DD284044A5 - Verfahren zur herstellung von desulfatohirudinmutanten - Google Patents

Verfahren zur herstellung von desulfatohirudinmutanten Download PDF

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Publication number
DD284044A5
DD284044A5 DD89330939A DD33093989A DD284044A5 DD 284044 A5 DD284044 A5 DD 284044A5 DD 89330939 A DD89330939 A DD 89330939A DD 33093989 A DD33093989 A DD 33093989A DD 284044 A5 DD284044 A5 DD 284044A5
Authority
DD
German Democratic Republic
Prior art keywords
giu
dna
asn
leu
desulphatohirudin
Prior art date
Application number
DD89330939A
Other languages
German (de)
English (en)
Inventor
Stuart R Stone
Stanley Dennis
Jan Hofsteenge
Bernd Meyhack
Andrew Wallace
Hugo Grossenbacher
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ����`��@���k��, ���@���`������@��k�� filed Critical ����`��@���k��
Publication of DD284044A5 publication Critical patent/DD284044A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DD89330939A 1988-07-19 1989-07-18 Verfahren zur herstellung von desulfatohirudinmutanten DD284044A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888817161A GB8817161D0 (en) 1988-07-19 1988-07-19 Modified proteins

Publications (1)

Publication Number Publication Date
DD284044A5 true DD284044A5 (de) 1990-10-31

Family

ID=10640715

Family Applications (1)

Application Number Title Priority Date Filing Date
DD89330939A DD284044A5 (de) 1988-07-19 1989-07-18 Verfahren zur herstellung von desulfatohirudinmutanten

Country Status (13)

Country Link
EP (1) EP0352227A3 (no)
JP (1) JPH02119792A (no)
KR (1) KR900001849A (no)
AU (1) AU3804689A (no)
DD (1) DD284044A5 (no)
DK (1) DK354989A (no)
FI (1) FI893450A (no)
GB (1) GB8817161D0 (no)
HU (1) HUT51670A (no)
IL (1) IL91002A0 (no)
NO (1) NO892948L (no)
PT (1) PT91189A (no)
ZA (1) ZA895461B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
US5837808A (en) * 1991-08-20 1998-11-17 Baxter International Inc. Analogs of hirudin
GB9401447D0 (en) 1994-01-26 1994-03-23 Ciba Geigy Ag Pharmaceutical compositions
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
CN115677850B (zh) * 2021-07-24 2024-03-08 王大勇 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE64956T1 (de) * 1984-06-14 1991-07-15 Ciba Geigy Ag Verfahren zur herstellung von thrombininhibitoren.
FR2607517B2 (fr) * 1986-12-01 1989-12-22 Transgene Sa Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu

Also Published As

Publication number Publication date
DK354989A (da) 1990-01-20
FI893450A0 (fi) 1989-07-17
EP0352227A2 (en) 1990-01-24
NO892948L (no) 1990-01-22
EP0352227A3 (en) 1990-07-11
NO892948D0 (no) 1989-07-18
JPH02119792A (ja) 1990-05-07
IL91002A0 (en) 1990-02-09
FI893450A (fi) 1990-01-20
AU3804689A (en) 1990-01-25
ZA895461B (en) 1990-02-28
HUT51670A (en) 1990-05-28
PT91189A (pt) 1990-02-08
KR900001849A (ko) 1990-02-27
DK354989D0 (da) 1989-07-18
GB8817161D0 (en) 1988-08-24

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