DE2748466A1 - 4a-aryloctahydro-1h-2-pyrindine - Google Patents

4a-aryloctahydro-1h-2-pyrindine

Info

Publication number
DE2748466A1
DE2748466A1 DE19772748466 DE2748466A DE2748466A1 DE 2748466 A1 DE2748466 A1 DE 2748466A1 DE 19772748466 DE19772748466 DE 19772748466 DE 2748466 A DE2748466 A DE 2748466A DE 2748466 A1 DE2748466 A1 DE 2748466A1
Authority
DE
Germany
Prior art keywords
group
pyrindine
carbon atoms
formula
octahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19772748466
Other languages
German (de)
English (en)
Inventor
Dennis Michael Zimmerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE2748466A1 publication Critical patent/DE2748466A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DE19772748466 1976-11-02 1977-10-28 4a-aryloctahydro-1h-2-pyrindine Withdrawn DE2748466A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02

Publications (1)

Publication Number Publication Date
DE2748466A1 true DE2748466A1 (de) 1978-05-03

Family

ID=24965981

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772748466 Withdrawn DE2748466A1 (de) 1976-11-02 1977-10-28 4a-aryloctahydro-1h-2-pyrindine

Country Status (26)

Country Link
JP (1) JPS5356669A (fr)
AR (1) AR223454A1 (fr)
AT (1) ATA782177A (fr)
AU (1) AU513679B2 (fr)
BE (1) BE860314A (fr)
CA (1) CA1100136A (fr)
CS (1) CS211380B2 (fr)
DD (1) DD133795A5 (fr)
DE (1) DE2748466A1 (fr)
DK (1) DK485277A (fr)
ES (3) ES463783A1 (fr)
FR (1) FR2369267A1 (fr)
GB (1) GB1590155A (fr)
GR (1) GR70053B (fr)
HU (1) HU176231B (fr)
IE (1) IE45901B1 (fr)
IL (1) IL53236A0 (fr)
NL (1) NL7712053A (fr)
NZ (1) NZ185539A (fr)
PH (1) PH12590A (fr)
PL (3) PL109690B1 (fr)
PT (1) PT67194B (fr)
RO (3) RO78300A (fr)
SE (3) SE7712218L (fr)
SU (3) SU812174A3 (fr)
ZA (1) ZA776497B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020158A1 (fr) * 1994-12-23 1996-07-04 Smithkline Beecham Corporation Monomeres de 3,3-(disubstitue)cyclohexan-1-one et composes apparentes

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ189230A (en) * 1977-12-27 1981-05-15 Lilly Co Eli Trans-4a-aryl-2-substituted-octahydro-1h-2-pyrindines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
WO2011140425A1 (fr) 2010-05-06 2011-11-10 Vertex Pharmaceuticals Incorporated Amides de chromène hétérocyclique-pipéridine spirocyclique utiles comme modulateurs des canaux ioniques
PT2670752E (pt) 2011-02-02 2016-06-14 Vertex Pharma Piperidinamidas pirrolopirazina-espirocíclicas como moduladores de canais iónicos
WO2012112743A1 (fr) 2011-02-18 2012-08-23 Vertex Pharmaceuticals Incorporated Amides de pipéridine spirocyclique chromanique en tant que modulateurs des canaux ioniques
MX347982B (es) 2011-03-14 2017-05-22 Vertex Pharma Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020158A1 (fr) * 1994-12-23 1996-07-04 Smithkline Beecham Corporation Monomeres de 3,3-(disubstitue)cyclohexan-1-one et composes apparentes
US5892098A (en) * 1994-12-23 1999-04-06 Smithkline Beecham Corporation 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds

Also Published As

Publication number Publication date
AR223454A1 (es) 1981-08-31
JPS5356669A (en) 1978-05-23
ATA782177A (de) 1981-10-15
PL108466B1 (en) 1980-04-30
IE45901L (en) 1978-05-02
CS211380B2 (en) 1982-02-26
PL201885A1 (pl) 1978-12-04
BE860314A (fr) 1978-04-28
SE7712218L (sv) 1978-05-03
SU845777A3 (ru) 1981-07-07
HU176231B (en) 1981-01-28
PT67194A (en) 1977-11-01
RO78300A (fr) 1982-04-12
ES472276A1 (es) 1979-10-01
SU812174A3 (ru) 1981-03-07
NL7712053A (nl) 1978-05-05
GB1590155A (en) 1981-05-28
PL108610B1 (en) 1980-04-30
RO77935A (fr) 1981-12-25
FR2369267A1 (fr) 1978-05-26
ZA776497B (en) 1979-06-27
ES463784A1 (es) 1978-06-16
NZ185539A (en) 1979-12-11
IL53236A0 (en) 1977-12-30
IE45901B1 (en) 1982-12-29
SE8103107L (sv) 1981-05-18
PT67194B (en) 1979-03-23
AU3023577A (en) 1979-05-10
SU913941A3 (en) 1982-03-15
DK485277A (da) 1978-05-03
RO72900A (fr) 1981-11-04
SE8103106L (sv) 1981-05-18
GR70053B (fr) 1982-07-26
ES463783A1 (es) 1979-07-16
FR2369267B1 (fr) 1980-05-16
PL109690B1 (en) 1980-06-30
AU513679B2 (en) 1980-12-18
CA1100136A (fr) 1981-04-28
DD133795A5 (de) 1979-01-24
PH12590A (en) 1979-06-27

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee
8128 New person/name/address of the agent

Representative=s name: SPOTT, G., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 800