DE602005007215D1 - Kleinmolekülige hemmer für mrp1 und andere multiarzneimitteltransporter - Google Patents
Kleinmolekülige hemmer für mrp1 und andere multiarzneimitteltransporterInfo
- Publication number
- DE602005007215D1 DE602005007215D1 DE602005007215T DE602005007215T DE602005007215D1 DE 602005007215 D1 DE602005007215 D1 DE 602005007215D1 DE 602005007215 T DE602005007215 T DE 602005007215T DE 602005007215 T DE602005007215 T DE 602005007215T DE 602005007215 D1 DE602005007215 D1 DE 602005007215D1
- Authority
- DE
- Germany
- Prior art keywords
- mrp1
- hemmer
- transporters
- medicinal
- small molecular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57114904P | 2004-05-14 | 2004-05-14 | |
PCT/US2005/016832 WO2005113004A2 (en) | 2004-05-14 | 2005-05-13 | Small molecule inhibitors for mrp1 and other multidrug transporters |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005007215D1 true DE602005007215D1 (de) | 2008-07-10 |
Family
ID=34969673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005007215T Active DE602005007215D1 (de) | 2004-05-14 | 2005-05-13 | Kleinmolekülige hemmer für mrp1 und andere multiarzneimitteltransporter |
Country Status (7)
Country | Link |
---|---|
US (1) | US8318724B2 (de) |
EP (1) | EP1753422B1 (de) |
AT (1) | ATE396725T1 (de) |
AU (1) | AU2005244872B2 (de) |
DE (1) | DE602005007215D1 (de) |
NZ (1) | NZ551424A (de) |
WO (1) | WO2005113004A2 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102088852A (zh) * | 2008-07-10 | 2011-06-08 | 南方研究所 | 5-喹啉酮和咪唑并嘧啶化合物和其用途 |
RS63320B1 (sr) | 2010-12-08 | 2022-07-29 | The U S A As Represented By The Secretary Department Of Health And Human Services | Supstituisani pirazolopirimidini kao aktivatori glukocerebrozidaze |
KR101629540B1 (ko) * | 2013-02-25 | 2016-06-13 | 중앙대학교 산학협력단 | 신규 벤조 이미다조 이미다졸 유도체 및 이를 유효성분으로 함유하는 피부 미백용 조성물 |
EA201790995A1 (ru) | 2014-11-06 | 2017-10-31 | Лизосомел Терапьютикс Инк. | ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ И ИХ ПРИМЕНЕНИЕ ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ |
MX2018012207A (es) | 2016-04-06 | 2019-03-28 | Lysosomal Therapeutics Inc | Compuestos de pirrol[1,2-a]pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos. |
JP7046827B2 (ja) | 2016-04-06 | 2022-04-04 | リソソーマル・セラピューティクス・インコーポレイテッド | イミダゾ[1,5-a]ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用 |
EP3440080A4 (de) * | 2016-04-06 | 2020-01-22 | Lysosomal Therapeutics Inc. | Pyrazolo[1,5-a]pyrimidinyl-carboxamid-verbindungen und deren verwendung in der behandlung von medizinischen störungen |
BR112018072552A8 (pt) | 2016-05-05 | 2023-03-14 | Lysosomal Therapeutics Inc | Compostos de imidazo [1,2-b]piridazinas e imidazo [1,5-b] piridazinas substituídas, composição farmacêutica que os compreende e seu uso no tratamento de distúrbios médicos |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2126636T3 (es) * | 1992-05-19 | 1999-04-01 | Adir | Derivados del bencimidazol con actividad antidiabetica y antiagregante plaquetaria. |
AU693791B2 (en) * | 1994-05-12 | 1998-07-09 | Orsolya Csuka | Compounds for reversing drug resistance |
WO1999051236A1 (en) * | 1998-04-08 | 1999-10-14 | Eli Lilly And Company | Methods for inhibiting mrp1 |
CA2404665A1 (en) * | 2000-03-30 | 2001-10-11 | The Penn State Research Foundation | Novel compounds for enhancing chemotherapy |
AU2002254342A1 (en) * | 2001-03-23 | 2002-10-08 | The Board Of Trustees Of The University Of Illinois | Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same |
-
2005
- 2005-05-13 DE DE602005007215T patent/DE602005007215D1/de active Active
- 2005-05-13 WO PCT/US2005/016832 patent/WO2005113004A2/en active Application Filing
- 2005-05-13 NZ NZ551424A patent/NZ551424A/en not_active IP Right Cessation
- 2005-05-13 AT AT05748307T patent/ATE396725T1/de not_active IP Right Cessation
- 2005-05-13 US US11/579,779 patent/US8318724B2/en not_active Expired - Fee Related
- 2005-05-13 AU AU2005244872A patent/AU2005244872B2/en not_active Ceased
- 2005-05-13 EP EP05748307A patent/EP1753422B1/de active Active
Also Published As
Publication number | Publication date |
---|---|
US8318724B2 (en) | 2012-11-27 |
AU2005244872B2 (en) | 2008-09-11 |
US20080032966A1 (en) | 2008-02-07 |
AU2005244872A1 (en) | 2005-12-01 |
ATE396725T1 (de) | 2008-06-15 |
EP1753422A2 (de) | 2007-02-21 |
WO2005113004A3 (en) | 2006-02-09 |
EP1753422B1 (de) | 2008-05-28 |
NZ551424A (en) | 2009-10-30 |
WO2005113004A2 (en) | 2005-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: THE CLEVELAND CLINIC FOUNDATION, CLEVELAND, OH, US Owner name: CHILDREN S CANCER INSTITUTE AUSTRALIA FOR MEDI, AU |
|
8364 | No opposition during term of opposition |