DE602004011770D1 - Fusionsproteine - Google Patents

Fusionsproteine

Info

Publication number
DE602004011770D1
DE602004011770D1 DE602004011770T DE602004011770T DE602004011770D1 DE 602004011770 D1 DE602004011770 D1 DE 602004011770D1 DE 602004011770 T DE602004011770 T DE 602004011770T DE 602004011770 T DE602004011770 T DE 602004011770T DE 602004011770 D1 DE602004011770 D1 DE 602004011770D1
Authority
DE
Germany
Prior art keywords
fusion proteins
fusion protein
reduced
immnunogenic
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004011770T
Other languages
English (en)
Other versions
DE602004011770T2 (de
Inventor
Wolfgang Glaesner
Rohn Lee Millican
Yu Tian
Sheng-Hung Rainbow Tschang
Andrew Mark Vick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE602004011770D1 publication Critical patent/DE602004011770D1/de
Application granted granted Critical
Publication of DE602004011770T2 publication Critical patent/DE602004011770T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE602004011770T 2003-06-12 2004-06-10 Fusionsproteine Expired - Lifetime DE602004011770T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US47788003P 2003-06-12 2003-06-12
US477880P 2003-06-12
US57090804P 2004-05-13 2004-05-13
US570908P 2004-05-13
PCT/US2004/016611 WO2004110472A2 (en) 2003-06-12 2004-06-10 Fusion proteins

Publications (2)

Publication Number Publication Date
DE602004011770D1 true DE602004011770D1 (de) 2008-03-27
DE602004011770T2 DE602004011770T2 (de) 2009-02-05

Family

ID=33555478

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004011770T Expired - Lifetime DE602004011770T2 (de) 2003-06-12 2004-06-10 Fusionsproteine

Country Status (17)

Country Link
US (1) US20070253966A1 (de)
EP (1) EP1641483B1 (de)
JP (1) JP2007505643A (de)
CN (1) CN1802167A (de)
AT (1) ATE385806T1 (de)
AU (1) AU2004247042A1 (de)
BR (1) BRPI0411112A (de)
CA (1) CA2526169A1 (de)
CY (1) CY1107248T1 (de)
DE (1) DE602004011770T2 (de)
DK (1) DK1641483T3 (de)
ES (1) ES2298785T3 (de)
MX (1) MXPA05013564A (de)
PL (1) PL1641483T3 (de)
PT (1) PT1641483E (de)
SI (1) SI1641483T1 (de)
WO (1) WO2004110472A2 (de)

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US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
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US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
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Also Published As

Publication number Publication date
EP1641483B1 (de) 2008-02-13
CY1107248T1 (el) 2012-11-21
PL1641483T3 (pl) 2008-07-31
CA2526169A1 (en) 2004-12-23
BRPI0411112A (pt) 2006-07-18
US20070253966A1 (en) 2007-11-01
PT1641483E (pt) 2008-04-29
DK1641483T3 (da) 2008-06-02
WO2004110472A3 (en) 2005-02-03
ATE385806T1 (de) 2008-03-15
AU2004247042A1 (en) 2004-12-23
WO2004110472A2 (en) 2004-12-23
SI1641483T1 (sl) 2008-08-31
MXPA05013564A (es) 2006-03-09
CN1802167A (zh) 2006-07-12
DE602004011770T2 (de) 2009-02-05
ES2298785T3 (es) 2008-05-16
EP1641483A2 (de) 2006-04-05
JP2007505643A (ja) 2007-03-15

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