RS63320B1 - Supstituisani pirazolopirimidini kao aktivatori glukocerebrozidaze - Google Patents

Supstituisani pirazolopirimidini kao aktivatori glukocerebrozidaze

Info

Publication number
RS63320B1
RS63320B1 RS20220422A RSP20220422A RS63320B1 RS 63320 B1 RS63320 B1 RS 63320B1 RS 20220422 A RS20220422 A RS 20220422A RS P20220422 A RSP20220422 A RS P20220422A RS 63320 B1 RS63320 B1 RS 63320B1
Authority
RS
Serbia
Prior art keywords
substituted pyrazolopyrimidines
glucocerebrosidase
activators
glucocerebrosidase activators
pyrazolopyrimidines
Prior art date
Application number
RS20220422A
Other languages
English (en)
Inventor
Juan Jose Marugan
Noel Southall
M Ehud Goldin
Samarjit Patnaik
Ellen Sidransky
Omid Motabar
Wendy Westbrook
Wei Zheng
Original Assignee
The U S A As Represented By The Secretary Department Of Health And Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The U S A As Represented By The Secretary Department Of Health And Human Services filed Critical The U S A As Represented By The Secretary Department Of Health And Human Services
Publication of RS63320B1 publication Critical patent/RS63320B1/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RS20220422A 2010-12-08 2011-12-08 Supstituisani pirazolopirimidini kao aktivatori glukocerebrozidaze RS63320B1 (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42094610P 2010-12-08 2010-12-08
EP18165005.2A EP3366688B1 (en) 2010-12-08 2011-12-08 Substituted pyrazolopyrimidines as glucocerebrosidase activators

Publications (1)

Publication Number Publication Date
RS63320B1 true RS63320B1 (sr) 2022-07-29

Family

ID=45498099

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20220422A RS63320B1 (sr) 2010-12-08 2011-12-08 Supstituisani pirazolopirimidini kao aktivatori glukocerebrozidaze

Country Status (23)

Country Link
US (3) US9353117B2 (sr)
EP (2) EP3366688B1 (sr)
JP (1) JP6154746B2 (sr)
KR (1) KR101931224B1 (sr)
CN (1) CN103534255B (sr)
AU (1) AU2011338377B2 (sr)
BR (1) BR112013014242B1 (sr)
CA (1) CA2820362C (sr)
DK (2) DK2649075T3 (sr)
ES (2) ES2912284T3 (sr)
HR (1) HRP20220512T1 (sr)
HU (1) HUE038635T2 (sr)
IL (2) IL226767B (sr)
LT (1) LT3366688T (sr)
MX (1) MX354506B (sr)
PL (2) PL3366688T3 (sr)
PT (2) PT2649075T (sr)
RS (1) RS63320B1 (sr)
RU (1) RU2603637C2 (sr)
SI (2) SI2649075T1 (sr)
TR (1) TR201810523T4 (sr)
WO (1) WO2012078855A1 (sr)
ZA (1) ZA201304215B (sr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9353117B2 (en) 2010-12-08 2016-05-31 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Substituted pyrazolopyrimidines as glucocerebrosidase activators
WO2012177997A1 (en) 2011-06-22 2012-12-27 The General Hospital Corporation Treatment of proteinopathies
EP2723746A1 (en) 2011-06-22 2014-04-30 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
CA2839703A1 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
MX2013015274A (es) 2011-06-24 2014-03-31 Amgen Inc Anatagonista trpm8 y su uso en tratamientos.
US9957271B2 (en) 2011-10-20 2018-05-01 Glaxosmithkline Llc Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
CN107501275B (zh) 2012-12-07 2019-11-22 沃泰克斯药物股份有限公司 可用作atr激酶抑制剂的化合物
EP2970286A1 (en) 2013-03-15 2016-01-20 Vertex Pharmaceuticals Inc. Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
WO2014143242A1 (en) 2013-03-15 2014-09-18 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
EP2970289A1 (en) 2013-03-15 2016-01-20 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
EA201690713A1 (ru) 2013-10-04 2016-08-31 Инфинити Фармасьютикалз, Инк. Гетероциклические соединения и их применения
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
RU2720408C2 (ru) 2013-12-06 2020-04-29 Вертекс Фармасьютикалз Инкорпорейтед Способ получения ингибиторов atr киназы (варианты)
DK3119397T3 (da) 2014-03-19 2022-03-28 Infinity Pharmaceuticals Inc Heterocykliske forbindelser til anvendelse i behandling af PI3K-gamma-medierede lidelser
AU2015271030B2 (en) 2014-06-05 2019-05-16 Vertex Pharmaceuticals Incorporated Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo [1,5-a] pyrimidin-3-carboxamide compound useful as ATR kinase inhibitor, the preparation of said compound and different solid forms thereof
ES2733847T3 (es) 2014-06-17 2019-12-03 Vertex Pharma Método para tratar cáncer usando una combinación de inhibidores de CHK1 y ATR
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
AU2015342021B2 (en) 2014-11-03 2020-02-27 Bayer Pharma Aktiengesellschaft Piperidinylpyrazolopyrimidinones and their use
ES2958391T3 (es) 2014-11-06 2024-02-08 Bial R&D Invest S A Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos
JP6734860B2 (ja) * 2014-11-06 2020-08-05 リソソーマル・セラピューティクス・インコーポレイテッドＬｙｓｏｓｏｍａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 置換ピラゾロ［１，５−ａ］ピリミジンおよび医療疾患の治療におけるその使用
EP3215509B1 (en) 2014-11-06 2020-02-26 Lysosomal Therapeutics Inc. Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
CN108290894A (zh) * 2015-07-01 2018-07-17 西北大学 被取代的4-甲基-吡咯并[1,2-a]嘧啶-8-甲酰胺类化合物及其调节葡糖脑苷脂酶活性的用途
WO2017040877A1 (en) * 2015-09-04 2017-03-09 Lysosomal Therapeutics Inc. Heterobicyclic pyrimidinone compounds and their use in the treatment of medical disorders
WO2017040879A1 (en) * 2015-09-04 2017-03-09 Lysosomal Therapeutics Inc. Thiazolo(3,2-a) pyrimidinone and other heterobicyclic pyrimidinone compounds for use in medical therapy
AU2016322552B2 (en) 2015-09-14 2021-03-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
WO2017059357A1 (en) 2015-09-30 2017-04-06 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna damaging agents and atr inhibitors
WO2017161137A1 (en) * 2016-03-16 2017-09-21 Lysosomal Therapeutics Inc. Methods and compositions for treating a neurodegenerative disorder in a sphingotyped subject
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
CA3020287A1 (en) * 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
MX2018012208A (es) * 2016-04-06 2019-03-28 Lysosomal Therapeutics Inc Compuestos a base de imidazo [1,5-a] pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos.
JP7034935B2 (ja) * 2016-04-06 2022-03-14 リソソーマル・セラピューティクス・インコーポレイテッド ピロロ［１，２－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用
WO2017192931A1 (en) 2016-05-05 2017-11-09 Lysosomal Therapeutics Inc. SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
WO2017192930A1 (en) 2016-05-05 2017-11-09 Lysosomal Therapeutics Inc. SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
US20190389865A1 (en) * 2016-05-05 2019-12-26 Lysosomal Therapeutics Inc. SUBSTITUTED PYRROLO[1,2-a]TRIAZINES AND RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3535273A1 (en) * 2016-11-02 2019-09-11 H. Hoffnabb-La Roche Ag PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
CN117946114A (zh) * 2017-07-28 2024-04-30 武田药品工业株式会社 Tyk2抑制剂与其用途
CN111148743B (zh) 2017-10-06 2023-12-15 福马治疗有限公司 抑制泛素特异性肽酶30
JP7317721B2 (ja) 2018-01-31 2023-07-31 武田薬品工業株式会社 複素環化合物
US10882865B2 (en) 2018-08-31 2021-01-05 Northwestern University Pyrrolopyrimidine compounds and uses thereof for modulating glucocerebrosidase activity
US11891400B2 (en) 2018-09-10 2024-02-06 Eli Lilly And Company Pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives useful in the treatment of psoriasis and systemic lupus erythematosus
EP4218934A1 (en) 2018-10-05 2023-08-02 Forma Therapeutics, Inc. Inhibiting ubiquitin-specific protease 30 (usp30)
EP3866789A4 (en) * 2018-10-15 2022-07-06 Nimbus Lakshmi, Inc. TYK2 INHIBITORS AND USES THEREOF
MX2022002152A (es) * 2019-08-21 2022-05-18 Scripps Research Inst Agonistas biciclicos del estimulador de genes de interferon sting.
US20220380314A1 (en) 2019-09-17 2022-12-01 Bial - R&D Investments, S.A. Substituted, saturated and unsaturated n-heterocyclic carboxamides and related compounds for their use in the treatment of medical disorders
AU2020349519A1 (en) 2019-09-17 2022-03-17 Bial-R&D Investments, S.A. Substituted N-heterocyclic carboxamides as acid ceramidase inhibitors and their use as medicaments
BR112022004791A2 (pt) 2019-09-17 2022-06-21 Bial R&D Invest S A Carboxamidas de imidazol substituídas e seu uso no tratamento de distúrbios médicos
TWI810520B (zh) 2020-02-12 2023-08-01 美商美國禮來大藥廠 7-(甲基胺基)吡唑并[1,5-a]嘧啶-3-甲醯胺化合物

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037373A2 (en) 2002-10-21 2004-05-06 The Scripps Research Institute CHEMICAL CHAPERONES AND THEIR EFFECT UPON THE CELLULAR ACTIVITY OF β-GLUCOSIDASE
JP2004277337A (ja) * 2003-03-14 2004-10-07 Sumitomo Pharmaceut Co Ltd ピラゾロ［１，５−ａ］ピリミジン誘導体
EP1615697A2 (en) * 2003-04-11 2006-01-18 Novo Nordisk A/S New pyrazolo[1,5-a] pyrimidine derivatives and pharmaceutical use thereof
WO2005046612A2 (en) 2003-11-12 2005-05-26 Amicus Therapeutics Inc. Hydroxy piperidine derivatives to treat gaucher disease
US7488721B2 (en) * 2004-05-13 2009-02-10 Mcmaster University Real time methylumbelliferone-based assay
NZ551424A (en) 2004-05-14 2009-10-30 Childrenaes Cancer Inst Austra Small molecule inhibitors for MRP1 and other multidrug transporters
CN100528876C (zh) 2004-06-21 2009-08-19 弗·哈夫曼-拉罗切有限公司 吡唑并嘧啶衍生物
DE102005007534A1 (de) * 2005-02-17 2006-08-31 Bayer Cropscience Ag Pyrazolopyrimidine
US20070155737A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
AU2006251989B2 (en) 2005-05-20 2010-05-27 Alantos-Pharmaceuticals, Inc. Pyrimidine or triazine fused bicyclic metalloprotease inhibitors
WO2007008541A2 (en) 2005-07-08 2007-01-18 Kalypsys, Inc. Cellular cholesterol absorption modifiers
JP4987871B2 (ja) 2005-08-15 2012-07-25 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３アンタゴニストとしてのピペリジン及びピペラジン誘導体
US8372851B2 (en) * 2005-10-21 2013-02-12 Exelixis, Inc. Pyrazolo pyrimidines as casein kinase II (CK2) modulators
US8188097B2 (en) * 2005-10-21 2012-05-29 Mitsubishi Tanabe Pharma Corporation Pyrazolo[1,5-A]pyrimidine compounds
WO2008054947A2 (en) 2006-10-02 2008-05-08 The Brigham And Women's Hospital, Inc. Structure of acid beta-glucosidase and methods for identifying therapeutic agents
US20090275586A1 (en) 2006-10-06 2009-11-05 Kalypsys, Inc. Heterocyclic inhibitors of pde4
WO2008063671A2 (en) 2006-11-20 2008-05-29 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
JP5586453B2 (ja) 2007-04-13 2014-09-10 アミカス セラピューティックス インコーポレイテッド 特異的薬理シャペロンによるゴーシェ病の治療および代理マーカーを用いた治療の監視
WO2008134036A1 (en) 2007-04-27 2008-11-06 Panacos Pharmaceuticals, Inc. ALPHA-SUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-α]PYRIMIDINE AMIDE DERIVATIVES
AU2008254774B2 (en) 2007-05-16 2013-11-14 The Brigham And Women's Hospital, Inc. Treatment of synucleinopathies
WO2008154207A1 (en) 2007-06-08 2008-12-18 The Burnham Institute For Medical Research Methods and compounds for regulating apoptosis
JP5337405B2 (ja) 2007-09-17 2013-11-06 ザ・ホスピタル・フォー・シック・チルドレン ゴーシェ病の治療方法
WO2009049421A1 (en) 2007-10-18 2009-04-23 The Hospital For Sick Children Compositions and methods for enhancing enzyme activity in gaucher, gm1-gangliosidosis/morquio b disease, and parkinson's disease
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
JP5767965B2 (ja) * 2008-06-10 2015-08-26 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． キナーゼを調節する５ｈ−ピロロ［２，３−ｂ］ピラジン誘導体、およびその適応症
WO2010003023A2 (en) 2008-07-01 2010-01-07 Zacharon Pharmaceuticals, Inc. Heparan sulfate inhibitors
WO2010086040A1 (en) * 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
US9353117B2 (en) 2010-12-08 2016-05-31 The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services Substituted pyrazolopyrimidines as glucocerebrosidase activators
JP6734860B2 (ja) * 2014-11-06 2020-08-05 リソソーマル・セラピューティクス・インコーポレイテッドＬｙｓｏｓｏｍａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 置換ピラゾロ［１，５−ａ］ピリミジンおよび医療疾患の治療におけるその使用

Also Published As

Publication number Publication date
KR20140010012A (ko) 2014-01-23
US20160346284A1 (en) 2016-12-01
WO2012078855A1 (en) 2012-06-14
MX354506B (es) 2018-01-16
TR201810523T4 (tr) 2018-08-27
CN103534255B (zh) 2016-12-21
CA2820362C (en) 2020-03-24
IL226767B (en) 2018-06-28
EP2649075A1 (en) 2013-10-16
LT3366688T (lt) 2022-05-25
ZA201304215B (en) 2014-03-26
DK2649075T3 (en) 2018-07-30
HRP20220512T1 (hr) 2022-05-27
AU2011338377A8 (en) 2015-10-29
EP3366688A1 (en) 2018-08-29
SI3366688T1 (sl) 2022-07-29
US9353117B2 (en) 2016-05-31
BR112013014242A2 (pt) 2018-06-26
EP3366688B1 (en) 2022-02-09
JP6154746B2 (ja) 2017-06-28
JP2013544893A (ja) 2013-12-19
IL259648B (en) 2021-03-25
KR101931224B1 (ko) 2018-12-20
CN103534255A (zh) 2014-01-22
RU2013126094A (ru) 2015-01-20
IL259648A (en) 2018-07-31
SI2649075T1 (sl) 2018-10-30
PL3366688T3 (pl) 2022-05-23
RU2603637C2 (ru) 2016-11-27
US20140249145A1 (en) 2014-09-04
US10925874B2 (en) 2021-02-23
MX2013006462A (es) 2013-10-01
PT3366688T (pt) 2022-05-11
ES2681218T3 (es) 2018-09-12
AU2011338377B2 (en) 2016-08-04
US20180263988A1 (en) 2018-09-20
BR112013014242B1 (pt) 2022-02-22
CA2820362A1 (en) 2012-06-14
DK3366688T3 (da) 2022-05-02
ES2912284T3 (es) 2022-05-25
US9974789B2 (en) 2018-05-22
PL2649075T3 (pl) 2018-09-28
EP2649075B1 (en) 2018-04-25
PT2649075T (pt) 2018-07-30
HUE038635T2 (hu) 2018-11-28
AU2011338377A1 (en) 2013-07-04

Similar Documents

Publication Publication Date Title
IL259648A (en) Pyrazolopyrimidines are converted as glucoserbrosidase activators
HK1182594A1 (en) N3-substituted-n1-sulfonyl-5-fluoropyrimidinone derivatives n3--n1--5-
AP2013006790A0 (en) Substituted imidazopyradazines
ZA201209117B (en) Tetrahydro-pyrido-pyrimidine derivatives
EP2534256A4 (en) NEW USES
HK1190406A1 (zh) 雙環 激活劑
EP2543670A4 (en) PYRAZOLOPYRIMIDINE DERIVATIVE
AP3429A (en) Substituted sodium-1h-pyrazole-5-olate
EP2541164A4 (en) COOLER
GB2490849B (en) Di-aspirin derivatives
EP2603559A4 (en) POLYISOCYANURATE COMPOSITION
HK1174625A1 (en) Pyrrazolopyridine derivatives
IL225312A0 (en) New combinations
HU1000243D0 (en) 8-hidroxy-quinoline derivatives
AU4538P (en) H22 Grevillea juniperina
ZA201209248B (en) Amido-tropane derivatives
IL220983A0 (en) 2-aldoximino-5-fluoropyrimidine derivatives
AU332681S (en) Spindle
GB201008355D0 (en) Solid supports
GB201019442D0 (en) Novel combinations
AU2010900285A0 (en) Sparger