DE3571928D1 - Conjugates associated with a covalent bond to a monovalent carboxylic ionophore and a macromolecule, their use as potentializers of immunotoxines and the activated intermediate ionophores - Google Patents

Conjugates associated with a covalent bond to a monovalent carboxylic ionophore and a macromolecule, their use as potentializers of immunotoxines and the activated intermediate ionophores

Info

Publication number
DE3571928D1
DE3571928D1 DE8585400998T DE3571928T DE3571928D1 DE 3571928 D1 DE3571928 D1 DE 3571928D1 DE 8585400998 T DE8585400998 T DE 8585400998T DE 3571928 T DE3571928 T DE 3571928T DE 3571928 D1 DE3571928 D1 DE 3571928D1
Authority
DE
Germany
Prior art keywords
potentializers
immunotoxines
ionophores
macromolecule
covalent bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585400998T
Other languages
English (en)
Inventor
Franz K Jansen
Pierre Gros
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8408073A external-priority patent/FR2564839B1/fr
Priority claimed from FR8411208A external-priority patent/FR2567521B1/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of DE3571928D1 publication Critical patent/DE3571928D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE8585400998T 1984-05-23 1985-05-21 Conjugates associated with a covalent bond to a monovalent carboxylic ionophore and a macromolecule, their use as potentializers of immunotoxines and the activated intermediate ionophores Expired DE3571928D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8408073A FR2564839B1 (fr) 1984-05-23 1984-05-23 Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines
FR8411208A FR2567521B1 (fr) 1984-07-13 1984-07-13 Nouveaux ionophores actives

Publications (1)

Publication Number Publication Date
DE3571928D1 true DE3571928D1 (en) 1989-09-07

Family

ID=26223983

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585400998T Expired DE3571928D1 (en) 1984-05-23 1985-05-21 Conjugates associated with a covalent bond to a monovalent carboxylic ionophore and a macromolecule, their use as potentializers of immunotoxines and the activated intermediate ionophores

Country Status (12)

Country Link
US (3) US4919928A (de)
EP (1) EP0162781B1 (de)
AU (1) AU600651B2 (de)
CA (1) CA1314245C (de)
DE (1) DE3571928D1 (de)
DK (1) DK164457C (de)
ES (1) ES8604228A1 (de)
GR (1) GR851229B (de)
IE (1) IE58480B1 (de)
IL (1) IL75228A (de)
NZ (1) NZ212118A (de)
PT (1) PT80501B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1314245C (en) * 1984-05-23 1993-03-09 Franz Jansen Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators
ES2059464T3 (es) * 1987-10-30 1994-11-16 American Cyanamid Co Formas especificamente dirigidas de agentes antitumorales de metiltritio.
US5219564A (en) * 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
US5612034A (en) * 1990-10-03 1997-03-18 Redcell, Inc. Super-globuling for in vivo extended lifetimes
KR100710461B1 (ko) * 2005-10-12 2007-04-24 (주)씨에스이 소음기를 구비한 진공포장장치
CN110167577B (zh) * 2016-11-16 2024-05-10 普渡研究基金会 配体离子载体共轭物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3832358A (en) * 1973-01-15 1974-08-27 Lilly Co Eli Deshydroxymethyl derivatives of monensin
FR2437213A1 (fr) * 1978-09-28 1980-04-25 Cm Ind Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation
US4431665A (en) * 1979-08-13 1984-02-14 Syntex (U.S.A.) Inc. Acylated laidlomycin derivatives
FR2463144A1 (fr) * 1979-08-13 1981-02-20 Syntex Inc Nouveaux diesters de laidlomycine, leur procede de production, compositions a usage veterinaire les contenant et leur utilisation pour accroitre le rendement d'assimilation des aliments chez un ruminant
JPS57106626A (en) * 1980-12-22 1982-07-02 Teijin Ltd Cytotoxic protein complex and its preparation
FR2498192A2 (fr) * 1981-01-22 1982-07-23 Pasteur Institut Nouveau compose polypeptidique thiole provenant d'un fragment de la toxine tetanique, son procede d'obtention et ses applications
FR2516794B1 (fr) * 1981-11-20 1985-10-25 Sanofi Sa Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique
FR2521010B1 (fr) * 1982-02-09 1985-07-19 Sanofi Sa Medicaments comportant en tant qu'association au moins une immunotoxine et au moins un ionophore carboxylique monovalent
FR2522968B1 (fr) * 1982-03-10 1986-03-28 Sanofi Sa Medicament cytotoxique forme de l'association d'a u moins une immunotoxine et de la chloroquine
JPS59116232A (ja) * 1982-12-24 1984-07-05 Teijin Ltd 細胞毒性複合体及びその製造法
JPS59116229A (ja) * 1982-12-24 1984-07-05 Teijin Ltd 細胞毒性複合体を活性成分とする癌治療用剤およびその製造法
CA1214774A (en) * 1983-02-10 1986-12-02 Yusei Shiraga Benzodiazepine derivative
US4542027A (en) * 1984-02-23 1985-09-17 Syntex (U.S.A.) Inc. Laidlomycin phenylcarbamate
CA1314245C (en) * 1984-05-23 1993-03-09 Franz Jansen Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators

Also Published As

Publication number Publication date
ES8604228A1 (es) 1986-01-16
ES543367A0 (es) 1986-01-16
IE58480B1 (en) 1993-09-22
EP0162781B1 (de) 1989-08-02
DK164457B (da) 1992-06-29
GR851229B (de) 1985-11-25
IL75228A (en) 1990-06-10
EP0162781A1 (de) 1985-11-27
DK164457C (da) 1992-11-16
IE851279L (en) 1985-11-23
IL75228A0 (en) 1985-09-29
US4919928A (en) 1990-04-24
DK224785D0 (da) 1985-05-21
PT80501A (fr) 1985-06-01
PT80501B (fr) 1986-12-16
AU4279385A (en) 1985-11-28
NZ212118A (en) 1990-11-27
US5144009A (en) 1992-09-01
AU600651B2 (en) 1990-08-23
US4977280A (en) 1990-12-11
DK224785A (da) 1985-11-24
CA1314245C (en) 1993-03-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee