DE517935C - Process for the preparation of a durable water-soluble iodine and silver containing medicament - Google Patents
Process for the preparation of a durable water-soluble iodine and silver containing medicamentInfo
- Publication number
- DE517935C DE517935C DED55439D DED0055439D DE517935C DE 517935 C DE517935 C DE 517935C DE D55439 D DED55439 D DE D55439D DE D0055439 D DED0055439 D DE D0055439D DE 517935 C DE517935 C DE 517935C
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- durable water
- silver containing
- containing medicament
- silver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims description 9
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims description 5
- 229910052740 iodine Inorganic materials 0.000 title claims description 5
- 239000011630 iodine Substances 0.000 title claims description 5
- 229910052709 silver Inorganic materials 0.000 title claims description 5
- 239000004332 silver Substances 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 4
- 239000003814 drug Substances 0.000 title description 2
- 238000002360 preparation method Methods 0.000 title description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- 229940126601 medicinal product Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940036571 iodine therapy Drugs 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Description
Verfahren zur Herstellung eines haltbaren wasserlöslichen, Jod und Silber Gegenstand. der vorliegenden Erfindung bildet ein Verfahren zur Herstellung eines Jod und Silber enthaltenden wasserlöslichen Arzneimittels, das für intramuskuläre Injektionen bestimmt ist. Nachdem sich herausgestellt hatte, daß bei bakteriellen Erkrankungen, besonders Tuberkulose, die Wirkung der bekannten intramuskulären Injektionen von kolloidalem Silber durch Kombination mit einer Jodtherapie besonders gesteigert werden kann, ergab sich das Bedürfnis, eine Lösung herzustellen, welche die beiden Komponenten enthielt, so daß man sie mit einer Injektion in den Körper einführen konnte.Process for producing a durable water-soluble, iodine and Silver object. of the present invention provides a method of manufacture of a water-soluble drug containing iodine and silver used for intramuscular Injections is intended. After it was found that bacterial Diseases, especially tuberculosis, the effect of the well-known intramuscular injections of colloidal silver when combined with iodine therapy the need arose to produce a solution which the two Components contained so that they can be injected into the body could.
Vereinigte man Lösungen des kolloidalen Silbers mit anorganischen Jodsalzen oder auch einer Reihe bekannter wasserlöslicher organischer Jodpräparate, so kam es nach mehr oder minder langer Zeit zur Ausscheidung von Jodsilber. Überraschenderweise zeigte sich nun, daß das 1\Tatriumsalz -der 7-Jod-8-oxychinolig;-5-sulfosäure, von der es bekannt ist, daß sie sich bereits durch Kochen mit Wasser oder durch die Einwirkung verdünnter Salzsäure zersetzt (vgl. z. B. die Patentschriften 72 g¢2 und zgo g56), mit der wässerigen Lösung von kolloidalem Silber eine Lösung ergab, die bei längerer Aufbewahrung klar blieb.Solutions of colloidal silver were combined with inorganic ones Iodized salts or a number of well-known water-soluble organic iodine preparations, so after a more or less long time iodized silver was precipitated. Surprisingly It was now found that the sodium salt of 7-iodo-8-oxyquinolig; -5-sulfonic acid, of which is known to have been made by boiling with water or by the The action of dilute hydrochloric acid decomposes (cf., for example, patents 72 g [2 and zgo g56), with the aqueous solution of colloidal silver resulted in a solution, which remained clear after prolonged storage.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DED55439D DE517935C (en) | 1928-04-12 | 1928-04-12 | Process for the preparation of a durable water-soluble iodine and silver containing medicament |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DED55439D DE517935C (en) | 1928-04-12 | 1928-04-12 | Process for the preparation of a durable water-soluble iodine and silver containing medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE517935C true DE517935C (en) | 1931-02-09 |
Family
ID=7056534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DED55439D Expired DE517935C (en) | 1928-04-12 | 1928-04-12 | Process for the preparation of a durable water-soluble iodine and silver containing medicament |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE517935C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8865227B2 (en) | 2007-12-20 | 2014-10-21 | Smith & Nephew (Overseas) Limited | Metal carbonate particles and methods of making thereof |
-
1928
- 1928-04-12 DE DED55439D patent/DE517935C/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8865227B2 (en) | 2007-12-20 | 2014-10-21 | Smith & Nephew (Overseas) Limited | Metal carbonate particles and methods of making thereof |
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