DE3466220D1 - Process for debromination of dibromopenicillanic acid and derivatives - Google Patents

Process for debromination of dibromopenicillanic acid and derivatives

Info

Publication number
DE3466220D1
DE3466220D1 DE8484303735T DE3466220T DE3466220D1 DE 3466220 D1 DE3466220 D1 DE 3466220D1 DE 8484303735 T DE8484303735 T DE 8484303735T DE 3466220 T DE3466220 T DE 3466220T DE 3466220 D1 DE3466220 D1 DE 3466220D1
Authority
DE
Germany
Prior art keywords
debromination
derivatives
beta
dibromopenicillanic acid
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484303735T
Other languages
English (en)
Inventor
Donald Klein Pirie
Paul Douglas Weeks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE3466220D1 publication Critical patent/DE3466220D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE8484303735T 1983-06-06 1984-06-04 Process for debromination of dibromopenicillanic acid and derivatives Expired DE3466220D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/501,731 US4468351A (en) 1983-06-06 1983-06-06 Process for debromination of dibromopenicillanic acid and derivatives

Publications (1)

Publication Number Publication Date
DE3466220D1 true DE3466220D1 (en) 1987-10-22

Family

ID=23994800

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484303735T Expired DE3466220D1 (en) 1983-06-06 1984-06-04 Process for debromination of dibromopenicillanic acid and derivatives

Country Status (22)

Country Link
US (1) US4468351A (de)
EP (1) EP0129360B1 (de)
JP (1) JPS608293A (de)
KR (1) KR870000324B1 (de)
AT (1) ATE29722T1 (de)
AU (1) AU551236B2 (de)
CA (1) CA1210388A (de)
DE (1) DE3466220D1 (de)
DK (1) DK275684A (de)
ES (1) ES8602807A1 (de)
FI (1) FI82938C (de)
GR (1) GR81625B (de)
HU (1) HU193931B (de)
IE (1) IE57561B1 (de)
IL (1) IL72004A (de)
NO (1) NO162722C (de)
NZ (1) NZ208379A (de)
PH (1) PH20990A (de)
PL (1) PL143370B1 (de)
PT (1) PT78691A (de)
YU (1) YU44872B (de)
ZA (1) ZA844185B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588527A (en) * 1983-06-06 1986-05-13 Pfizer Inc. Process for preparing penicillanic acid 1,1-dioxide derivatives
EP0139048A1 (de) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Verfahren zur Dehalogenierung von 6,6-Dibromopenicillansäure-1,1-Dioxyd
US4596677A (en) * 1984-04-06 1986-06-24 Bristol-Myers Company Anhydropenicillin intermediates
US4816580A (en) * 1986-04-10 1989-03-28 Leo Pharmaceutical Products Ltd. A/S Improved method for preparing penicillanic acid derivatives
US4885370A (en) * 1987-03-11 1989-12-05 Pfizer Inc. Synthetic method for indol-2(3H)-ones
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
GB2343676A (en) 1998-11-12 2000-05-17 Merck & Co Inc Selective mono-debromination of polybromoalkyl aryl ketones
CA2537406C (en) * 2003-09-03 2010-09-14 Otsuka Chemical Co., Ltd. Process for producing penicillanic acid compound
CN102702228A (zh) * 2012-06-26 2012-10-03 齐鲁天和惠世制药有限公司 一种舒巴坦制备方法
CN104910184B (zh) * 2015-04-27 2017-03-29 齐鲁天和惠世制药有限公司 一种6,6‑二溴青霉烷酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180506A (en) * 1978-01-18 1979-12-25 Rex Pratt 6β-Bromo penicillanic acid
DE3068390D1 (en) * 1979-01-10 1984-08-09 Beecham Group Plc Penicillin derivatives, process for their preparation and pharmaceutical compositions containing certain of these compounds
US4420426A (en) * 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
GB2051046B (en) * 1979-05-21 1984-03-28 Leo Pharm Prod Ltd Penicillanic acid derivatives
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4427678A (en) * 1982-01-11 1984-01-24 Pfizer Inc. 6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-lactamase inhibitors
PT76527B (en) * 1982-04-19 1985-12-09 Gist Brocades Nv A process for the preparation of penicillanic acid 1,1-dioxide and derivatives thereof

Also Published As

Publication number Publication date
ATE29722T1 (de) 1987-10-15
IL72004A (en) 1988-07-31
PH20990A (en) 1987-06-18
PL248046A1 (en) 1985-10-22
ES533149A0 (es) 1985-12-01
NO162722C (no) 1990-02-07
US4468351A (en) 1984-08-28
NZ208379A (en) 1987-05-29
AU551236B2 (en) 1986-04-24
PT78691A (en) 1984-07-01
GR81625B (de) 1984-12-11
EP0129360B1 (de) 1987-09-16
ZA844185B (en) 1986-01-29
NO162722B (no) 1989-10-30
IE841392L (en) 1984-12-06
CA1210388A (en) 1986-08-26
FI82938B (fi) 1991-01-31
PL143370B1 (en) 1988-02-29
FI82938C (fi) 1991-05-10
ES8602807A1 (es) 1985-12-01
JPS608293A (ja) 1985-01-17
FI842253A (fi) 1984-12-07
DK275684D0 (da) 1984-06-04
IL72004A0 (en) 1984-10-31
IE57561B1 (en) 1992-12-16
HUT34204A (en) 1985-02-28
KR850000452A (ko) 1985-02-27
JPH0342277B2 (de) 1991-06-26
FI842253A0 (fi) 1984-06-05
AU2907984A (en) 1984-12-13
KR870000324B1 (ko) 1987-02-27
YU97284A (en) 1986-10-31
EP0129360A1 (de) 1984-12-27
DK275684A (da) 1984-12-07
NO842250L (no) 1984-12-07
YU44872B (en) 1991-04-30
HU193931B (en) 1987-12-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee