DE3768074D1 - Verfahren zur kontrollierten herstellung von glykosaminoglykanen mit niedrigem molekulargewicht. - Google Patents

Verfahren zur kontrollierten herstellung von glykosaminoglykanen mit niedrigem molekulargewicht.

Info

Publication number
DE3768074D1
DE3768074D1 DE8787116862T DE3768074T DE3768074D1 DE 3768074 D1 DE3768074 D1 DE 3768074D1 DE 8787116862 T DE8787116862 T DE 8787116862T DE 3768074 T DE3768074 T DE 3768074T DE 3768074 D1 DE3768074 D1 DE 3768074D1
Authority
DE
Germany
Prior art keywords
molecular weight
glucosaminoglycans
low molecular
controlled production
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787116862T
Other languages
English (en)
Inventor
Gianni Ferrari
Walter Recchia
Ambrosi Luigi De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mediolanum Farmaceutici SpA
Original Assignee
Laboratori Derivati Organici SpA
Mediolanum Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratori Derivati Organici SpA, Mediolanum Farmaceutici SpA filed Critical Laboratori Derivati Organici SpA
Application granted granted Critical
Publication of DE3768074D1 publication Critical patent/DE3768074D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/081—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing particle radiation or gamma-radiation
    • B01J19/082—Gamma-radiation only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
DE8787116862T 1986-11-24 1987-11-16 Verfahren zur kontrollierten herstellung von glykosaminoglykanen mit niedrigem molekulargewicht. Expired - Fee Related DE3768074D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8622434A IT1213384B (it) 1986-11-24 1986-11-24 Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.

Publications (1)

Publication Number Publication Date
DE3768074D1 true DE3768074D1 (de) 1991-03-28

Family

ID=11196265

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787116862T Expired - Fee Related DE3768074D1 (de) 1986-11-24 1987-11-16 Verfahren zur kontrollierten herstellung von glykosaminoglykanen mit niedrigem molekulargewicht.

Country Status (15)

Country Link
US (1) US4987222A (de)
EP (1) EP0269937B1 (de)
JP (1) JPS63213502A (de)
KR (1) KR880005936A (de)
AT (1) ATE60924T1 (de)
AU (1) AU603622B2 (de)
CA (1) CA1305134C (de)
DE (1) DE3768074D1 (de)
DK (1) DK602387A (de)
ES (1) ES2020993B3 (de)
FI (1) FI88045C (de)
GR (1) GR3001670T3 (de)
IT (1) IT1213384B (de)
NO (1) NO874777L (de)
PT (1) PT86191B (de)

Families Citing this family (36)

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Publication number Priority date Publication date Assignee Title
JPH0748559B2 (ja) * 1988-11-30 1995-05-24 シャープ株式会社 半導体装置
EP0421508B1 (de) * 1989-10-04 1993-12-15 Akzo Nobel N.V. Sulfatierte Glykosaminoglykuronane mit antithrombotischer Wirkung.
IT1240615B (it) * 1990-04-03 1993-12-17 Mediolanum Farmaceutici Spa Impiego del dermatan solfato nella prevenzione e terapia dell'invecchiamento cerebrale e degli stati di deficit funzionale del sistema nervoso centrale
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5230832A (en) * 1991-01-24 1993-07-27 Brandeis University Galactomannan-agarose binary gel for nucleic acid electrophoresis
IT1256236B (it) * 1992-12-23 1995-11-29 Mediolanum Farmaceutici Srl Oligosaccaridi aventi attivita' biologica e procedimento per la loro preparazione di glicosaminoglicani
FR2718025B1 (fr) * 1994-03-30 1996-06-21 Paris Val Marne Universite Médicament et composition pharmaceutique pour le traitement des lésions du système nerveux.
US5585361A (en) * 1994-06-07 1996-12-17 Genzyme Corporation Methods for the inhibition of platelet adherence and aggregation
EP0795560B1 (de) * 1994-12-01 2003-12-10 Seikagaku Corporation Keratansulfatoligosaccharid-fraktion und sie enthaltendes medikament
DE19646901A1 (de) * 1996-11-13 1998-05-14 Helmut Prof Dr Heusinger Verfahren zum Herstellen von Abbauprodukten polymerer Glycosaminoglycane mittels Ultraschall
DE29900874U1 (de) 1999-01-20 1999-07-22 Knoll AG, 67061 Ludwigshafen Organprotektive Lösungen
DE19920688A1 (de) * 1999-05-05 2000-11-23 Manfred Kuhn Radiolytisch modifizierte Heteropolysaccharide
IT1312107B1 (it) * 1999-05-14 2002-04-04 Umberto Cornelli Glicosaminoglicani aventi peso molecolare medio di 2400 d atti altrattamento della demenza senile
AU1502700A (en) * 1999-11-30 2001-06-12 Dalian Yaweite Biology Engineering Co., Ltd. The alginate having low molecular weight, methods of manufacturing it and its use
US6383344B1 (en) * 2000-07-19 2002-05-07 Genzyme Corporation Molecular weight reduction of polymer using irradiation treatment
US6969705B2 (en) * 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US6610810B2 (en) 2001-03-13 2003-08-26 Glyn Owen Phillips Biopolymers obtained by solid state irradiation in an unsaturated gaseous atmosphere
US7618652B2 (en) * 2001-03-23 2009-11-17 Hepmarin As Glycosaminoglycan anticoagulants derived from fish
EP1344781A1 (de) * 2002-03-12 2003-09-17 Laboratori Derivati Organici S.P.A. Verfahren zur Depolymerisierung von Glykosaminoglykanen und so hergestellte Produkte
ITMI20021372A1 (it) * 2002-06-21 2003-12-22 Derivati Organici Lab Processo per la depolimerizzazione fisica dei glicosamminogliacani e prodotti da esso ottenuti
US20040171819A1 (en) * 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
EP1440683A1 (de) * 2003-01-23 2004-07-28 Cognis France S.A. Verwendung von Oligoglucosaminen in kosmetischen oder dermatologischen Zubereitungen
US20040161476A1 (en) * 2003-02-19 2004-08-19 Hahn Sungtack Samuel Cystitis treatment with high dose chondroitin sulfate
US7956046B2 (en) * 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
EP1524276A1 (de) * 2003-10-16 2005-04-20 Laboratori Derivati Organici S.P.A. Mehrstufenverfahren für die physikalisische Depolymerisation von Heparin und die so erhaltenen Produkte
US20050154196A1 (en) * 2004-01-13 2005-07-14 Seikagaku Corporation Process for producing sugar in which molecular weight is lowered
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
US7939512B2 (en) 2004-10-13 2011-05-10 Laboratori Derivati Organici Spa Multistep process for the physical depolymerization of heparin and products obtained therefrom
AU2009250803A1 (en) * 2008-05-20 2009-11-26 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
RU2014137454A (ru) * 2012-02-17 2016-04-10 Кимфлексор, С.Л. Серебряные и золотые соли частично деполимеризованного гликозаминогликана
CN104884475B (zh) * 2012-12-28 2017-11-07 杜邦营养生物科学有限公司 藻酸的解聚
WO2020121179A1 (en) * 2018-12-11 2020-06-18 Universita' Degli Studi Di Salerno Composition for the treatment of skin lesions
KR102240239B1 (ko) * 2019-04-23 2021-04-14 (주)티엠비 저분자량 히알루론산의 제조방법 및 이로부터 제조된 저분자량 히알루론산
EP3997238A1 (de) 2019-07-09 2022-05-18 Optimvia, LLC Verfahren zur synthese von antikoagulierenden polysacchariden
CN111040047A (zh) * 2019-12-11 2020-04-21 东营天东制药有限公司 一种酶-超滤法精制低分子硫酸皮肤素的工艺、应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE136572C (de) * 1902-12-05
US3453194A (en) * 1966-08-03 1969-07-01 Dow Corning Anticoagulant surfaces produced by radiation grafting heparin to a silicone substrate
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
IT1075117B (it) * 1977-02-14 1985-04-22 Fedeli Gianfranco Complesso polisaccaridico arterioso,processo per la sua preparazione e suo impiego in terapia umana
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity
FR2495935A1 (fr) * 1980-12-15 1982-06-18 Choay Sa Fractions mucopolysaccharidiques possedant des proprietes biologiques, leur procede de preparation et leur application en tant que medicaments
EP0066908B1 (de) * 1981-05-21 1985-08-28 Akzo N.V. Antithrombotikum auf Basis von Polysacchariden, Verfahren zur dessen Herstellung und medizinale Zusammensetzungen
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DK196986D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
US4788307A (en) * 1986-04-30 1988-11-29 Choay S.A. Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity

Also Published As

Publication number Publication date
ATE60924T1 (de) 1991-03-15
EP0269937B1 (de) 1991-02-20
FI88045B (fi) 1992-12-15
NO874777L (no) 1988-05-25
GR3001670T3 (en) 1992-11-23
FI88045C (fi) 1993-03-25
AU603622B2 (en) 1990-11-22
AU8160987A (en) 1988-05-26
IT1213384B (it) 1989-12-20
PT86191B (pt) 1990-11-07
JPS63213502A (ja) 1988-09-06
FI875185A0 (fi) 1987-11-24
FI875185A (fi) 1988-05-25
ES2020993B3 (es) 1991-10-16
PT86191A (en) 1987-12-01
NO874777D0 (no) 1987-11-16
EP0269937A3 (en) 1989-03-08
EP0269937A2 (de) 1988-06-08
CA1305134C (en) 1992-07-14
US4987222A (en) 1991-01-22
JPH0588881B2 (de) 1993-12-24
DK602387D0 (da) 1987-11-17
DK602387A (da) 1988-09-15
KR880005936A (ko) 1988-07-21
IT8622434A0 (it) 1986-11-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MEDIOLANUM FARMACEUTICI S.P.A. LABORATORI DERIVATI

8339 Ceased/non-payment of the annual fee