DE19975042I2 - Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen. - Google Patents
Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen.Info
- Publication number
- DE19975042I2 DE19975042I2 DE1999175042 DE19975042C DE19975042I2 DE 19975042 I2 DE19975042 I2 DE 19975042I2 DE 1999175042 DE1999175042 DE 1999175042 DE 19975042 C DE19975042 C DE 19975042C DE 19975042 I2 DE19975042 I2 DE 19975042I2
- Authority
- DE
- Germany
- Prior art keywords
- pdgf
- chain
- biologically active
- factor
- secretion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/11011—Alpharetrovirus, e.g. avian leucosis virus
- C12N2740/11022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/22—Viral peptide or viral protein
- Y10S930/221—Retrovirus related, or human immunodeficiency virus related, or simian immunodeficiency virus related
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Dry Formation Of Fiberboard And The Like (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/660,496 US4769328A (en) | 1984-10-12 | 1984-10-12 | Expression of biologically active PDGF analogs in yeast |
US06/705,175 US4801542A (en) | 1984-10-12 | 1985-02-25 | Expression of biologically active PDGF analogs in eucaryotic cells |
CA000492370A CA1340212C (en) | 1984-10-12 | 1985-10-07 | Expression of biologically active platelet derived growth factor analogsin eucaryotic cells |
CA 617115 CA1340846E (en) | 1984-10-12 | 1999-06-11 | Expression of biologically active platelet derived growth factor analogs in eucaryotic cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DE19975042I2 true DE19975042I2 (de) | 2004-01-29 |
Family
ID=45478613
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE199191121387T Pending DE487116T1 (de) | 1984-10-12 | 1985-10-10 | Von blutplaettchen abstammende biologisch aktive analoga eines wachstumsfaktors in eukaryotischen zellen. |
DE3588218T Expired - Lifetime DE3588218T2 (de) | 1984-10-12 | 1985-10-10 | Von Blutplättchen abstammende biologisch aktive Analoga eines Wachstumsfaktors in eukaryotischen Zellen |
DE1999175042 Active DE19975042I2 (de) | 1984-10-12 | 1985-10-10 | Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen. |
DE3586960T Expired - Lifetime DE3586960T3 (de) | 1984-10-12 | 1985-10-10 | Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE199191121387T Pending DE487116T1 (de) | 1984-10-12 | 1985-10-10 | Von blutplaettchen abstammende biologisch aktive analoga eines wachstumsfaktors in eukaryotischen zellen. |
DE3588218T Expired - Lifetime DE3588218T2 (de) | 1984-10-12 | 1985-10-10 | Von Blutplättchen abstammende biologisch aktive Analoga eines Wachstumsfaktors in eukaryotischen Zellen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3586960T Expired - Lifetime DE3586960T3 (de) | 1984-10-12 | 1985-10-10 | Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen |
Country Status (9)
Country | Link |
---|---|
US (1) | US4801542A (de) |
EP (1) | EP0177957B2 (de) |
JP (2) | JP2837407B2 (de) |
AT (2) | ATE188255T1 (de) |
AU (2) | AU4845485A (de) |
CA (2) | CA1340212C (de) |
DE (4) | DE487116T1 (de) |
LU (1) | LU90408I2 (de) |
NL (1) | NL990016I2 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5474982A (en) * | 1986-08-13 | 1995-12-12 | Zymogenetics, Inc. | PDGF analogs and methods of use |
EP0259632B1 (de) * | 1986-08-13 | 1995-12-13 | Zymogenetics, Inc. | Expression von biologisch-aktiven PDGF-Analogen in eukaryotischen Zellen |
US5019559A (en) * | 1986-11-14 | 1991-05-28 | President And Fellows Of Harvard College | Wound healing using PDGF and IGF-II |
WO1988007057A1 (en) * | 1987-03-13 | 1988-09-22 | Amgen Inc. | Purified platelet-derived growth factor and methods for purification thereof |
US6939849B1 (en) | 1987-04-22 | 2005-09-06 | Chiron Corporation | Recombinant PDGF A-chain homodimers and methods of use |
EP0682110A1 (de) * | 1987-04-22 | 1995-11-15 | Chiron Corporation | Für PDGF-A-Ketten Polypeptiden kodierende, rekombinante DNA |
US5219759A (en) * | 1987-04-22 | 1993-06-15 | Chiron Corporation | Recombinant DNA encoding PDGF A-chain polypeptide and expression vectors |
US5094941A (en) * | 1987-12-31 | 1992-03-10 | Zymogenetics, Inc. | Monoclonal antibodies to PDGF |
US5759815A (en) * | 1988-02-11 | 1998-06-02 | Creative Biomolecules, Inc. | Production of platelet derived growth factor (PDGF) an muteins thereof |
JP2892726B2 (ja) * | 1988-06-30 | 1999-05-17 | コア セラピューティクス,インコーポレイティド | 血小板阻止ペプチド |
US5037743A (en) * | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
DE3900770A1 (de) * | 1989-01-12 | 1990-07-26 | Juergen Prof Dr Hoppe | Verfahren zur herstellung von pdgf-a und pdgf-aa |
US6899882B1 (en) * | 1989-03-24 | 2005-05-31 | The Regents Of The University Of California | Endothelial cell growth factor methods of isolation and expression |
US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
US5219739A (en) * | 1989-07-27 | 1993-06-15 | Scios Nova Inc. | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 |
US5272064A (en) * | 1989-12-19 | 1993-12-21 | Amgen Inc. | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
US6172039B1 (en) | 1990-04-16 | 2001-01-09 | Apex Bioscience, Inc. | Expression of recombinant hemoglobin and hemoglobin variants in yeast |
WO1992001716A1 (en) * | 1990-07-23 | 1992-02-06 | Zymogenetics, Inc. | Protease resistant pdgf and methods of use |
US5886141A (en) * | 1990-10-26 | 1999-03-23 | Takeda Chemical Industries, Ltd. | Smooth muscle mitogen peptides and DNA coding therefor |
GB9101645D0 (en) * | 1991-01-25 | 1991-03-06 | British Bio Technology | Compounds |
DE69306273T2 (de) * | 1992-02-10 | 1997-04-03 | Childrens Medical Center | Mitogen für die glatte Muskulatur und dessen kodierende DNS |
ES2224178T3 (es) * | 1995-10-11 | 2005-03-01 | Chiron Corporation | Cobinacion de pdgf, kgf,igf e igfbp para la cicatrizacion de heridas. |
ATE398139T1 (de) | 1996-12-13 | 2008-07-15 | Novartis Vaccines & Diagnostic | Analyse und separation von pdgf-proteinen |
DE69838483T2 (de) | 1997-10-14 | 2008-07-03 | Darwin Molecular Corp. | Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten |
US6194169B1 (en) * | 1998-06-04 | 2001-02-27 | The University Of Kentucky Research Foundation | Enhanced expression of human platelet-derived growth factor in Pichia pastoris |
CA2352532C (en) | 1998-11-27 | 2014-10-14 | Darwin Discovery Ltd. | Compositions and methods for increasing bone mineralization |
US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
US7063850B1 (en) * | 1998-12-22 | 2006-06-20 | University Of Tennessee Research Foundation | Protective antigen of group A Streptococci |
US6358733B1 (en) * | 2000-05-19 | 2002-03-19 | Apolife, Inc. | Expression of heterologous multi-domain proteins in yeast |
WO2002090600A2 (en) | 2001-05-08 | 2002-11-14 | Darwin Molecular Corporation | A method for regulating immune function in primates using the foxp3 protein |
MXPA04003852A (es) * | 2001-10-26 | 2005-02-17 | Univ Tennessee Res Foundation | Composiciones de vacuna estreptococica multivalente, y metodos para sus uso. |
JP2006506317A (ja) | 2002-01-11 | 2006-02-23 | バイオマリン ファーマシューティカル インコーポレイテッド | 治療用リソソーム酵素の送達のための酵素送達系としてのp97の使用 |
US20030139333A1 (en) * | 2002-01-18 | 2003-07-24 | Genetix Pharmaceuticals, Inc. | Methods and compositions for promoting angiogenesis |
US20050048041A1 (en) * | 2003-01-13 | 2005-03-03 | Rao Mahendra S. | Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products |
