JO3271B1 - مشتقات الكوينولين المضادة للجراثيم - Google Patents
مشتقات الكوينولين المضادة للجراثيمInfo
- Publication number
- JO3271B1 JO3271B1 JOP/2007/0504A JOP20070504A JO3271B1 JO 3271 B1 JO3271 B1 JO 3271B1 JO P20070504 A JOP20070504 A JO P20070504A JO 3271 B1 JO3271 B1 JO 3271B1
- Authority
- JO
- Jordan
- Prior art keywords
- compounds
- quinoline derivatives
- pharmaceutically acceptable
- treatment
- bacterial infection
- Prior art date
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title abstract 2
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
يتعلق الاختراع الحالي بمشتقات كوينولين (quinoline derivatives)جديدة مستبدلة طبقا للصيغة العامة (la) او الصيغة (lb): متضمنة اي شكل ايزومري فراغي كيميائيا (stereomically isomeric) منها، بشكل N-اكسيد (N-oxide) من ذلك او بمادة منحلة ( solvate) منها. ان المركبات المحددة تكون مفيدة لمعالجة عدوى بكتيرية (bacterial infection). يتعلق الاختراع بتركيبة تشمل مادة حاملة (carrier) مقبولة دوائياو، كمقوم نشط (active ingredient)، كمية مؤثرة علاجيا من المركبات المحددة، باستخدام المركبات او التركيبات المحددة لتصنيع دواء (medicament) لمعالجة عدوى بكتيرية (bacterial infection) وبعملية لتحضير المركبات المحددة.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06125499 | 2006-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
JO3271B1 true JO3271B1 (ar) | 2018-09-16 |
Family
ID=38126091
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2007/0504A JO3271B1 (ar) | 2006-12-06 | 2007-11-29 | مشتقات الكوينولين المضادة للجراثيم |
Country Status (33)
Country | Link |
---|---|
US (1) | US8415475B2 (ar) |
EP (1) | EP2099758B1 (ar) |
JP (1) | JP5466011B2 (ar) |
KR (1) | KR101490222B1 (ar) |
CN (2) | CN101553470A (ar) |
AP (1) | AP2479A (ar) |
AR (1) | AR064151A1 (ar) |
AU (1) | AU2007328887B2 (ar) |
BR (1) | BRPI0720220B8 (ar) |
CA (1) | CA2669819C (ar) |
CL (1) | CL2007003514A1 (ar) |
CY (1) | CY1117766T1 (ar) |
DK (1) | DK2099758T3 (ar) |
EA (1) | EA016733B1 (ar) |
ES (1) | ES2573689T3 (ar) |
HK (1) | HK1208437A1 (ar) |
HR (1) | HRP20160585T1 (ar) |
HU (1) | HUE028769T2 (ar) |
IL (1) | IL199083A (ar) |
JO (1) | JO3271B1 (ar) |
ME (1) | ME02498B (ar) |
MX (1) | MX2009005978A (ar) |
MY (1) | MY181645A (ar) |
NO (1) | NO341983B1 (ar) |
NZ (1) | NZ576823A (ar) |
PL (1) | PL2099758T3 (ar) |
PT (1) | PT2099758E (ar) |
RS (1) | RS54794B1 (ar) |
SI (1) | SI2099758T1 (ar) |
TW (1) | TWI406659B (ar) |
UA (1) | UA100972C2 (ar) |
WO (1) | WO2008068267A1 (ar) |
ZA (1) | ZA200903950B (ar) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9617244B2 (en) | 2012-04-27 | 2017-04-11 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
IN2014MN02364A (ar) | 2012-04-27 | 2015-08-14 | Janssen Pharmaceutica Nv | |
EP2909189B8 (en) | 2012-10-16 | 2017-04-19 | Janssen Pharmaceutica NV | Heteroaryl linked quinolinyl modulators of ror-gamma-t |
RS56283B1 (sr) | 2012-10-16 | 2017-12-29 | Janssen Pharmaceutica Nv | Metilen vezani hinolinil modulatori ror-gama-t |
CA2888485C (en) | 2012-10-16 | 2021-01-26 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of ror.gamma.t |
AU2014334619A1 (en) | 2013-10-15 | 2016-04-21 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORyt |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
ES2742843T3 (es) | 2013-10-15 | 2020-02-17 | Janssen Pharmaceutica Nv | Moduladores de quinolinilo de ROR(gamma)t |
US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
WO2016008381A1 (zh) * | 2014-07-14 | 2016-01-21 | 辰欣药业股份有限公司 | 吡啶衍生物及其作为抗分支杆菌的应用 |
CN105330595B (zh) * | 2014-07-14 | 2019-12-10 | 上海嘉坦医药科技有限公司 | 吡啶衍生物及其作为抗分支杆菌的应用 |
ES2948805T3 (es) * | 2015-01-27 | 2023-09-19 | Janssen Pharmaceutica Nv | Composiciones dispersables |
CN108473428B (zh) * | 2016-01-13 | 2021-07-23 | 上海嘉坦医药科技有限公司 | 一种吡啶衍生物类化合物的制备方法及其中间体和晶型 |
CN105601566A (zh) * | 2016-02-02 | 2016-05-25 | 张敏 | 一种护理烧伤后感染的药物组合物 |
BR122023025283A2 (pt) * | 2016-03-07 | 2024-02-20 | The Global Alliance For Tb Drug Dev Inc | Compostos antibacterianos e seus usos |
WO2018048882A1 (en) | 2016-09-06 | 2018-03-15 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for bacterial infection |
JP2021511364A (ja) * | 2018-01-29 | 2021-05-06 | カディラ ヘルスケア リミティド | 抗菌剤として有用な複素環式化合物 |
CA3198350A1 (en) * | 2020-10-22 | 2022-04-28 | Lunella Biotech, Inc. | Mitochondrial atp inhibitors targeting the gamma subunit prevent metastasis |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001503411A (ja) * | 1996-10-28 | 2001-03-13 | ディパートメント オブ ジ アーミー,ユー.エス.ガバメント | 抗生物質耐性感染症の処置のための化合物、組成物および方法 |
EP1527050B1 (en) * | 2002-07-25 | 2010-04-07 | Janssen Pharmaceutica N.V. | Quinoline derivatives and their use as mycobacterial inhibitors |
BRPI0507076B8 (pt) | 2004-01-23 | 2021-05-25 | Janssen Pharmaceutica Nv | quinolinas substituídas, seu processo de preparação, composição farmacêutica que as compreende e seu uso como inibidores micobacterianos |
KR101160182B1 (ko) * | 2004-01-23 | 2012-06-26 | 얀센 파마슈티카 엔.브이. | 퀴놀린 유도체 및 마이코박테리아 저해제로서의 용도 |
ATE395336T1 (de) * | 2004-01-29 | 2008-05-15 | Janssen Pharmaceutica Nv | Chinolinderivate zur verwendung als inhibitoren von mycobakterien |
CN1976704B (zh) | 2004-05-28 | 2012-12-05 | 詹森药业有限公司 | 取代的喹啉衍生物在治疗耐药性分枝杆菌性疾病中的用途 |
JP2008515395A (ja) | 2004-09-28 | 2008-05-15 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 細菌のatp合成酵素の結合ドメイン |
EE05394B1 (et) | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
EE05697B1 (et) * | 2005-06-08 | 2014-02-17 | Janssen Pharmaceutica N.V. | Kinoliini derivaadid kui antibakteriaalsed toimeained |
JO2855B1 (ar) * | 2005-08-03 | 2015-03-15 | شركة جانسين فارماسوتيكا ان. في | مشتقات كوينولين بصفة عوامل مضادة للبكتيريا |
JO2837B1 (ar) * | 2005-08-03 | 2014-09-15 | جانسن فارمسيتكا ان في | مشتقات كوينولين بصفة عوامل مضادة للبكتيريا |
JO2952B1 (ar) * | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | مشتقات كوينولين بصفة عوامل مضادة للبكتيريا |
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2007
- 2007-11-29 JO JOP/2007/0504A patent/JO3271B1/ar active
- 2007-12-04 CA CA2669819A patent/CA2669819C/en active Active
- 2007-12-04 WO PCT/EP2007/063313 patent/WO2008068267A1/en active Application Filing
- 2007-12-04 AP AP2009004874A patent/AP2479A/xx active
- 2007-12-04 US US12/516,065 patent/US8415475B2/en active Active
- 2007-12-04 ME MEP-2016-109A patent/ME02498B/me unknown
- 2007-12-04 SI SI200731779A patent/SI2099758T1/sl unknown
- 2007-12-04 CN CNA2007800449358A patent/CN101553470A/zh active Pending
- 2007-12-04 AU AU2007328887A patent/AU2007328887B2/en active Active
- 2007-12-04 ES ES07847811.2T patent/ES2573689T3/es active Active
- 2007-12-04 PL PL07847811T patent/PL2099758T3/pl unknown
- 2007-12-04 RS RS20160374A patent/RS54794B1/sr unknown
- 2007-12-04 DK DK07847811.2T patent/DK2099758T3/en active
- 2007-12-04 EP EP07847811.2A patent/EP2099758B1/en active Active
- 2007-12-04 EA EA200970535A patent/EA016733B1/ru unknown
- 2007-12-04 JP JP2009539738A patent/JP5466011B2/ja active Active
- 2007-12-04 PT PT07847811T patent/PT2099758E/pt unknown
- 2007-12-04 KR KR1020097012967A patent/KR101490222B1/ko active IP Right Grant
- 2007-12-04 BR BRPI0720220A patent/BRPI0720220B8/pt active IP Right Grant
- 2007-12-04 HU HUE07847811A patent/HUE028769T2/en unknown
- 2007-12-04 UA UAA200904716A patent/UA100972C2/ru unknown
- 2007-12-04 MY MYPI20092283A patent/MY181645A/en unknown
- 2007-12-04 MX MX2009005978A patent/MX2009005978A/es active IP Right Grant
- 2007-12-04 NZ NZ576823A patent/NZ576823A/en unknown
- 2007-12-04 CN CN201510088659.1A patent/CN104744361B/zh active Active
- 2007-12-05 TW TW096146217A patent/TWI406659B/zh active
- 2007-12-05 CL CL200703514A patent/CL2007003514A1/es unknown
- 2007-12-05 AR ARP070105444A patent/AR064151A1/es unknown
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2009
- 2009-06-02 IL IL199083A patent/IL199083A/en active IP Right Grant
- 2009-06-05 ZA ZA200903950A patent/ZA200903950B/xx unknown
- 2009-07-06 NO NO20092542A patent/NO341983B1/no unknown
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2015
- 2015-09-10 HK HK15108797.1A patent/HK1208437A1/xx unknown
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2016
- 2016-05-31 HR HRP20160585TT patent/HRP20160585T1/hr unknown
- 2016-06-08 CY CY20161100496T patent/CY1117766T1/el unknown
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