DE60002949T2 - Verfahren zur Herstellung des Neuraminidase-Inhibitoren ro-64-0796 - Google Patents

Verfahren zur Herstellung des Neuraminidase-Inhibitoren ro-64-0796 Download PDF

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Publication number
DE60002949T2
DE60002949T2 DE60002949T DE60002949T DE60002949T2 DE 60002949 T2 DE60002949 T2 DE 60002949T2 DE 60002949 T DE60002949 T DE 60002949T DE 60002949 T DE60002949 T DE 60002949T DE 60002949 T2 DE60002949 T2 DE 60002949T2
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DE
Germany
Prior art keywords
formula
amino
group
independently
represent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60002949T
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German (de)
English (en)
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DE60002949D1 (de
Inventor
Martin Karpf
Rene Trussardi
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of DE60002949D1 publication Critical patent/DE60002949D1/de
Publication of DE60002949T2 publication Critical patent/DE60002949T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
    • C07C209/16—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Plant Substances (AREA)
DE60002949T 1999-06-11 2000-06-03 Verfahren zur Herstellung des Neuraminidase-Inhibitoren ro-64-0796 Expired - Lifetime DE60002949T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP99111418 1999-06-11
EP99111418 1999-06-11
EP00103588 2000-02-21
EP00103588 2000-02-21

Publications (2)

Publication Number Publication Date
DE60002949D1 DE60002949D1 (de) 2003-07-03
DE60002949T2 true DE60002949T2 (de) 2004-05-19

Family

ID=26070572

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60002949T Expired - Lifetime DE60002949T2 (de) 1999-06-11 2000-06-03 Verfahren zur Herstellung des Neuraminidase-Inhibitoren ro-64-0796

Country Status (10)

Country Link
US (2) US6437171B1 (zh)
EP (1) EP1059283B1 (zh)
JP (1) JP4656696B2 (zh)
KR (1) KR100679780B1 (zh)
CN (1) CN1191230C (zh)
AT (1) ATE241589T1 (zh)
CA (1) CA2310714C (zh)
DE (1) DE60002949T2 (zh)
DK (1) DK1059283T3 (zh)
ES (1) ES2198244T3 (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60002949T2 (de) * 1999-06-11 2004-05-19 F. Hoffmann-La Roche Ag Verfahren zur Herstellung des Neuraminidase-Inhibitoren ro-64-0796
JP2001131144A (ja) * 1999-11-02 2001-05-15 Sagami Chem Res Center ７−アザビシクロ［４．１．０］ヘプト−３−エン−３−カルボン酸エステル類の製造方法
US6518048B2 (en) * 2000-04-10 2003-02-11 Hoffmann-La Roche Inc. Stereo-specific synthesis of shimikic acid derivatives with improved efficiency
GB0202563D0 (en) * 2002-02-04 2002-03-20 Glaxo Group Ltd Process
US7122684B2 (en) * 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
EP1723107A2 (en) 2004-02-23 2006-11-22 Cadila Healthcare Ltd. Process for manufacture of racemic carvedilol
WO2006024436A1 (en) * 2004-09-02 2006-03-09 F. Hoffmann-La Roche Ag Process for the preparation of 4,5-diamino shikimicacid
KR100819759B1 (ko) * 2005-12-01 2008-04-07 (주)파인켐 아자이드 화합물의 폭발성을 제거한 공정을 이용한 1,2-다이아미노 화합물 또는 이의 부가염 제조 방법
WO2008028057A2 (en) * 2006-08-30 2008-03-06 President And Fellows Of Harvard College Shikimic acid-derived compounds for inhibition and detection of aurora a-associated tumors
JP5698128B2 (ja) * 2009-06-09 2015-04-08 国立大学法人 岡山大学 ジヒドロキシヘキセン酸エステル及びその製造方法
JP4496351B1 (ja) * 2009-09-01 2010-07-07 国立大学法人 岡山大学 １，３−ジオキソラン化合物及びその製造方法
CN113024396B (zh) * 2019-12-25 2024-01-30 上海奥博生物医药股份有限公司 一种奥司他韦的制备方法及其中间体
CN111153818B (zh) * 2020-03-13 2023-03-28 遂成药业股份有限公司 一种制备抗病毒药物达菲中间体叔丁胺衍生物i的方法
CN111499536B (zh) * 2020-05-06 2022-10-18 湖南欧亚药业有限公司 一种奥司他韦的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1593775A1 (de) * 1967-04-13 1971-03-25 Basf Ag Verfahren zur Herstellung von 1,2-Diaminen
JPS57144247A (en) * 1981-03-02 1982-09-06 Lion Corp Preparation of n-substituted amino-alcohol compound
JPH04368356A (ja) * 1991-06-12 1992-12-21 Nitto Denko Corp Ｎ，ｎ−ジメチル−３−アミノ−２−メチル−２−プロパノールの製造方法。
DE759917T1 (de) 1995-02-27 1998-10-22 Gilead Sciences Inc Neue selektive inhibitoren viraler oder bakterieller neuraminidasen
US5866601A (en) 1995-02-27 1999-02-02 Gilead Sciences, Inc. Carbocyclic compounds
US5763483A (en) 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
US6518438B2 (en) * 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
EP0920410B1 (en) * 1996-08-23 2002-03-27 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
US5859284A (en) 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
US5994377A (en) 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
JPH10251190A (ja) * 1997-03-11 1998-09-22 Sumitomo Chem Co Ltd 芳香族ケトン化合物、その製造方法およびその中間体
US5886213A (en) 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds
TR200000723T2 (tr) * 1997-09-17 2001-06-21 Gilead Sciences, Inc. Altı elemanlı halkalar ihtiva eden bileşikler ve ilaç olarak kullanımları.
JP3075558B2 (ja) * 1998-01-16 2000-08-14 日本たばこ産業株式会社 光学活性アミノアルコール類の製造方法
DE60002949T2 (de) * 1999-06-11 2004-05-19 F. Hoffmann-La Roche Ag Verfahren zur Herstellung des Neuraminidase-Inhibitoren ro-64-0796

Also Published As

Publication number Publication date
US6437171B1 (en) 2002-08-20
ATE241589T1 (de) 2003-06-15
KR20010049507A (ko) 2001-06-15
CN1191230C (zh) 2005-03-02
DE60002949D1 (de) 2003-07-03
US20020095040A1 (en) 2002-07-18
ES2198244T3 (es) 2004-02-01
CA2310714A1 (en) 2000-12-11
DK1059283T3 (da) 2003-09-15
CN1277957A (zh) 2000-12-27
CA2310714C (en) 2008-08-19
KR100679780B1 (ko) 2007-02-07
EP1059283B1 (en) 2003-05-28
JP2001031631A (ja) 2001-02-06
US6939986B2 (en) 2005-09-06
EP1059283A1 (en) 2000-12-13
JP4656696B2 (ja) 2011-03-23

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