DE3586075D1 - Verfahren zur bestimmung von endotoxin. - Google Patents
Verfahren zur bestimmung von endotoxin.Info
- Publication number
- DE3586075D1 DE3586075D1 DE8585107877T DE3586075T DE3586075D1 DE 3586075 D1 DE3586075 D1 DE 3586075D1 DE 8585107877 T DE8585107877 T DE 8585107877T DE 3586075 T DE3586075 T DE 3586075T DE 3586075 D1 DE3586075 D1 DE 3586075D1
- Authority
- DE
- Germany
- Prior art keywords
- time
- gelation
- light amount
- transmitted light
- gelation point
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
- G01N21/83—Turbidimetric titration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/04—Batch operation; multisample devices
- G01N2201/0407—Batch operation; multisample devices with multiple optical units, e.g. one per sample
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13244584A JPS6111641A (ja) | 1984-06-27 | 1984-06-27 | エンドトキシンの測定方法および装置 |
JP28161684A JPS61159162A (ja) | 1984-12-28 | 1984-12-28 | エンドトキシンの測定方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3586075D1 true DE3586075D1 (de) | 1992-06-25 |
Family
ID=26467021
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE89114580T Expired - Fee Related DE3587510T2 (de) | 1984-06-27 | 1985-06-25 | Gerät zur Messung von Endotoxin. |
DE8585107877T Expired - Lifetime DE3586075D1 (de) | 1984-06-27 | 1985-06-25 | Verfahren zur bestimmung von endotoxin. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE89114580T Expired - Fee Related DE3587510T2 (de) | 1984-06-27 | 1985-06-25 | Gerät zur Messung von Endotoxin. |
Country Status (4)
Country | Link |
---|---|
US (1) | US4740460A (de) |
EP (2) | EP0347951B1 (de) |
AT (2) | ATE76507T1 (de) |
DE (2) | DE3587510T2 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4936682A (en) * | 1987-08-11 | 1990-06-26 | Associates Of Cape Cod, Inc. | Instrument for independently and kinetically measuring light transpassion through a plurality of samples |
JPH0715474B2 (ja) * | 1988-02-27 | 1995-02-22 | 和光純薬工業株式会社 | エンドトキシンの測定法 |
EP0350273B1 (de) * | 1988-07-05 | 1994-07-13 | Wako Pure Chemical Industries Ltd | Verfahren zur Bestimmung von Endotoxinen |
US5342785A (en) * | 1988-07-05 | 1994-08-30 | Tanabe Seiyaku Co., Ltd. | Method for determining pyrogen content |
US5306641A (en) * | 1990-07-27 | 1994-04-26 | Saccocio Edward J | Apparatus and method for determining gel rate of polymerizable compositions |
US5167145B1 (en) * | 1990-09-19 | 2000-05-23 | David M Butler | Measurement of blood coagulation time using infrared electromagnetic energy |
US5526111A (en) * | 1993-08-31 | 1996-06-11 | Boehringer Mannheim Corporation | Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control |
US5522255A (en) * | 1993-08-31 | 1996-06-04 | Boehringer Mannheim Corporation | Fluid dose, flow and coagulation sensor for medical instrument |
JP3061418B2 (ja) * | 1993-11-22 | 2000-07-10 | 生化学工業株式会社 | リムルス試薬反応性物質の測定方法 |
US5637474A (en) * | 1994-10-31 | 1997-06-10 | Wako Pure Chemical Industries, Ltd. | Process for measuring amount of endotoxin or (1→3)-β-D-glucan by kinetic turbidimetric method |
US6118541A (en) * | 1998-04-13 | 2000-09-12 | Dade Behring Inc. | Method to determine the effectiveness of a chemical mixing system |
CN1296714C (zh) * | 2003-04-09 | 2007-01-24 | 中国科学院大连化学物理研究所 | 测定鲎试剂灵敏度的方法 |
JP2007510911A (ja) * | 2003-11-07 | 2007-04-26 | キャンブレックス・バイオ・サイエンス・ウォーカーズヴィル・インコーポレーテッド | 内毒素レベルを測定するオンライン装置および方法 |
CN100383528C (zh) * | 2004-07-02 | 2008-04-23 | 中国科学院大连化学物理研究所 | 一种通过测定浊度值来进行细菌内毒素检查的方法 |
EP2141483A4 (de) * | 2007-04-20 | 2013-11-13 | Wako Pure Chem Ind Ltd | Glasküvette-fläschchen zur untersuchung einer geringen probenmenge |
