DE19975042I2 - Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen. - Google Patents

Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen.

Info

Publication number
DE19975042I2
DE19975042I2 DE1999175042 DE19975042C DE19975042I2 DE 19975042 I2 DE19975042 I2 DE 19975042I2 DE 1999175042 DE1999175042 DE 1999175042 DE 19975042 C DE19975042 C DE 19975042C DE 19975042 I2 DE19975042 I2 DE 19975042I2
Authority
DE
Germany
Prior art keywords
pdgf
chain
biologically active
factor
secretion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE1999175042
Other languages
English (en)
Inventor
Mark Joseph Murray
James Darrel Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45478613&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE19975042(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/660,496 external-priority patent/US4769328A/en
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of DE19975042I2 publication Critical patent/DE19975042I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/11011—Alpharetrovirus, e.g. avian leucosis virus
    • C12N2740/11022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/22—Viral peptide or viral protein
    • Y10S930/221—Retrovirus related, or human immunodeficiency virus related, or simian immunodeficiency virus related

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Dry Formation Of Fiberboard And The Like (AREA)
DE1999175042 1984-10-12 1985-10-10 Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen. Active DE19975042I2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/660,496 US4769328A (en) 1984-10-12 1984-10-12 Expression of biologically active PDGF analogs in yeast
US06/705,175 US4801542A (en) 1984-10-12 1985-02-25 Expression of biologically active PDGF analogs in eucaryotic cells
CA000492370A CA1340212C (en) 1984-10-12 1985-10-07 Expression of biologically active platelet derived growth factor analogsin eucaryotic cells
CA 617115 CA1340846E (en) 1984-10-12 1999-06-11 Expression of biologically active platelet derived growth factor analogs in eucaryotic cells

Publications (1)

Publication Number Publication Date
DE19975042I2 true DE19975042I2 (de) 2004-01-29

Family

ID=45478613

Family Applications (4)

Application Number Title Priority Date Filing Date
DE199191121387T Pending DE487116T1 (de) 1984-10-12 1985-10-10 Von blutplaettchen abstammende biologisch aktive analoga eines wachstumsfaktors in eukaryotischen zellen.
DE3588218T Expired - Lifetime DE3588218T2 (de) 1984-10-12 1985-10-10 Von Blutplättchen abstammende biologisch aktive Analoga eines Wachstumsfaktors in eukaryotischen Zellen
DE1999175042 Active DE19975042I2 (de) 1984-10-12 1985-10-10 Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen.
DE3586960T Expired - Lifetime DE3586960T3 (de) 1984-10-12 1985-10-10 Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE199191121387T Pending DE487116T1 (de) 1984-10-12 1985-10-10 Von blutplaettchen abstammende biologisch aktive analoga eines wachstumsfaktors in eukaryotischen zellen.
DE3588218T Expired - Lifetime DE3588218T2 (de) 1984-10-12 1985-10-10 Von Blutplättchen abstammende biologisch aktive Analoga eines Wachstumsfaktors in eukaryotischen Zellen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3586960T Expired - Lifetime DE3586960T3 (de) 1984-10-12 1985-10-10 Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen

Country Status (9)

Country Link
US (1) US4801542A (de)
EP (1) EP0177957B2 (de)
JP (2) JP2837407B2 (de)
AT (2) ATE188255T1 (de)
AU (2) AU4845485A (de)
CA (2) CA1340212C (de)
DE (4) DE487116T1 (de)
LU (1) LU90408I2 (de)
NL (1) NL990016I2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474982A (en) * 1986-08-13 1995-12-12 Zymogenetics, Inc. PDGF analogs and methods of use
EP0259632B1 (de) * 1986-08-13 1995-12-13 Zymogenetics, Inc. Expression von biologisch-aktiven PDGF-Analogen in eukaryotischen Zellen
US5019559A (en) * 1986-11-14 1991-05-28 President And Fellows Of Harvard College Wound healing using PDGF and IGF-II
WO1988007057A1 (en) * 1987-03-13 1988-09-22 Amgen Inc. Purified platelet-derived growth factor and methods for purification thereof
US6939849B1 (en) 1987-04-22 2005-09-06 Chiron Corporation Recombinant PDGF A-chain homodimers and methods of use
EP0682110A1 (de) * 1987-04-22 1995-11-15 Chiron Corporation Für PDGF-A-Ketten Polypeptiden kodierende, rekombinante DNA
US5219759A (en) * 1987-04-22 1993-06-15 Chiron Corporation Recombinant DNA encoding PDGF A-chain polypeptide and expression vectors
US5094941A (en) * 1987-12-31 1992-03-10 Zymogenetics, Inc. Monoclonal antibodies to PDGF
US5759815A (en) * 1988-02-11 1998-06-02 Creative Biomolecules, Inc. Production of platelet derived growth factor (PDGF) an muteins thereof
JP2892726B2 (ja) * 1988-06-30 1999-05-17 コア セラピューティクス，インコーポレイティド 血小板阻止ペプチド
US5037743A (en) * 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
DE3900770A1 (de) * 1989-01-12 1990-07-26 Juergen Prof Dr Hoppe Verfahren zur herstellung von pdgf-a und pdgf-aa
US6899882B1 (en) * 1989-03-24 2005-05-31 The Regents Of The University Of California Endothelial cell growth factor methods of isolation and expression
US5686410A (en) * 1989-07-20 1997-11-11 Novartis Ag Polypeptide derivatives
US5219739A (en) * 1989-07-27 1993-06-15 Scios Nova Inc. DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121
US5272064A (en) * 1989-12-19 1993-12-21 Amgen Inc. DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
WO1992001716A1 (en) * 1990-07-23 1992-02-06 Zymogenetics, Inc. Protease resistant pdgf and methods of use
US5886141A (en) * 1990-10-26 1999-03-23 Takeda Chemical Industries, Ltd. Smooth muscle mitogen peptides and DNA coding therefor
GB9101645D0 (en) * 1991-01-25 1991-03-06 British Bio Technology Compounds
DE69306273T2 (de) * 1992-02-10 1997-04-03 Childrens Medical Center Mitogen für die glatte Muskulatur und dessen kodierende DNS
ES2224178T3 (es) * 1995-10-11 2005-03-01 Chiron Corporation Cobinacion de pdgf, kgf,igf e igfbp para la cicatrizacion de heridas.
ATE398139T1 (de) 1996-12-13 2008-07-15 Novartis Vaccines & Diagnostic Analyse und separation von pdgf-proteinen
DE69838483T2 (de) 1997-10-14 2008-07-03 Darwin Molecular Corp. Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten
US6194169B1 (en) * 1998-06-04 2001-02-27 The University Of Kentucky Research Foundation Enhanced expression of human platelet-derived growth factor in Pichia pastoris
CA2352532C (en) 1998-11-27 2014-10-14 Darwin Discovery Ltd. Compositions and methods for increasing bone mineralization
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
US7063850B1 (en) * 1998-12-22 2006-06-20 University Of Tennessee Research Foundation Protective antigen of group A Streptococci
US6358733B1 (en) * 2000-05-19 2002-03-19 Apolife, Inc. Expression of heterologous multi-domain proteins in yeast
WO2002090600A2 (en) 2001-05-08 2002-11-14 Darwin Molecular Corporation A method for regulating immune function in primates using the foxp3 protein
MXPA04003852A (es) * 2001-10-26 2005-02-17 Univ Tennessee Res Foundation Composiciones de vacuna estreptococica multivalente, y metodos para sus uso.
JP2006506317A (ja) 2002-01-11 2006-02-23 バイオマリン ファーマシューティカル インコーポレイテッド 治療用リソソーム酵素の送達のための酵素送達系としてのｐ９７の使用
US20030139333A1 (en) * 2002-01-18 2003-07-24 Genetix Pharmaceuticals, Inc. Methods and compositions for promoting angiogenesis
US20050048041A1 (en) * 2003-01-13 2005-03-03 Rao Mahendra S. Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products
US20080119433A1 (en) * 2006-07-06 2008-05-22 Aaron Thomas Tabor Compositions and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance
EP2094301A4 (de) * 2006-11-30 2012-02-01 Taplmmune Inc Behandlung von poxviridae mit tap-1 und/oder tap-2 als molekulares adjuvans
CN102471769A (zh) 2009-07-17 2012-05-23 亚伦·T.·塔波尔 用于具有美容功能的细胞的遗传修饰以提高美容外观的方法和组合物
US9150846B2 (en) 2011-07-05 2015-10-06 Bioasis Technologies, Inc. P97-antibody conjugates and methods of use
PT2739649T (pt) 2011-08-05 2018-01-03 Bioasis Technologies Inc Fragmentos de p97 com atividade de transferência
AU2013296557B2 (en) 2012-07-31 2019-04-18 Bioasis Technologies Inc. Dephosphorylated lysosomal storage disease proteins and methods of use thereof
CN110478481A (zh) 2013-03-13 2019-11-22 比奥阿赛斯技术有限公司 p97片段及其应用
AU2014236208B2 (en) 2013-03-14 2018-07-19 Genvivo, Inc. Thymidine kinase diagnostic assay for gene therapy applications
JP6603227B2 (ja) 2014-02-03 2019-11-06 バイオアシス テクノロジーズ インコーポレイテッド Ｐ９７融合タンパク質
WO2015126729A1 (en) 2014-02-19 2015-08-27 Bioasis Technologies, Inc. P97-ids fusion proteins
CA2943890A1 (en) 2014-05-01 2015-11-05 Bioasis Technologies, Inc. P97-polynucleotide conjugates
EP3206670A4 (de) 2014-10-14 2018-06-20 Samuel Lynch Zusammensetzung zur behandlung von wunden

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350687A (en) * 1980-02-10 1982-09-21 Research Corporation Platelet derived cell growth factor
AU600885B2 (en) * 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs

Also Published As

Publication number Publication date
AU5488590A (en) 1991-01-31
EP0177957B1 (de) 1993-01-07
NL990016I2 (nl) 1999-11-01
ATE84312T1 (de) 1993-01-15
US4801542A (en) 1989-01-31
DE3586960D1 (de) 1993-02-18
LU90408I2 (fr) 1999-08-25
ATE188255T1 (de) 2000-01-15
DE487116T1 (de) 1992-10-15
AU638010B2 (en) 1993-06-17
JPH10117790A (ja) 1998-05-12
NL990016I1 (nl) 1999-08-02
DE3588218D1 (de) 2000-02-03
JP2837407B2 (ja) 1998-12-16
EP0177957A3 (en) 1988-02-03
EP0177957A2 (de) 1986-04-16
JPS62278A (ja) 1987-01-06
DE3586960T2 (de) 1993-05-13
CA1340212C (en) 1998-12-15
DE3588218T2 (de) 2000-05-18
JP3145968B2 (ja) 2001-03-12
AU4845485A (en) 1986-04-17
CA1340846E (en) 1999-12-07
DE3586960T3 (de) 2005-01-20
EP0177957B2 (de) 2004-08-25

Similar Documents

Publication Publication Date Title
DE19975042I2 (de) Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen.
KR910015309A (ko) 종양괴사인자(tnf) 억제제 및 그 제조방법
NO174965C (no) Syntetisk polypeptidanalog av humaninsulinlignende vekstfaktor med redusert binding til bærerproteiner i serum, samt syntetiske gener som koder for slike analoger og preparater som omfatter en slik analog
IL88223A0 (en) Polypeptides,process,nucleotide sequences,expression vectors and host organisms for their production and pharmaceutical compositions comprising them
DE69020335D1 (de) B-ketten-analoge des von blutplättchen abstammenden wachstumsfaktors und verfahren zu deren homogener herstellung.
DE3786321D1 (de) Expression von protein-c.
NO179106C (no) Fremgangsmåte for fremstilling av og ekspresjonssystem som koder for og kan uttrykke et rekombinant proteinkompleks med humanfaktor V111:C-aktivitet
ATE50596T1 (de) Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung.
AU7681687A (en) Expression of platelet-derived growth factor and analogues
ATE93272T1 (de) Expression von protein c.
DK92784D0 (da) Dna-struktur til anvendelse ved fremstilling af insulin
EP0287075A3 (en) Process for the construction of an animal cell line for the production of human beta-interferon
ES2078243T3 (es) Mejoras en o relativas a la expresion eucariotica.
PT82860B (pt) Metodo para a producao da hormona de crescimento suina
AU6020086A (en) High level production of bovine growth hormone
JPS6437291A (en) Human cytochrome c gene and use thereof
DE3650477D1 (de) Produktion von Cystinreste enthaltenden aktiven Proteinen
HUP9800520A2 (hu) Génexpresszió emlős sejtekben
SU592399A1 (ru) Стимул тор выгонки лука
JPS6479200A (en) Human placental decidual cell-derived protein
DE58909205D1 (de) Expressionsvektor und Verfahren zur regulierbaren Herstellung von Proteinen in Eukaryonten.
JPS54110384A (en) Culturing medium for humanized lymphocyte