DE3885374D1 - Stabile wässerige Thrombinlösung. - Google Patents

Stabile wässerige Thrombinlösung.

Info

Publication number
DE3885374D1
DE3885374D1 DE88307274T DE3885374T DE3885374D1 DE 3885374 D1 DE3885374 D1 DE 3885374D1 DE 88307274 T DE88307274 T DE 88307274T DE 3885374 T DE3885374 T DE 3885374T DE 3885374 D1 DE3885374 D1 DE 3885374D1
Authority
DE
Germany
Prior art keywords
stable aqueous
thrombin solution
aqueous thrombin
solution
stable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88307274T
Other languages
English (en)
Other versions
DE3885374T2 (de
Inventor
Hideo Nishimaki
Kenmi Miyano
Shouju Kameyama
Kazuo Takechi
Yoshiro Iga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Publication of DE3885374D1 publication Critical patent/DE3885374D1/de
Application granted granted Critical
Publication of DE3885374T2 publication Critical patent/DE3885374T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DE88307274T 1987-08-05 1988-08-05 Stabile wässerige Thrombinlösung. Expired - Fee Related DE3885374T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62196558A JPS6440433A (en) 1987-08-05 1987-08-05 Aqueous liquid composition of thrombin

Publications (2)

Publication Number Publication Date
DE3885374D1 true DE3885374D1 (de) 1993-12-09
DE3885374T2 DE3885374T2 (de) 1994-02-24

Family

ID=16359731

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88307274T Expired - Fee Related DE3885374T2 (de) 1987-08-05 1988-08-05 Stabile wässerige Thrombinlösung.

Country Status (5)

Country Link
US (1) US5130244A (de)
EP (1) EP0302754B1 (de)
JP (1) JPS6440433A (de)
DE (1) DE3885374T2 (de)
ES (1) ES2045131T3 (de)

Families Citing this family (55)

