AU2001228805A1 - Method of converting functional group through halogen-metal exchange reaction - Google Patents
Method of converting functional group through halogen-metal exchange reactionInfo
- Publication number
- AU2001228805A1 AU2001228805A1 AU2001228805A AU2880501A AU2001228805A1 AU 2001228805 A1 AU2001228805 A1 AU 2001228805A1 AU 2001228805 A AU2001228805 A AU 2001228805A AU 2880501 A AU2880501 A AU 2880501A AU 2001228805 A1 AU2001228805 A1 AU 2001228805A1
- Authority
- AU
- Australia
- Prior art keywords
- halogen
- compound
- functional group
- exchange reaction
- metal exchange
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
- C07F3/02—Magnesium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
- C07F7/0827—Syntheses with formation of a Si-C bond
Abstract
A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group. Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixture of a magnesium compound represented by the formula R<1>-Mg-X (I) (wherein R<1> represents a halogen atom or an optionally substituted hydrocarbon residue; and X<1> represents a halogen atom) and an organolithium compound represented by the formula R<2>-Li (II)(wherein R<2> represents an optionally substituted hydrocarbon residue) or a product of the reaction of the magnesium compound with the organolithium compound; and a process for producing with the reagent a compound in which a halogen atom of a halogen compound has been replaced with an electrophilic group.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000-024613 | 2000-02-02 | ||
JP2000024613 | 2000-02-02 | ||
PCT/JP2001/000463 WO2001057046A1 (en) | 2000-02-02 | 2001-01-24 | Method of converting functional group through halogen-metal exchange reaction |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001228805A1 true AU2001228805A1 (en) | 2001-08-14 |
Family
ID=18550569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001228805A Abandoned AU2001228805A1 (en) | 2000-02-02 | 2001-01-24 | Method of converting functional group through halogen-metal exchange reaction |
Country Status (8)
Country | Link |
---|---|
US (2) | US6946559B2 (en) |
EP (1) | EP1253152B1 (en) |
CN (1) | CN1308331C (en) |
AT (1) | ATE447578T1 (en) |
AU (1) | AU2001228805A1 (en) |
CA (1) | CA2399089C (en) |
DE (1) | DE60140348D1 (en) |
WO (1) | WO2001057046A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050104233A1 (en) * | 2002-05-31 | 2005-05-19 | Shinji Kato | Method of substituent introduction through halogen-metal exchange reaction |
EP1582523A1 (en) * | 2004-04-02 | 2005-10-05 | Ludwig-Maximilians-Universität München | Method of preparing organomagnesium compounds |
PE20060115A1 (en) | 2004-07-23 | 2006-03-23 | Basf Ag | 2- (PYRIDIN-2-IL) -PYRIMIDINES AS FUNGICIDE AGENTS |
TW201011043A (en) | 2008-06-20 | 2010-03-16 | Chugai Pharmaceutical Co Ltd | Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives |
EP2593419A1 (en) | 2010-07-15 | 2013-05-22 | Albemarle Corporation | Processes for producing 4-bromo-2-methoxybenzaldehyde |
CN102993086A (en) * | 2012-10-11 | 2013-03-27 | 南通市华峰化工有限责任公司 | Method for synthesizing 2,6-dibromo pyridine |
CN108059590A (en) * | 2017-12-14 | 2018-05-22 | 珠海奥博凯生物医药技术有限公司 | A kind of preparation method of 3- trifluoromethoxies -4- chlorobenzaldehydes |
EP3810585A1 (en) * | 2018-06-22 | 2021-04-28 | Bayer Aktiengesellschaft | Process for preparing tricyclic compounds |
WO2023152081A1 (en) | 2022-02-09 | 2023-08-17 | Inke, S.A. | Process for preparing pyridinoylpiperidines 5-ht1f agonists and salts thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1505652A (en) * | 1974-06-06 | 1978-03-30 | Ici Ltd | Oligomerising ethylene |
US3972953A (en) * | 1975-01-22 | 1976-08-03 | Sun Ventures, Inc. | Group VIII metal complex catalyzed halogen exchange reaction |
JPS56112916A (en) | 1980-02-13 | 1981-09-05 | Asahi Chem Ind Co Ltd | Production of conjugated diene polymer |
DE19643648A1 (en) | 1996-10-22 | 1998-04-23 | Basf Ag | Process for the implementation of Grignard compounds with carbonyl compounds and subsequent hydrolysis |
CN1114593C (en) * | 1998-05-08 | 2003-07-16 | 陶氏益农有限责任公司 | Preparation of 2-substituted pyridines |
DE19937537A1 (en) | 1999-08-09 | 2001-03-08 | Gruenenthal Gmbh | Substituted 2-dialkylaminoalkylbiphenyl derivatives |
-
2001
- 2001-01-24 DE DE60140348T patent/DE60140348D1/en not_active Expired - Lifetime
- 2001-01-24 WO PCT/JP2001/000463 patent/WO2001057046A1/en active Application Filing
- 2001-01-24 US US10/182,622 patent/US6946559B2/en not_active Expired - Fee Related
- 2001-01-24 EP EP01948984A patent/EP1253152B1/en not_active Revoked
- 2001-01-24 AU AU2001228805A patent/AU2001228805A1/en not_active Abandoned
- 2001-01-24 CN CNB018041361A patent/CN1308331C/en not_active Expired - Fee Related
- 2001-01-24 AT AT01948984T patent/ATE447578T1/en not_active IP Right Cessation
- 2001-01-24 CA CA2399089A patent/CA2399089C/en not_active Expired - Fee Related
-
2005
- 2005-03-11 US US11/077,292 patent/US7439535B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1253152A4 (en) | 2008-08-20 |
CA2399089C (en) | 2010-05-11 |
CN1308331C (en) | 2007-04-04 |
CN1608071A (en) | 2005-04-20 |
EP1253152B1 (en) | 2009-11-04 |
US7439535B2 (en) | 2008-10-21 |
EP1253152A1 (en) | 2002-10-30 |
ATE447578T1 (en) | 2009-11-15 |
US6946559B2 (en) | 2005-09-20 |
DE60140348D1 (en) | 2009-12-17 |
US20050156336A1 (en) | 2005-07-21 |
US20030130511A1 (en) | 2003-07-10 |
WO2001057046A1 (en) | 2001-08-09 |
CA2399089A1 (en) | 2001-08-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL165502A0 (en) | Method for preparing 3-halo-4,5-dihydro-1h-pyrazoles | |
EP1225163A3 (en) | Process for producing isopulegol | |
EP1626045A4 (en) | Processes for producing 3-substituted 2-chloro-5-fluoropyridine or salt thereof | |
BR0108590A (en) | Rapid conversion of metal containing compounds to form metals or metal oxides | |
AU2001228805A1 (en) | Method of converting functional group through halogen-metal exchange reaction | |
AU2003293585A1 (en) | Intermediate cefdinir salts | |
EP1099703A3 (en) | Process for preparing alkoxysilanes | |
GB2354252A (en) | Phthalocyanine compounds used in inks for ink-jet printing | |
WO1999067232A3 (en) | Process for the preparation of 3-aryl-benzofuranones | |
EP1327626A4 (en) | Method of purifying plavastatin | |
DE60105314D1 (en) | METHOD FOR PRODUCING TAXAN DERIVATIVES | |
GB0019124D0 (en) | Novel process | |
AU2002354100A1 (en) | Process for preparation of diphosphine compounds and intermediates for the process | |
EP1238704A3 (en) | Catalyst comprising a cyclic imide compound and process for producing organic compounds using the catalyst | |
AU2001236108A1 (en) | Process for preparing unsaturated compounds by pyrolysis | |
ID27440A (en) | PROCESS FOR PREPARING | |
GR3032474T3 (en) | Selective dehalogenation method | |
WO2004024681A3 (en) | Novel compounds comprising a thiocarbonyl-sulfanyl group, which can be used for the radical synthesis of alpha-perfluoroalkylamines | |
ATE380171T1 (en) | METHOD FOR PRODUCING TERBINAFINE | |
EP1010684A4 (en) | Process for producing 3,4-dihydroxy-3-cyclobutene-1,2-dione | |
EP1342711A3 (en) | Process for producing aromatic compounds | |
DE69818655D1 (en) | METHOD FOR PRODUCING BORON CONNECTIONS | |
HU0201195D0 (en) | ||
EP1300389A3 (en) | Process for producing 1-acyl-1-cyclopropanecarboxylate derivatives | |
WO2002051845A3 (en) | Triazolopyrimidines |