogen, Inc. Modulation of IAPs for the treatment of proliferative diseases
EP0856579A1 (de) 1997-01-31 1998-08-05 BIOGNOSTIK GESELLSCHAFT FÜR BIOMOLEKULARE DIAGNOSTIK mbH Ein Verfahren zur Zubereitung von Antisense Oligonukleotiden
AU6643898A (en) 1997-03-07 1998-09-22 Telefonaktiebolaget Lm Ericsson (Publ) "return to prior agent" feature in multi-destination call delivery services
WO2000017355A2 (en) 1998-09-18 2000-03-30 Incyte Pharmaceuticals, Inc. Human cytoskeleton associated proteins
JP2003521231A (ja) 1999-01-29 2003-07-15 インサイト・ファーマスーティカルズ・インコーポレイテッド 核酸結合タンパク質
WO2002059377A2 (en) 2001-01-24 2002-08-01 Protein Design Labs Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
GB0111218D0 (en) * 2001-05-08 2001-06-27 Cancer Res Ventures Ltd Assays methods and means
WO2002092002A2 (en) 2001-05-11 2002-11-21 The Burnham Institute Screening, diagnostic and therapeutic methods relating to riz
US6955905B2 (en) * 2001-07-18 2005-10-18 The Burnham Institute PR/SET-domain containing nucleic acids, polypeptides, antibodies and methods of use
JP2005508306A (ja) 2001-07-23 2005-03-31 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物
ATE356223T1 (de) 2001-09-25 2007-03-15 Japan President Univ Tokyo Gen und protein mit bezug zu hepatozellulärem karzinom
JP3742415B2 (ja) 2003-02-10 2006-02-01 三洋化成工業株式会社 Rb1遺伝子産物に対する自己抗体を検出するための免疫測定用試薬
EP1599586B9 (de) 2003-02-28 2012-03-14 Oncotherapy Science, Inc. Rna-interferenz für das gen znfn3a1 als verfahren zur hemmung des wachstums von krebszellen
JP4851451B2 (ja) 2005-02-28 2012-01-11 オンコセラピー・サイエンス株式会社 乳癌関連遺伝子znfn3a1
TW200741009A (en) 2005-07-01 2007-11-01 Oncotherapy Science Inc Methods of modulating SMYD3 for treatment of cancer
WO2008152816A1 (en) 2007-06-14 2008-12-18 Oncotherapy Science, Inc. Methods of identifying agents that modulate methylation of vegfr1 by smyd3

Also Published As

Publication number Publication date
WO2005071102A3 (en) 2005-11-17
JP4614954B2 (ja) 2011-01-19
CN1954082A (zh) 2007-04-25
CN1954082B (zh) 2011-08-17
TW200533920A (en) 2005-10-16
US8221993B2 (en) 2012-07-17
EP1718761A2 (de) 2006-11-08
ATE421596T1 (de) 2009-02-15
ES2321527T3 (es) 2009-06-08
CA2554053A1 (en) 2005-08-04
JP2007519391A (ja) 2007-07-19
EP1718761B1 (de) 2009-01-21
WO2005071102A2 (en) 2005-08-04
TWI350373B (en) 2011-10-11
US20090035303A1 (en) 2009-02-05
KR20060129025A (ko) 2006-12-14

Similar Documents

Publication Publication Date Title
DE602005012483D1 (de) Verfahren zum nachweis einer methyltransferaseaktivität sowie verfahren zum screening auf modulatoren der methyltransferaseaktivität
DE602005003293D1 (de) Verfahren zur Markierung von pharmazeutischen Produkten
DE69918089D1 (de) Btk inhibitoren und verfahren zur identifizierung und verwendung
ATE315230T1 (de) Verfahren zum identifizieren von prostaglandin d2 rezeptor modulatoren
TW200741009A (en) Methods of modulating SMYD3 for treatment of cancer
ATE416786T1 (de) Verfahren zur behandlung von dickdarmkrebs mit botulinum neurotoxin
DE60228542D1 (de) Verfahren und Vorrichtung zum Prüfen der Oberfläche von Substraten
DE60104392D1 (de) Verfahren zum nachweis der effektivität einer krebstherapie
DE602005004218D1 (de) System und Verfahren zum Erfassen unbefugten Betretens
DE602004000494D1 (de) Vorrichtung und Verfahren zum Lesen der Seriennummern von Banknoten
DE602004008282D1 (de) System und verfahren zur gesichtserkennung
DE602004009960D1 (de) System und verfahren zum erkennen und vergleichen anatomischer strukturen unter verwendung von erscheinungsbild und form
DE60335843D1 (de) System und Verfahren zum Schützen von Sicherheitsregistern
DE602005014669D1 (de) System und verfahren zur verpackung von produkten
DE602005023270D1 (de) Vorrichtung und verfahren zur modellierung von beziehungen zwischen signalen
DE60309299D1 (de) System und Verfahren zur Ablaufverfolgung von Banknoten
DE60321965D1 (de) Amidfunktionelle polymere, zusammensetzungen und verfahren
ATE463162T1 (de) Verfahren zur verstärkung der wirksamkeit von ethaboxam
ATE384942T1 (de) Verfahren zur strahlungshärtung von beschichtungen
ATE440604T1 (de) Verfahren zum evaluieren und behandeln von krebs
ATE397098T1 (de) Verfahren zur diagnostik von eierstock endometriose
DE502005008526D1 (de) Verfahren zur Prüfung der Dichtigkeit von Behältern
ATE543429T1 (de) Verfahren zur bestimmung des sympathikus-tonus und messsystem dafür
FI20031697A0 (fi) Menetelmä ja laitteisto puun tai puutuotteiden käsittelemiseksi
DE602004023335D1 (de) Plasmabeschichtungssystem zur beschichtung von substraten sowie darauf bezogenes verfahren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition