DE60140348D1 - Verfahren zur verwandlung einer funktionellen gruppe durch halogen-metal-austausch - Google Patents
Verfahren zur verwandlung einer funktionellen gruppe durch halogen-metal-austauschInfo
- Publication number
- DE60140348D1 DE60140348D1 DE60140348T DE60140348T DE60140348D1 DE 60140348 D1 DE60140348 D1 DE 60140348D1 DE 60140348 T DE60140348 T DE 60140348T DE 60140348 T DE60140348 T DE 60140348T DE 60140348 D1 DE60140348 D1 DE 60140348D1
- Authority
- DE
- Germany
- Prior art keywords
- halogen
- compound
- functional group
- metal exchange
- transformation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229910052751 metal Inorganic materials 0.000 title abstract 2
- 239000002184 metal Substances 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 title 1
- 150000002367 halogens Chemical class 0.000 title 1
- 230000009466 transformation Effects 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 150000002366 halogen compounds Chemical class 0.000 abstract 2
- 150000002430 hydrocarbons Chemical group 0.000 abstract 2
- 150000002681 magnesium compounds Chemical class 0.000 abstract 2
- 150000002900 organolithium compounds Chemical class 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
- C07F7/0827—Syntheses with formation of a Si-C bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000024613 | 2000-02-02 | ||
PCT/JP2001/000463 WO2001057046A1 (fr) | 2000-02-02 | 2001-01-24 | Procede de conversion d'un groupe fonctionnel par reaction d'echange halogene-metal |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60140348D1 true DE60140348D1 (de) | 2009-12-17 |
Family
ID=18550569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60140348T Expired - Lifetime DE60140348D1 (de) | 2000-02-02 | 2001-01-24 | Verfahren zur verwandlung einer funktionellen gruppe durch halogen-metal-austausch |
Country Status (8)
Country | Link |
---|---|
US (2) | US6946559B2 (de) |
EP (1) | EP1253152B1 (de) |
CN (1) | CN1308331C (de) |
AT (1) | ATE447578T1 (de) |
AU (1) | AU2001228805A1 (de) |
CA (1) | CA2399089C (de) |
DE (1) | DE60140348D1 (de) |
WO (1) | WO2001057046A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003101916A1 (fr) * | 2002-05-31 | 2003-12-11 | Banyu Pharmaceutical Co., Ltd. | Procede d'introduction de substituants par une reaction d'echange halogene-metal |
EP1582523A1 (de) * | 2004-04-02 | 2005-10-05 | Ludwig-Maximilians-Universität München | Verfahren zur Herstellung von Organomagnesiumverbindungen |
PE20060115A1 (es) | 2004-07-23 | 2006-03-23 | Basf Ag | 2-(piridin-2-il)-pirimidinas como agentes fungicidas |
TW201011043A (en) | 2008-06-20 | 2010-03-16 | Chugai Pharmaceutical Co Ltd | Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives |
WO2012009173A1 (en) | 2010-07-15 | 2012-01-19 | Albemarle Corporation | Processes for producing 4-bromo-2-methoxybenzaldehyde |
CN102993086A (zh) * | 2012-10-11 | 2013-03-27 | 南通市华峰化工有限责任公司 | 一种2,6-二溴吡啶的合成方法 |
CN108059590A (zh) * | 2017-12-14 | 2018-05-22 | 珠海奥博凯生物医药技术有限公司 | 一种3-三氟甲氧基-4-氯苯甲醛的制备方法 |
CN108212044B (zh) * | 2018-01-30 | 2024-04-26 | 凯莱英医药化学(阜新)技术有限公司 | 金属-溴代芳烃的连续置换反应设备、连续置换方法及二者的应用 |
WO2019243243A1 (de) * | 2018-06-22 | 2019-12-26 | Bayer Aktiengesellschaft | Herstellungsverfahren für trizyclische verbindungen |
WO2023152081A1 (en) | 2022-02-09 | 2023-08-17 | Inke, S.A. | Process for preparing pyridinoylpiperidines 5-ht1f agonists and salts thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1505652A (en) * | 1974-06-06 | 1978-03-30 | Ici Ltd | Oligomerising ethylene |
US3972953A (en) * | 1975-01-22 | 1976-08-03 | Sun Ventures, Inc. | Group VIII metal complex catalyzed halogen exchange reaction |
JPS56112916A (en) * | 1980-02-13 | 1981-09-05 | Asahi Chem Ind Co Ltd | Production of conjugated diene polymer |
DE19643648A1 (de) * | 1996-10-22 | 1998-04-23 | Basf Ag | Verfahren zur Umsetzung von Grignardverbindungen mit Carbonylverbindungen und anschließender Hydrolyse |
IL129596A (en) * | 1998-05-08 | 2003-10-31 | Dow Agrosciences Llc | Preparation of 2-substituted pyridines |
DE19937537A1 (de) | 1999-08-09 | 2001-03-08 | Gruenenthal Gmbh | Substituierte 2-Dialkylaminoalkylbiphenyl-Derivate |
-
2001
- 2001-01-24 EP EP01948984A patent/EP1253152B1/de not_active Revoked
- 2001-01-24 WO PCT/JP2001/000463 patent/WO2001057046A1/ja active Application Filing
- 2001-01-24 CA CA2399089A patent/CA2399089C/en not_active Expired - Fee Related
- 2001-01-24 CN CNB018041361A patent/CN1308331C/zh not_active Expired - Fee Related
- 2001-01-24 DE DE60140348T patent/DE60140348D1/de not_active Expired - Lifetime
- 2001-01-24 AT AT01948984T patent/ATE447578T1/de not_active IP Right Cessation
- 2001-01-24 AU AU2001228805A patent/AU2001228805A1/en not_active Abandoned
- 2001-01-24 US US10/182,622 patent/US6946559B2/en not_active Expired - Fee Related
-
2005
- 2005-03-11 US US11/077,292 patent/US7439535B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20030130511A1 (en) | 2003-07-10 |
AU2001228805A1 (en) | 2001-08-14 |
US7439535B2 (en) | 2008-10-21 |
US20050156336A1 (en) | 2005-07-21 |
CN1608071A (zh) | 2005-04-20 |
CA2399089A1 (en) | 2001-08-09 |
ATE447578T1 (de) | 2009-11-15 |
EP1253152A1 (de) | 2002-10-30 |
CN1308331C (zh) | 2007-04-04 |
WO2001057046A1 (fr) | 2001-08-09 |
EP1253152B1 (de) | 2009-11-04 |
US6946559B2 (en) | 2005-09-20 |
CA2399089C (en) | 2010-05-11 |
EP1253152A4 (de) | 2008-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |