DE2307299B2 - Test substance for determining kidney clearance - Google Patents

Test substance for determining kidney clearance

Info

Publication number
DE2307299B2
DE2307299B2 DE2307299A DE2307299A DE2307299B2 DE 2307299 B2 DE2307299 B2 DE 2307299B2 DE 2307299 A DE2307299 A DE 2307299A DE 2307299 A DE2307299 A DE 2307299A DE 2307299 B2 DE2307299 B2 DE 2307299B2
Authority
DE
Germany
Prior art keywords
isomaltite
test substance
inulin
clearance
kidney clearance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE2307299A
Other languages
German (de)
Other versions
DE2307299C3 (en
DE2307299A1 (en
Inventor
Hubert Dr. 6719 Obrigheim Schiweck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sueddeutsche Zucker AG
Original Assignee
Sueddeutsche Zucker AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sueddeutsche Zucker AG filed Critical Sueddeutsche Zucker AG
Priority to DE2307299A priority Critical patent/DE2307299C3/en
Priority to CH359473A priority patent/CH592141A5/xx
Priority to CH15177A priority patent/CH590060A5/xx
Priority to ES413408A priority patent/ES413408A1/en
Priority to DD180074*A priority patent/DD111803A5/xx
Priority to DD170142A priority patent/DD108323A5/xx
Priority to CA168,500A priority patent/CA1003774A/en
Priority to SE7508323A priority patent/SE405064B/en
Priority to FR7313025A priority patent/FR2179966A1/en
Priority to SE7305094A priority patent/SE393808B/en
Priority to DK198273A priority patent/DK152384C/en
Priority to NLAANVRAGE7305163,A priority patent/NL173816C/en
Priority to IE584/73A priority patent/IE37528B1/en
Publication of DE2307299A1 publication Critical patent/DE2307299A1/en
Priority to AT48775A priority patent/AT339506B/en
Priority to DK46876A priority patent/DK146703C/en
Publication of DE2307299B2 publication Critical patent/DE2307299B2/en
Application granted granted Critical
Publication of DE2307299C3 publication Critical patent/DE2307299C3/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/34—Sugar alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Claims (1)

Patentanspruch:Claim: Testsubstanz zur Nieren-Clearance-Bestimmung, dadurch gekennzeichnet, daß sie aus Isomaltit bestehtTest substance for determining kidney clearance, characterized in that it consists of isomaltite Die Erfindung betrifft die Verwendung von Isomaltit als Testsubstanz zur Nieren-Clearance-Bestimmung.The invention relates to the use of isomaltite as a test substance for determining kidney clearance. Bekanntlich wird die Nieren-Clearance-Bestimmung mit Inulin als Testsubstanz durchgeführt Da das Inulin ein hochmolekulares Polysaccharid ist (Molekulargewicht etwa 5000), ist es in wäßrigen Lösungen nur schwer löslich und kann daher nur in warmem Zustand injiziert werden. Aus diesem Grunde hat man neuerdings versucht, das Inulin teilweise abzubauen und die entstehenden Polyfruktusane zur Clearance-Bestimmung zu verwenden. Inulin und auch Polyfruktusane sind keine chemisch einheitlichen Verbindungen (unterschiedliches Molekulargewicht) und daher als Testsubstanz nicht optimal geeignet
Dagegen ist das Isomaltit eine gut kristallisierende Verbindung, daher in der benötigten Reinheit leicht herstellbar und gut wasserlöslich. Ferner enthält das Isomaltit keine reduzierenden Endgruppen und verändert sich bei der notwendigen Sterilisierung nicht
Überraschenderweise hat sich gezeigt, daß IsomaltitIt is known that kidney clearance is determined with inulin as the test substance. Since inulin is a high molecular weight polysaccharide (molecular weight about 5000), it is only sparingly soluble in aqueous solutions and can therefore only be injected when it is warm. For this reason, attempts have recently been made to partially break down the inulin and to use the resulting polyfructusans to determine the clearance. Inulin and polyfructusane are not chemically uniform compounds (different molecular weights) and are therefore not ideally suited as test substances
In contrast, isomaltite is a compound that crystallizes well and is therefore easy to produce in the required purity and is readily soluble in water. Furthermore, the isomaltite does not contain any reducing end groups and does not change during the necessary sterilization
Surprisingly, it has been shown that isomaltite ίο in einfacher und exakter Weise als Testsubstanz für die Nicren-Chlearance-Bestimmung eingesetzt werden kann. Demgemäß ist Gegenstand der Erfindung eine Testsubstanz zur Nieren-Chlearance-Bestimmung, die dadurch gekennzeichnet ist, daß sie aus- Isomaltit bestehtίο in a simple and exact way as a test substance for the Nicren chlearance determination can be used. Accordingly, the invention provides a Test substance for kidney clearance determination, which is characterized in that it consists of isomaltite consists Isomaltit in Form einer Infusionslösung intravenös appliziert, verteilt sich ungespalten im Körp^iwasser und wird über die Niere unverändert ausgeschieden. Da Isomaltit gut wasserlöslich ist und analytisch leicht erfaßt werden kann, ist es als Testsubstanz den bisher bekannten Tesisubsianzen zur Nieren-Ciearance-Bestinunung überlegen.Isomaltite applied intravenously in the form of an infusion solution, is distributed uncleaved in the body water and is excreted unchanged via the kidneys. Because isomaltite is readily soluble in water and analytically easy can be detected, it is as a test substance the previously known Tesisubsianzen for kidney Ciearance determination think.
DE2307299A 1972-04-12 1973-02-14 Test substance for determining kidney clearance Expired DE2307299C3 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
DE2307299A DE2307299C3 (en) 1973-02-14 1973-02-14 Test substance for determining kidney clearance
CH359473A CH592141A5 (en) 1972-04-12 1973-03-12
CH15177A CH590060A5 (en) 1973-02-14 1973-03-12
ES413408A ES413408A1 (en) 1972-04-12 1973-04-06 Isomalite manufacturing procedure. (Machine-translation by Google Translate, not legally binding)
DD170142A DD108323A5 (en) 1972-04-12 1973-04-09
DD180074*A DD111803A5 (en) 1972-04-12 1973-04-09
SE7305094A SE393808B (en) 1972-04-12 1973-04-11 PROCEDURE FOR THE PREPARATION OF ISOMALTITE
FR7313025A FR2179966A1 (en) 1972-04-12 1973-04-11 Isomaltite - by hydrogenation of isomaltose
CA168,500A CA1003774A (en) 1972-04-12 1973-04-11 Preparation of isomaltitol from isomaltulose obtained enzymatically from saccharose
DK198273A DK152384C (en) 1972-04-12 1973-04-11 PROCEDURE FOR MANUFACTURING ISOMALTIT
SE7508323A SE405064B (en) 1972-04-12 1973-04-11 USE OF ISOMALTITOL AS A CALORIOUS CLEANER
IE584/73A IE37528B1 (en) 1972-04-12 1973-04-12 Process for the preparation of isomaltitol
NLAANVRAGE7305163,A NL173816C (en) 1972-04-12 1973-04-12 PROCESS FOR PREPARING FOOD AND FUNCTIONS AND PROCESS FOR PREPARING A SWEETENER PREPARATION.
AT48775A AT339506B (en) 1973-02-14 1975-01-23 TEST SUBSTANCE FOR KIDNEY CLEARANCE DETERMINATION
DK46876A DK146703C (en) 1973-02-14 1976-02-04 RENEWAL FOR CLEARANCE DETERMINATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2307299A DE2307299C3 (en) 1973-02-14 1973-02-14 Test substance for determining kidney clearance

Publications (3)

Publication Number Publication Date
DE2307299A1 DE2307299A1 (en) 1974-08-22
DE2307299B2 true DE2307299B2 (en) 1981-01-15
DE2307299C3 DE2307299C3 (en) 1981-11-26

Family

ID=5871912

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2307299A Expired DE2307299C3 (en) 1972-04-12 1973-02-14 Test substance for determining kidney clearance

Country Status (2)

Country Link
CH (1) CH590060A5 (en)
DE (1) DE2307299C3 (en)

Also Published As

Publication number Publication date
DE2307299C3 (en) 1981-11-26
CH590060A5 (en) 1977-07-29
DE2307299A1 (en) 1974-08-22

Similar Documents

Publication Publication Date Title
DE2559509C2 (en) 2-Oxyindole derivatives substituted in the 5-position, processes for their preparation and medicaments which contain them
DE1617576A1 (en) Stable, aqueous oxytetracycline solutions and process for their preparation
DE2506579A1 (en) OXYTETRACYCLINE SOLUTION FOR PARENTERAL, PERORAL AND LOCAL APPLICATION AND METHOD FOR THEIR PRODUCTION
CH690490C2 (en) Anthracyclinglycosidlösung.
DE505012C (en) Process for the preparation of green developable iodized silver photographic emulsions
DE2307299B2 (en) Test substance for determining kidney clearance
DE2413512A1 (en) METHOD FOR EXTENDING THE EFFECT OF PHARMACEUTICAL SUBSTANCES
DE1518440C3 (en) Process for the preparation of a salt of a sulfomethyl derivative of polymyxin B or E.
AT339506B (en) TEST SUBSTANCE FOR KIDNEY CLEARANCE DETERMINATION
DE2829408A1 (en) PERMANENT INJECTABLE CHLORAMPHENICOL COMPOSITION
DE489726C (en) Process for the preparation of poorly soluble salts of organic bases and alkaloids
DE2122514C3 (en) 3,3 ', 4', 5,7-penta-O-benzylquercetin
DE2501805A1 (en) MEDICINAL PREPARATIONS AND METHODS FOR THEIR MANUFACTURING
DE833839C (en) Process for the preparation of water-soluble double compounds of antihistamines
DE872826C (en) Process for the preparation of easily flowing, highly concentrated aqueous suspensions of procaine-penicillin
SU423473A1 (en) DIAGNOSTIC TOOL
AT329556B (en) PROCESS FOR PRODUCING A NEW STABLE POLYMORPHIC CRYSTALLINE FORM OF 1-HYDROXY-3- (1 ', 1'-DIMETHYLHEPTYL) -6,6-DIMETHYL-6,6A, 7,8,10,10A-HEXAHYDRO-9H-DIBENZO ( B, D) PYRAN-9-ON
DE556454C (en) Process for the production of azo dyes on the fiber
DE752680C (en) Anion exchange
AT117213B (en) Process for the preparation of poorly soluble salts of organic bases and of alkaloids.
DE2556001B2 (en) Injectable ready-to-use solutions containing alkali anrenoate
DE647380C (en) Process for solubilizing hexamethylene tetramine silver salicylate in water
AT301556B (en) Process for the preparation of new 10,11-dihydro-dibenzo [b, f] azepine derivatives as well as their acid addition salts and quaternary ammonium derivatives
AT287919B (en) Process for the preparation of injection solutions of therapeutically valuable benzodiazepine derivatives
DE711158C (en) Process for the preparation of gold double compounds of the china alkaloids and their derivatives

Legal Events

Date Code Title Description
OD Request for examination
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee