DE4418115A1 - Galenische Formulierungen - Google Patents
Galenische FormulierungenInfo
- Publication number
- DE4418115A1 DE4418115A1 DE4418115A DE4418115A DE4418115A1 DE 4418115 A1 DE4418115 A1 DE 4418115A1 DE 4418115 A DE4418115 A DE 4418115A DE 4418115 A DE4418115 A DE 4418115A DE 4418115 A1 DE4418115 A1 DE 4418115A1
- Authority
- DE
- Germany
- Prior art keywords
- carrier
- weight
- macrolide
- oil
- triglycerides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Description
- i) ein Reaktionsprodukt aus Rizinusöl und Ethylenoxid,
- ii) ein Umesterungsprodukt von einem Pflanzenöl und Glycerol, das hauptsächlich Mono-, Di- und Triglyceride von Linolsäure oder Ölsäure oder ein polyoxyalkyliertes Pflanzenöl umfaßt,
- iii) 1,2-Propylenglycol und
- iv) Ethanol.
- i) Reaktionsprodukte eines natürlichen oder hydrierten Rizinusöls und Ethylenoxids. Das natürliche oder hydrierte Rizinusöl kann mit Ethylenoxid in einem Molarverhältnis von ungefähr 1 : 35 bis ungefähr 1 : 60 reagiert werden, mit wahlfreier Entfernung der Polyethylenglycolkomponente von den Produkten. Es sind verschiedene solche oberflächenaktiven Stoffe im Handel erhältlich. Die Polyethylenglycol-hydrierten Rizinusöle, die unter dem Handelsnamen CREMOPHOR erhältlich sind, sind besonders geeignet. Besonders geeignet sind CREMOPHOR RH 40, das eine Verseifungszahl von ungefähr 50 bis 60 hat, eine Säurenzahl, die kleiner als ungefähr 1 ist, einen Wassergehalt (Fischer), der kleiner als ungefähr 2% ist, eine nD⁶⁰ von ungefähr 1,453 bis 1,457 und einen HLB-Wert von ungefähr 14 bis 16; und CREMOPHOR RH 60, das eine Verseifungszahl von ungefähr 40 bis 50 hat, eine Säurenzahl, die kleiner als ungefähr 1 ist, eine Jodzahl, die kleiner als ungefähr 1 ist, einen Wassergehalt (Fischer) von ungefähr 4,5 bis 5,5%, eine nD²⁵ von ungefähr 1,453 bis 1,457 und einen HLB-Wert von ungefähr 15 bis 17. Ein besonders bevorzugtes Produkt dieser Klasse ist CREMOPHOR RH40. Polyethylenglycolrizinusöle, die unter dem Handelsnamen CREMOPHOR EL erhältlich sind, sind auch geeignet, wobei CREMOPHOR EL ein Molekulargewicht (durch Dampfosmometrie) von ungefähr 1630 hat, eine Verseifungszahl von ungefähr 65 bis 70, eine Säurenzahl von ungefähr 2, eine Jodzahl von ungefähr 28 bis 32 und eine nD²⁵ von ungefähr 1,471. Ähnliche oder identische Produkte, die auch benutzt werden können, sind unter den Handelsnamen NIKKOL (z. B. NIKKOL HCO-40 und NIKKOL HCO-60), MAPEG (z. B. MAPEG CO-40h), INCROCAS (z. B. INCROCAS 40), und TAGAT (z. B. TAGAT RH 40) erhältlich. Diese oberflächenaktiven Stoffe werden weiter in Fiedler loc. cit. beschrieben.
