DE3144236C2 - Verwendung von "aktivem" Chondroitinsulfat A und C zur Verbesserung der Aufnahme von Transplantaten, Implantaten oder chirurgischen Instrumenten durch den menschlichen Körper - Google Patents

Verwendung von "aktivem" Chondroitinsulfat A und C zur Verbesserung der Aufnahme von Transplantaten, Implantaten oder chirurgischen Instrumenten durch den menschlichen Körper

Info

Publication number: DE3144236C2
Authority: DE; Germany
Prior art keywords: chondroitin sulfate; active; implants; transplants; human body
Prior art date: 1981-05-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

DE3144236A

Other languages

German (de)

English (en)

Other versions

DE3144236A1 (de

Inventor

Lester M. Dr.med. Los Angeles Calif. Morrison

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Biomed Research Inc

Original Assignee

Biomed Research Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-05-14

Filing date

1981-11-06

Publication date

1987-04-30

1981-11-06 Application filed by Biomed Research Inc filed Critical Biomed Research Inc

1982-11-25 Publication of DE3144236A1 publication Critical patent/DE3144236A1/de

1987-04-30 Application granted granted Critical

1987-04-30 Publication of DE3144236C2 publication Critical patent/DE3144236C2/de

Status Expired legal-status Critical Current

Links

239000007943 implant Substances 0.000 title claims abstract description 21
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 title claims abstract description 16
229920001287 Chondroitin sulfate Polymers 0.000 title claims abstract description 16
229940059329 chondroitin sulfate Drugs 0.000 title claims abstract description 16
238000010521 absorption reaction Methods 0.000 title abstract description 3
239000000203 mixture Substances 0.000 claims abstract description 12
KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 claims abstract description 10
239000000126 substance Substances 0.000 claims abstract description 7
239000007864 aqueous solution Substances 0.000 claims description 3
239000002674 ointment Substances 0.000 claims description 3
239000000969 carrier Substances 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
210000001519 tissue Anatomy 0.000 description 21
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
239000003795 chemical substances by application Substances 0.000 description 12
239000000243 solution Substances 0.000 description 12
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 10
239000002244 precipitate Substances 0.000 description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 description 8
238000002054 transplantation Methods 0.000 description 8
238000002513 implantation Methods 0.000 description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
230000006378 damage Effects 0.000 description 6
238000000034 method Methods 0.000 description 6
239000011248 coating agent Substances 0.000 description 5
238000000576 coating method Methods 0.000 description 5
229940079593 drug Drugs 0.000 description 5
239000003814 drug Substances 0.000 description 5
239000007788 liquid Substances 0.000 description 5
239000000463 material Substances 0.000 description 5
210000000056 organ Anatomy 0.000 description 5
238000003756 stirring Methods 0.000 description 5
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
238000005119 centrifugation Methods 0.000 description 4
239000008367 deionised water Substances 0.000 description 4
229910021641 deionized water Inorganic materials 0.000 description 4
241000283690 Bos taurus Species 0.000 description 3
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
229960000583 acetic acid Drugs 0.000 description 3
210000000845 cartilage Anatomy 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
239000012362 glacial acetic acid Substances 0.000 description 3
210000002216 heart Anatomy 0.000 description 3
210000003709 heart valve Anatomy 0.000 description 3
210000003734 kidney Anatomy 0.000 description 3
210000004072 lung Anatomy 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
210000003491 skin Anatomy 0.000 description 3
239000007787 solid Substances 0.000 description 3
239000006228 supernatant Substances 0.000 description 3
238000002560 therapeutic procedure Methods 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
241000251730 Chondrichthyes Species 0.000 description 2
241000282412 Homo Species 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
210000000988 bone and bone Anatomy 0.000 description 2
239000004053 dental implant Substances 0.000 description 2
238000011161 development Methods 0.000 description 2
230000018109 developmental process Effects 0.000 description 2
238000000605 extraction Methods 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
238000001914 filtration Methods 0.000 description 2
239000012467 final product Substances 0.000 description 2
210000001624 hip Anatomy 0.000 description 2
210000000987 immune system Anatomy 0.000 description 2
238000007912 intraperitoneal administration Methods 0.000 description 2
230000001050 lubricating effect Effects 0.000 description 2
229940126601 medicinal product Drugs 0.000 description 2
230000000399 orthopedic effect Effects 0.000 description 2
239000012286 potassium permanganate Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
239000002994 raw material Substances 0.000 description 2
239000007858 starting material Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
210000003437 trachea Anatomy 0.000 description 2
239000003981 vehicle Substances 0.000 description 2
206010006803 Burns third degree Diseases 0.000 description 1
208000024172 Cardiovascular disease Diseases 0.000 description 1
206010053567 Coagulopathies Diseases 0.000 description 1
ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
102000003886 Glycoproteins Human genes 0.000 description 1
108090000288 Glycoproteins Proteins 0.000 description 1
229920002683 Glycosaminoglycan Polymers 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
108090000526 Papain Proteins 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
206010060932 Postoperative adhesion Diseases 0.000 description 1
239000004365 Protease Substances 0.000 description 1
206010066902 Surgical failure Diseases 0.000 description 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
206010052779 Transplant rejections Diseases 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
238000012084 abdominal surgery Methods 0.000 description 1
238000013019 agitation Methods 0.000 description 1
239000010775 animal oil Substances 0.000 description 1
238000013459 approach Methods 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000017531 blood circulation Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000000872 buffer Substances 0.000 description 1
VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
239000001639 calcium acetate Substances 0.000 description 1
229960005147 calcium acetate Drugs 0.000 description 1
235000011092 calcium acetate Nutrition 0.000 description 1
229960001927 cetylpyridinium chloride Drugs 0.000 description 1
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
230000035602 clotting Effects 0.000 description 1
239000012050 conventional carrier Substances 0.000 description 1
210000004087 cornea Anatomy 0.000 description 1
238000010908 decantation Methods 0.000 description 1
238000004042 decolorization Methods 0.000 description 1
230000007560 devascularization Effects 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000006196 drop Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
239000003248 enzyme activator Substances 0.000 description 1
239000003889 eye drop Substances 0.000 description 1
229940012356 eye drops Drugs 0.000 description 1
239000003925 fat Substances 0.000 description 1
238000005189 flocculation Methods 0.000 description 1
230000016615 flocculation Effects 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
230000035876 healing Effects 0.000 description 1
210000004394 hip joint Anatomy 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
230000016788 immune system process Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000002329 infrared spectrum Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
208000014674 injury Diseases 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
210000003127 knee Anatomy 0.000 description 1
210000000629 knee joint Anatomy 0.000 description 1
210000002414 leg Anatomy 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
230000011164 ossification Effects 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229940055729 papain Drugs 0.000 description 1
235000019834 papain Nutrition 0.000 description 1
238000004816 paper chromatography Methods 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000009117 preventive therapy Methods 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000008929 regeneration Effects 0.000 description 1
238000011069 regeneration method Methods 0.000 description 1
210000001525 retina Anatomy 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
238000002791 soaking Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
239000008227 sterile water for injection Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
229910052719 titanium Inorganic materials 0.000 description 1
239000010936 titanium Substances 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
230000002792 vascular Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/08—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
Transplantation (AREA)
Medicinal Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dermatology (AREA)
Materials Engineering (AREA)
Hematology (AREA)
Surgery (AREA)
Materials For Medical Uses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Prostheses (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

DE3144236A 1981-05-14 1981-11-06 Verwendung von "aktivem" Chondroitinsulfat A und C zur Verbesserung der Aufnahme von Transplantaten, Implantaten oder chirurgischen Instrumenten durch den menschlichen Körper Expired DE3144236C2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US26378881A	1981-05-14	1981-05-14

Publications (2)

Publication Number	Publication Date
DE3144236A1 DE3144236A1 (de)	1982-11-25
DE3144236C2 true DE3144236C2 (de)	1987-04-30

Family

ID=23003232

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE3144236A Expired DE3144236C2 (de)	1981-05-14	1981-11-06	Verwendung von "aktivem" Chondroitinsulfat A und C zur Verbesserung der Aufnahme von Transplantaten, Implantaten oder chirurgischen Instrumenten durch den menschlichen Körper

Country Status (7)

Country	Link
JP (1)	JPS57188522A (nl)
CA (1)	CA1179264A (nl)
DE (1)	DE3144236C2 (nl)
DK (1)	DK70382A (nl)
FR (1)	FR2505656A1 (nl)
GB (1)	GB2098506B (nl)
SE (1)	SE8107352L (nl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0121008A3 (en) *	1983-03-29	1985-03-27	Marcel E. Nimni	Coating for bioprosthetic device and method of making same
GB2297925B (en) *	1992-04-07	1996-10-16	Wilhelm Env Tech Inc	Flue gas conditioning system
WO1993019852A1 (en) *	1992-04-07	1993-10-14	Wilhelm Environmental Technologies, Inc.	Flue gas conditioning system
CA2351593C (en) *	1998-11-11	2012-02-21	The Board Of Regents Of The University Of Oklahoma	Polymer grafting by polysaccharide synthases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3895106A (en) *	1970-04-15	1975-07-15	Morrison L M	Novel CSA and CSC for use in man and mammals to inhibit atherosclerosis and the recurrence of cardiovascular incidents in atherosclerotic mammals
DE2037942C2 (de) *	1970-04-15	1982-11-18	Biomed Research, Inc., 90048 Los Angeles, Calif.	Arzneimittel enthaltend ein "aktives" Chondroitinsulfat als Wirkstoff zur Verhinderung des Auftretens atherosklerotischer Läsionen und zur Verhinderung des Auftretens von Herzanfällen
JPS5235710A (en) *	1975-09-16	1977-03-18	Ulvac Corp	In-material-heat reflection plate device in heating furnaces
US4302577A (en) *	1979-10-05	1981-11-24	Biomed Research Inc.	Process for preparing CSA or CSC

1981
- 1981-09-10 GB GB8127345A patent/GB2098506B/en not_active Expired
- 1981-10-13 JP JP56162145A patent/JPS57188522A/ja active Pending
- 1981-11-02 CA CA000389215A patent/CA1179264A/en not_active Expired
- 1981-11-06 DE DE3144236A patent/DE3144236C2/de not_active Expired
- 1981-12-08 SE SE8107352A patent/SE8107352L/xx not_active Application Discontinuation
1982
- 1982-02-08 FR FR8201965A patent/FR2505656A1/fr active Pending
- 1982-02-17 DK DK70382A patent/DK70382A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA1179264A (en)	1984-12-11
SE8107352L (sv)	1982-11-15
GB2098506B (en)	1984-10-03
DK70382A (da)	1982-11-15
JPS57188522A (en)	1982-11-19
FR2505656A1 (fr)	1982-11-19
GB2098506A (en)	1982-11-24
DE3144236A1 (de)	1982-11-25

Legal Events

Date	Code	Title
1982-11-25	OP8	Request for examination as to paragraph 44 patent law
1987-04-30	D2	Grant after examination
1987-10-22	8364	No opposition during term of opposition
1988-11-17	8339	Ceased/non-payment of the annual fee

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