US20100129260A1 (en) * | 2007-05-01 | 2010-05-27 | Yoshiaki Shirasawa | Gelation measuring apparatus and sample cell |
JP5188311B2 (ja) | 2008-07-30 | 2013-04-24 | 興和株式会社 | 生物由来の生理活性物質の測定方法及び測定装置 |
KR20120001755A (ko) * | 2009-03-13 | 2012-01-04 | 코와 가부시키가이샤 | 생물 유래의 생리 활성 물질의 측정 방법, 그것을 실행하기 위한 프로그램, 및 생물 유래의 생리 활성 물질의 측정 장치 |
CA2843219C (en) * | 2011-09-01 | 2018-02-20 | Fresenius Medical Care Holdings, Inc. | Kit for sampling and detection of endotoxin in aqueous solution |
CN104215745A (zh) * | 2014-09-21 | 2014-12-17 | 四川制药制剂有限公司 | 注射用盐酸头孢替安中细菌内毒素含量的测定方法 |
US11892397B2 (en) * | 2017-10-17 | 2024-02-06 | Board Of Regents, The University Of Texas System | Endotoxin testing assay and method of same |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3458287A (en) * | 1965-04-29 | 1969-07-29 | Medical Laboratory Automation | Method and means of determining endpoint times in blood clotting tests |
US4038029A (en) * | 1976-01-20 | 1977-07-26 | Worthington Biochemical Corporation | Limulus lysate turbidity test for pyrogens |
FR2344841A1 (fr) * | 1976-03-16 | 1977-10-14 | Ucc Union Chimique Cont | Correcteur electronique du temps de coagulation du sang |
US4268171A (en) * | 1977-07-18 | 1981-05-19 | Beckman Instruments, Inc. | Method determining concentration in rate nephelometric immunochemical analysis |
JPS54108693A (en) * | 1978-02-14 | 1979-08-25 | Mitsubishi Chem Ind | Method and device for optically measuring antigennantibody reaction |
US4205954A (en) * | 1978-05-26 | 1980-06-03 | Warner-Lambert Company | Kinetic latex agglutinometry |
IT1105662B (it) * | 1978-09-07 | 1985-11-04 | Salus Istituto Diagnostico Di | Apparecchiatura per studiare e fenomeni della emocoagulazione e dell'aggregazione delle piastrine |
DE3005923A1 (de) * | 1980-02-16 | 1981-09-03 | Compur-Electronic GmbH, 8000 München | Photometrisches verfahren und photometrische vorrichtung zur bestimmung von reaktionsablaeufen |
IT1208062B (it) * | 1981-03-23 | 1989-06-06 | Croce F Dr Salus Ricerca | Dei fenomeni di emocoagulazione, dispositivo di rivelazione ottica concentrazione, ed aggregazione delle piastrine o simili. |
JPS589050A (ja) * | 1981-07-10 | 1983-01-19 | Japan Organo Co Ltd | エンドトキシン含有量の測定方法および装置 |
EP0083617A1 (de) * | 1981-07-11 | 1983-07-20 | JOCHIMSEN, Siegfried | Blutgerinnungszeitmessgerät und verfahren zum erfassen und messen der blutgerinnungszeit |
JPS58135459A (ja) * | 1982-02-05 | 1983-08-12 | Dai Ichi Seiyaku Co Ltd | エンドトキシンの定量法 |
US4454752A (en) * | 1982-06-21 | 1984-06-19 | Medical Laboratory Automation, Inc. | Test circuit for use in coagulation instrument |
JPS5942451A (ja) * | 1982-09-01 | 1984-03-09 | Japan Organo Co Ltd | エンドトキシンの定量分析法 |
-
1985
- 1985-06-25 DE DE89114580T patent/DE3587510T2/de not_active Expired - Fee Related
- 1985-06-25 AT AT85107877T patent/ATE76507T1/de not_active IP Right Cessation
- 1985-06-25 AT AT89114580T patent/ATE92630T1/de not_active IP Right Cessation
- 1985-06-25 DE DE8585107877T patent/DE3586075D1/de not_active Expired - Lifetime
- 1985-06-25 EP EP89114580A patent/EP0347951B1/de not_active Expired - Lifetime
- 1985-06-25 EP EP85107877A patent/EP0173021B1/de not_active Expired
- 1985-06-26 US US06/748,805 patent/US4740460A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE76507T1 (de) | 1992-06-15 |
EP0173021B1 (de) | 1992-05-20 |
ATE92630T1 (de) | 1993-08-15 |
EP0347951A3 (en) | 1990-06-06 |
EP0173021A3 (en) | 1986-10-08 |
DE3587510D1 (de) | 1993-09-09 |
US4740460A (en) | 1988-04-26 |
EP0347951A2 (de) | 1989-12-27 |
EP0173021A2 (de) | 1986-03-05 |
EP0347951B1 (de) | 1993-08-04 |
DE3587510T2 (de) | 1994-03-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |