DE3866735D1 - Verfahren zur herstellung einer thiazepin-verbindung. - Google Patents

Verfahren zur herstellung einer thiazepin-verbindung.

Info

Publication number
DE3866735D1
DE3866735D1 DE8888301891T DE3866735T DE3866735D1 DE 3866735 D1 DE3866735 D1 DE 3866735D1 DE 8888301891 T DE8888301891 T DE 8888301891T DE 3866735 T DE3866735 T DE 3866735T DE 3866735 D1 DE3866735 D1 DE 3866735D1
Authority
DE
Germany
Prior art keywords
producing
thiazepine compound
thiazepine
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888301891T
Other languages
English (en)
Inventor
Alan Charles Barker
Robert Jeffrey Copeland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Application granted granted Critical
Publication of DE3866735D1 publication Critical patent/DE3866735D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8888301891T 1987-03-10 1988-03-04 Verfahren zur herstellung einer thiazepin-verbindung. Expired - Lifetime DE3866735D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878705574A GB8705574D0 (en) 1987-03-10 1987-03-10 Preparation of thiazepine compound

Publications (1)

Publication Number Publication Date
DE3866735D1 true DE3866735D1 (de) 1992-01-23

Family

ID=10613643

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888301891T Expired - Lifetime DE3866735D1 (de) 1987-03-10 1988-03-04 Verfahren zur herstellung einer thiazepin-verbindung.

Country Status (25)

Country Link
EP (1) EP0282236B1 (de)
JP (1) JPH0688991B2 (de)
KR (1) KR960007088B1 (de)
AR (1) AR245707A1 (de)
AT (1) ATE70271T1 (de)
AU (1) AU595099B2 (de)
CA (1) CA1337345C (de)
DD (1) DD271703A5 (de)
DE (1) DE3866735D1 (de)
DK (1) DK175310B1 (de)
ES (1) ES2037822T3 (de)
FI (1) FI87778C (de)
GB (2) GB8705574D0 (de)
GR (1) GR3003324T3 (de)
HU (1) HU202231B (de)
IE (1) IE61122B1 (de)
IL (1) IL85564A (de)
MW (1) MW388A1 (de)
MY (1) MY103221A (de)
NO (1) NO174421C (de)
NZ (1) NZ223813A (de)
PH (1) PH25529A (de)
PT (1) PT86934B (de)
ZA (1) ZA881350B (de)
ZW (1) ZW2188A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0396581B1 (de) * 1987-12-15 1992-01-15 Siemens Aktiengesellschaft Verfahren zur herstellung von drähten oder bändern aus hochtemperatur-supraleitern und dabei verwendeter hüllkörper
GB9109557D0 (en) * 1991-05-02 1991-06-26 Wellcome Found Chemical compounds
GB9611328D0 (en) * 1996-05-31 1996-08-07 Zeneca Ltd Pharmaceutical compositions
GB9716161D0 (en) * 1997-08-01 1997-10-08 Zeneca Ltd Process
GB9922271D0 (en) * 1999-09-21 1999-11-17 Zeneca Ltd Formulation
WO2003080065A1 (en) * 2002-03-20 2003-10-02 Teva Pharmaceutical Industries Ltd. Crystalline forms of quetiapine hemifumarate
KR100707050B1 (ko) 2002-11-28 2007-04-13 에스케이 주식회사 10Ｈ-디벤조[ｂ,ｆ][1,4]티아제핀-11-온의 제조방법
CA2516646A1 (en) 2003-02-22 2004-09-10 Teva Pharmaceutical Industries Ltd. Synthesis of quetiapine and pharmaceutically acceptable salts thereof
US7053115B2 (en) 2003-04-07 2006-05-30 Hetero Drugs Limited Crystalline form of dorzolamide hydrochloride
ES2223294B2 (es) * 2003-08-08 2005-10-01 Vita Cientifica, S.L. Procedimiento de preparacion de un compuesto farmaceuticamente activo.
WO2005028459A1 (en) * 2003-09-23 2005-03-31 Fermion Oy Preparation method for quetiapine
PL368245A1 (en) * 2004-05-28 2005-12-12 CELON PHARMA Sp.z o.o. Method for manufacture of quetiapine
KR101038389B1 (ko) * 2004-06-23 2011-06-01 에스케이바이오팜 주식회사 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[ｂ,ｆ][1,4]티아제핀의 제조방법
WO2006056772A2 (en) * 2004-11-23 2006-06-01 Pliva Hrvatska D.O.O. Salts of quetiapine
GB0425729D0 (en) * 2004-11-23 2004-12-22 Pliva Res & Dev Ltd Heterocyclic compounds
EP1841751A1 (de) 2005-01-24 2007-10-10 IPCA Laboratories Limited Grosstechnische herstellung von 11-[4-{2-(2-hydroxyethoxy)ethyl}-1-piperazinyl]dibenzo[b,f]-[1,4]thiazepin
ES2234447B1 (es) * 2005-03-07 2006-03-01 Union Quimico-Farmaceutica S.A. Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
EP1869007A1 (de) 2005-04-14 2007-12-26 Teva Pharmaceutical Industries Ltd Verfahren zur herstellung von quetiapinfumaraten
WO2006135544A1 (en) * 2005-06-10 2006-12-21 Cambrex Charles City, Inc. SYNTHESIS OF 11-(4[-(2-HYDROXYETHOXY)ETHYL]-PIPERAZINYL)-DIBENZO[b,f][1,4]THIAZEPINE AND ITS FUMARATE SALT
WO2007004234A1 (en) * 2005-07-04 2007-01-11 Usv Limited A PROCESS FOR THE PREPARATION OF 2-[2-(4-DIBENZO[b,f] [L,4] THIAZEPIN-11-yl-1- PIPERAZINYL)ETHOXY] ETHANOL FUMARATE
GB0516603D0 (en) * 2005-08-12 2005-09-21 Sandoz Ag Processes for the preparation of organic compounds useful as serotonin receptor antagonists
WO2007048870A1 (en) * 2005-10-28 2007-05-03 Fermion Oy Quetiapine hemifumarate purification by crystallization
PT103884A (pt) 2006-11-17 2008-05-19 Astrazeneca Ab Composições de libertação prolongada e métodos para a sua preparação
AU2009208909A1 (en) 2008-01-31 2009-08-06 Fermion Oy A process for the preparation of quetiapine
CN102131791B (zh) 2008-06-20 2014-12-24 阿斯利康(瑞典)有限公司 二苯并硫杂氮杂*衍生物及其用途
PT2262486E (pt) 2008-08-01 2013-03-27 Tovarna Zdravil D D Novo Mesto Krka Composição de quetiapina
EP2153834A3 (de) 2008-08-07 2010-02-24 Farmaprojects, S.A. Pharmazeutische Zusammensetzungen mit anhaltender Freisetzung, die Quetiapinsalze umfassen
CN101676275B (zh) * 2008-09-17 2014-05-07 北京德众万全药物技术开发有限公司 一种富马酸喹硫平的制备方法
WO2010089259A2 (en) 2009-02-04 2010-08-12 Woerwag R&D Gmbh Sustained release composition containing quetiapine
WO2010100623A1 (en) 2009-03-04 2010-09-10 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate
WO2011121602A1 (en) 2010-03-29 2011-10-06 Hikal Limited Process for preparation of dibenzothiazepinone compounds
TR201008261A1 (tr) 2010-10-08 2012-04-24 Sanovel İlaç San. Ve Ti̇c. A.Ş. Kontrollü salım gerçekleştiren ketiapin formülasyonları
EP2848244A1 (de) 2013-09-16 2015-03-18 Yildiz Özsoy Erginer Tablettenformulierungen mit verzögerter Freisetzung aus Quetiapin
CN103524455A (zh) * 2013-10-30 2014-01-22 苏州敬业医药化工有限公司 一种制备2-氯-二苯并[b,f][1,4]硫氮杂卓-11-[10H]酮的方法
CN104447615A (zh) * 2014-02-28 2015-03-25 广东东阳光药业有限公司 喹硫平中间体的制备方法
CN104016945B (zh) * 2014-05-27 2016-06-29 渭南畅通药化科技有限公司 一种半富马酸喹硫平的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792426A (fr) * 1971-12-09 1973-06-07 Wander Ag Dr A Nouveaux derives de la dibenzo(b,f)(1,4)thiazepine, leur preparation etleur application comme medicaments
JPS60155171A (ja) * 1983-12-10 1985-08-15 Wako Pure Chem Ind Ltd ポリメトキシベンジルピペラジン誘導体
GB8607684D0 (en) * 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds

Also Published As

Publication number Publication date
JPH0688991B2 (ja) 1994-11-09
HU202231B (en) 1991-02-28
IL85564A (en) 1992-05-25
PT86934B (pt) 1992-05-29
GR3003324T3 (en) 1993-02-17
AR245707A1 (es) 1994-02-28
ATE70271T1 (de) 1991-12-15
IE880507L (en) 1988-09-10
KR960007088B1 (ko) 1996-05-27
IE61122B1 (en) 1994-10-05
PH25529A (en) 1991-07-24
GB8804063D0 (en) 1988-03-23
DK113088A (da) 1988-09-11
EP0282236A1 (de) 1988-09-14
FI87778B (fi) 1992-11-13
NO174421C (no) 1994-05-04
FI87778C (fi) 1993-02-25
NO881044D0 (no) 1988-03-09
FI881087A (fi) 1988-09-11
KR880011151A (ko) 1988-10-26
PT86934A (pt) 1988-04-01
ZW2188A1 (en) 1989-10-04
IL85564A0 (en) 1988-08-31
GB8705574D0 (en) 1987-04-15
NZ223813A (en) 1990-11-27
HUT50336A (en) 1990-01-29
FI881087A0 (fi) 1988-03-09
NO881044L (no) 1988-09-12
JPS63243081A (ja) 1988-10-07
AU1237888A (en) 1988-09-08
ES2037822T3 (es) 1993-07-01
AU595099B2 (en) 1990-03-22
DD271703A5 (de) 1989-09-13
DK113088D0 (da) 1988-03-02
DK175310B1 (da) 2004-08-16
EP0282236B1 (de) 1991-12-11
ZA881350B (en) 1988-12-28
MW388A1 (en) 1988-10-12
MY103221A (en) 1993-05-29
CA1337345C (en) 1995-10-17
NO174421B (no) 1994-01-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ZENECA LTD., LONDON, GB

8327 Change in the person/name/address of the patent owner

Owner name: ASTRAZENECA UK LTD., LONDON, GB