- ii) Polyoxyethylensorbitanfettsäureester, zum Beispiel Mono- und Trilauryl-,
-palmityl, -stearyl und -oleylester der Art, die im Handel unter dem Handelsnamen
TWEEN (Fiedler, loc.cit. S. 1300-1304) bekannt und erhältlich sind,
einschließlich der Produkte TWEEN
20[Polyoxyethylen(20)sorbitanmonolaurat],
21[Polyoxyethylen(4)sorbitanmonolaurat],
40[Polyoxyethylen(20)sorbitanmonopalmitat],
60[Polyoxyethylen(20)sorbitanmonostearat],
65[Polyoxyethylen(20)sorbitantristearat],
80[Polyoxyethylen(20)sorbitanmonooleat],
81[Polyoxyethylen(5)sorbitanmonooleat],
85[Polyoxyethylen(20)sorbitantrioleat]
Besonders bevorzugte Produkte dieser Klasse sind TWEEN 40 und TWEEN 80. - iii) Polyoxyethylenfettsäureester, zum Beispiel Polyoxyethylenstearinsäureester der Art, die im Handel unter dem Handelsnamen MYRJ (Fiedler, loc. cit., 2, S. 834- 835) bekannt und erhältlich sind. Ein besonders bevorzugtes Produkt dieser Klasse ist MYJR 52 mit einer D²⁵ von ungefähr 1,1, einem Schmelzpunkt von ungefähr 40 bis 44°C, einen HLB-Wert von ungefähr 16,9, einen Säurenwert von ungefähr 0 bis 1 und einer Verseifungszahl von ungefähr 25 bis 35.
- iv) Polyoxyethylen-Polyoxypropylencopolymere und -blockcopolymere, zum Beispiel der Art, die unter den Handelsnamen PLURONIC, EMKALYX und POLOXAMER (Fiedler, loc. cit., 2, S. 959) bekannt und erhältlich sind. Ein besonders bevorzugtes Produkt dieser Klasse ist PLURONIC F68, mit einem Schmelzpunkt von ungefähr 52°C und einem Molekulargewicht von ungefähr 6800 bis 8975. Ein weiteres bevorzugtes Produkt dieser Klasse ist POLOXAMER 188.
- v) Dioctylsulfosuccinat oder Di-[2-ethylhexyl]succinat (Fiedler, loc. cit., 1, S. 107- 108).
- vi) Phospholipide, insbesonders Lecithine (Fiedler, loc. cit., 2, S. 943-944).
Geeignete Lecithine schließen insbesonders Sojalecithine ein. - vii) Propylenglycolmono- und -difettsäureester wie Propylenglycoldicaprylat (auch im Handel unter dem Handelsnamen MIGLYOL 840 bekannt und erhältlich), Propylenglycoldilaurat, Propylenglycolhydroxystearat, Propylenglycolisostearat, Propylenglycollaurat, Propylenglycolricinoleat, Propylenglycolstearat und so weiter (Fiedler, loc. cit., 2, S. 808-809).
- a) Behandlung und Verhinderung von Organtransplantatabweisung, zum Beispiel für die Behandlung der Empfänger von Herz-, Lungen-, kombinierten Herz-Lungen-, Leber-, Nieren-, Pankreas-, Haut- oder Corneatransplantate. Die pharmazeutischen Zusammensetzungen sind auch für die Verhinderung von Transplantat-gegen-Empfänger-Erkrankung angezeigt, was manchmal nach Knochenmarkstransplantationen stattfindet.
- b) Behandlung und Verhinderung von Autoimmunerkrankungen und von entzündlichen Zuständen, besonders entzündliche Zuständen mit einer Aetiologie, die eine Autoimmunkomponente wie Arthritis einschließen (zum Beispiel rheumatoide Arthritis, Arthritis chronica progrediente und Arthritis deformans) und rheumatische Erkrankungen. Spezifische Autoimmunerkrankungen, für die die pharmazeutischen Zusammensetzungen benutzt werden können, schließen autoimmune hämatologische Erkrankungen ein (einschließlich z. B. hämatologische Anämie, aplastische Anämie, Anämie roter Blutzellen und idiopathische Thrombocytopenia), systemische lupus Erythematosus, Polychondritis, Sklerodoma, Wegener Granulomatosis, Dermatomyositis, chronische aktive Hepatitis, Myasthenia gravis, Psoriasis, Steven-Johnson Syndrom, idiopathische Sprue, autoimmune entzündliche Darmerkrankung (einschließlich z. B. ulcerative Colitis und Crohn′s Erkrankung), endokrine Ophthalmopathy, Greaves Erkrankung, Sarcoidosis, multiple Sklerose, primäre billiäre Zirrhose, jugendliche Diabetes (Diabetes mellitus Typ I), Uveitis (vordere und hintere), Keratoconjunctivits sicca und vemale Keratoconjunctivitis, interstitiale Lungenfibrose, psoriatische Arthritis, Giomerulonephritis (mit und ohne nephrotischem Syndrom, z. B. einschließlich idiopathischem nephrotischem Syndrom oder Nephropathie minimaler Änderung) und jugendliche Dermatomyositis.
