ATE447578T1 - Verfahren zur verwandlung einer funktionellen gruppe durch halogen-metal-austausch - Google Patents
Verfahren zur verwandlung einer funktionellen gruppe durch halogen-metal-austauschInfo
- Publication number
- ATE447578T1 ATE447578T1 AT01948984T AT01948984T ATE447578T1 AT E447578 T1 ATE447578 T1 AT E447578T1 AT 01948984 T AT01948984 T AT 01948984T AT 01948984 T AT01948984 T AT 01948984T AT E447578 T1 ATE447578 T1 AT E447578T1
- Authority
- AT
- Austria
- Prior art keywords
- halogen
- compound
- functional group
- halogen atom
- metal exchange
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229910052751 metal Inorganic materials 0.000 title abstract 2
- 239000002184 metal Substances 0.000 title abstract 2
- 230000001131 transforming effect Effects 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 150000002366 halogen compounds Chemical class 0.000 abstract 2
- 150000002430 hydrocarbons Chemical group 0.000 abstract 2
- 150000002681 magnesium compounds Chemical class 0.000 abstract 2
- 150000002900 organolithium compounds Chemical class 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
- C07F7/0827—Syntheses with formation of a Si-C bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000024613 | 2000-02-02 | ||
PCT/JP2001/000463 WO2001057046A1 (fr) | 2000-02-02 | 2001-01-24 | Procede de conversion d'un groupe fonctionnel par reaction d'echange halogene-metal |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE447578T1 true ATE447578T1 (de) | 2009-11-15 |
Family
ID=18550569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01948984T ATE447578T1 (de) | 2000-02-02 | 2001-01-24 | Verfahren zur verwandlung einer funktionellen gruppe durch halogen-metal-austausch |
Country Status (8)
Country | Link |
---|---|
US (2) | US6946559B2 (de) |
EP (1) | EP1253152B1 (de) |
CN (1) | CN1308331C (de) |
AT (1) | ATE447578T1 (de) |
AU (1) | AU2001228805A1 (de) |
CA (1) | CA2399089C (de) |
DE (1) | DE60140348D1 (de) |
WO (1) | WO2001057046A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1510510A1 (de) * | 2002-05-31 | 2005-03-02 | Banyu Pharmaceutical Co., Ltd. | Verfahren zur einführung eines substituenten durch eine halogen-metall-austauschreaktion |
EP1582523A1 (de) * | 2004-04-02 | 2005-10-05 | Ludwig-Maximilians-Universität München | Verfahren zur Herstellung von Organomagnesiumverbindungen |
PE20060115A1 (es) | 2004-07-23 | 2006-03-23 | Basf Ag | 2-(piridin-2-il)-pirimidinas como agentes fungicidas |
TW201011043A (en) | 2008-06-20 | 2010-03-16 | Chugai Pharmaceutical Co Ltd | Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives |
CN103025696B (zh) | 2010-07-15 | 2015-08-12 | 阿尔比马尔公司 | 用于制备4-溴代-2-甲氧基苯甲醛的方法 |
CN102993086A (zh) * | 2012-10-11 | 2013-03-27 | 南通市华峰化工有限责任公司 | 一种2,6-二溴吡啶的合成方法 |
CN108059590A (zh) * | 2017-12-14 | 2018-05-22 | 珠海奥博凯生物医药技术有限公司 | 一种3-三氟甲氧基-4-氯苯甲醛的制备方法 |
CN108212044B (zh) * | 2018-01-30 | 2024-04-26 | 凯莱英医药化学(阜新)技术有限公司 | 金属-溴代芳烃的连续置换反应设备、连续置换方法及二者的应用 |
MX2020013827A (es) * | 2018-06-22 | 2021-03-25 | Bayer Ag | Proceso de preparacion de compuestos triciclicos. |
WO2023152081A1 (en) | 2022-02-09 | 2023-08-17 | Inke, S.A. | Process for preparing pyridinoylpiperidines 5-ht1f agonists and salts thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1505652A (en) * | 1974-06-06 | 1978-03-30 | Ici Ltd | Oligomerising ethylene |
US3972953A (en) * | 1975-01-22 | 1976-08-03 | Sun Ventures, Inc. | Group VIII metal complex catalyzed halogen exchange reaction |
JPS56112916A (en) * | 1980-02-13 | 1981-09-05 | Asahi Chem Ind Co Ltd | Production of conjugated diene polymer |
DE19643648A1 (de) * | 1996-10-22 | 1998-04-23 | Basf Ag | Verfahren zur Umsetzung von Grignardverbindungen mit Carbonylverbindungen und anschließender Hydrolyse |
CN1114593C (zh) * | 1998-05-08 | 2003-07-16 | 陶氏益农有限责任公司 | 2位被取代的吡啶的制备 |
DE19937537A1 (de) | 1999-08-09 | 2001-03-08 | Gruenenthal Gmbh | Substituierte 2-Dialkylaminoalkylbiphenyl-Derivate |
-
2001
- 2001-01-24 US US10/182,622 patent/US6946559B2/en not_active Expired - Fee Related
- 2001-01-24 WO PCT/JP2001/000463 patent/WO2001057046A1/ja active Application Filing
- 2001-01-24 AU AU2001228805A patent/AU2001228805A1/en not_active Abandoned
- 2001-01-24 DE DE60140348T patent/DE60140348D1/de not_active Expired - Lifetime
- 2001-01-24 AT AT01948984T patent/ATE447578T1/de not_active IP Right Cessation
- 2001-01-24 EP EP01948984A patent/EP1253152B1/de not_active Revoked
- 2001-01-24 CA CA2399089A patent/CA2399089C/en not_active Expired - Fee Related
- 2001-01-24 CN CNB018041361A patent/CN1308331C/zh not_active Expired - Fee Related
-
2005
- 2005-03-11 US US11/077,292 patent/US7439535B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2001057046A1 (fr) | 2001-08-09 |
CA2399089A1 (en) | 2001-08-09 |
AU2001228805A1 (en) | 2001-08-14 |
EP1253152B1 (de) | 2009-11-04 |
US6946559B2 (en) | 2005-09-20 |
US7439535B2 (en) | 2008-10-21 |
US20050156336A1 (en) | 2005-07-21 |
EP1253152A4 (de) | 2008-08-20 |
EP1253152A1 (de) | 2002-10-30 |
CA2399089C (en) | 2010-05-11 |
DE60140348D1 (de) | 2009-12-17 |
CN1608071A (zh) | 2005-04-20 |
US20030130511A1 (en) | 2003-07-10 |
CN1308331C (zh) | 2007-04-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE447578T1 (de) | Verfahren zur verwandlung einer funktionellen gruppe durch halogen-metal-austausch | |
ATE536875T1 (de) | Verfahren und zwischenzusammensetzungen zur herstellung von statinen, insbesondere rosuvastatin | |
ATE404569T1 (de) | Verfahren zur herstellung von organomagnesiumverbindungen | |
ATE480520T1 (de) | Verfahren zur herstellung von 3-substituiertem 2- chlor-5-fluorpyridin bzw. einem salz davon | |
EP1253138A3 (de) | Tertiäre Amine mit einer Esterstruktur und Verfahren zu deren Herstellung | |
ATE318254T1 (de) | Verfahren zur herstellung einer wässrigen alkaliacrylat-lösung | |
ATE374228T1 (de) | Verfahren und vorrichtung für die herstellung einer ein bituminöses bindemittel enthaltenden baumischung | |
DE60214864D1 (de) | Verfahren zur herstellung von nukleinsäuren bestehend aus stochastisch kombinierten anteilen von ausgangsnukleinsäuren | |
MXPA03005429A (es) | Procedimiento para preparacion de imidazotriazinonas sustituidas con sulfonamida. | |
ATE234827T1 (de) | Verfahren zur herstellung von 3-aryl- benzofuranonen | |
ES2181528A1 (es) | Procedimiento de preparacion de oxidos mixtos porosos, materiales asi obtenidos y sus usos. | |
DE69409085D1 (de) | Verfahren zur Herstellung von Zeolithen | |
ATE275149T1 (de) | Verfahren zur herstellung von taxanderivaten | |
ATE419230T1 (de) | Verfahren zur herstellung von 2,6-dihalo-para- trifluoromethylanilin | |
DE60239859D1 (de) | Verfahren zur photonenerzeugung durch sonolumineszenz | |
DE60221454D1 (de) | Verfahren zur Herstellung von Blechplatten durch Ziehen über ein Werkzeug oder "Form" | |
ATE380171T1 (de) | Verfahren zur herstellung von terbinafine | |
ATE284837T1 (de) | Verfahren zur herstellung einer salzfreien, waessrigen hydroxylaminloesung | |
ATE272637T1 (de) | Verfahren zur herstellung einer substituierten imidazopyridinverbindung | |
ATE527213T1 (de) | Verfahren zur herstellung von ammoniumpolythiomolybdat | |
ATE417814T1 (de) | Verfahren zur herstellung von tetracarbonsäuren | |
ATE528358T1 (de) | Verfahren zur herstellung einer azoverbindung | |
WO2005056566A3 (de) | Verfahren zur herstellung von orthometallierten und orthosubstituierten aromatischen verbindungen | |
ATE475665T1 (de) | Verfahren zur herstellung von halogenorganischen alkoxysilanen | |
ATE419229T1 (de) | Verfahren zur herstellung von makrocyclischen ketonen durch dieckmann-kondensation in der gasphase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |