DE602005005810D1 - Verwendung von substituierten chinolin-derivaten zur behandlung von arzneimittelresistenten mycobakteriellen erkrankungen - Google Patents

Verwendung von substituierten chinolin-derivaten zur behandlung von arzneimittelresistenten mycobakteriellen erkrankungen

Info

Publication number
DE602005005810D1
DE602005005810D1 DE602005005810T DE602005005810T DE602005005810D1 DE 602005005810 D1 DE602005005810 D1 DE 602005005810D1 DE 602005005810 T DE602005005810 T DE 602005005810T DE 602005005810 T DE602005005810 T DE 602005005810T DE 602005005810 D1 DE602005005810 D1 DE 602005005810D1
Authority
DE
Germany
Prior art keywords
chinolin
drug
derivatives
substituted
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005005810T
Other languages
English (en)
Other versions
DE602005005810T2 (de
Inventor
Koenraad Jozef Andries
Gestel Jozef Frans Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34929150&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602005005810(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE602005005810D1 publication Critical patent/DE602005005810D1/de
Application granted granted Critical
Publication of DE602005005810T2 publication Critical patent/DE602005005810T2/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE602005005810T 2004-05-28 2005-05-24 Verwendung von substituierten chinolin-derivaten zur behandlung von arzneimittelresistenten mycobakteriellen erkrankungen Active DE602005005810T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04102402 2004-05-28
EP04102402 2004-05-28
PCT/EP2005/052371 WO2005117875A1 (en) 2004-05-28 2005-05-24 Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases

Publications (2)

Publication Number Publication Date
DE602005005810D1 true DE602005005810D1 (de) 2008-05-15
DE602005005810T2 DE602005005810T2 (de) 2009-04-09

Family

ID=34929150

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005005810T Active DE602005005810T2 (de) 2004-05-28 2005-05-24 Verwendung von substituierten chinolin-derivaten zur behandlung von arzneimittelresistenten mycobakteriellen erkrankungen

Country Status (35)

Country Link
US (2) US20070249667A1 (de)
EP (1) EP1753427B1 (de)
JP (2) JP5081617B2 (de)
KR (2) KR20130024969A (de)
CN (2) CN102908347A (de)
AP (1) AP2037A (de)
AR (1) AR049127A1 (de)
AT (1) ATE390925T1 (de)
AU (1) AU2005249231B2 (de)
BR (1) BRPI0510414B1 (de)
CA (1) CA2566544C (de)
CL (1) CL2009001980A1 (de)
CY (1) CY1110388T1 (de)
DE (1) DE602005005810T2 (de)
DK (1) DK1753427T3 (de)
EA (1) EA010651B1 (de)
ES (1) ES2306146T3 (de)
HK (1) HK1106136A1 (de)
HR (1) HRP20080307T3 (de)
IL (1) IL179630A (de)
JO (1) JO2524B1 (de)
ME (1) ME01105B (de)
MX (1) MXPA06013888A (de)
MY (1) MY140611A (de)
NO (1) NO338624B1 (de)
NZ (1) NZ550840A (de)
PA (1) PA8635201A1 (de)
PL (1) PL1753427T3 (de)
PT (1) PT1753427E (de)
RS (1) RS50585B (de)
SI (1) SI1753427T1 (de)
TW (1) TWI363625B (de)
UA (1) UA90267C2 (de)
WO (1) WO2005117875A1 (de)
ZA (1) ZA200609899B (de)

Families Citing this family (37)

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MXPA06013888A (es) * 2004-05-28 2007-01-26 Janssen Pharmaceutica Nv Uso de derivados de quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacos.
KR101301573B1 (ko) * 2004-12-24 2013-09-04 얀센 파마슈티카 엔.브이. 잠재성 튜버큐로시스의 치료법
EE05697B1 (et) * 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained
JP5349730B2 (ja) * 2005-06-09 2013-11-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗バクテリア剤としてのキノリン誘導体
JO3270B1 (ar) * 2005-06-28 2018-09-16 Janssen Pharmaceutica Nv مشتقات كوينولين بصفة عوامل مضادة للبكتيريا
JO2752B1 (en) * 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
CA2612614C (en) * 2005-06-28 2017-07-25 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
US8686002B2 (en) 2005-08-21 2014-04-01 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
UA97813C2 (uk) * 2006-12-05 2012-03-26 Янссен Фармацевтика Н.В. Фумаратна сіль (альфа s, бета r)-6-бром-альфа-[2-(диметиламіно)етил]-2-метоксі-альфа-1-нафталеніл-бета-феніл-3-хінолінетанолу
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2685B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO3271B1 (ar) * 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
JO2725B1 (en) * 2006-12-06 2013-09-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2970B1 (en) * 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2684B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
MD4009C2 (ro) * 2008-07-15 2010-08-31 Институт Химии Академии Наук Молдовы Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos
RU2404971C2 (ru) * 2008-12-02 2010-11-27 ЗАО "Фарм-Синтез" Новые производные хинолина, способ их получения, их применение для лечения микобактериальных инфекций, фармацевтическая композиция на их основе
AU2010292148A1 (en) * 2009-09-11 2012-04-12 Vertex Pharmaceuticals Incorporated Compositions of N-benzyl-3-(4-chlorophenyl)-2- [methyl-[2-oxo-2-(3,4,5-trimethoxyphenyl) acetyl]amino]-N- [3-(4-pyridyl)-1-[2-[4-pyridyl)ethy]propyl]propanamide and uses thereof
CN102249935B (zh) * 2010-05-17 2015-05-20 中国人民解放军军事医学科学院毒物药物研究所 芳香2-丁醇类化合物及其医药用途
WO2013160431A1 (en) 2012-04-27 2013-10-31 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
ES2576491T3 (es) 2012-04-27 2016-07-07 Janssen Pharmaceutica, N.V. Derivados de quinolina antibacterianos
CN105330595B (zh) * 2014-07-14 2019-12-10 上海嘉坦医药科技有限公司 吡啶衍生物及其作为抗分支杆菌的应用
RU2664587C1 (ru) * 2014-07-14 2018-08-21 Шанхай Цзя Тань Фарматек Ко. Лтд. Производные пиридина и их применение против микобактерий
SG11201705944TA (en) * 2015-01-27 2017-08-30 Janssen Pharmaceutica Nv Dispersible compositions
CN106279017A (zh) * 2015-05-21 2017-01-04 重庆圣华曦药业股份有限公司 贝达喹啉晶型、组合物及其制备方法
US10196360B2 (en) 2015-10-20 2019-02-05 Zhejiang Hisun Pharmaceutical Co., Ltd. Crystal forms of bedaquiline fumarate and preparation methods therefor
WO2017121323A1 (zh) * 2016-01-13 2017-07-20 辰欣药业股份有限公司 一种吡啶衍生物类化合物的制备方法及其中间体和晶型
CA3016068C (en) * 2016-03-07 2024-02-27 The Global Alliance For Tb Drug Development, Inc. Antibacterial compounds and uses thereof
CN107243008B (zh) * 2017-04-13 2021-03-30 中国科学院广州生物医药与健康研究院 吡唑并[1,5-a]吡啶类化合物的新应用及一种治疗脓肿分枝杆菌感染的组合物
US11407742B2 (en) * 2017-09-01 2022-08-09 The Kitasato Institute Compound having therapeutic activity against mycobacterium avium complex infection, and method for producing same
WO2020047596A1 (en) * 2018-09-04 2020-03-12 Monash University Antibacterial compounds and methods of use
JP2022516671A (ja) 2019-01-09 2022-03-01 ヤンセン ファーマシューティカ エヌ．ベー． 非結核性抗酸菌症の処置における組合せ
CN110804016B (zh) * 2019-12-05 2022-11-04 福建省微生物研究所 抗结核分枝杆菌的二芳基喹啉衍生物
US20230346770A1 (en) 2020-11-12 2023-11-02 Janssen Pharmaceutica Nv Combination of bedaquiline, ethambutol and a macrolide in the treatment of nontuberculous mycobacterial diseases
CN117050006A (zh) * 2022-05-13 2023-11-14 广州嘉越医药科技有限公司 一种吡啶衍生物、中间体、制备方法和应用
CN117122595A (zh) * 2022-05-27 2023-11-28 广州嘉越医药科技有限公司 吡啶衍生物的用途
WO2023232838A1 (en) 2022-05-31 2023-12-07 Janssen Pharmaceutica Nv Bedaquiline for use in the treatment of leprosy

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US5399558A (en) * 1993-11-24 1995-03-21 Pathogenesis Corporation Isoflavonoid antibacterial compounds, compositions and use
EP0936866A4 (de) * 1996-10-28 2001-04-11 Dept Of The Army Us Government Verbindungen, zusammensetzungen und methoden zur behandlung von antibiotika-resisten infektionen
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
DK2301544T3 (da) * 2002-07-25 2013-01-02 Janssen Pharmaceutica Nv Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer
MXPA06013888A (es) * 2004-05-28 2007-01-26 Janssen Pharmaceutica Nv Uso de derivados de quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacos.
EE05697B1 (et) * 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained

Also Published As

Publication number Publication date
EA010651B1 (ru) 2008-10-30
EP1753427A1 (de) 2007-02-21
BRPI0510414A (pt) 2007-10-23
ZA200609899B (en) 2009-01-28
ES2306146T3 (es) 2008-11-01
AP2006003828A0 (en) 2006-12-31
US20100168133A1 (en) 2010-07-01
CA2566544C (en) 2012-04-17
RS50585B (sr) 2010-05-07
ME01105B (me) 2013-03-20
CN102908347A (zh) 2013-02-06
NO338624B1 (no) 2016-09-19
AP2037A (en) 2009-10-09
JO2524B1 (en) 2010-03-17
TW200608974A (en) 2006-03-16
UA90267C2 (ru) 2010-04-26
IL179630A0 (en) 2007-07-04
NZ550840A (en) 2010-01-29
KR20130024969A (ko) 2013-03-08
AR049127A1 (es) 2006-06-28
AU2005249231B2 (en) 2010-11-11
HK1106136A1 (en) 2008-03-07
TWI363625B (en) 2012-05-11
KR101371653B1 (ko) 2014-03-07
IL179630A (en) 2011-05-31
DE602005005810T2 (de) 2009-04-09
JP5081617B2 (ja) 2012-11-28
JP2012229239A (ja) 2012-11-22
AU2005249231A1 (en) 2005-12-15
CL2009001980A1 (es) 2010-04-16
CN1976704B (zh) 2012-12-05
JP5675718B2 (ja) 2015-02-25
PL1753427T3 (pl) 2008-09-30
MXPA06013888A (es) 2007-01-26
MY140611A (en) 2009-12-31
EA200602260A1 (ru) 2007-04-27
EP1753427B1 (de) 2008-04-02
SI1753427T1 (sl) 2008-10-31
CN1976704A (zh) 2007-06-06
JP2008500992A (ja) 2008-01-17
HRP20080307T3 (en) 2008-07-31
PA8635201A1 (es) 2006-05-16
BRPI0510414B1 (pt) 2022-04-05
CA2566544A1 (en) 2005-12-15
DK1753427T3 (da) 2008-07-21
US20070249667A1 (en) 2007-10-25
WO2005117875A1 (en) 2005-12-15
ATE390925T1 (de) 2008-04-15
CY1110388T1 (el) 2015-04-29
KR20070017393A (ko) 2007-02-09
PT1753427E (pt) 2008-07-04
NO20066041L (no) 2007-02-27

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