- c) Behandlung und Verhinderung von Asthma.
- d) Behandlung von Multi-Drug Resistance (MDR=Widerstand gegen eine Vielzahl von chemischen Cytostatika. Die Rapamycinverbindungen unterdrücken P-Glucoproteine (Pgp), die Membrantransportmoleküle sind, die MDR zugeordnet sind. MDR ist besonders problematisch in Krebspatienten und AIDS-Patienten, die nicht auf konventionelle Chemotherapie reagieren, da die Medikation von Pgp aus den Zellen gepumpt wird. Daher sind die pharmazeutischen Verbindungen nützlich, um die Wirksamkeit von anderen chemotherapeutischen Mitteln bei der Behandlung und Kontrolle von Multidrug widerstehenden Zuständen zu verbessern, wie Multidrug widerstehendem Krebs oder AIDS.
Claims (9)
- i) ein Reaktionsprodukt eines Rizinusöls und Ethylenoxids,
- ii) ein Umesterungsprodukt von einem Pflanzenöl und Glycerol, das hauptsächlich Mono-, Di- und Triglyceride von Linol- oder Ölsäure oder ein polyoxyalkyliertes Pflanzenöl umfaßt,
- iii) 1,2-Propylenglycol und
- iv) Ethanol.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4447972A DE4447972B4 (de) | 1993-05-27 | 1994-05-24 | Galenische Formulierungen |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9310974 | 1993-05-27 | ||
GB939310974A GB9310974D0 (en) | 1993-05-27 | 1993-05-27 | Organic compounds |
GB939320463A GB9320463D0 (en) | 1993-10-05 | 1993-10-05 | Organic compounds |
GB9320463 | 1993-10-05 | ||
DE4448048 | 1994-05-24 | ||
DE4448049 | 1994-05-24 | ||
DE4447972A DE4447972B4 (de) | 1993-05-27 | 1994-05-24 | Galenische Formulierungen |
Publications (2)
Publication Number | Publication Date |
---|---|
DE4418115A1 true DE4418115A1 (de) | 1994-12-01 |
DE4418115B4 DE4418115B4 (de) | 2009-07-23 |
Family
ID=26302958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4418115A Expired - Fee Related DE4418115B4 (de) | 1993-05-27 | 1994-05-24 | Galenische Formulierungen |
Country Status (11)
Country | Link |
---|---|
US (4) | US5932243A (de) |
JP (3) | JP3121203B2 (de) |
AT (1) | AT408521B (de) |
BE (1) | BE1008329A3 (de) |
CA (1) | CA2124259C (de) |
CH (1) | CH686761A5 (de) |
DE (1) | DE4418115B4 (de) |
ES (1) | ES2098180B1 (de) |
FR (1) | FR2705566B1 (de) |
HK (1) | HK1011278A1 (de) |
IT (1) | IT1272992B (de) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996013249A1 (en) * | 1994-10-26 | 1996-05-09 | Novartis Ag | Pharmaceutical compositions |
WO1996013273A1 (en) * | 1994-10-26 | 1996-05-09 | Novartis Ag | Pharmaceutical compositions |
FR2741537A1 (fr) * | 1995-11-29 | 1997-05-30 | Sandoz Sa | Compositions pharmaceutiques comprenant un hydroxyacide gras polyethoxyle sature |
GB2308545A (en) * | 1994-10-26 | 1997-07-02 | Ciba Geigy Ag | Pharmaceutical compositions |
WO1999024036A1 (en) * | 1997-11-07 | 1999-05-20 | Aberdeen University | Skin penetration enhancing components |
EP0978288A1 (de) * | 1997-04-11 | 2000-02-09 | Fujisawa Pharmaceutical Co., Ltd. | Medizinische zusammensetzung |
WO2000048571A1 (en) * | 1999-02-16 | 2000-08-24 | Novartis Ag | Spontaneously dispersible n-benzoyl staurosporine compositions |
US6197781B1 (en) | 1995-07-14 | 2001-03-06 | Novartis Ag | Pharmaceutical compositions |
US6486124B2 (en) | 1994-11-03 | 2002-11-26 | Novartis Ag | Cyclosporin compositions and process therefor |
EP1273288A1 (de) * | 1996-01-19 | 2003-01-08 | Novartis AG | Arzneizusammensetzungen enthaltend Rapamycinderivate |
WO2004011000A1 (en) * | 2002-07-30 | 2004-02-05 | Wyeth | Parenteral formulations containing a rapamycin hydroxyester |
FR2849055A1 (fr) * | 2002-12-18 | 2004-06-25 | Exonhit Therapeutics Sa | Nouvelle cible moleculaire de l'angiogenese et utilisations |
US9278065B2 (en) | 2007-08-09 | 2016-03-08 | Ems S/A | Delivery systems for solubilising water-insoluble pharmaceutical active ingredients |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
PT649651E (pt) | 1993-09-28 | 2001-03-30 | Scherer Gmbh R P | Preparacao de capsulas de gelatina macia |
US7205279B2 (en) * | 1995-10-25 | 2007-04-17 | Novartis Ag | Pharmaceutical compositions |
US5561138A (en) * | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
US20050053594A1 (en) * | 1995-11-16 | 2005-03-10 | Dario Alessi | RAC-PK as a therapeutic agent or in diagnostics, screening method for agents and process for activating RAC-PK |
US5858401A (en) * | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
US6465016B2 (en) * | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
US7255877B2 (en) * | 1996-08-22 | 2007-08-14 | Jagotec Ag | Fenofibrate microparticles |
CA2230748C (en) * | 1997-03-14 | 2010-08-03 | American Home Products Corporation | Rapamycin formulations for oral administration |
US6273913B1 (en) * | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
US6241762B1 (en) | 1998-03-30 | 2001-06-05 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
US7208010B2 (en) | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
US20070087028A1 (en) * | 1998-04-16 | 2007-04-19 | Robert Falotico | Intraluminal devices for the prevention and treatment of vascular disease |
JP2002516267A (ja) | 1998-05-29 | 2002-06-04 | アールティーピー・ファーマ・インコーポレーテッド | 熱的に保護された微粒子組成物及びその最終蒸気滅菌 |
PL201578B1 (pl) | 1998-11-20 | 2009-04-30 | Skyepharma Canada Inc | Stała terapeutyczna postać dawkowania nierozpuszczalnego lub słabo rozpuszczalnego w wodzie związku |
AU769429C (en) | 1998-12-30 | 2004-10-28 | Dexcel Limited | Dispersible concentrate for the delivery of cyclosporin |
US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
GB9912476D0 (en) | 1999-05-28 | 1999-07-28 | Novartis Ag | Organic compounds |
US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US6790228B2 (en) | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US7807211B2 (en) | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
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US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
SE0000773D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
SE0000774D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
US8236048B2 (en) | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US6623765B1 (en) * | 2000-08-01 | 2003-09-23 | University Of Florida, Research Foundation, Incorporated | Microemulsion and micelle systems for solubilizing drugs |
US20070225379A1 (en) * | 2001-08-03 | 2007-09-27 | Carrara Dario Norberto R | Transdermal delivery of systemically active central nervous system drugs |
US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
CA2418135C (en) * | 2000-08-03 | 2011-09-20 | Antares Pharma Ipl Ag | Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels |
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WO2002026139A1 (en) | 2000-09-29 | 2002-04-04 | Cordis Corporation | Coated medical devices |
ATE300255T1 (de) | 2000-10-16 | 2005-08-15 | Conor Medsystems Inc | Expandierbare medizinische vorrichtung zum zuführen eines heilmittels |
US7842083B2 (en) | 2001-08-20 | 2010-11-30 | Innovational Holdings, Llc. | Expandable medical device with improved spatial distribution |
SE0102993D0 (sv) * | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
US20030217129A1 (en) * | 2002-05-15 | 2003-11-20 | Lucent Technologies Inc. | Self-organizing intelligent network architecture and methodology |
KR20040015624A (ko) * | 2002-08-13 | 2004-02-19 | 대한뉴팜(주) | 플로르페니콜을 활성성분으로 함유하는 경구투여용약제학적 조성물 |
GB0218996D0 (en) * | 2002-08-14 | 2002-09-25 | Novartis Ag | Organic compounds |
WO2004062669A1 (en) * | 2003-01-16 | 2004-07-29 | Sucampo Ag | Use of a macrolide compound for treating dry eye |
US7071248B2 (en) * | 2003-01-21 | 2006-07-04 | Ashland Licensing And Intellectual Property, Llc | Adhesive additives and adhesive compositions containing an adhesive additive |
US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
US20050049209A1 (en) * | 2003-08-06 | 2005-03-03 | Chen Andrew Xian | Pharmaceutical compositions for delivering macrolides |
US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
ATE534373T1 (de) | 2003-10-10 | 2011-12-15 | Antares Pharma Ipl Ag | Transdermale pharmazeutische formulierung zur minimierung von rückständen auf der haut |
US7387788B1 (en) | 2003-10-10 | 2008-06-17 | Antares Pharma Ipl Ag | Pharmaceutical compositions of nicotine and methods of use thereof |
US8007737B2 (en) * | 2004-04-14 | 2011-08-30 | Wyeth | Use of antioxidants to prevent oxidation and reduce drug degradation in drug eluting medical devices |
US7425340B2 (en) * | 2004-05-07 | 2008-09-16 | Antares Pharma Ipl Ag | Permeation enhancing compositions for anticholinergic agents |
CN100361656C (zh) * | 2004-08-27 | 2008-01-16 | 石药集团中奇制药技术(石家庄)有限公司 | 丁苯酞自乳化释药体系及其制备方法和应用 |
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KR100699582B1 (ko) | 2005-07-11 | 2007-03-23 | 삼성전기주식회사 | 출력 버퍼회로 |
US20070015691A1 (en) | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
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- 1994-05-24 DE DE4418115A patent/DE4418115B4/de not_active Expired - Fee Related
- 1994-05-24 IT ITRM940324A patent/IT1272992B/it active IP Right Grant
- 1994-05-25 CA CA2124259A patent/CA2124259C/en not_active Expired - Fee Related
- 1994-05-25 AT AT0106594A patent/AT408521B/de not_active IP Right Cessation
- 1994-05-26 JP JP06112554A patent/JP3121203B2/ja not_active Expired - Fee Related
- 1994-05-26 BE BE9400531A patent/BE1008329A3/fr not_active IP Right Cessation
- 1994-05-26 ES ES09401166A patent/ES2098180B1/es not_active Expired - Fee Related
- 1994-05-26 FR FR9406515A patent/FR2705566B1/fr not_active Expired - Fee Related
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1997
- 1997-08-22 US US08/916,243 patent/US5932243A/en not_active Expired - Lifetime
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1998
- 1998-11-10 HK HK98111891A patent/HK1011278A1/xx not_active IP Right Cessation
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1999
- 1999-03-08 JP JP06012899A patent/JP3933339B2/ja not_active Expired - Fee Related
-
2000
- 2000-03-22 US US09/532,999 patent/US6565859B1/en not_active Expired - Fee Related
-
2003
- 2003-03-12 US US10/387,147 patent/US20030166517A1/en not_active Abandoned
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2004
- 2004-05-18 US US10/847,694 patent/US7025975B2/en not_active Expired - Fee Related
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EP1147766A3 (de) * | 1994-10-26 | 2001-10-31 | Novartis AG | Arzneimittel |
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GB2308545B (en) * | 1994-10-26 | 1999-06-02 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
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US6956043B2 (en) | 1995-07-14 | 2005-10-18 | Novartis Ag | Pharmaceutical compositions comprising 33-epi-chloro-33-desoxy-ascomycin solid dispersions |
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EP1604650A2 (de) * | 1995-11-29 | 2005-12-14 | Novartis AG | Pharmazeutische Zusammensetzungen von Macroliden oder Cyclosporine mit einer polyethoxylierten Hydroxy-Fettsäure |
EP1604650A3 (de) * | 1995-11-29 | 2008-04-02 | Novartis AG | Pharmazeutische Zusammensetzungen von Macroliden oder Cyclosporine mit einer polyethoxylierten Hydroxy-Fettsäure |
BE1010112A4 (fr) * | 1995-11-29 | 1997-12-02 | Ciba Geigy Ag | Compositions pharmaceutiques. |
FR2741537A1 (fr) * | 1995-11-29 | 1997-05-30 | Sandoz Sa | Compositions pharmaceutiques comprenant un hydroxyacide gras polyethoxyle sature |
EP1074263A2 (de) * | 1995-11-29 | 2001-02-07 | Novartis AG | Pharmazeutische Zusammensetzungen von Macroliden oder Cyclosporine mit einer Polyethoxylierten hydroxy-fettsäure |
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US6951841B2 (en) | 1995-11-29 | 2005-10-04 | Novartis Ag | Pharmaceutical compositions of macrolides or cyclosporine with a polyethoxylated saturated hydroxy-fatty acid |
EP1273288A1 (de) * | 1996-01-19 | 2003-01-08 | Novartis AG | Arzneizusammensetzungen enthaltend Rapamycinderivate |
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EP0978288A4 (de) * | 1997-04-11 | 2006-07-12 | Astellas Pharma Inc | Medizinische zusammensetzung |
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WO1999024036A1 (en) * | 1997-11-07 | 1999-05-20 | Aberdeen University | Skin penetration enhancing components |
US8575147B2 (en) | 1999-02-16 | 2013-11-05 | Novartis Ag | Spontaneously dispersible N-benzoyl staurosporine compositions |
CN100367930C (zh) * | 1999-02-16 | 2008-02-13 | 诺瓦提斯公司 | 可自发分散的n-苯甲酰基-星形孢菌素组合物 |
WO2000048571A1 (en) * | 1999-02-16 | 2000-08-24 | Novartis Ag | Spontaneously dispersible n-benzoyl staurosporine compositions |
US8722664B2 (en) | 1999-02-16 | 2014-05-13 | Novartis Ag | Spontaneously dispersible N-benzoyl staurosporine compositions |
WO2004011000A1 (en) * | 2002-07-30 | 2004-02-05 | Wyeth | Parenteral formulations containing a rapamycin hydroxyester |
US8026276B2 (en) | 2002-07-30 | 2011-09-27 | Wyeth Llc | Parenteral CCI-779 formulations containing cosolvents, an antioxidant, and a surfactant |
US8299116B2 (en) | 2002-07-30 | 2012-10-30 | Wyeth Llc | CCI-779 concentrate formulations |
US8455539B2 (en) | 2002-07-30 | 2013-06-04 | Wyeth Llc | CCI-779 concentrate formulations |
US8722700B2 (en) | 2002-07-30 | 2014-05-13 | Wyeth Llc | CCI-779 formulations for parenteral administration |
FR2849055A1 (fr) * | 2002-12-18 | 2004-06-25 | Exonhit Therapeutics Sa | Nouvelle cible moleculaire de l'angiogenese et utilisations |
US9278065B2 (en) | 2007-08-09 | 2016-03-08 | Ems S/A | Delivery systems for solubilising water-insoluble pharmaceutical active ingredients |
Also Published As
Publication number | Publication date |
---|---|
CA2124259C (en) | 2012-01-10 |
US5932243A (en) | 1999-08-03 |
ATA106594A (de) | 2001-05-15 |
US7025975B2 (en) | 2006-04-11 |
JP2007039471A (ja) | 2007-02-15 |
CH686761A5 (de) | 1996-06-28 |
JPH11315022A (ja) | 1999-11-16 |
ES2098180A1 (es) | 1997-04-16 |
JP4709729B2 (ja) | 2011-06-22 |
US20040209911A1 (en) | 2004-10-21 |
US6565859B1 (en) | 2003-05-20 |
JPH07138161A (ja) | 1995-05-30 |
DE4418115B4 (de) | 2009-07-23 |
FR2705566B1 (fr) | 1996-04-05 |
ITRM940324A1 (it) | 1995-11-24 |
ES2098180B1 (es) | 1998-07-01 |
HK1011278A1 (en) | 1999-07-09 |
FR2705566A1 (fr) | 1994-12-02 |
US20030166517A1 (en) | 2003-09-04 |
JP3121203B2 (ja) | 2000-12-25 |
ITRM940324A0 (it) | 1994-05-24 |
BE1008329A3 (fr) | 1996-04-02 |
AT408521B (de) | 2001-12-27 |
JP3933339B2 (ja) | 2007-06-20 |
CA2124259A1 (en) | 1994-11-28 |
IT1272992B (it) | 1997-07-01 |
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