DE3883033D1 - Heterocyclische verbindungen und ihre herstellung und anwendung. - Google Patents

Heterocyclische verbindungen und ihre herstellung und anwendung.

Info

Publication number: DE3883033D1
Authority: DE; Germany
Prior art keywords: alkyl; heterocyclic compounds; production; application; alkynyl
Prior art date: 1987-03-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE8888301783T

Other languages

English (en)

Other versions

DE3883033T2 (de

Inventor

Frank Waetjen

Holger Claus Hansen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novo Nordisk AS

Original Assignee

Novo Nordisk AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-18

Filing date

1988-03-01

Publication date

1993-09-16

1988-03-01 Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS

1993-09-16 Publication of DE3883033D1 publication Critical patent/DE3883033D1/de

1993-12-16 Application granted granted Critical

1993-12-16 Publication of DE3883033T2 publication Critical patent/DE3883033T2/de

2008-03-02 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 2
125000006728 (C1-C6) alkynyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
229940125681 anticonvulsant agent Drugs 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
229940005530 anxiolytics Drugs 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000003326 hypnotic agent Substances 0.000 abstract 1
230000000147 hypnotic effect Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000002664 nootropic agent Substances 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Anesthesiology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Luminescent Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

DE88301783T 1987-03-18 1988-03-01 Heterocyclische Verbindungen und ihre Herstellung und Anwendung. Expired - Fee Related DE3883033T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK137487A DK155524C (da)	1987-03-18	1987-03-18	Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse

Publications (2)

Publication Number	Publication Date
DE3883033D1 true DE3883033D1 (de)	1993-09-16
DE3883033T2 DE3883033T2 (de)	1993-12-16

Family

ID=8104158

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE88301783T Expired - Fee Related DE3883033T2 (de)	1987-03-18	1988-03-01	Heterocyclische Verbindungen und ihre Herstellung und Anwendung.

Country Status (18)

Country	Link
US (2)	US4873244A (de)
EP (1)	EP0283162B1 (de)
JP (1)	JPS6463581A (de)
KR (1)	KR960010455B1 (de)
AT (1)	ATE92926T1 (de)
AU (1)	AU607469B2 (de)
CA (1)	CA1308712C (de)
DE (1)	DE3883033T2 (de)
DK (1)	DK155524C (de)
ES (1)	ES2058251T3 (de)
FI (1)	FI92700C (de)
IE (1)	IE62320B1 (de)
IL (1)	IL85295A (de)
NO (1)	NO169340C (de)
NZ (1)	NZ223777A (de)
PH (2)	PH24076A (de)
PT (1)	PT87013B (de)
ZA (1)	ZA881140B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK160876C (da) *	1987-12-08	1991-10-14	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar
IL90315A0 (en) *	1988-06-01	1989-12-15	Ferrosan As	Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
DK161148C (da) *	1988-06-14	1991-11-18	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeprater indeholdende forbindelserne
DK626288D0 (da) *	1988-11-10	1988-11-10	Ferrosan As	Kemisk proces til fremstilling af imidazoquinoxaliner og mellemprodukter til brug i processen
DK588489D0 (da) *	1989-11-22	1989-11-22	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
DK588389D0 (da) *	1989-11-22	1989-11-22	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
FR2659329B1 (fr) *	1990-03-09	1994-06-03	Adir	Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant.
US5276028A (en) *	1990-06-22	1994-01-04	Nordisk A/S	Imidazoquinoxaline compounds
DK204291D0 (da) *	1991-12-20	1991-12-20	Novo Nordisk As	Heterocykliske forbindelser deres fremstilling og anvendelse
US5371080A (en) *	1990-06-22	1994-12-06	Novo Nordisk A/S	Imidazoquinazoline compounds and their use
DK151890D0 (da) *	1990-06-22	1990-06-22	Ferrosan As	Heterocykliske forbindelser deres fremstilling og brug
AU8396491A (en) *	1990-09-04	1992-03-30	Upjohn Company, The	Oxygenated quinoxalines
WO1992022552A1 (en) *	1991-06-14	1992-12-23	The Upjohn Company	IMIDAZO[1,5-a]QUINOXALINES
WO1993012113A1 (en) *	1991-12-17	1993-06-24	The Upjohn Company	3-SUBSTITUTED IMIDAZO (1,5-a) AND IMIDAZO (1,5-a)-TRIAZOLO (1,5-c) QUINOXALINES AND QUINAZOLINES WITH CNS ACTIVITY
EP0625982B1 (de) *	1992-02-13	2002-06-12	PHARMACIA & UPJOHN COMPANY	4-oxo-und 4h-imidazo(5,1-c)(1,4)benzoxazine nützlich als benzodiazepinrezeptor-bindemittel.
EP0626966A1 (de) *	1992-02-19	1994-12-07	PHARMACIA & UPJOHN COMPANY	3-substituierte lumidazo(1,5-a)-chinoxaline und chinozoline mit zns wirksamkeit
US5367077A (en) *	1992-04-08	1994-11-22	Neurogen Corporation	Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands
USRE35840E (en) *	1993-11-19	1998-07-07	Pharmacia & Upjohn Company	Imidazo 1,5-a!quinolines for treatment of anxiety and sleep disorders
JPH09510695A (ja) *	1994-01-03	1997-10-28	エイシア・ファーマシュウティカルズ，インコーポレイテッド	８−アザ、６−アザ、および６，８−ジアザ−１，４−ジヒドロキノキサリン−２，３−ジオン類およびそのグリシン／ｎｍｄａリセプターに対するアンタゴニストとしての使用
FR2799757B1 (fr) *	1999-10-15	2001-12-14	Adir	Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EE200300342A (et) *	2001-01-26	2003-12-15	Bristol-Myers Squibb Company	Imidasolüüli derivaadid kui kortikotropiini vabastava faktori inhibiitorid, nende saamismeetodid ning kasutamine
WO2017149469A1 (en)	2016-03-03	2017-09-08	Emcure Pharmaceuticals Limited	Heterocyclic compounds useful as ido and/or tdo modulators

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4440929A (en) *	1981-07-16	1984-04-03	Usv Pharmaceutical Corporation	Imidazoquinoxaline compounds
DE3661197D1 (en) *	1985-05-17	1988-12-22	Ferrosan As	Oxadiazolylimidazobenzodiazepines, process for their preparation and pharmaceutical compositions
US4771051A (en) *	1985-05-17	1988-09-13	A/S Ferrosan	3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments
DK476885D0 (da) *	1985-10-17	1985-10-17	Ferrosan As	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
ATE80392T1 (de) *	1985-10-17	1992-09-15	Novo Nordisk As	Oxadiazolylacetonitrile, ihre herstellung und anwendung.
DK160876C (da) *	1987-12-08	1991-10-14	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar
IL90315A0 (en) *	1988-06-01	1989-12-15	Ferrosan As	Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them

1987
- 1987-03-18 DK DK137487A patent/DK155524C/da not_active IP Right Cessation
1988
- 1988-02-02 IL IL85295A patent/IL85295A/xx not_active IP Right Cessation
- 1988-02-10 PH PH36480A patent/PH24076A/en unknown
- 1988-02-16 US US07/156,363 patent/US4873244A/en not_active Expired - Fee Related
- 1988-02-18 IE IE43888A patent/IE62320B1/en not_active IP Right Cessation
- 1988-02-18 ZA ZA881140A patent/ZA881140B/xx unknown
- 1988-02-22 FI FI880815A patent/FI92700C/fi not_active IP Right Cessation
- 1988-03-01 EP EP88301783A patent/EP0283162B1/de not_active Expired - Lifetime
- 1988-03-01 DE DE88301783T patent/DE3883033T2/de not_active Expired - Fee Related
- 1988-03-01 AT AT88301783T patent/ATE92926T1/de not_active IP Right Cessation
- 1988-03-01 ES ES88301783T patent/ES2058251T3/es not_active Expired - Lifetime
- 1988-03-07 NZ NZ223777A patent/NZ223777A/xx unknown
- 1988-03-16 KR KR1019880002727A patent/KR960010455B1/ko not_active IP Right Cessation
- 1988-03-17 CA CA000561758A patent/CA1308712C/en not_active Expired - Lifetime
- 1988-03-17 JP JP63062068A patent/JPS6463581A/ja active Pending
- 1988-03-17 NO NO881191A patent/NO169340C/no unknown
- 1988-03-18 PT PT87013A patent/PT87013B/pt not_active IP Right Cessation
- 1988-03-18 AU AU13259/88A patent/AU607469B2/en not_active Ceased
- 1988-07-18 PH PH37235A patent/PH24165A/en unknown
1989
- 1989-04-20 US US07/340,901 patent/US4902686A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU607469B2 (en)	1991-03-07
IE880438L (en)	1988-09-18
FI92700B (fi)	1994-09-15
NO881191D0 (no)	1988-03-17
IL85295A (en)	1991-12-12
PT87013B (pt)	1995-03-01
DK137487A (da)	1988-09-19
US4902686A (en)	1990-02-20
FI880815A0 (fi)	1988-02-22
KR960010455B1 (ko)	1996-08-01
PH24165A (en)	1990-03-22
US4873244A (en)	1989-10-10
CA1308712C (en)	1992-10-13
DE3883033T2 (de)	1993-12-16
IE62320B1 (en)	1995-01-25
ZA881140B (en)	1988-08-15
AU1325988A (en)	1988-09-22
JPS6463581A (en)	1989-03-09
DK137487D0 (da)	1987-03-18
PT87013A (pt)	1989-03-30
ATE92926T1 (de)	1993-08-15
ES2058251T3 (es)	1994-11-01
EP0283162A3 (en)	1990-05-30
PH24076A (en)	1990-03-05
NO169340C (no)	1992-06-10
DK155524B (da)	1989-04-17
EP0283162A2 (de)	1988-09-21
NO881191L (no)	1988-09-19
NZ223777A (en)	1989-09-27
FI880815A (fi)	1988-09-19
FI92700C (fi)	1994-12-27
DK155524C (da)	1989-09-11
NO169340B (no)	1992-03-02
KR880011157A (ko)	1988-10-26
EP0283162B1 (de)	1993-08-11

Legal Events

Date	Code	Title	Description
1994-09-08	8364	No opposition during term of opposition
1995-11-23	8328	Change in the person/name/address of the agent	Free format text: BARZ, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80803 MUENCHEN
1999-04-08	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
ATE92926T1 (de)	1993-08-15	Heterocyclische verbindungen und ihre herstellung und anwendung.
FI915920A (fi)	1992-06-19	Serotoninantagonister.
DE3766401D1 (de)	1991-01-10	Benzodiazepinderivate und ihre herstellung und verwendung.
ATE44381T1 (de)	1989-07-15	Heterocyclische verbindungen und ihre herstellung und verwendung.
DE3786562D1 (de)	1993-08-26	2,6-dideoxy-2-fluoro-l-talopyranose, derivate davon und herstellung dieser verbindungen.
ATE131168T1 (de)	1995-12-15	Tetrazyklische imidazochinazolinderivate, deren herstellung und pharmazeutische zusammensetzungen.
ATE100107T1 (de)	1994-01-15	Heterozyklische verbindungen und ihre herstellung und verwendung.