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US5192657A (en) * 1990-12-18 1993-03-09 Ortho Diagnostic Systems, Inc. Stabilized proteolytic solution and reagent kit
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
DK83092D0 (da) * 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
AU4784693A (en) * 1992-07-24 1994-02-14 Oklahoma Medical Research Foundation Blockade of protein c activation reduces microvascular surgical blood loss
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
US5834028A (en) * 1993-12-17 1998-11-10 Mochida Pharmaceutical Co., Ltd. Soluble thrombomodulin-containing composition
JPH07308190A (ja) * 1994-05-18 1995-11-28 Green Cross Corp:The トロンビンの製造方法
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography
AU726163B2 (en) * 1996-04-04 2000-11-02 Baxter Healthcare Sa Hemostatic sponge based on collagen
WO2000062828A1 (en) * 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
AU7977298A (en) * 1997-06-18 1999-01-04 Cohesion Technologies, Inc. Compositions containing thrombin and microfibrillar collagen, and methods for preparation and use thereof
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
GB9916537D0 (en) * 1999-07-14 1999-09-15 Univ Hull Culture of microorganisms for the synthesis of a polyunsaturated fatty acid
EP1221479B1 (de) * 1999-09-27 2006-11-22 Sysmex Corporation Verfahren zur stabilisierung von thrombin
DE10012732A1 (de) 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
GB2377455A (en) * 2001-02-09 2003-01-15 Univ Hull Method of culturing crypthecodinium cohnii
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
JP4767253B2 (ja) * 2004-06-22 2011-09-07 ザイモジェネティクス， インコーポレイテッド トロンビン組成物
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
KR100827297B1 (ko) 2005-03-17 2008-05-06 세키스이가가쿠 고교가부시키가이샤 혈액응고 촉진제 및 혈액 검사용 용기
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP1852108A1 (de) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG Zusammensetzungen von DPP-IV-Inhibitoren
EA030606B1 (ru) 2006-05-04 2018-08-31 Бёрингер Ингельхайм Интернациональ Гмбх Способы приготовления лекарственного средства, содержащего полиморфы
US8580532B2 (en) 2006-12-21 2013-11-12 Sekisui Medical Co., Ltd. Method for stabilizing α-thrombin in thrombin-containing solution
CA2937487C (en) * 2007-06-15 2018-01-09 Zymogenetics, Inc. Stabilized thrombin compositions
EP3542801A1 (de) * 2007-08-17 2019-09-25 Boehringer Ingelheim International GmbH Purinderivate zur verwendung bei der behandlung von fap-bedingten erkrankungen
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
PE20110297A1 (es) * 2008-08-15 2011-05-26 Boehringer Ingelheim Int Inhibidores de dpp-4 para la cicatrizacion de heridas
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
JP2012512848A (ja) 2008-12-23 2012-06-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 有機化合物の塩の形態
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
BR112012012641A2 (pt) 2009-11-27 2020-08-11 Boehringer Ingelheim International Gmbh TRATAMENTO DE PACIENTES DIABÉTICOS GENOTIPADOS COM INIBIDORES DE DPP-lVTAL COMO LINAGLIPTINA
WO2011138421A1 (en) 2010-05-05 2011-11-10 Boehringer Ingelheim International Gmbh Combination therapy
EP3366304B1 (de) 2010-06-24 2020-05-13 Boehringer Ingelheim International GmbH Diabetestherapie
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
WO2013010964A1 (en) 2011-07-15 2013-01-24 Boehringer Ingelheim International Gmbh Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
CN102290821B (zh) * 2011-08-31 2013-09-04 东南大学 一种电力***阻尼控制器参数适应性的判断方法
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
WO2013171167A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US9149529B2 (en) 2012-10-24 2015-10-06 Orthovita, Inc. Stable compositions containing thrombin and methods for preparation and use thereof
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
CN105148284B (zh) * 2015-08-19 2018-12-21 北京美创新跃医疗器械有限公司 一种组合物、稳定剂及其用途、凝血酶的保存方法、制备方法及凝血酶制剂、试剂盒
EP3468562A1 (de) 2016-06-10 2019-04-17 Boehringer Ingelheim International GmbH Kombinationen aus linagliptin und metformin
CN106434610B (zh) * 2016-09-30 2018-08-31 迈克生物股份有限公司 凝血酶溶液
CN106480007B (zh) * 2016-09-30 2018-02-23 迈克生物股份有限公司 凝血酶溶液的稳定剂
CN106350501B (zh) * 2016-09-30 2018-06-01 迈克生物股份有限公司 凝血酶溶液的稳定剂
CN106350500B (zh) * 2016-09-30 2018-02-23 迈克生物股份有限公司 凝血酶溶液
CN106350499B (zh) * 2016-09-30 2018-07-10 迈克生物股份有限公司 凝血酶溶液的稳定剂
CN106337044B (zh) * 2016-09-30 2018-08-31 迈克生物股份有限公司 凝血酶溶液
CN112578130A (zh) * 2019-09-30 2021-03-30 积水医疗科技(苏州)有限公司 凝血酶溶液、试剂盒、凝血酶的稳定化方法、检测试剂以及凝血酶时间的测定方法

Family Cites Families (8)

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FR866349A (fr) * 1939-06-29 1941-07-28 Ste Ind Chim Bale Procédé de fabrication de préparations de thrombine facilement solubles dans l'eau
US2433299A (en) * 1944-01-22 1947-12-23 Parke Davis & Co Blood coagulant and method of preserving same
JPS5739849A (en) * 1980-06-30 1982-03-05 Apuraido Medical Debaishizu In Prepared bandage having coagulant composition and method
US4363319A (en) * 1980-06-30 1982-12-14 Applied Medical Devices, Inc. Ready-to-use bandage incorporating a coagulant composition and method of preparing same
JPS6054287B2 (ja) * 1983-10-19 1985-11-29 株式会社ミドリ十字 血漿蛋白の加熱処理方法
JPS6281327A (ja) * 1985-10-04 1987-04-14 Green Cross Corp:The 人トロンビン製剤の加熱処理方法
US4696812A (en) * 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
JPS63243032A (ja) * 1987-03-27 1988-10-07 Green Cross Corp:The トロンビンの加熱処理方法

Also Published As

Publication number Publication date
EP0302754B1 (de) 1993-11-03
ES2045131T3 (es) 1994-01-16
DE3885374T2 (de) 1994-02-24
US5130244A (en) 1992-07-14
JPS6440433A (en) 1989-02-10
EP0302754A2 (de) 1989-02-08
EP0302754A3 (en) 1989-11-02

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Legal Events

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8339 Ceased/non-payment of the annual fee