US20080119433A1 (en) * | 2006-07-06 | 2008-05-22 | Aaron Thomas Tabor | Compositions and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance |
EP2094301A4 (de) * | 2006-11-30 | 2012-02-01 | Taplmmune Inc | Behandlung von poxviridae mit tap-1 und/oder tap-2 als molekulares adjuvans |
CN102471769A (zh) | 2009-07-17 | 2012-05-23 | 亚伦·T.·塔波尔 | 用于具有美容功能的细胞的遗传修饰以提高美容外观的方法和组合物 |
US9150846B2 (en) | 2011-07-05 | 2015-10-06 | Bioasis Technologies, Inc. | P97-antibody conjugates and methods of use |
PT2739649T (pt) | 2011-08-05 | 2018-01-03 | Bioasis Technologies Inc | Fragmentos de p97 com atividade de transferência |
AU2013296557B2 (en) | 2012-07-31 | 2019-04-18 | Bioasis Technologies Inc. | Dephosphorylated lysosomal storage disease proteins and methods of use thereof |
CN110478481A (zh) | 2013-03-13 | 2019-11-22 | 比奥阿赛斯技术有限公司 | p97片段及其应用 |
AU2014236208B2 (en) | 2013-03-14 | 2018-07-19 | Genvivo, Inc. | Thymidine kinase diagnostic assay for gene therapy applications |
JP6603227B2 (ja) | 2014-02-03 | 2019-11-06 | バイオアシス テクノロジーズ インコーポレイテッド | P97融合タンパク質 |
WO2015126729A1 (en) | 2014-02-19 | 2015-08-27 | Bioasis Technologies, Inc. | P97-ids fusion proteins |
CA2943890A1 (en) | 2014-05-01 | 2015-11-05 | Bioasis Technologies, Inc. | P97-polynucleotide conjugates |
EP3206670A4 (de) | 2014-10-14 | 2018-06-20 | Samuel Lynch | Zusammensetzung zur behandlung von wunden |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4350687A (en) * | 1980-02-10 | 1982-09-21 | Research Corporation | Platelet derived cell growth factor |
AU600885B2 (en) * | 1984-05-25 | 1990-08-30 | Zymogenetics Inc. | Stable DNA constructs |
-
1985
- 1985-02-25 US US06/705,175 patent/US4801542A/en not_active Expired - Lifetime
- 1985-10-07 CA CA000492370A patent/CA1340212C/en not_active Expired - Lifetime
- 1985-10-10 AT AT91121387T patent/ATE188255T1/de not_active IP Right Cessation
- 1985-10-10 DE DE199191121387T patent/DE487116T1/de active Pending
- 1985-10-10 DE DE3588218T patent/DE3588218T2/de not_active Expired - Lifetime
- 1985-10-10 DE DE1999175042 patent/DE19975042I2/de active Active
- 1985-10-10 EP EP85112852A patent/EP0177957B2/de not_active Expired - Lifetime
- 1985-10-10 AU AU48454/85A patent/AU4845485A/en not_active Abandoned
- 1985-10-10 AT AT85112852T patent/ATE84312T1/de active
- 1985-10-10 DE DE3586960T patent/DE3586960T3/de not_active Expired - Lifetime
- 1985-10-11 JP JP60226637A patent/JP2837407B2/ja not_active Expired - Lifetime
-
1990
- 1990-05-10 AU AU54885/90A patent/AU638010B2/en not_active Expired
-
1997
- 1997-10-16 JP JP28366397A patent/JP3145968B2/ja not_active Expired - Lifetime
-
1999
- 1999-05-28 NL NL990016C patent/NL990016I2/nl unknown
- 1999-06-11 CA CA 617115 patent/CA1340846E/en not_active Expired - Lifetime
- 1999-06-25 LU LU90408C patent/LU90408I2/fr unknown
Also Published As
Publication number | Publication date |
---|---|
AU5488590A (en) | 1991-01-31 |
EP0177957B1 (de) | 1993-01-07 |
NL990016I2 (nl) | 1999-11-01 |
ATE84312T1 (de) | 1993-01-15 |
US4801542A (en) | 1989-01-31 |
DE3586960D1 (de) | 1993-02-18 |
LU90408I2 (fr) | 1999-08-25 |
ATE188255T1 (de) | 2000-01-15 |
DE487116T1 (de) | 1992-10-15 |
AU638010B2 (en) | 1993-06-17 |
JPH10117790A (ja) | 1998-05-12 |
NL990016I1 (nl) | 1999-08-02 |
DE3588218D1 (de) | 2000-02-03 |
JP2837407B2 (ja) | 1998-12-16 |
EP0177957A3 (en) | 1988-02-03 |
EP0177957A2 (de) | 1986-04-16 |
JPS62278A (ja) | 1987-01-06 |
DE3586960T2 (de) | 1993-05-13 |
CA1340212C (en) | 1998-12-15 |
DE3588218T2 (de) | 2000-05-18 |
JP3145968B2 (ja) | 2001-03-12 |
AU4845485A (en) | 1986-04-17 |
CA1340846E (en) | 1999-12-07 |
DE3586960T3 (de) | 2005-01-20 |
EP0177957B2 (de) | 2004-08-25 |
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